Thrombopoietin promotes NHEJ DNA repair in hematopoietic stem cells through specific activation of Erk and NF- B pathways and their target, IEX-1

Erk1 and Erk2 are required for maintenance of hematopoietic stem cells and adult hematopoiesis

(2013) G. Chan et al.   BLOOD

Deletion of the NF- B subunit p65/RelA in the hematopoietic compartment leads to defects in hematopoietic stem cell function

(2013) S. J. Stein et al.   BLOOD

Megakaryocytes promote murine osteoblastic HSC niche expansion and stem cell engraftment after radioablative conditioning

(2013) T. S. Olson et al.   BLOOD

Myelodysplastic syndrome: An inability to appropriately respond to damaged DNA?

(2013) Ting Zhou et al.   EXPERIMENTAL HEMATOLOGY

Simultaneous analysis of the expression of 14 genes with individual prognostic value in myelodysplastic syndrome patients at diagnosis: WT1 detection in peripheral blood adversely affects survival

(2012) Carlos Santamaría et al.   ANNALS OF HEMATOLOGY

DNA damage-induced cell death: From specific DNA lesions to the DNA damage response and apoptosis

(2012) Wynand P. Roos et al.   CANCER LETTERS

Temporal Changes in PTEN and mTORC2 Regulation of Hematopoietic Stem Cell Self-Renewal and Leukemia Suppression

(2012) Jeffrey A. Magee et al.   Cell Stem Cell

Non-homologous end joining mediated DNA repair is impaired in the NUP98-HOXD13 mouse model for myelodysplastic syndrome

(2012) Abdul Gafoor Puthiyaveetil et al.   LEUKEMIA RESEARCH

ERK1 Regulates the Hematopoietic Stem Cell Niches

(2012) Nathalie Saulnier et al.   PLoS One

Signaling Profiling at the Single-Cell Level Identifies a Distinct Signaling Signature in Murine Hematopoietic Stem Cells

(2012) Juan Du et al.   STEM CELLS

Extracellular Signal-Regulated Kinases Modulate DNA Damage Response - A Contributing Factor to Using MEK Inhibitors in Cancer Therapy

(2011) F. Wei et al.   CURRENT MEDICINAL CHEMISTRY

Signals from the Nucleus: Activation of NF- B by Cytosolic ATM in the DNA Damage Response

(2011) K. Hadian et al.   Science Signaling

Ionizing radiation and hematopoietic malignancies: Altering the adaptive landscape

(2010) Courtney J. Fleenor et al.   CELL CYCLE

ATM-dependent expression of IEX-1 controls nuclear accumulation of Mcl-1 and the DNA damage response

(2010) P Pawlikowska et al.   CELL DEATH AND DIFFERENTIATION

Hematopoietic Stem Cell Quiescence Promotes Error-Prone DNA Repair and Mutagenesis

(2010) Mary Mohrin et al.   Cell Stem Cell

Restoration and reversible expansion of the osteoblastic hematopoietic stem cell niche after marrow radioablation

(2009) M. Dominici et al.   BLOOD

Total body irradiation causes residual bone marrow injury by induction of persistent oxidative stress in murine hematopoietic stem cells

(2009) Yong Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Differential gene expression of bone marrow-derived CD34+ cells is associated with survival of patients suffering from myelodysplastic syndrome

(2009) Wolf C. Prall et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Nanofluidic proteomic assay for serial analysis of oncoprotein activation in clinical specimens

(2009) Alice C Fan et al.   NATURE MEDICINE

Phenotypic and Functional Changes Induced in Hematopoietic Stem/Progenitor Cells After Gamma-Ray Radiation Exposure

(2009) Arthur J. Simonnet et al.   STEM CELLS

DNA instability in low-risk myelodysplastic syndromes: refractory anemia with or without ring sideroblasts

(2008) B. Novotna et al.   HUMAN MOLECULAR GENETICS

Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair

(2008) M. Toulany et al.   MOLECULAR CANCER THERAPEUTICS