The power of DNA double-strand break (DSB) repair testing to predict breast cancer susceptibility

BRCA1-mediated repression of mutagenic end-joining of DNA double-strand breaks requires complex formation with BACH1

(2011) Lisa Dohrn et al.   BIOCHEMICAL JOURNAL

Expression of DNA repair genes in ovarian cancer samples: Biological and clinical considerations

(2011) M. Ganzinelli et al.   EUROPEAN JOURNAL OF CANCER

Functional characterization connects individual patient mutations in ataxia telangiectasia mutated (ATM) with dysfunction of specific DNA double-strand break-repair signaling pathways

(2011) Marlen Keimling et al.   FASEB JOURNAL

Targeting poly(ADP-ribose) polymerase activity for cancer therapy

(2010) Frédérique Mégnin-Chanet et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Estrogens, regulation of p53 and breast cancer risk: a balancing act

(2010) D. Joseph Jerry et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Histone  H2AX and Poly(ADP-Ribose) as Clinical Pharmacodynamic Biomarkers

(2010) C. E. Redon et al.   CLINICAL CANCER RESEARCH

Development of a Functional Assay for Homologous Recombination Status in Primary Cultures of Epithelial Ovarian Tumor and Correlation with Sensitivity to Poly(ADP-Ribose) Polymerase Inhibitors

(2010) A. Mukhopadhyay et al.   CLINICAL CANCER RESEARCH

The role of BRCA mutation testing in determining breast cancer therapy

(2010) Alison H. Trainer et al.   Nature Reviews Clinical Oncology

DNA resection in eukaryotes: deciding how to fix the break

(2010) Pablo Huertas   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Genetic polymorphisms in DNA repair and damage response genes and late normal tissue complications of radiotherapy for breast cancer

(2009) J Chang-Claude et al.   BRITISH JOURNAL OF CANCER

DNA double-strand break repair activities in mammary epithelial cells--influence of endogenous p53 variants

(2009) M. Keimling et al.   CARCINOGENESIS

Utility of DNA Repair Protein Foci for the Detection of Putative BRCA1 Pathway Defects in Breast Cancer Biopsies

(2009) H. Willers et al.   MOLECULAR CANCER RESEARCH

Inhibition of Poly(ADP-Ribose) Polymerase in Tumors fromBRCAMutation Carriers

(2009) Peter C. Fong et al.   NEW ENGLAND JOURNAL OF MEDICINE

First Revision of the German S3 Guideline ‘Diagnosis, Therapy, and Follow-Up of Breast Cancer’

(2008) Achim Wöckel et al.   Breast Care

Functional Assays for Classification of BRCA2 Variants of Uncertain Significance

(2008) D. J. Farrugia et al.   CANCER RESEARCH

Hereditary breast cancer: new genetic developments, new therapeutic avenues

(2008) Philippe M. Campeau et al.   HUMAN GENETICS

A sensitive test for the detection of specific DSB repair defects in primary cells from breast cancer specimens

(2008) Marlen Keimling et al.   INTERNATIONAL JOURNAL OF CANCER

A Synthetic Lethal Therapeutic Approach: Poly(ADP) Ribose Polymerase Inhibitors for the Treatment of Cancers Deficient in DNA Double-Strand Break Repair

(2008) Alan Ashworth   JOURNAL OF CLINICAL ONCOLOGY

The emerging landscape of breast cancer susceptibility

(2007) Michael R Stratton et al.   NATURE GENETICS