The DLK signalling pathway—a double-edged sword in neural development and regeneration

DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury

(2013) T. A. Watkins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death

(2013) D. S. Welsbie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kinesin-13 and Tubulin Posttranslational Modifications Regulate Microtubule Growth in Axon Regeneration

(2012) Anindya Ghosh-Roy et al.   DEVELOPMENTAL CELL

Axonal transcription factors signal retrogradely in lesioned peripheral nerve

(2012) Keren Ben-Yaakov et al.   EMBO JOURNAL

Axon degeneration: Molecular mechanisms of a self-destruction pathway

(2012) Jack T. Wang et al.   JOURNAL OF CELL BIOLOGY

Regulation of DLK-1 Kinase Activity by Calcium-Mediated Dissociation from an Inhibitory Isoform

(2012) Dong Yan et al.   NEURON

Dual Leucine Zipper Kinase Is Required for Retrograde Injury Signaling and Axonal Regeneration

(2012) Jung Eun Shin et al.   NEURON

SCG10 is a JNK target in the axonal degeneration pathway

(2012) J. E. Shin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Highwire Ubiquitin Ligase Promotes Axonal Degeneration by Tuning Levels of Nmnat Protein

(2012) Xin Xiong et al.   PLOS BIOLOGY

Growth Cone MKK7 mRNA Targeting Regulates MAP1b-Dependent Microtubule Bundling to Control Neurite Elongation

(2012) Daniel Feltrin et al.   PLOS BIOLOGY

Neuronal Intrinsic Mechanisms of Axon Regeneration

(2011) Kai Liu et al.   Annual Review of Neuroscience

DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity

(2011) Arundhati Sengupta Ghosh et al.   JOURNAL OF CELL BIOLOGY

ZPK/DLK, a Mitogen-Activated Protein Kinase Kinase Kinase, Is a Critical Mediator of Programmed Cell Death of Motoneurons

(2011) A. Itoh et al.   JOURNAL OF NEUROSCIENCE

Axon Formation in Neocortical Neurons Depends on Stage-Specific Regulation of Microtubule Stability by the Dual Leucine Zipper Kinase-c-Jun N-Terminal Kinase Pathway

(2011) S.-i. Hirai et al.   JOURNAL OF NEUROSCIENCE

Cytoplasmic Linker Proteins Regulate Neuronal Polarization through Microtubule and Growth Cone Dynamics

(2011) D. Neukirchen et al.   JOURNAL OF NEUROSCIENCE

Taxol Facilitates Axon Regeneration in the Mature CNS

(2011) V. Sengottuvel et al.   JOURNAL OF NEUROSCIENCE

Axon Regeneration Pathways Identified by Systematic Genetic Screening in C. elegans

(2011) Lizhen Chen et al.   NEURON

In vivo imaging reveals a phase-specific role of STAT3 during central and peripheral nervous system axon regeneration

(2011) F. M. Bareyre et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Axon regeneration requires coordinate activation of p38 and JNK MAPK pathways

(2011) P. Nix et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microtubule Stabilization Reduces Scarring and Causes Axon Regeneration After Spinal Cord Injury

(2011) F. Hellal et al.   SCIENCE

Axon regeneration mechanisms: insights from C. elegans

(2011) Lizhen Chen et al.   TRENDS IN CELL BIOLOGY

Wallerian Degeneration, WldS, and Nmnat

(2010) Michael P. Coleman et al.   Annual Review of Neuroscience

Protein turnover of the Wallenda/DLK kinase regulates a retrograde response to axonal injury

(2010) Xin Xiong et al.   JOURNAL OF CELL BIOLOGY

A JIP3-Regulated GSK3 /DCX Signaling Pathway Restricts Axon Branching

(2010) P. M. Bilimoria et al.   JOURNAL OF NEUROSCIENCE

Rac1 Regulates Neuronal Polarization through the WAVE Complex

(2010) S. Tahirovic et al.   JOURNAL OF NEUROSCIENCE

Calcium and Cyclic AMP Promote Axonal Regeneration in Caenorhabditis elegans and Require DLK-1 Kinase

(2010) A. Ghosh-Roy et al.   JOURNAL OF NEUROSCIENCE

Caenorhabditis elegans EFA-6 limits microtubule growth at the cell cortex

(2010) Sean M. O'Rourke et al.   NATURE CELL BIOLOGY

Initiating and Growing an Axon

(2010) F. Polleux et al.   Cold Spring Harbor Perspectives in Biology

Impaired regenerative response of primary sensory neurons in ZPK/DLK gene-trap mice

(2009) Aki Itoh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The DLK-1 Kinase Promotes mRNA Stability and Local Translation in C. elegans Synapses and Axon Regeneration

(2009) Dong Yan et al.   CELL

Local calcium-dependent mechanisms determine whether a cut axonal end assembles a retarded endbulb or competent growth cone

(2009) Dotan Kamber et al.   EXPERIMENTAL NEUROLOGY

A dual leucine kinase–dependent axon self-destruction program promotes Wallerian degeneration

(2009) Bradley R Miller et al.   NATURE NEUROSCIENCE

Role of dual leucine zipper-bearing kinase (DLK/MUK/ZPK) in axonal growth

(2009) Kaoru Eto et al.   NEUROSCIENCE RESEARCH

Axon Regeneration Requires a Conserved MAP Kinase Pathway

(2009) M. Hammarlund et al.   SCIENCE

Neuronal Polarity

(2009) S. Tahirovic et al.   Cold Spring Harbor Perspectives in Biology

Nerve injury signaling

(2008) Namiko Abe et al.   CURRENT OPINION IN NEUROBIOLOGY

Microtubule stabilization specifies initial neuronal polarization

(2008) Harald Witte et al.   JOURNAL OF CELL BIOLOGY

Antiapoptotic and Trophic Effects of Dominant-Negative Forms of Dual Leucine Zipper Kinase in Dopamine Neurons of the Substantia Nigra In Vivo

(2008) X. Chen et al.   JOURNAL OF NEUROSCIENCE

Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway

(2008) K. K. Park et al.   SCIENCE