CpG methylation regulates allelic expression of GDF5 by modulating binding of SP1 and SP3 repressor proteins to the osteoarthritis susceptibility SNP rs143383

Growth Differentiation Factor-5 Enhances In Vitro Mesenchymal Stromal Cell Chondrogenesis and Hypertrophy

(2013) Cynthia M. Coleman et al.   STEM CELLS AND DEVELOPMENT

The Identification of Trans-acting Factors That Regulate the Expression of GDF5 via the Osteoarthritis Susceptibility SNP rs143383

(2013) Catherine M. Syddall et al.   PLoS Genetics

Epigenetic Mechanisms and Non-coding RNAs in Osteoarthritis

(2013) Matt J. Barter et al.   Current Rheumatology Reports

Homeostatic Mechanisms in Articular Cartilage and Role of Inflammation in Osteoarthritis

(2013) Xavier Houard et al.   Current Rheumatology Reports

Osteoarthritis: A disease of the joint as an organ

(2012) Richard F. Loeser et al.   ARTHRITIS AND RHEUMATISM

Overexpression of GDF5 through an Adenovirus Vector Stimulates Osteogenesis of Human Mesenchymal Stem Cells in vitro and in vivo

(2012) Xiangjun Cheng et al.   CELLS TISSUES ORGANS

Effect of Growth Differentiation Factor 5 on the Proliferation and Tenogenic Differentiation Potential of Human Mesenchymal Stem Cells in vitro

(2012) Sik-Loo Tan et al.   CELLS TISSUES ORGANS

cAMP response element-binding (CREB) recruitment following a specific CpG demethylation leads to the elevated expression of the matrix metalloproteinase 13 in human articular chondrocytes and osteoarthritis

(2012) Catherine Bui et al.   FASEB JOURNAL

Changes in the epigenetic status of theSOX-9promoter in human osteoarthritic cartilage

(2012) Kyung-Il Kim et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Functions of DNA methylation: islands, start sites, gene bodies and beyond

(2012) Peter A. Jones   NATURE REVIEWS GENETICS

Identification of the pathogenic pathways in osteoarthritic hip cartilage: commonality and discord between hip and knee OA

(2012) Y. Xu et al.   OSTEOARTHRITIS AND CARTILAGE

DNA Methylation and Gene Expression Changes in Monozygotic Twins Discordant for Psoriasis: Identification of Epigenetically Dysregulated Genes

(2012) Kristina Gervin et al.   PLoS Genetics

Delayed Fracture Healing in Growth Differentiation Factor 5-deficient Mice: A Pilot Study

(2011) Cynthia M. Coleman et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Allele-specific methylation in the human genome

(2011) Emma L. Meaburn et al.   Epigenetics

Genotype of an individual single nucleotide polymorphism regulates DNA methylation at theTRPC3alternative promoter

(2011) Alex Martin-Trujillo et al.   Epigenetics

Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation

(2011) Louise N. Reynard et al.   HUMAN MOLECULAR GENETICS

Disease-associated epigenetic changes in monozygotic twins discordant for schizophrenia and bipolar disorder

(2011) Emma L. Dempster et al.   HUMAN MOLECULAR GENETICS

Molecular differentiation between osteophytic and articular cartilage – clues for a transient and permanent chondrocyte phenotype

(2011) K. Gelse et al.   OSTEOARTHRITIS AND CARTILAGE

A genetic association study between growth differentiation factor 5 (GDF 5) polymorphism and knee osteoarthritis in Thai population

(2011) Tulyapruek Tawonsawatruk et al.   Journal of Orthopaedic Surgery and Research

Identification of Type 1 Diabetes–Associated DNA Methylation Variable Positions That Precede Disease Diagnosis

(2011) Vardhman K. Rakyan et al.   PLoS Genetics

DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines

(2011) Jordana T Bell et al.   GENOME BIOLOGY

Genetic Control of Individual Differences in Gene-Specific Methylation in Human Brain

(2010) Dandan Zhang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Allelic Skewing of DNA Methylation Is Widespread across the Genome

(2010) Leonard C. Schalkwyk et al.   AMERICAN JOURNAL OF HUMAN GENETICS

GDF5 deficiency in mice is associated with instability-driven joint damage, gait and subchondral bone changes

(2010) M. Daans et al.   ANNALS OF THE RHEUMATIC DISEASES

GDF5 single-nucleotide polymorphism rs143383 is associated with lumbar disc degeneration in Northern European women

(2010) F. M. K. Williams et al.   ARTHRITIS AND RHEUMATISM

Allele-specific DNA methylation: beyond imprinting

(2010) B. Tycko   HUMAN MOLECULAR GENETICS

Evidence of association between GDF5 polymorphisms and congenital dislocation of the hip in a Caucasian population

(2010) K. Rouault et al.   OSTEOARTHRITIS AND CARTILAGE

Components of the transforming growth factor-  family and the pathogenesis of human Achilles tendon pathology--a genetic association study

(2010) M. Posthumus et al.   RHEUMATOLOGY

Abundant Quantitative Trait Loci Exist for DNA Methylation and Gene Expression in Human Brain

(2010) J. Raphael Gibbs et al.   PLoS Genetics

Large-scale analysis of association betweenGDF5andFRZBvariants and osteoarthritis of the hip, knee, and hand

(2009) Evangelos Evangelou et al.   ARTHRITIS AND RHEUMATISM

DNA demethylation at specific CpG sites in theIL1Bpromoter in response to inflammatory cytokines in human articular chondrocytes

(2009) Ko Hashimoto et al.   ARTHRITIS AND RHEUMATISM

Functional analysis of the osteoarthritis susceptibility-associatedGDF5regulatory polymorphism

(2009) Rainer J. Egli et al.   ARTHRITIS AND RHEUMATISM

Deaf1 isoforms control the expression of genes encoding peripheral tissue antigens in the pancreatic lymph nodes during type 1 diabetes

(2009) Linda Yip et al.   NATURE IMMUNOLOGY

Epigenetic Silencing of Cell Adhesion Molecule 1 in Different Cancer Progenitor Cells of Transgenic c-Myc and c-Raf Mouse Lung Tumors

(2008) S. M. Reamon-Buettner et al.   CANCER RESEARCH

A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5' UTR of GDF5 with osteoarthritis susceptibility

(2008) K. Chapman et al.   HUMAN MOLECULAR GENETICS

Brachydactyly type A2 associated with a defect in proGDF5 processing

(2008) Frank Plöger et al.   HUMAN MOLECULAR GENETICS

DNA methylation is not responsible for p21WAF1/CIP1 down-regulation in osteoarthritic chondrocytes

(2008) S. Sesselmann et al.   OSTEOARTHRITIS AND CARTILAGE