Article
Dermatology
Maya Ben-Yehuda Greenwald, Carlotta Tacconi, Marko Jukic, Natasha Joshi, Paul Hiebert, Juergen Brinckmann, Hermann Tenor, Reto Naef, Sabine Werner
Summary: TOP-N53, a compound with dual-acting activity as a nitric oxide donor and phosphodiesterase 5 inhibitor, demonstrates remarkable healing-promoting effects by promoting keratinocyte proliferation, angiogenesis, and collagen maturation in healthy mice and partially rescuing healing impairment in mice with genetically determined type II diabetes.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yuri Inoue, Ching-Wei Liao, Yuki Tsunakawa, I-Lin Tsai, Satoru Takahashi, Michito Hamada
Summary: Macrophages play important roles in wound repair, and MAFB is a crucial gene involved in regulating the process. Experimental evidence shows that MAFB is expressed in macrophages and regulates multiple genes associated with wound healing. These findings highlight the significance of MAFB as a potential therapeutic target in wound healing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dermatology
Reimon Yamaguchi, Xin Guo, Jianbo Zheng, Jing Zhang, Jia Han, Akihiro Shioya, Hidetaka Uramoto, Takashi Mochizuki, Sohsuke Yamada
Summary: PRDX4 plays a crucial role in wound healing process by reducing oxidative stress, inflammation, and promoting angiogenesis. Overexpression of PRDX4 can accelerate wound healing in aged mice, making fibroblasts more resistant to oxidative damage caused by hydrogen peroxide.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Medicine, Research & Experimental
Xuan Wu, Xuan Zhou, Shuo Liang, Xingyu Zhu, Zhan Dong
Summary: The study showed that PQQ can prevent and protect against delayed bone fracture healing induced by OVX by inhibiting oxidative stress, promoting osteoblastic bone formation, and inhibiting osteoclastic bone resorption. This provides insight into the mechanism of PQQ supplementation in promoting fracture healing and supports its potential clinical application in bone fracture treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Endocrinology & Metabolism
Fuxian Lv, Zhenlan Li, Yuling Jing, Liyuan Sun, Zhiwei Li, Haoyang Duan
Summary: The clinical efficacy of ESWT in treating bone nonunion is widely recognized, but the biological mechanism behind this healing effect is still unclear.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Jose Valdes-Fernandez, Tania Lopez-Martinez, Purificacion Ripalda-Cemborain, Isabel A. Calvo, Borja Saez, Juan Antonio Romero-Torrecilla, Javier Aldazabal, Emma Muinos-Lopez, Veronica Montiel, Josune Orbe, Jose Antonio Rodriguez, Jose Antonio Paramo, Felipe Prosper, Froilan Granero-Molto
Summary: The study highlights the vital role of MMP-10 in cartilage resorption during secondary fracture healing, with its expression by hematopoietic cells being crucial for optimal bone regeneration. Global silencing of Mmp10 results in impaired fracture healing, characterized by delayed cartilage resorption and decreased gelatinase activity, specifically in macrophages lacking proMMP-9 processing capacity.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Daniel Rizzolo, Bo Kong, Rulaiha E. Taylor, Anita Brinker, Michael Goedken, Brian Buckley, Grace L. Guo
Summary: This study utilized a mouse model lacking CYP7A1 and CYP27A1 to demonstrate that female DKO mice exhibit significantly reduced BA concentrations but a similar gene expression pattern to WT mice in relation to BA regulation, synthesis, and transport. Additionally, female DKO mice responded similarly to a synthetic FXR agonist compared to WT mice.
ACTA PHARMACEUTICA SINICA B
(2021)
Article
Medicine, Research & Experimental
Jiatong Liu, Jun Zhang, Xi Lin, Brendan F. Boyce, Hengwei Zhang, Lianping Xing
Summary: Cellular senescence plays an important role in fracture healing in aged mice. Senescent cells inhibit the growth and proliferation of mesenchymal progenitor cells (MPCs) by expressing high levels of TGF-beta 1. The administration of senolytic drugs dasatinib plus quercetin can deplete senescent cells and accelerate fracture healing in aged mice.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Biology
Kai Sun, Chun Wang, Jianqiu Xiao, Michael D. Brodt, Luorongxin Yuan, Tong Yang, Yael Alippe, Huimin Hu, Dingjun Hao, Yousef Abu-Amer, Matthew J. Silva, Jie Shen, Gabriel Mbalaviele
Summary: Amino-terminal fragments of proteolytically cleaved GSDMs form plasma membrane pores, leading to pyroptosis. GSDMD and GSDME play roles in bone microenvironment and contribute to fracture healing. Both GSDMD and GSDME regulate inflammatory responses through the GSDM-IL-1 axis, promoting bone healing after fracture.
Article
Biochemistry & Molecular Biology
Francesco De Francesco, Pasquale Gravina, Stefano Varagona, Stefania Setti, Antonio Gigante, Michele Riccio
Summary: This study found that administration of biophysical stimulation promotes fracture healing and improves the union rate compared to non-treatment. Patients who received biophysical stimulation experienced less distress during the fracture and repair period, resulting in reduced immobilization time and better patient hand outcomes.
Article
Endocrinology & Metabolism
Takayuki Nabeshima, Manabu Tsukamoto, Ke-Yong Wang, Yosuke Mano, Daisuke Arakawa, Kenji Kosugi, Takafumi Tajima, Yoshiaki Yamanaka, Hitoshi Suzuki, Makoto Kawasaki, Soshi Uchida, Eiichiro Nakamura, Kagaku Azuma, Akinori Sakai
Summary: The effect of COPD pathogenesis on bone fracture healing is unclear. This study found that delayed bone healing and impaired nuclear translocation of Nrf2 are involved in the delayed cortical bone healing in COPD mice. Sulforaphane, an Nrf2 activator, improved the delayed cortical bone healing in the mice model. These findings suggest that Nrf2 may be a potential target for bone fracture treatment in COPD patients.
Article
Pharmacology & Pharmacy
Jun Peng, Sheng Xiao, Juan Xie, Wan Fu
Summary: Appropriate fracture pain management not only improves the patient's subjective perception, but also increases compliance with rehabilitation training. Bulleyaconitine A (BLA), a non-addictive analgesic medicine, has the potential to be used as a promising treatment for fracture pain. BLA can alleviate fracture-induced mechanical and thermal hyperalgesia, promote bone mineralization, and therefore enhance fracture healing.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Orthopedics
Megumi Hanaka, Kousuke Iba, Hikaru Hayakawa, Kenta Kiyomoto, Koji Ibe, Atsushi Teramoto, Makoto Emori, Toshihiko Yamashita
Summary: This study investigates the role of tetranectin in regulating tissue formation during the healing process of injured tendons. The results show that tetranectin is involved in the inflammatory phase of tendon healing and may enhance tissue formation. Tetranectin-null mice exhibit decreased inflammatory response and delayed tendon healing compared to wild-type mice.
JOURNAL OF ORTHOPAEDIC SCIENCE
(2022)
Article
Biology
Yuqi Guo, Jianlu Wei, Chuanju Liu, Xin Li, Wenbo Yan
Summary: Diabetic patients are more prone to osteoporotic fractures with impaired healing. This study found that metformin can promote fracture healing and remodeling, improving the proliferation, osteogenesis, and chondrogenesis abilities of bone marrow stromal cells (BMSCs).
Article
Medicine, Research & Experimental
Jen-Chieh Lai, Hsin-Pei Li, Gary Ro-Lin Chang, Ying-Wei Lan, Yu-Hsuan Chen, Yan-Shen Tseng, Min-Yu Tu, Chien-Fu Chen, Hsiao-Ling Chen, Chuan-Mu Chen
Summary: This study found that kefir peptides (KPs) can promote fracture healing by promoting osteogenic differentiation and may be used as a nutritional supplement to accelerate healing.
Article
Orthopedics
John T. Martin, Dong Hwa Kim, Andrew H. Milby, Christian G. Pfeifer, Lachlan J. Smith, Dawn M. Elliott, Harvey E. Smith, Robert L. Mauck
JOURNAL OF ORTHOPAEDIC RESEARCH
(2017)
Article
Orthopedics
Su-Jin Heo, Spencer E. Szczesny, Dong Hwa Kim, Kamiel S. Saleh, Robert L. Mauck
JOURNAL OF ORTHOPAEDIC RESEARCH
(2018)
Article
Orthopedics
Minwook Kim, Sean T. Garrity, David R. Steinberg, George R. Dodge, Robert L. Mauck
JOURNAL OF ORTHOPAEDIC RESEARCH
(2018)
Article
Multidisciplinary Sciences
Feini Qu, Julianne L. Holloway, John L. Esterhai, Jason A. Burdick, Robert L. Mauck
NATURE COMMUNICATIONS
(2017)
Article
Engineering, Biomedical
Sarah E. Gullbrand, Dong Hwa Kim, Edward Bonnevie, Beth G. Ashinsky, Lachlan J. Smith, Dawn M. Elliott, Robert L. Mauck, Harvey E. Smith
ACTA BIOMATERIALIA
(2018)
Article
Rehabilitation
Zuozhen Tian, Xiaoyuan Ma, Miersalijiang Yasen, Robert L. Mauck, Ling Qin, Frances S. Shofer, Lachlan J. Smith, Maurizio Pacifici, Motomi Enomoto-Iwamoto, Yejia Zhang
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2018)
Article
Cell & Tissue Engineering
Farzad Yousefi, Minwook Kim, Syeda Yusra Nahri, Robert L. Mauck, Nancy Pleshko
TISSUE ENGINEERING PART A
(2018)
Article
Multidisciplinary Sciences
Feini Qu, Qing Li, Xiao Wang, Xuan Cao, Miltiadis H. Zgonis, John L. Esterhai, Vivek B. Shenoy, Lin Han, Robert L. Mauck
SCIENTIFIC REPORTS
(2018)
Article
Engineering, Biomedical
Mi Y. Kwon, Sebastian L. Vega, William M. Gramlich, Minwook Kim, Robert L. Mauck, Jason A. Burdick
ADVANCED HEALTHCARE MATERIALS
(2018)
Review
Biochemistry & Molecular Biology
Cliodhna E. Murray, Cynthia M. Coleman
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Orthopedics
Adam S. Galbraith, Clara Sanz-Nogues, Sharon Glynn, Cynthia M. Coleman, Colin Murphy
JOURNAL OF ORTHOPAEDIC RESEARCH
(2020)
Article
Multidisciplinary Sciences
David C. Browe, Cynthia M. Coleman, Frank P. Barry, Stephen J. Elliman
SCIENTIFIC REPORTS
(2019)
Article
Endocrinology & Metabolism
Eoin Parle, Sherdya Tio, Annie Behre, John J. Carey, Colin G. Murphy, Timothy F. O'Brien, William A. Curtin, Stephen R. Kearns, John P. McCabe, Cynthia M. Coleman, Ted J. Vaughan, Laoise M. McNamara
Article
Engineering, Biomedical
Sarah E. Gullbrand, Thomas P. Schaer, Prateek Agarwal, Justin R. Bendigo, George R. Dodge, Weiliam Chen, Dawn M. Elliott, Robert L. Mauck, Neil R. Malhotra, Lachlan J. Smith
ACTA BIOMATERIALIA
(2017)
Article
Health Care Sciences & Services
Clara Sanz-Nogues, Mohamad Mustafa, Helen Burke, Timothy O'Brien, Cynthia M. Coleman