Nucleoside Analogues: Synthesis and Biological Properties of Azanucleoside Derivatives

Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a carbamoyl linker

(2013) Kamil Kokosza et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Acyclic phosph(on)ate inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase

(2013) Keith Clinch et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and biological evaluation of furopyrimidine N,O-nucleosides

(2013) Roberto Romeo et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Electrochemical synthesis of azanucleoside derivatives using a lithium perchlorate–nitromethane system

(2013) Shokaku Kim et al.   CHEMICAL COMMUNICATIONS

Synthesis of Nucleobase-Functionalized Morpholino-Modified Nucleoside Monomers Through Palladium-Catalyzed Cross-Coupling Reactions

(2013) Bappaditya Nandi et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Tuning the Stereoselectivity in One-Pot Scission/Addition Processes: Synthesis of Azanucleotide Analogues from Proline Derivatives

(2013) Javier Miguélez-Ramos et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Inhibition of the Escherichia coli 6-Oxopurine Phosphoribosyltransferases by Nucleoside Phosphonates: Potential for New Antibacterial Agents

(2013) Dianne T. Keough et al.   JOURNAL OF MEDICINAL CHEMISTRY

Peptide Vectors for the Nonviral Delivery of Nucleic Acids

(2012) Jan Hoyer et al.   ACCOUNTS OF CHEMICAL RESEARCH

In Vivo Validation of Thymidylate Kinase (TMK) with a Rationally Designed, Selective Antibacterial Compound

(2012) Thomas A. Keating et al.   ACS Chemical Biology

Truncated phosphonated C-1′-branched N,O-nucleosides: A new class of antiviral agents

(2012) Roberto Romeo et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Transition state analogue inhibitors of human methylthioadenosine phosphorylase and bacterial methylthioadenosine/S-adenosylhomocysteine nucleosidase incorporating acyclic ribooxacarbenium ion mimics

(2012) Keith Clinch et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Trimeric purine nucleoside phosphorylase: Exploring postulated one-third-of-the-sites binding in the transition state

(2012) Beata Wielgus-Kutrowska et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, evaluation of anti-HIV-1 and anti-HCV activity of novel 2′,3′-dideoxy-2′,2′-difluoro-4′-azanucleosides

(2012) Saúl Martínez-Montero et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Sulfonylpiperidines as novel, antibacterial inhibitors of Gram-positive thymidylate kinase (TMK)

(2012) Gabriel Martínez-Botella et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Practical biocatalytic desymmetrization of meso-N-heterocyclic dicarboxamides and their application in the construction of aza-sugar containing nucleoside analogs

(2012) Peng Chen et al.   CHEMICAL COMMUNICATIONS

Acyclic Immucillin Phosphonates: Second-Generation Inhibitors of Plasmodium falciparum Hypoxanthine- Guanine-Xanthine Phosphoribosyltransferase

(2012) Keith Z. Hazleton et al.   CHEMISTRY & BIOLOGY

Truncated Reverse Isoxazolidinyl Nucleosides: A New Class of Allosteric HIV-1 Reverse Transcriptase Inhibitors

(2012) Roberto Romeo et al.   ChemMedChem

Fluorophosphonylated Nucleoside Derivatives as New Series of Thymidine Phosphorylase Multisubstrate Inhibitors

(2012) Sonia Amel Diab et al.   JOURNAL OF MEDICINAL CHEMISTRY

N-Phosphonocarbonylpyrrolidine Derivatives of Guanine: A New Class of Bi-Substrate Inhibitors of Human Purine Nucleoside Phosphorylase

(2012) Dominik Rejman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of (2S)-1-[4-(2-{6-Amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-9-yl}ethyl)piperidin-1-yl]-2-hydroxypropan-1-one (MPC-3100), a Purine-Based Hsp90 Inhibitor

(2012) Se-Ho Kim et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Novel N-Branched Acyclic Nucleoside Phosphonates As Potent and Selective Inhibitors of Human, Plasmodium falciparum and Plasmodium vivax 6-Oxopurine Phosphoribosyltransferases

(2012) Dana Hocková et al.   JOURNAL OF MEDICINAL CHEMISTRY

O-Nucleoside, S-Nucleoside, and N-Nucleoside Probes of Lumazine Synthase and Riboflavin Synthase

(2012) Arindam Talukdar et al.   JOURNAL OF ORGANIC CHEMISTRY

Design and Divergent Synthesis of Aza Nucleosides from a Chiral Imino Sugar

(2012) Saúl Martı́nez-Montero et al.   JOURNAL OF ORGANIC CHEMISTRY

Structure-Activity Relationships in the Development of Allosteric Hepatitis C Virus RNA-Dependent RNA Polymerase Inhibitors: Ten Years of Research

(2012) Romain Haudecoeur et al.   MEDICINAL RESEARCH REVIEWS

Improved Protocol for the Synthesis of Flexibly Protected Morpholino Monomers from Unprotected Ribonucleosides

(2012) Sankha Pattanayak et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Small molecule control of bacterial biofilms

(2012) Roberta J. Worthington et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Lithium bromide–DBU mediated synthesis of chlorophosphoramidate-activated morpholino nucleoside subunits

(2012) Sankha Pattanayak et al.   TETRAHEDRON LETTERS

Synthesis of isoxazoles by hypervalent iodine-induced cycloaddition of nitrile oxides to alkynes

(2011) Anup M. Jawalekar et al.   CHEMICAL COMMUNICATIONS

Design, synthesis, antiviral and cytostatic evaluation of novel isoxazolidine nucleotide analogues with a 1,2,3-triazole linker

(2011) Dorota G. Piotrowska et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The Synthesis and Conformation of Dihydroxypiperidinyl Derivates of Nucleobases as Novel Iminosugar Nucleoside Analogs

(2011) Dominik Rejman et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of 5-Alkynyl Isoxazolidinyl Nucleosides

(2011) Roberto Romeo et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Stereoselective Synthesis of PSI-352938: A β-d-2′-Deoxy-2′-α-fluoro-2′-β-C-methyl-3′,5′-cyclic Phosphate Nucleotide Prodrug for the Treatment of HCV

(2011) P. Ganapati Reddy et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of 3-Guaninyl- and 3-Adeninyl-5-hydroxymethyl-2-pyrrolidinone Nucleosides

(2011) Abdullah Saleh et al.   JOURNAL OF ORGANIC CHEMISTRY

1,3-Dipolar cycloaddition approach to pyrrolidine analogues of C-nucleosides related to pseudouridine

(2011) Evdoxia Coutouli-Argyropoulou et al.   TETRAHEDRON

Synthesis of novel azanorbornylpurine derivatives

(2011) Hubert Hřebabecký et al.   TETRAHEDRON

High-yield synthesis of pyrrolidinyl PNA monomers

(2011) Pedro Merino et al.   TETRAHEDRON LETTERS

Synthesis and biological evaluation of diastereoisomerically pure N,O-nucleosides

(2010) Olga Bortolini et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Chemical Synthesis of Heterocyclic−Sugar Nucleoside Analogues

(2010) Giovanni Romeo et al.   CHEMICAL REVIEWS

Exploring new inhibitors of Plasmodium falciparum purine nucleoside phosphorylase

(2010) Huaqing Cui et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent Developments in the Synthesis of Pyrrolidine-Containing Iminosugars

(2010) Bridget L. Stocker et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

One-Pot Conversion of Proline Derivatives into Iodinated Iminosugar-Based Nucleosides, Useful Precursors of Highly Functionalized Nucleoside Analogues

(2010) Alicia Boto et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

One-Pot Synthesis of Azanucleosides from Proline Derivatives - Stereoselectivity in Sequential Processes

(2010) Alicia Boto et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Potential therapeutic applications of antisense morpholino oligonucleotides in modulation of splicing in primary immunodeficiency diseases

(2010) Liutao Du et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Design and Synthesis of Potent “Sulfur-Free” Transition State Analogue Inhibitors of 5′-Methylthioadenosine Nucleosidase and 5′-Methylthioadenosine Phosphorylase

(2010) Alistair I. Longshaw et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of C-4′Truncated Phosphonated Carbocyclic 2′-Oxa-3′-azanucleosides as Antiviral Agents

(2010) Anna Piperno et al.   JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Acyclic Nucleosides with a Chiral Amino Side Chain by the Mitsunobu Coupling Reaction

(2010) Hai-Ming Guo et al.   JOURNAL OF ORGANIC CHEMISTRY

Amino acids attached to 2′-amino-LNA: synthesis and excellent duplex stability

(2010) Marie W. Johannsen et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The synthesis of piperidine nucleoside analogs—a comparison of several methods to access the introduction of nucleobases

(2010) Soňa Kovačková et al.   TETRAHEDRON

RNA interference in mammalian cells by siRNAs modified with morpholino nucleoside analogues

(2009) Nan Zhang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and antiviral activity evaluation of acyclic 2′-azanucleosides bearing a phosphonomethoxy function in the side chain

(2009) Mariola Koszytkowska-Stawińska et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of analogs of forodesine HCl, a human purine nucleoside phosphorylase inhibitor—Part I

(2009) Vivekanand P. Kamath et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of analogs of forodesine HCl, a human purine nucleoside phosphorylase inhibitor—Part II

(2009) Vivekanand P. Kamath et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of modified homo-N-nucleosides from the reactions of mesityl nitrile oxide with 9-allylpurines and their influence on lipid peroxidation and thrombin inhibition

(2009) Andreas Thalassitis et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The application of the phosphoramidate ProTide approach confers micromolar potency against Hepatitis C virus on inactive agent 4′-azidoinosine: Kinase bypass on a dual base/sugar modified nucleoside

(2009) Christopher McGuigan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The phosphoramidate ProTide approach greatly enhances the activity of β-2′-C-methylguanosine against hepatitis C virus

(2009) Christopher McGuigan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structural diversity of nucleoside phosphonic acids as a key factor in the discovery of potent inhibitors of rat T-cell lymphoma thymidine phosphorylase

(2009) Petr Kočalka et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Effect of chirality of l/d-proline and prochiral glycine as the linker amino acid in five-atom linked thymidinyl-(α-amino acid)-thymidine dimers

(2009) Seema Bagmare et al.   CHEMICAL COMMUNICATIONS

Synthesis and hybridization of oligonucleotides modified at AMP sites with adenine pyrrolidine phosphonate nucleotides

(2009) Dominik Rejman et al.   COLLECTION OF CZECHOSLOVAK CHEMICAL COMMUNICATIONS

Non-natural nucleic acids for synthetic biology

(2009) Daniel H Appella   CURRENT OPINION IN CHEMICAL BIOLOGY

Third-Generation Immucillins: Syntheses and Bioactivities of Acyclic Immucillin Inhibitors of Human Purine Nucleoside Phosphorylase

(2009) Keith Clinch et al.   JOURNAL OF MEDICINAL CHEMISTRY

Stereoselective Synthesis and Biological Evaluations of Novel 3′-Deoxy-4′-azaribonucleosides as Inhibitors of Hepatitis C Virus RNA Replication

(2009) Ugo Chiacchio et al.   JOURNAL OF MEDICINAL CHEMISTRY

Highlights in the Discovery of Antiviral Drugs: A Personal Retrospective

(2009) Erik De Clercq   JOURNAL OF MEDICINAL CHEMISTRY

An Efficient Route to AcyclicC-Nucleosides and Fused-Ring Analogues of Uridine fromexo-Glycals

(2009) Gérald Enderlin et al.   JOURNAL OF ORGANIC CHEMISTRY

1,3-Dipolar cycloadditions: applications to the synthesis of antiviral agents

(2009) Carmen Nájera et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Development of a Practical Synthesis of a Purine Nucleoside Phosphorylase Inhibitor: BCX-4208

(2009) Vivekanand P. Kamath et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Highly stereoselective synthesis of novel cyclobutane-fused azanucleosides

(2009) Ramon Flores et al.   TETRAHEDRON

Pyrrolidine N-alkylphosphonates and related nucleotide analogues: synthesis and stereochemistry

(2009) Dominik Rejman et al.   TETRAHEDRON

Recent advances in the synthesis of fluorinated nucleosides

(2009) Xiao-Long Qiu et al.   TETRAHEDRON

Alternative route towards the convergent synthesis of a human purine nucleoside phosphorylase inhibitor—forodesine HCl

(2009) Vivekanand P. Kamath et al.   TETRAHEDRON LETTERS

Preparation of isoxazolidinyl nucleoside enantiomers by lipase-catalysed kinetic resolution

(2009) Caterina Carnovale et al.   TETRAHEDRON-ASYMMETRY

N-Arylmethyl substituted iminoribitol derivatives as inhibitors of a purine specific nucleoside hydrolase

(2008) Annelies Goeminne et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and antiviral evaluation of acyclic azanucleosides developed from sulfanilamide as a lead structure

(2008) Rafał Gawin et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Immucillins in custom catalytic-site cavities

(2008) Andrew S. Murkin et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of 2′,3′-dideoxy-6′,6′-difluoro-3′-azanucleosides

(2008) Xuyi Yue et al.   JOURNAL OF FLUORINE CHEMISTRY

A β-Fluoroamine Inhibitor of Purine Nucleoside Phosphorylase

(2008) Jennifer M. Mason et al.   JOURNAL OF MEDICINAL CHEMISTRY

Azetidine Based Transition State Analogue Inhibitors ofN-Ribosyl Hydrolases and Phosphorylases

(2008) Gary B. Evans et al.   JOURNAL OF MEDICINAL CHEMISTRY

Transition-State Interactions Revealed in Purine Nucleoside Phosphorylase by Binding Isotope Effects

(2008) Andrew S. Murkin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Diastereoselective synthesis of d-xylo-isoxazolidinyl nucleosides

(2008) Eva Hýrošová et al.   TETRAHEDRON

Synthesis of N-methyl-d-ribopyranuronamide nucleosides

(2008) Shiqiong Yang et al.   TETRAHEDRON

Solvent-free, microwave assisted 1,3-cycloaddition of nitrones with vinyl nucleobases for the synthesis of N,O-nucleosides

(2008) Olga Bortolini et al.   TETRAHEDRON

Prolinol-based nucleoside phosphonic acids: new isosteric conformationally flexible nucleotide analogues

(2008) Václav Vaněk et al.   TETRAHEDRON

Novel oligonucleotide analogues containing a morpholinoamidine unit

(2008) Sonia Pérez-Rentero et al.   TETRAHEDRON

Diastereoselective synthesis of a collection of new homonucleoside mimetics containing pyrrolo[1,2-b]isoxazoline and pyrrolidine rings

(2008) Vanni Mannucci et al.   TETRAHEDRON-ASYMMETRY

Chimeric (α-amino acid + nucleoside-β-amino acid)npeptide oligomers show sequence specific DNA/RNA recognition

(2007) Khirud Gogoi et al.   CHEMICAL COMMUNICATIONS

l-Enantiomers of Transition State Analogue Inhibitors Bound to Human Purine Nucleoside Phosphorylase

(2007) Agnes Rinaldo-Matthis et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY