期刊
BIOORGANIC & MEDICINAL CHEMISTRY
卷 17, 期 11, 页码 3756-3762出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2009.04.054
关键词
Azanucleosides; Acyclic nucleoside phosphonates; Nucleoside analogs; Antiviral agents; Sulfonamides
资金
- Ministry of Science and Higher Education, Poland [1 T09B 013 30]
- Concerted Research Actions (GOA) [05/19]
Acyclic 2'-azanucleosides with a phosphonomethoxy function in the side chain were obtained by coupling of diethyl {2-[N-(pivaloyloxymethyl)-N-(p-toluenesulfonyl)amino]ethoxymethyl} phosphonate with the pyrimidine nucleobases via the Vorbruggen-type protocol. The compounds were evaluated in vitro for activity against a broad variety of RNA and DNA viruses. (C) 2009 Elsevier Ltd. All rights reserved.
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