期刊
TETRAHEDRON LETTERS
卷 53, 期 49, 页码 6714-6717出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2012.09.126
关键词
Morpholino subunit; Chlorophosphoramidate; Nucleosides; Lithium bromide; DBU
资金
- Department of Biotechnology, Government of India [BT/PR13426/BRB/10/761/2009]
- CSIR
An efficient and rapid protocol for the synthesis of chlorophosphoramidate-activated morpholino sub-units has been developed. A unique combination of lithium bromide-DBU has been found to activate the 7'-hydroxyl toward the reaction. All the four morpholino units of adenosine, guanosine, cytosine, and thymine responded smoothly to the developed protocol. (C) 2012 Elsevier Ltd. All rights reserved.
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