期刊
TETRAHEDRON
卷 67, 期 7, 页码 1485-1500出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2010.12.029
关键词
Piperidine derivatives; Nucleoside analogs; Nucleobase; Proline
资金
- Ministry of Education, Youth and Sports of the Czech Republic [2B06065, ChemGen LC06077, Z40550506]
- Ministry of Health of the Czech Republic [NR/9138-3]
This work deals with the synthesis of piperidine and hydroxypiperidine analogs of nucleosides. Starting from commercially available 3-hydroxypiperidine, proline or 4-hydroxyproline, a series of piperidine derivatives of both purine and pyrimidine nucleobases was prepared. Various methods of nucleobase attachment were evaluated. The prepared compounds were tested for cytostatic, antibacterial, and antiviral properties but no significant activity was found. (C) 2010 Elsevier Ltd. All rights reserved.
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