期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 52, 期 13, 页码 4054-4057出版社
AMER CHEMICAL SOC
DOI: 10.1021/jm900197j
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3'-Deoxy-4'-azaribonucleosides (15a-d) were synthesized starting from the commercially available (4R)-trans-4-hydroxy-L-proline 7. From biological evaluations, 15b and 15d emerged as potent inhibitors of HCV replication on a replicon assay. These findings demonstrate that synthesized pyrrolidine nucleosides represent a new template for antiviral or other biological studies and could be considered for novel combination therapy against HCV infection using nucleoside inhibitors and non-nucleoside inhibitors of HCV NS5B.
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