A domino reaction of 2-isocyanophenyloxyacrylate and aryne to synthesize arenes with vicinal olefin and benzoxazole

Ytterbium and silver co-catalyzed synthesis of pyrrole-fused bicyclic skeletons from enynones and isocyanides

(2018) Feng Li et al.   CHEMICAL COMMUNICATIONS

Domino Aryne Annulation via a Nucleophilic–Ene Process

(2018) Hai Xu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Construction of Polycyclic Indole Derivatives via Multiple Aryne Reactions with Azaheptafulvenes

(2018) Zhen Wang et al.   ORGANIC LETTERS

Iron-Catalyzed Aerobic Oxidation and Annulation Reaction of Pyridine and α-Substituted Allenoate toward Functionalized Indolizine

(2018) Tao Jin et al.   ORGANIC LETTERS

When Ethyl Isocyanoacetate Meets Isatins: A 1,3-Dipolar/Inverse 1,3-Dipolar/Olefination Reaction for Access to 3-Ylideneoxindoles

(2018) Wen-Kui Yuan et al.   ORGANIC LETTERS

Aryne Trifunctionalization Enabled by 3-Silylaryne as a 1,2-Benzdiyne Equivalent

(2018) Chunjie Lv et al.   ORGANIC LETTERS

Selective Aryne Formation via Grob Fragmentation from the [2+2] Cycloadducts of 3-Triflyloxyarynes

(2017) Jiarong Shi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Chemoselective Double Annulation of Two Different Isocyanides: Rapid Access to Trifluoromethylated Indole-Fused Heterocycles

(2017) Yuelei Gao et al.   ORGANIC LETTERS

Synthesis of Diverse o-Arylthio-Substituted Diaryl Ethers by Direct Oxythiolation of Arynes with Diaryl Sulfoxides Involving Migratory O-Arylation

(2017) Tsubasa Matsuzawa et al.   ORGANIC LETTERS

(3 + 2)-Annulation of p-Quinamine and Aryne: A Strategy To Construct the Multisubstituted Hydrocarbazoles

(2017) Dengyu Xu et al.   ORGANIC LETTERS

Cobalt(II)-Catalyzed Synthesis of Sulfonyl Guanidines via Nitrene Radical Coupling with Isonitriles: A Combined Experimental and Computational Study

(2017) Zheng-Yang Gu et al.   ACS Catalysis

Employing Arynes in Diels–Alder Reactions and Transition-Metal-Free Multicomponent Coupling and Arylation Reactions

(2016) Sachin Suresh Bhojgude et al.   ACCOUNTS OF CHEMICAL RESEARCH

Cross-Cycloaddition of Two Different Isocyanides: Chemoselective Heterodimerization and [3+2]-Cyclization of 1,4-Diazabutatriene

(2016) Zhongyan Hu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Diversely Functionalized Oxindoles Enabled by Migratory Insertion of Isocyanide to a Transient σ-Alkylpalladium(II) Complex

(2016) Wangqing Kong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Switchable [3+2] and [4+2] Heteroannulation of Primary Propargylamines with Isonitriles to Imidazoles and 1,6-Dihydropyrimidines: Catalyst Loading Enabled Reaction Divergence

(2016) Shuo Tong et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of o-Alkenylated 2-Arylbenzoxazoles via Rh-Catalyzed Oxidative Olefination of 2-Arylbenzoxazoles: Scope Investigation, Structural Features, and Mechanism Studies

(2016) Quan Zhou et al.   JOURNAL OF ORGANIC CHEMISTRY

Aryne 1,2,3-Trifunctionalization with Aryl Allyl Sulfoxides

(2016) Yuanyuan Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Vicinal Diamination of Arenes with Domino Aryne Precursors

(2016) Lu Li et al.   ORGANIC LETTERS

Synthesis of 2-Benzylphenyl Ketones by Aryne Insertion into Unactivated C–C Bonds

(2016) Bin Rao et al.   ORGANIC LETTERS

Temperature-Dependent Double Isocyanide Insertion Reaction To Construct a Polycyclic Skeleton

(2016) Yaming Tian et al.   ORGANIC LETTERS

Exploiting the Reactivity of Isocyanide: Coupling Reaction between Isocyanide and Toluene Derivatives Using the Isocyano Group as an N1 Synthon

(2016) Zhiqiang Liu et al.   ORGANIC LETTERS

Aryne Relay Chemistry en Route to Aminoarenes: Synthesis of 3-Aminoaryne Precursors via Regioselective Silylamination of 3-(Triflyloxy)arynes

(2016) Suguru Yoshida et al.   ORGANIC LETTERS

Bu4NI-Catalyzed α-Oxyacylation of Carbonyl Compounds with Toluene Derivatives

(2016) Chengliang Li et al.   ORGANIC LETTERS

Synthesis of Aryl Ketoamides via Aryne Insertion into Imides

(2016) Austin C. Wright et al.   ORGANIC LETTERS

Transition-Metal-Free Synthesis of 2-Arylimidazolones via Cascade Reaction between Arynes and α,α′-Disubstituted α-Isocyanoacetamides

(2016) Alessandro Gesù et al.   ORGANIC LETTERS

Formal Total Synthesis of (±)-Cephalotaxine and Congeners via Aryne Insertion Reaction

(2016) Pashikanti Gouthami et al.   ORGANIC LETTERS

Multiple Aryne Insertions into Oxindoles: Synthesis of Bioactive 3,3-Diarylated Oxindoles and Dibenzo[b,e]azepin-6-ones

(2016) Ramesh Samineni et al.   ORGANIC LETTERS

Double Heteroatom Functionalization of Arenes Using Benzyne Three-Component Coupling

(2015) José-Antonio García-López et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pyridynes and indolynes as building blocks for functionalized heterocycles and natural products

(2015) Adam E. Goetz et al.   CHEMICAL COMMUNICATIONS

The Renaissance and Bright Future of Synthetic Aryne Chemistry

(2015) Suguru Yoshida et al.   CHEMISTRY LETTERS

Direct Thioamination of Arynes via Reaction with Sulfilimines and Migratory N-Arylation

(2015) Suguru Yoshida et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Activation of Aryl Thiocyanates Followed by Aryne Insertion: Access to 1,2-Thiobenzonitriles

(2015) Martin Pawliczek et al.   ORGANIC LETTERS

Indium(III) Chloride-Catalyzed Isocyanide Insertion Reaction to Construct Complex Spirooxindole

(2015) Yaming Tian et al.   ORGANIC LETTERS

Tuning the Reactivity of Isocyano Group: Synthesis of Imidazoles and Imidazoliums from Propargylamines and Isonitriles in the Presence of Multiple Catalysts

(2014) Shuo Tong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Isocyanide-Based Multicomponent Reactions: Concise Synthesis of Spirocyclic Oxindoles with Molecular Complexity by Using a [1,5]-Hydrogen Shift as the Key Step

(2014) Shikuan Su et al.   CHEMISTRY-A EUROPEAN JOURNAL

Practical Synthesis of Phthalimides and Benzamides by a Multicomponent Reaction Involving Arynes, Isocyanides, and CO2/H2O

(2014) Trinadh Kaicharla et al.   ORGANIC LETTERS

Multicomponent Cascade Cycloaddition Involving Tropone, Allenoate, and Isocyanide: A Rapid Access to a 7,6,5-Fused Tricyclic Skeleton

(2014) Shuanglong Jia et al.   ORGANIC LETTERS

Three-Component Metal-Free Arylation of Isocyanides

(2013) Unnamatla M. V. Basavanag et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent advances in isocyanide insertion chemistry

(2013) Guanyinsheng Qiu et al.   CHEMICAL SOCIETY REVIEWS

Aryne Cycloaddition Reactions in the Synthesis of Large Polycyclic Aromatic Compounds

(2013) Dolores Pérez et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Design, Generation, and Synthetic Application of Borylzincate: Borylation of Aryl Halides and Borylzincation of Benzynes/Terminal Alkyne

(2013) Yuki Nagashima et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of Substituted Pyridines from Cascade [1 + 5] Cycloaddition of Isonitriles to N-Formylmethyl-Substituted Enamides, Aerobic Oxidative Aromatization, and Acyl Transfer Reaction

(2013) Chuan-Hu Lei et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct Solvent-Free Regioselective Construction of Pyrrolo[1,2-a][1,10]phenanthrolines Based on Isocyanide-Based Multicomponent Reactions

(2013) Ming Li et al.   ORGANIC LETTERS

Addition of Cyclic Ureas and 1-Methyl-2-oxazolidone to Pyridynes: A New Approach to Pyridodiazepines, Pyridodiazocines, and Pyridooxazepines

(2013) Nozomi Saito et al.   ORGANIC LETTERS

Aminocyanation by the Addition of N–CN Bonds to Arynes: Chemoselective Synthesis of 1,2-Bifunctional Aminobenzonitriles

(2013) Bin Rao et al.   ORGANIC LETTERS

Arynes in Transition-Metal-Free Multicomponent Coupling Reactions

(2012) Sachin Suresh Bhojgude et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Arynes and Cyclohexyne in Natural Product Synthesis

(2012) Christian M. Gampe et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Comprehensive History of Arynes in Natural Product Total Synthesis

(2012) Pamela M. Tadross et al.   CHEMICAL REVIEWS

Recent advances in transition-metal-free carbon–carbon and carbon–heteroatom bond-forming reactions using arynes

(2012) Anup Bhunia et al.   CHEMICAL SOCIETY REVIEWS

Chemo- and Regioselective Assembly of Polysubstituted Pyridines and Isoquinolines from Isocyanides, Arynes, and Terminal Alkynes

(2012) Feng Sha et al.   JOURNAL OF ORGANIC CHEMISTRY

Development of an Intramolecular Aryne Ene Reaction and Application to the Formal Synthesis of (±)-Crinine

(2012) David A. Candito et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Use of benzynes for the synthesis of heterocycles

(2012) Anton V. Dubrovskiy et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Construction of Naphtho-Fused Oxindoles via the Aryne Diels–Alder Reaction with Methyleneindolinones

(2012) Jian Li et al.   ORGANIC LETTERS

Palladium-Catalyzed Cascade Process Consisting of Isocyanide Insertion and Benzylic C(sp3)–H Activation: Concise Synthesis of Indole Derivatives

(2012) Takeshi Nanjo et al.   ORGANIC LETTERS

Three-Component Coupling of Arynes and Organic Bromides

(2011) Hiroto Yoshida et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Benzannulated Bicycles by Three-Component Aryne Reactions

(2011) Kevin M. Allan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multicomponent Reaction Design in the Quest for Molecular Complexity and Diversity

(2011) Eelco Ruijter et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly Selective Insertion of Arynes into a C(sp)−O(sp3) σ Bond

(2011) Krzysztof Z. Ła̧czkowski et al.   ORGANIC LETTERS

Diversity-oriented synthesis leads to an effective class of bifunctional linchpins uniting anion relay chemistry (ARC) with benzyne reactivity

(2011) A. B. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Isocyanides in the Synthesis of Nitrogen Heterocycles

(2010) Alexander V. Lygin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Aryne Acyl-Alkylation in the General and Convergent Synthesis of Benzannulated Macrolactone Natural Products: An Enantioselective Synthesis of (−)-Curvularin

(2010) Pamela M. Tadross et al.   ORGANIC LETTERS

Intermolecular C−O Addition of Carboxylic Acids to Arynes

(2010) Anton V. Dubrovskiy et al.   ORGANIC LETTERS

The Benzyne Aza-Claisen Reaction

(2009) Alastair A. Cant et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Multicomponent Reaction of Arynes, Isocyanides, and Terminal Alkynes: Highly Chemo- and Regioselective Synthesis of Polysubstituted Pyridines and Isoquinolines

(2009) Feng Sha et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION