Switchable [3+2] and [4+2] Heteroannulation of Primary Propargylamines with Isonitriles to Imidazoles and 1,6-Dihydropyrimidines: Catalyst Loading Enabled Reaction Divergence

Synthesis of Oxazolidin-2-ones by Oxidative Coupling of Isonitriles, Phenyl Vinyl Selenone, and Water

(2016) Thomas Buyck et al.   CHEMISTRY-A EUROPEAN JOURNAL

Pd-Catalyzed α-Selective C–H Functionalization of Olefins: En Route to 4-Imino-β-Lactams

(2016) Wei-Jun Kong et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Synthesis of Tetracyclic Pyrroloindolines and Constrained Tryptamines by a Switchable Cascade Reaction

(2015) Corien de Graaff et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent advances in the synthesis of nitrogen heterocycles via radical cascade reactions using isonitriles as radical acceptors

(2015) Bo Zhang et al.   CHEMICAL SOCIETY REVIEWS

Silver-catalysed reactions of alkynes: recent advances

(2015) Guichun Fang et al.   CHEMICAL SOCIETY REVIEWS

Modular Access to Tetrasubstituted Imidazolium Salts through Acid-Catalyzed Addition of Isocyanides to Propargylamines

(2015) Ouldouz Ghashghaei et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Naamidine A and Selective Access to N2-Acyl-2-aminoimidazole Analogues

(2015) Joseph B. Gibbons et al.   JOURNAL OF ORGANIC CHEMISTRY

SilverCatalyzed Cascade Carboxylation and Cyclization of Trimethyl(2-methylenebut-3-yn-1-yl)silane Derivatives

(2015) Kohei Sekine et al.   ORGANIC LETTERS

Copper-Catalyzed Formal [4 + 1] Cycloaddition of Benzamides and Isonitriles via Directed C–H Cleavage

(2015) Kazutaka Takamatsu et al.   ORGANIC LETTERS

Tuning the Reactivity of Isocyano Group: Synthesis of Imidazoles and Imidazoliums from Propargylamines and Isonitriles in the Presence of Multiple Catalysts

(2014) Shuo Tong et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Ln[N(SiMe3)2]3-Catalyzed Cross-Diinsertion of CN/CC into an NH Bond: Facile Synthesis of 1,2,4-Trisubstituted Imidazoles from Propargylamines and Nitriles

(2014) Longcheng Hong et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synthesis of Indolyl Imidazole Derivatives via Base-Promoted Tandem Reaction of N-[2-(1-Alkynyl)phenyl]carbodiimides with Isocyanides

(2014) Wenyan Hao et al.   JOURNAL OF ORGANIC CHEMISTRY

Tandem Insertion–Cyclization Reaction of Isocyanides in the Synthesis of 1,4-Diaryl-1H-imidazoles: Presence of N-Arylformimidate Intermediate

(2014) Benjamin Pooi et al.   JOURNAL OF ORGANIC CHEMISTRY

Triple Role of Phenylselenonyl Group Enabled a One-Pot Synthesis of 1,3-Oxazinan-2-ones From α-Isocyanoacetates, Phenyl Vinyl Selenones, and Water

(2014) Thomas Buyck et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Overcoming the limitations of directed C–H functionalizations of heterocycles

(2014) Yue-Jin Liu et al.   NATURE

Pd-Catalyzed Oxidative Annulation of Hydrazides with Isocyanides: Synthesis of 2-Amino-1,3,4-oxadiazoles

(2014) Tao Fang et al.   ORGANIC LETTERS

Synthesis of Substituted 2-Aminoimidazoles via Pd-Catalyzed Alkyne Carboamination Reactions. Application to the Synthesis of Preclathridine Natural Products

(2014) Blane P. Zavesky et al.   ORGANIC LETTERS

[4+1] Cycloaddition of N-acylimine derivatives with isocyanides: efficient synthesis of 5-aminooxazoles and 5-aminothiazoles

(2014) Takahiro Soeta et al.   TETRAHEDRON

Exploiting the divalent nature of isonitriles: a novel Pictet–Spengler amidination process

(2014) Federico Medda et al.   TETRAHEDRON LETTERS

Copper-catalyzed three-component synthesis of 5-acetamidoimidazoles from carbodiimides, acyl chlorides and isocyanides

(2014) Giulia Sapuppo et al.   Organic Chemistry Frontiers

Zinc Bromide Promoted Coupling of Isonitriles with Carboxylic Acids To Form 2,4,5-Trisubstituted Oxazoles

(2013) Yann Odabachian et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Catalytic Enantioselective Michael Addition of α-Aryl-α-Isocyanoacetates to Vinyl Selenone: Synthesis of α,α-Disubstituted α-Amino Acids and (+)- and (−)-Trigonoliimine A

(2013) Thomas Buyck et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-Catalyzed Migratory Insertion of Isocyanides: An Emerging Platform in Cross-Coupling Chemistry

(2013) Tjøstil Vlaar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent advances in isocyanide insertion chemistry

(2013) Guanyinsheng Qiu et al.   CHEMICAL SOCIETY REVIEWS

Synthesis of Multifunctionalized 1,2,3,4-Tetrahydropyridines, 2,3-Dihydropyridin-4(1H)-ones, and Pyridines from Tandem Reactions Initiated by [5+1] Cycloaddition of N-Formylmethyl-Substituted Enamides to Isocyanides: Mechanistic Insight and Synthetic Appl

(2013) Chuan-Hu Lei et al.   CHEMISTRY-A EUROPEAN JOURNAL

Off the Beaten Track: The Use of Secondary Amines in the Ugi Reaction

(2013) Gian Cesare Tron   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Synthesis of Substituted Pyridines from Cascade [1 + 5] Cycloaddition of Isonitriles to N-Formylmethyl-Substituted Enamides, Aerobic Oxidative Aromatization, and Acyl Transfer Reaction

(2013) Chuan-Hu Lei et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Cationic dirhodium carboxylate-catalyzed synthesis of dihydropyrimidones from propargyl ureas

(2013) Miao Yang et al.   TETRAHEDRON

Palladium(II)-Catalyzed Cycloamidination via C(sp2)H Activation and Isocyanide Insertion

(2012) Yong Wang et al.   ADVANCED SYNTHESIS & CATALYSIS

A Fascinating Journey into History: Exploration of the World of Isonitriles En Route to Complex Amides

(2012) Rebecca M. Wilson et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Sustainable Synthesis of Diverse Privileged Heterocycles by Palladium-Catalyzed Aerobic Oxidative Isocyanide Insertion

(2012) Tjøstil Vlaar et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Multicomponent Reaction to Construct Spirocyclic Oxindoles with a Michael (Triple Michael)/Cyclization Cascade Sequence as the Key Step

(2012) Jian Li et al.   CHEMISTRY-A EUROPEAN JOURNAL

Synergistic Effect of Palladium and Copper Catalysts: Catalytic Cyclizative Dimerization of ortho-(1-Alkynyl)benzamides Leading to Axially Chiral 1,3-Butadienes

(2012) Bo Yao et al.   CHEMISTRY-A EUROPEAN JOURNAL

Straightforward Assembly of Phenylimidazoquinoxalines via a One-Pot Two-Step MCR Process

(2012) Fabio De Moliner et al.   ORGANIC LETTERS

[5 + 1] Cycloaddition of C,N-Cyclic N′-Acyl Azomethine Imines with Isocyanides

(2012) Takahiro Soeta et al.   ORGANIC LETTERS

Efficient One-Pot Synthesis of Unsymmetrical Gold(I) N-Heterocyclic Carbene Complexes and Their Use as Catalysts

(2012) A. Stephen K. Hashmi et al.   ORGANOMETALLICS

Silver Hexafluoroantimonate-Catalyzed Three-Component [2+2+1] Cycloadditions of Allenoates, Dual Activated Olefins, and Isocyanides

(2011) Jian Li et al.   ADVANCED SYNTHESIS & CATALYSIS

Cyclizations of Alkynes: Revisiting Baldwin’s Rules for Ring Closure

(2011) Kerry Gilmore et al.   CHEMICAL REVIEWS

Synthesis of Heterocycles via Electrophilic Cyclization of Alkynes Containing Heteroatom

(2011) Benhur Godoi et al.   CHEMICAL REVIEWS

Renaissance of Organic Synthesis Using Isocyanides

(2011) Mamoru Tobisu et al.   CHEMISTRY LETTERS

Synthesis of 4-Aminoquinazolines by Palladium-Catalyzed Intramolecular Imidoylation of N-(2-Bromoaryl)amidines

(2011) Gitte Van Baelen et al.   CHEMISTRY-A EUROPEAN JOURNAL

Palladium-Catalyzed Intramolecular C(sp2)–H Amidination by Isonitrile Insertion Provides Direct Access to 4-Aminoquinazolines fromN-Arylamidines

(2011) Yong Wang et al.   ORGANIC LETTERS

Enantioselective synthesis of cyclic carbamimidates via a three-component reaction of imines, terminal alkynes, and p-toluenesulfonylisocyanate using a monophosphine gold(i) catalyst

(2011) Matthew J. Campbell et al.   Chemical Science

Palladium-Catalyzed Cyclization of Propargylic Compounds

(2010) Li-Na Guo et al.   ACCOUNTS OF CHEMICAL RESEARCH

Regioselective Functionalization of the Imidazole Ring via Transition Metal-Catalyzed CN and CC Bond Forming Reactions

(2010) Fabio Bellina et al.   ADVANCED SYNTHESIS & CATALYSIS

Carbenes Made Easy: Formation of Unsymmetrically Substituted N-Heterocyclic Carbene Complexes of Palladium(II), Platinum(II) and Gold(I) from Coordinated Isonitriles and their Catalytic Activity

(2010) A. Stephen K. Hashmi et al.   ADVANCED SYNTHESIS & CATALYSIS

Concise and Diversity-Oriented Route toward Polysubstituted 2-Aminoimidazole Alkaloids and Their Analogues

(2010) Denis S. Ermolat'ev et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Isocyanides in the Synthesis of Nitrogen Heterocycles

(2010) Alexander V. Lygin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Regioselective Rhodium(II)-Catalyzed Hydroaminations of Propargylguanidines

(2010) Morgan J. Gainer et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Isocyanoacetate Derivatives: Synthesis, Reactivity, and Application

(2010) Anton V. Gulevich et al.   CHEMICAL REVIEWS

Palladium-Catalyzed Cyclocoupling of 2-Halobiaryls with Isocyanides via the Cleavage of Carbon−Hydrogen Bonds

(2010) Mamoru Tobisu et al.   JOURNAL OF ORGANIC CHEMISTRY

Atom-Economical Synthesis ofN-Heterocycles via Cascade Inter-/Intramolecular C−N Bond-Forming Reactions Catalyzed by Ti Amides

(2010) Hao Shen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Macrocyclization of Linear Peptides Enabled by Amphoteric Molecules

(2010) Ryan Hili et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Silver-Catalyzed Intramolecular Cyclization ofo-(1-Alkynyl)benzamides: Efficient Synthesis of (1H)-Isochromen-1-imines

(2009) Guannan Liu et al.   ADVANCED SYNTHESIS & CATALYSIS

Product Selectivity Control in the Heteroannulation ofo-(1-Alkynyl)benzamides

(2009) Gabriele Bianchi et al.   ADVANCED SYNTHESIS & CATALYSIS

Addition-Hydroamination Reactions of Propargyl Cyanamides: Rapid Access to Highly Substituted 2-Aminoimidazoles

(2009) Robert L. Giles et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Alkyne activation with Brønsted acids, iodine, or gold complexes, and its fate leading to synthetic application

(2009) Yoshinori Yamamoto et al.   CHEMICAL COMMUNICATIONS

Multiple Multicomponent Macrocyclizations (MiBs): A Strategic Development Toward Macrocycle Diversity

(2009) Ludger A. Wessjohann et al.   CHEMICAL REVIEWS

Palladium-catalyzed Decarboxylative [4+1] Cyclization of γ-Methylidene-δ-valerolactones with Isocyanides

(2009) Soyoung Park et al.   CHEMISTRY LETTERS

Dichotomous Control ofE/Z-Geometry in Intramolecular Cyclization ofo-Alkynylbenzamide Derivatives Catalyzed by Organic Superbase P4-tBu in the Presence/Absence of Water

(2009) Chikashi Kanazawa et al.   Chemistry-An Asian Journal

Gold(I)-Catalyzed Tandem Reactions Initiated by Hydroamination of Alkynyl Carbamates: Application to the Synthesis of Nitidine

(2009) Taro Enomoto et al.   JOURNAL OF ORGANIC CHEMISTRY

Highly Efficient Access to Iminoisocoumarins and α-Iminopyrones via AgOTf-Catalyzed Intramolecular Enyne−Amide Cyclization

(2009) Ming Bian et al.   JOURNAL OF ORGANIC CHEMISTRY

Assembly of Substituted 3-Methyleneisoindolin-1-ones via a CuI/l-Proline-Catalyzed Domino Reaction Process of 2-Bromobenzamides and Terminal Alkynes

(2009) Li Li et al.   ORGANIC LETTERS

Synthesis of Pyrroles by Consecutive Multicomponent Reaction/[4 + 1] Cycloaddition of α-Iminonitriles with Isocyanides

(2009) Patrice Fontaine et al.   ORGANIC LETTERS

Coupling Isocyanide-Based Multicomponent Reactions with Aliphatic or Acyl Nucleophilic Substitution Processes

(2009) Luca Banfi et al.   SYNLETT

Ag-Mediated Reactions: Coupling and Heterocyclization Reactions

(2008) Jean-Marc Weibel et al.   CHEMICAL REVIEWS

Heterocycles as Key Substrates in Multicomponent Reactions: The Fast Lane towards Molecular Complexity

(2008) Nicolas Isambert et al.   CHEMISTRY-A EUROPEAN JOURNAL

Metal-Catalyzed One-Step Synthesis: Towards Direct Alternatives to Multistep Heterocycle and Amino Acid Derivative Formation

(2008) Bruce A. Arndtsen   CHEMISTRY-A EUROPEAN JOURNAL

InBr3-Promoted Divergent Approach to Polysubstituted Indoles and Quinolines from 2-Ethynylanilines: Switch from an Intramolecular Cyclization to an Intermolecular Dimerization by a Type of Terminal Substituent Group

(2008) Norio Sakai et al.   JOURNAL OF ORGANIC CHEMISTRY

Construction of Heterocycles by the Strategic Use of Alkyne π-Activation in Catalyzed Cascade Reactions

(2008) Stefan Kirsch   SYNTHESIS-STUTTGART

Beyond the Ugi reaction: less conventional interactions between isocyanides and iminium species

(2008) Laurent El Kaim et al.   TETRAHEDRON

Catalytic Enantioselective Passerini Three-Component Reaction

(2007) Shi-Xin Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION