Article
Chemistry, Organic
Jinhuan Dong, Lei Wang, Haoyue Li, Xinrong Leng, Xiaoyu Guo, Zhongyan Hu, Xianxiu Xu
Summary: A new method for solvent-dependent chemoselective Morita-Baylis-Hillman-type self-cyclization and dimerization of o-alkenyl arylisocyanides was developed, providing concise access to various 3-acylquinoline and pyrrolo[1,2-a:3,4-b ']diindole frameworks via distinct domino processes from the same starting materials.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Organic
Meysam Azizzade, Parviz Rashidi Ranjbar, Akram Sajadi
Summary: A novel regioselective annulation of propargylic alcohols with simple carbazoles has been developed for the synthesis of [3,2,1-jk]carbazole scaffolds. Additionally, in situ synthesis of propargyl alcohols from simple and easily accessible ketones was achieved during the one-pot synthesis of [3,2,1-jk]carbazoles.
Article
Chemistry, Organic
Chuan-Chuan Wang, Yan-Tao Yang, Qing-Long Wang, Xue-Hua Liu, Ya-Jing Chen
Summary: A regioselective and stereospecific reaction method has been developed for the preparation of functionalized 3,4-dihydro-2H-1,4-thiazines, while retaining the stereochemistry. This reaction is greatly influenced by the substituents on the aziridines and allows for the convenient synthesis of biologically interesting sulfoxide and sulfone analogues.
ORGANIC CHEMISTRY FRONTIERS
(2022)
Article
Chemistry, Organic
Samiran Dhara, Subhadeep Ghosh, Asish R. Das
Summary: Functionalized pyrrolo[2,1-b]quinazoline scaffolds were efficiently synthesized via domino ring opening cyclization (DROC) reactions. This transformation, catalyzed by iron, allows for the sequential construction of three new C-N bonds and two rings, and is applicable to a wide range of substrates.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Organic
Ekaterina A. Lystsova, Maksim V. Dmitriev, Andrey N. Maslivets, Ekaterina E. Khramtsova
Summary: A new synthetic approach to pyrrolobenzothiazoles is developed based on 1,4-thiazine ring contraction in 3-aroylpyrrolo[2,1-c][1,4]benzothiazine-1,2,4-triones under the action of nucleophiles. The proposed approach works well with alkanols, benzylamine, and arylamines. The synthesized pyrrolobenzothiazole derivatives represent an interest to pharmaceutics for targeted cancer therapy development.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Fei Tian, Wu-Lin Yang, Tao Ni, Jian Zhang, Wei-Ping Deng
Summary: The development of efficient methods for synthesizing chiral polycyclic indoles is crucial for their wide applications in medicines, pesticides, and other functional molecules. The study revealed novel indolyl substituted metal-allyl zwitterionic intermediates that could participate in asymmetric cycloaddition reactions with high selectivities, leading to the synthesis of diverse chiral polycyclic indoles.
SCIENCE CHINA-CHEMISTRY
(2021)
Article
Chemistry, Organic
Yifan Ouyang, Kaifu Wu, Wei Zhou, Qian Cai
Summary: An efficient and convenient method for the synthesis of pyrrole-fused tetracyclic skeletons is described in this study, utilizing CuI as a catalyst. The reaction involves tandem [3 + 2] cycloaddition and C-C coupling processes to form 7-membered cyclic ketones fused with pyrrole and biphenyl rings.
ORGANIC CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Organic
Asmaa Belabbes, Veronica Selva, Francisco Foubelo, M. De Gracia Retamosa, Jose M. Sansano
Summary: The synthesis of complex spiro{pyrrolidine-3,1'-pyrrolo[3,4-c]pyrrole} skeleton under mild conditions is presented, with the order of addition of a primary amine and two equivalents of corresponding maleimide being crucial for high yields. The mechanism was studied by simple tests, revealing the Michael type addition of the amine onto the maleimide as a key step. Interesting scaffold hybrids were prepared through sequential addition of two different maleimides, and a more intriguing architecture was obtained through a metathesis reaction between allylic residues in the molecule precursor.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Cheng Zhao, Man-Zhen Gu, Yi-Yuan Chen, Xiao-Wei Hu, Yi-Bing Xu, Xiao-Min Lin, Xin-Ni Liu, Long Chen, Guo-Shu Chen, Yun-Lin Liu
Summary: A base-catalyzed divergent synthesis of multisubstituted imidazoles has been developed through TosMIC-based [3 + 2] cyclization reaction, resulting in different substitution patterns of products.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Review
Chemistry, Organic
Prasanta Patra
Summary: This review presents a comprehensive literature on the synthetic methodology, biological activities, and fluorescence activities of pyrrolo[3,4-c]coumarins published in the last 20-30 years. Synthesizing pyrrolo[3,4-c]coumarins has been reported in the literature through various methods, including metal-catalyzed reactions and green reaction protocols using readily accessible substrates.
SYNTHETIC COMMUNICATIONS
(2022)
Article
Chemistry, Organic
Aurelien Dupeux, Veronique Michelet
Summary: A novel and mild synthetic route for preparing functionalized polycyclic indole skeletons via gold-mediated cycloisomerization/alkoxylation of 1,6-aldehyde-yne has been developed. This atom-economical catalytic process demonstrated remarkable selectivity in accessing functionalized 3,4-dihydro-1H-[1,4]oxazino[4,3-a]indole derivatives with high synthetic utility. Additionally, it could be optimized under asymmetric conditions with an enantiomeric excess of <= 86%.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Yan Chen, Andrey Shatskiy, Jian-Quan Liu, Markus D. Karkas, Xiang-Shan Wang
Summary: An unprecedented silver-promoted regioselective (4 + 1) annulation of isocyanoacetates with pyridinium salts is reported in this study, providing access to various synthetically useful N-fused heterocyclic scaffolds. The mechanism involves nucleophilic addition/protonation/elimination/cydoisomerization pathways. The protocol established in this research is controlled, facile, and modular.
Article
Biochemistry & Molecular Biology
Bastien Champciaux, Clement Raynaud, Albertus Viljoen, Loic Chene, Jerome Thibonnet, Stephane P. Vincent, Laurent Kremer, Emilie Thiery
Summary: This study focuses on the synthesis of 1,7- and 3,4-indole-fused lactones via a simple and efficient reaction sequence, with the evaluation of their activity against Mycobacterium tuberculosis showing that the oxazepino-indole structure is a new inhibitor of M. tuberculosis growth in vitro.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Organic
Lan Bao, Min Li, Lianshun Zhang, Yating Xue, Jinhuan Dong, Xianxiu Xu
Summary: We report a new isocyanide-based three-component reaction that generates an unprecedented zwitterionic intermediate from the chemoselective heterodimerization of weak electrophilic ortho-diisocyanoarenes and common isocyanides. This reactive zwitterion can react in situ with various trapping agents to form a range of structurally diverse quinoxalines.
Article
Chemistry, Multidisciplinary
Bradley K. Gall, Avery K. Smith, Eric M. Ferreira
Summary: A direct dearomative photocatalyzed (3+2) cycloaddition between indoles and vinyldiazo reagents is achieved using a novel oxidizing Cr-III photocatalyst. This transformation allows the synthesis of various fused indoline compounds, including densely functionalized ring systems, under base-free conditions. Experimental insights support a cycloaddition initiated by nucleophilic attack of the vinyldiazo species at C3 of the indole radical cation.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Oncology
Xuting Li, Shihao Chen, Jingping Zhang, Lezhi Li, Yingxia Li, Man Ye
Summary: This qualitative study explored the resilience process and protective factors in long-term survivors post lung cancer surgery, revealing three stages of resilience and five themes contributing to resilience. Future research could focus on the duration of each stage and interventions for educating cancer patients on resilience.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Nanoscience & Nanotechnology
Zhifang Yang, Wenliang Li, Jingping Zhang
Summary: This study explores high-capacity and efficient anode materials for rechargeable lithium-ion batteries. It is found that borophene and phosphorene can form stable heterojunctions with good conductivity. The theoretical capacity of these heterojunctions is high, and the average voltage is greatly reduced compared to bare phosphorene. Therefore, the B/P heterojunction shows great potential for application.
Article
Chemistry, Multidisciplinary
Shen-Gen Gong, Yan-Hong Shi, Yang Su, Yan-Fei Li, Lei Ding, Jian Lin, Guo-Duo Yang, Bing Li, Xing-Long Wu, Jing-Ping Zhang, Hai-Ming Xie, Hai-Zhu Sun
Summary: This study investigates a flexible 3D lamellar Mn(OH)(2) nanosheets electrode material, successfully achieving flexible materials in FASC with high capacitance, wide voltage range, and superior energy storage properties. The assembled FASC demonstrates the ability to maintain high energy density under high power density, showing potential for wearable electronics applications.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2021)
Article
Nanoscience & Nanotechnology
Yue-Ming Li, Wen-Hao Li, Wan-Yue Diao, Fang-Yu Tao, Xing-Long Wu, Xiao-Ying Zhang, Jing-Ping Zhang
Summary: The modification of zinc anodes using a ball-milling clay precipitate to create a three-dimensional framework on the surface of the zinc foil improves the stability and performance of zinc-ion batteries. It relieves the stress caused by volume change and ensures uniform ion flux, leading to a stable long cycle and inhibition of side reactions.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Fang-Yu Tao, Xiao-Ying Zhang, Dan Xie, Wan-Yue Diao, Chang Liu, Hai-Zhu Sun, Xing-Long Wu, Wen-Liang Li, Jing-Ping Zhang
Summary: This study presents a method to spatially confine lithium deposition using lithiophilic honeycomb-like layered double hydroxide nanosheet arrays, which effectively inhibits the dendritic lithium growth and volume change. The resulting symmetric cell exhibits low overpotential and a long lifespan, suggesting the great potential of this material for stabilizing lithium metal anodes.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Physical
Yang Su, Yan-Fei Li, Shen-Gen Gong, Yi-Han Song, Bing Li, Xing-Long Wu, Jing-Ping Zhang, Dong-Tao Liu, Chang-Lu Shao, Hai-Zhu Sun
Summary: According to the study, the design and synthesis of a heteroatom co-doped composite TiO2@MoSe2/RGO can improve the electrochemical performance and cycling stability of sodium-ion storage devices.
APPLIED SURFACE SCIENCE
(2023)
Article
Nanoscience & Nanotechnology
Rui Jiao, Yan-Fei Li, Guo-Duo Yang, Wen-Chen Wang, Lei Ding, Jian Lin, Yi-Han Song, Jia-Yu Zhang, Xing-Long Wu, Jing-Ping Zhang, Ming-Xiao Deng, Hai-Zhu Sun
Summary: Synthesizing alloy-type materials is an effective method to prevent lithium dendrites in Li metal anode due to their good lithiophilicity and easy electrochemical reaction with lithium. However, previous studies have neglected the alloying reaction process between Li+ and X. In this work, a novel approach involving the alloy reaction between Li+ and Zn is developed to inhibit lithium dendrites more effectively. A three-dimensional substrate material loaded with metallic Zn on the surface of Cu foam is synthesized, enabling a more uniform Li nucleation and growth. The full cell demonstrates a reversible capacity of 122.5 mAh g(-1) and a high capacity retention of 95% after 180 cycles.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Jian Lin, Yanfei Li, Yihan Song, Jingping Zhang, Haiming Xie, Haizhu Sun
Summary: The inner-outer dual space protection of MoS2 fibers is achieved by regulating the surface and interface structure of electrospinning precursors. This work provides a new idea for the preparation of stable anodes for alkali metal ion secondary batteries, with a decent cycling performance and satisfying rate capacities.
Article
Chemistry, Multidisciplinary
Wan-Yue Diao, Dan Xie, Yuan Sang, Fang-Yu Tao, Chang Liu, Hai-Zhu Sun, Wen-Liang Li, Xing-Long Wu, Jing-Ping Zhang
Summary: In this study, a liquid-dynamic and self-adaptive protective layer is constructed on the Zn metal surface to improve the reversibility and stability. The outer layer consists of liquid PFPE, which can adapt volume change and inhibit side reactions. The inner layer is composed of in-situ formed ZnF2, which accelerates ion transfer and restricts dendrite formation.
Article
Chemistry, Multidisciplinary
Chang Liu, Wen-Bin Jiang, Dan Xie, Wan-Yue Diao, Fang-Yu Tao, Xin-Zhe Wang, Hai-Zhu Sun, Wen-Liang Li, Xing-Long Wu, Jing-Ping Zhang
Summary: Reconstructing the inner Helmholtz layer (IHL) by introducing an electrolyte additive is a promising strategy to obtain stable Zn metal anodes in aqueous zinc ion batteries (AZIBs). The addition of (4-chloro-3-nitrophenyl) (pyridin-4-yl) methanone (CNPM) to the ZnSO4 electrolyte reshapes the Zn metal anode/electrolyte interface and changes the solvation structure of Zn2+. The CNPM adsorbs on the Zn anode surface and serves as zincophilic sites, leading to uniform Zn deposition along the (002) plane and suppressing dendrite growth and parasitic reactions.
Article
Chemistry, Multidisciplinary
Jiangyan Dang, Jingjing Qiu, Xiaoying Zhang, Ruifa Jin, Bowen Qin, Jingping Zhang
Summary: A series of mixed NiCoFe-MOFs with low crystallinity were successfully synthesized as direct electrocatalysts for the oxygen evolution reaction. The flower-like nanocatalyst NiCoFe-MOF-2 exhibited a hierarchical pore network, large specific surface area, adjustable electronic structure, effective mass transfer, and abundant exposed active sites, resulting in excellent electrocatalytic OER performance.
Article
Chemistry, Organic
Manzhu Zhao, Haiyan Yuan, Jingping Zhang
Summary: Computational studies revealed that the Pd-II-π-allyl coordinated mechanism is the most preferred pathway in the Pd-catalyzed regiodivergent coupling reaction of indazoles and isoprene. The regioselectivity of 1,2-insertion is influenced by the noncovalent interactions between the less bulky ligand L1, substrates, and (PhO)2PO2-. On the other hand, the regioselectivity of 4,3-insertion is primarily controlled by the steric repulsion of the t-Bu group of the bulky ligand L2 and substrate, as well as the geometry distortion. Similarly, the nucleophilic site selectivity at N-1 or N-2 of indazoles is determined by the cooperative effect of acid BF3 and solvent (PrOH)-Pr-i.
JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Physical
Danhong Wang, Zhifang Yang, Wenliang Li, Jingping Zhang
Summary: Two-dimensional materials have gained attention in metal-ion batteries due to their high specific surface area, abundant active sites, and good electronic properties. In this study, a new 2D B3S2 monolayer with high stability is designed based on first-principles calculations. The B3S2 monolayer exhibits metallic nature, low diffusion energy barrier, and high theoretical capacity as an anode material for sodium-ion batteries, making it a promising candidate in the field.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Bowen Qin, Xiaoying Zhang, Jiangyan Dang, Dan Yue, Bing Zhang, Weidong Li, Godefroid Gahungu, Zhenling Wang, Jingping Zhang
Summary: A 3D luminescent Zn-MOF with a pillared-layer structure was synthesized in this study. This compound showed promising applications in ion sensing and white-light emission.
Article
Chemistry, Organic
Li-Han Zhu, Hai-Yan Yuan, Jing-Ping Zhang
Summary: The study quantified the effects of electrostatic and noncovalent interactions on the activation model and enantioselectivity for N-triflylphosphoramide catalysis using DFT calculations. It found that the oxygen activated model is more effective than the nitrogen activated model, and that the chiral electrostatic environment of the chiral pocket controlled by charge distribution patterns distinguishes the preferred activation model, impacting enantioselectivity. Additionally, free hydroxyl substituents slightly enhance enantiocontrol through providing relative favorable distortion energy.
ORGANIC CHEMISTRY FRONTIERS
(2021)
