Chemical-induced contact allergy: from mechanistic understanding to risk prevention

Xenobiotica-metabolizing enzymes in the skin of rat, mouse, pig, guinea pig, man, and in human skin models

(2018) F. Oesch et al.   ARCHIVES OF TOXICOLOGY

Stable PEG-coated silver nanoparticles – A comprehensive toxicological profile

(2018) Iulia Pinzaru et al.   FOOD AND CHEMICAL TOXICOLOGY

In vitro assessment of silver nanoparticles immunotoxicity

(2018) Valentina Galbiati et al.   FOOD AND CHEMICAL TOXICOLOGY

Skin sensitisation quantitative risk assessment (QRA) based on aggregate dermal exposure to methylisothiazolinone in personal care and household cleaning products

(2018) J. Ezendam et al.   FOOD AND CHEMICAL TOXICOLOGY

Identification of polystyrene nanoparticle penetration across intact skin barrier as rare event at sites of focal particle aggregations

(2018) Nadine Döge et al.   Journal of Biophotonics

Syndecan-1 regulates dendritic cell migration in cutaneous hypersensitivity to haptens

(2017) Marco Averbeck et al.   EXPERIMENTAL DERMATOLOGY

HA metabolism in skin homeostasis and inflammatory disease

(2017) Rafaela-Maria Kavasi et al.   FOOD AND CHEMICAL TOXICOLOGY

Integrated decision strategies for skin sensitization hazard

(2017) Judy Strickland et al.   JOURNAL OF APPLIED TOXICOLOGY

Prediction of skin sensitization potency using machine learning approaches

(2017) Qingda Zang et al.   JOURNAL OF APPLIED TOXICOLOGY

The nature and biology of basement membranes

(2017) Ambra Pozzi et al.   MATRIX BIOLOGY

Amphiphilic poly-N-vinylpyrrolidone nanoparticles as carriers for non-steroidal, anti-inflammatory drugs: In vitro cytotoxicity and in vivo acute toxicity study

(2017) Andrey N. Kuskov et al.   Nanomedicine-Nanotechnology Biology and Medicine

Biocompatible Colloidal Suspensions Based on Magnetic Iron Oxide Nanoparticles: Synthesis, Characterization and Toxicological Profile

(2017) Dorina-Elena Coricovac et al.   Frontiers in Pharmacology

Quantitative Characterization of the T Cell Receptor Repertoire of Naïve and Memory Subsets Using an Integrated Experimental and Computational Pipeline Which Is Robust, Economical, and Versatile

(2017) Theres Oakes et al.   Frontiers in Immunology

IL-4 and human skin mast cells revisited: reinforcement of a pro-allergic phenotype upon prolonged exposure

(2016) Magda Babina et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Increased syndecan-4 expression in sera and skin of patients with atopic dermatitis

(2016) Momoko Nakao et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

A novel method to generate monocyte-derived dendritic cells during coculture with HaCaT facilitates detection of weak contact allergens in cosmetics

(2016) Janna Frombach et al.   ARCHIVES OF TOXICOLOGY

Protein bio-corona: critical issue in immune nanotoxicology

(2016) Monica Neagu et al.   ARCHIVES OF TOXICOLOGY

In vitro dermal penetration of nickel nanoparticles

(2016) Matteo Crosera et al.   CHEMOSPHERE

Drug nanocarrier, the future of atopic diseases: Advanced drug delivery systems and smart management of disease

(2016) Mei Shao et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Size dependent skin penetration of nanoparticles in murine and porcine dermatitis models

(2016) Céline Try et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Emerging aspects of nanotoxicology in health and disease: From agriculture and food sector to cancer therapeutics

(2016) Zoi Piperigkou et al.   FOOD AND CHEMICAL TOXICOLOGY

Amphiphilic poly-N-vynilpyrrolidone nanoparticles: Cytotoxicity and acute toxicity study

(2016) A.N. Kuskov et al.   FOOD AND CHEMICAL TOXICOLOGY

The Involvement of Protein Kinase D in T Cell-Induced Mast Cell Activation

(2016) Pazit Salamon et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Functions of Exosomes and Microbial Extracellular Vesicles in Allergy and Contact and Delayed-Type Hypersensitivity

(2016) Katarzyna Nazimek et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Integrated decision strategies for skin sensitization hazard

(2016) Judy Strickland et al.   JOURNAL OF APPLIED TOXICOLOGY

Allergic inflammation is augmented via histamine H4 receptor activation: The role of natural killer cells in vitro and in vivo

(2016) Sarah Ehling et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Mast Cells Limit the Exacerbation of Chronic Allergic Contact Dermatitis in Response to Repeated Allergen Exposure

(2016) Vladimir-Andrey Gimenez-Rivera et al.   JOURNAL OF IMMUNOLOGY

In vitro micro-physiological immune-competent model of the human skin

(2016) Qasem Ramadan et al.   LAB ON A CHIP

SENS-IS, a 3D reconstituted epidermis based model for quantifying chemical sensitization potency: Reproducibility and predictivity results from an inter-laboratory study

(2016) Françoise Cottrez et al.   TOXICOLOGY IN VITRO

Serum osteopontin levels in disseminated allergic contact dermatitis

(2015) Teresa Reduta et al.   Advances in Medical Sciences

From Mysterious Supernatant Entity to miRNA-150 in Antigen-Specific Exosomes: a History of Hapten-Specific T Suppressor Factor

(2015) Włodzimierz Ptak et al.   ARCHIVUM IMMUNOLOGIAE ET THERAPIAE EXPERIMENTALIS

Decoding the Matrix: Instructive Roles of Proteoglycan Receptors

(2015) Thomas Neill et al.   BIOCHEMISTRY

Nano-TiO2modulates the dermal sensitization potency of dinitrochlorobenzene after topical exposure

(2015) S. Smulders et al.   BRITISH JOURNAL OF DERMATOLOGY

Hyaluronan Does Not Regulate Human Epidermal Keratinocyte Proliferation and Differentiation

(2015) Jérémy Malaisse et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toll-Like Receptor 3 Increases Allergic and Irritant Contact Dermatitis

(2015) Naomi Nakamura et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Common clonal origin of central and resident memory T cells following skin immunization

(2015) Olivier Gaide et al.   NATURE MEDICINE

Cutaneous exposure to agglomerates of silica nanoparticles and allergen results in IgE-biased immune response and increased sensitivity to anaphylaxis in mice

(2015) Toshiro Hirai et al.   Particle and Fibre Toxicology

Hyaluronan regulates chemical allergen-induced IL-18 production in human keratinocytes

(2015) Dragana Nikitovic et al.   TOXICOLOGY LETTERS

Matrix Hyaluronan-Activated CD44 Signaling Promotes Keratinocyte Activities and Improves Abnormal Epidermal Functions

(2014) Lilly Y.W. Bourguignon   AMERICAN JOURNAL OF PATHOLOGY

Heparan sulfate proteoglycans and heparin regulate melanoma cell functions

(2014) D. Nikitovic et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Upconversion Nanoparticles: Design, Nanochemistry, and Applications in Theranostics

(2014) Guanying Chen et al.   CHEMICAL REVIEWS

Molecular profiling of contact dermatitis skin identifies allergen-dependent differences in immune response

(2014) Nikhil Dhingra et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Development of a multiparametricin vitromodel of skin sensitization

(2014) Muriel Guyard-Nicodème et al.   JOURNAL OF APPLIED TOXICOLOGY

Complexity of Danger: The Diverse Nature of Damage-associated Molecular Patterns

(2014) Liliana Schaefer   JOURNAL OF BIOLOGICAL CHEMISTRY

Hyaluronan digestion controls DC migration from the skin

(2014) Jun Muto et al.   JOURNAL OF CLINICAL INVESTIGATION

Neutrophils are required for both the sensitization and elicitation phase of contact hypersensitivity

(2014) Felix C. Weber et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Defective basement membrane in atopic dermatitis and possible role of IL-13

(2014) J.W. Shin et al.   JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

Topically applied ZnO nanoparticles suppress allergen induced skin inflammation but induce vigorous IgE production in the atopic dermatitis mouse model

(2014) Marit Ilves et al.   Particle and Fibre Toxicology

Performance of the N/TERT epidermal model for skin sensitizer identification via Nrf2-Keap1-ARE pathway activation

(2014) Mariam Alloul-Ramdhani et al.   TOXICOLOGY IN VITRO

Why does allergic contact dermatitis exist?

(2013) J.P. McFadden et al.   BRITISH JOURNAL OF DERMATOLOGY

TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis

(2013) Boyi Liu et al.   FASEB JOURNAL

Role of oxidative stress in chemical allergens induced skin cells activation

(2013) Emanuela Corsini et al.   FOOD AND CHEMICAL TOXICOLOGY

ROS-major mediators of extracellular matrix remodeling during tumor progression

(2013) Dragana Nikitovic et al.   FOOD AND CHEMICAL TOXICOLOGY

Antigen-specific, antibody-coated, exosome-like nanovesicles deliver suppressor T-cell microRNA-150 to effector T cells to inhibit contact sensitivity

(2013) Krzysztof Bryniarski et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

An epidermal equivalent assay for identification and ranking potency of contact sensitizers

(2013) Susan Gibbs et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Skin Penetration and Cellular Uptake of Amorphous Silica Nanoparticles with Variable Size, Surface Functionalization, and Colloidal Stability

(2012) Fiorenza Rancan et al.   ACS Nano

Allergic contact dermatitis induces upregulation of identical microRNAs in humans and mice

(2012) Marie T. Vennegaard et al.   CONTACT DERMATITIS

Allergic contact dermatitis: xenoinflammation of the skin

(2012) Stefan F Martin   CURRENT OPINION IN IMMUNOLOGY

Anin vitromethod for detecting chemical sensitization using human reconstructed skin models and its applicability to cosmetic, pharmaceutical, and medical device safety testing

(2012) James M. McKim et al.   Cutaneous and Ocular Toxicology

Crosstalk of regulatory T cells and tolerogenic dendritic cells prevents contact allergy in subjects with low zone tolerance

(2012) Ulrike Luckey et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Biology of Small Leucine-rich Proteoglycans in Bone Pathophysiology

(2012) Dragana Nikitovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IL-1 Receptor Signaling Is Required at Multiple Stages of Sensitization and Elicitation of the Contact Hypersensitivity Response

(2012) D. D. Kish et al.   JOURNAL OF IMMUNOLOGY

Relevance of xenobiotic enzymes in human skinin vitromodels to activate pro-sensitizers

(2012) Christine Jäckh et al.   Journal of Immunotoxicology

IgE and mast cells in allergic disease

(2012) Stephen J Galli et al.   NATURE MEDICINE

Contact Sensitizers Induce Skin Inflammation via ROS Production and Hyaluronic Acid Degradation

(2012) Philipp R. Esser et al.   PLoS One

Transfer of a two-tiered keratinocyte assay: IL-18 production by NCTC2544 to determine the skin sensitizing capacity and epidermal equivalent assay to determine sensitizer potency

(2012) Marc Teunis et al.   TOXICOLOGY IN VITRO

Data integration of non-animal tests for the development of a test battery to predict the skin sensitizing potential and potency of chemicals

(2012) Yuko Nukada et al.   TOXICOLOGY IN VITRO

Mechanisms of chemical-induced innate immunity in allergic contact dermatitis

(2011) S. F. Martin et al.   ALLERGY

Isoeugenol destabilizes IL-8 mRNA expression in THP-1 cells through induction of the negative regulator of mRNA stability tristetraprolin

(2011) Valentina Galbiati et al.   ARCHIVES OF TOXICOLOGY

The extracellular matrix of the dermis: flexible structures with dynamic functions

(2011) Thomas Krieg et al.   EXPERIMENTAL DERMATOLOGY

Small hyaluronan oligosaccharides induce inflammation by engaging both toll-like-4 and CD44 receptors in human chondrocytes

(2010) Giuseppe M. Campo et al.   BIOCHEMICAL PHARMACOLOGY

Reactive Oxygen Species and Hyaluronidase 2 Regulate Airway Epithelial Hyaluronan Fragmentation

(2010) Maria E. Monzon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential hyaluronan homeostasis and expression of proteoglycans in juvenile and adult human skin

(2010) Thrasivoulos G. Tzellos et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

A Novel In Vitro Method for the Detection and Characterization of Photosensitizers

(2010) Nadine Karschuk et al.   PLoS One

Classification of sensitizing and irritative potential in a combined in-vitro assay

(2010) Reinhard Wanner et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Basement Membranes: Cell Scaffoldings and Signaling Platforms

(2010) P. D. Yurchenco   Cold Spring Harbor Perspectives in Biology

Effector and regulatory mechanisms in allergic contact dermatitis

(2009) M. Vocanson et al.   ALLERGY

The Inflammasomes: Guardians of the Body

(2009) Fabio Martinon et al.   Annual Review of Immunology

Dendritic cells: biology of the skin

(2009) Mascha J. Toebak et al.   CONTACT DERMATITIS

Toll-like receptor 2 is important for the TH1 response to cutaneous sensitization

(2009) Haoli Jin et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Updating the skin sensitizationin vitrodata assessment paradigm in 2009

(2009) David A. Basketter et al.   JOURNAL OF APPLIED TOXICOLOGY

IL-17 and IFN-  Mediate the Elicitation of Contact Hypersensitivity Responses by Different Mechanisms and Both Are Required for Optimal Responses

(2009) D. He et al.   JOURNAL OF IMMUNOLOGY

Increased Hyaluronan Production and Decreased E-Cadherin Expression by Cytokine-Stimulated Keratinocytes Lead to Spongiosis Formation

(2009) Tomoyuki Ohtani et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Contrasting Roles of the IL-1 and IL-18 Receptors in MyD88-Dependent Contact Hypersensitivity

(2009) Paul A. Klekotka et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Perlecan regulates developmental angiogenesis by modulating the VEGF-VEGFR2 axis

(2009) Jason J. Zoeller et al.   MATRIX BIOLOGY

A Clear and Present Danger: Endogenous Ligands of Toll-like Receptors

(2009) Jacob A. Sloane et al.   NEUROMOLECULAR MEDICINE

Progress on the development of human in vitro dendritic cell based assays for assessment of the sensitizing potential of a compound

(2009) G. Galvão dos Santos et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Use of IL-18 production in a human keratinocyte cell line to discriminate contact sensitizers from irritants and low molecular weight respiratory allergens

(2009) Emanuela Corsini et al.   TOXICOLOGY IN VITRO

Mechanistic assessment of peptide reactivity assay to predict skin allergens with Kathon® CG isothiazolinones

(2009) Julien Mutschler et al.   TOXICOLOGY IN VITRO

Hyaluronan in skin: aspects of aging and its pharmacologic modulation

(2008) Robert Stern et al.   CLINICS IN DERMATOLOGY

Toll-like receptor and IL-12 signaling control susceptibility to contact hypersensitivity

(2008) Stefan F. Martin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Hyaluronic acid targets CD44 and inhibits FcɛRI signaling involving PKCδ, Rac1, ROS, and MAPK to exert anti-allergic effect

(2008) Youngmi Kim et al.   MOLECULAR IMMUNOLOGY

Allergic Contact Dermatitis––Formation, Structural Requirements, and Reactivity of Skin Sensitizers

(2007) Ann-Therese Karlberg et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Respiratory sensitization and allergy: Current research approaches and needs

(2007) Darrell R. Boverhof et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY