Review
Medicine, General & Internal
Rafaela-Maria Kavasi, Monica Neagu, Carolina Constantin, Adriana Munteanu, Mihaela Surcel, Aristidis Tsatsakis, George N. Tzanakakis, Dragana Nikitovic
Summary: This article discusses the structural and functional modulations of the keratinocyte carcinoma microenvironment, focusing on the extracellular matrix (ECM) and its role in the pathogenesis of skin cancer.
FRONTIERS IN MEDICINE
(2022)
Review
Cell & Tissue Engineering
Bogi Andersen, Junyan Duan, Satya Swaroop Karri
Summary: Diurnal oscillations in stem cell proliferation exist in multiple internal epithelia, and the circadian clock plays a crucial role in regulating these oscillations in epidermal stem cell proliferation. The circadian clock also regulates DNA repair and damage response in epidermal stem cells. Disruption of circadian rhythms can lead to asynchrony between metabolism and the cell cycle, resulting in oxidative DNA damage, dysfunction of epidermal stem cells, and skin aging.
Review
Medicine, General & Internal
Naoko Okiyama
Summary: Dermatomyositis is an autoimmune disease characterized by specific skin manifestations and heterogeneous clinical features. Myositis-specific autoantibodies are associated with distinct clinical features, including severity of myopathy, potential complications of interstitial lung disease, possible association with malignancies, and characteristic cutaneous manifestations in adult and juvenile patients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Carolyn G. Chen, Aastha Kapoor, Christopher Xie, Alison Moss, Rajanikanth Vadigepalli, Sylvie Ricard-Blum, Renato V. Iozzo
Summary: The accumulation of pro-angiogenic and pro-tumorigenic hyaluronan in the tumor stroma contributes to tumorigenesis and metastatic potential. The primary enzyme promoting hyaluronan build-up in breast cancer is HAS2. This study found that endorepellin, a fragment of perlecan, targets endothelial HAS2 and hyaluronan through autophagy, leading to the suppression of breast cancer growth and angiogenesis.
Article
Cell Biology
Kang Ko, Jean J. Merlet, Brett P. DerGarabedian, Huang Zhen, Yoko Suzuki-Horiuchi, Matthew L. Hedberg, Eileen Hu, Anh T. Nguyen, Stephen Prouty, Faizan Alawi, Matthew C. Walsh, Yongwon Choi, Sarah E. Millar, Ashley Cliff, Jonathon Romero, Michael R. Garvin, John T. Seykora, Daniel Jacobson, Dana T. Graves
Summary: The study reveals the important role of a specific subpopulation of Prx1(+) fibroblasts in immune regulation of the skin. Disruption of the Ikkb-NF-kappa B pathway in these fibroblasts triggers skin inflammation and results in overexpression of CCL11, leading to eosinophil infiltration and T(H)2 immune response, resembling human atopic dermatitis. Monoclonal antibody treatment targeting CCL11 shows promising efficacy in a mouse model.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Fatemeh Salabi, Hedieh Jafari
Summary: This study revealed the differences in gene expression in the venom glands of adult and juvenile Androctonus crassicauda scorpions, providing insights into the development of venom glands. Several important genes associated with scorpion venom gland development were identified.
Article
Multidisciplinary Sciences
Sophia Maschalidi, Parul Mehrotra, Burcu N. Keceli, Hannah K. L. De Cleene, Kim Lecomte, Renee Van der Cruyssen, Pauline Janssen, Jonathan Pinney, Geert van Loo, Dirk Elewaut, Ann Massie, Esther Hoste, Kodi S. Ravichandran
Summary: SLC7A11 acts as a negative regulator of efferocytosis, inhibiting its function can accelerate wound healing; it has important implications for wound management in diabetes.
Article
Medicine, Legal
Linda Allais, Elise Brisebard, Nicolas Ravas, Jean-Paul Briffaux, Marc Pallardy
Summary: The study characterized the main skin immune populations in Gottingen Minipigs for the first time, comparing healthy and immunocompromised piglets after CsA treatment, as well as exploring other pathological conditions using a contact dermatitis model. The results suggested an increase in Langerhans cells and dermal MHCH(low)CD163(+) cells after CsA treatment, and showed potential migration of immune cells in response to the contact dermatitis challenge. This data provides new information on skin immunotoxicology in Gottingen Minipigs and offers insight into the effects of therapeutic drugs on the developing immune system.
REGULATORY TOXICOLOGY AND PHARMACOLOGY
(2021)
Article
Dermatology
Pingping Lin, Guohong Zhang, Hang Li
Summary: This article summarizes the dynamic composition and potential roles of extracellular matrix in maintaining skin homeostasis, modulating wound healing, and abnormal scarring. It includes a review of the matrix components in normal skin, their primary roles in different phases of wound healing, and the identification of novel extracellular matrix in keloids.
DERMATOLOGIC SURGERY
(2023)
Article
Health Care Sciences & Services
Marco Volante, Ida Rapa, Jasna Metovic, Francesca Napoli, Cristian Tampieri, Eleonora Duregon, Massimo Terzolo, Mauro Papotti
Summary: This study identified dysregulation of 14 genes in adrenocortical carcinomas, with most being downregulated. However, three exceptions showed increased expression levels, including HAS-1, laminin alpha 3, and osteopontin genes, which could serve as potential diagnostic and prognostic biomarkers in adrenal cortical tumors.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Multidisciplinary Sciences
Samuel L. L. Goldsmith, Stuart J. J. Newfeld
Summary: This study investigated the regulatory mechanisms of dSmad2 on dILP2 and dILP5 in Drosophila insulin producing cells (IPCs) and circadian pacemaker cells (CPCs). The results showed that dSmad2 regulates dILP2 and dILP5 through different mechanisms in IPCs and CPCs. Furthermore, dSmad2 has no significant effect on insulin-like peptides in unmated adult females, independent of dCORL and upd2.
Article
Polymer Science
Alice Donato, Elisa Belluzzi, Elena Mattiuzzo, Rina Venerando, Massimiliano Cadamuro, Pietro Ruggieri, Vincenzo Vindigni, Paola Brun
Summary: The study demonstrates that a mixture of lactose-modified chitosan and hyaluronic acid can alleviate macrophage-induced inflammation, inhibit MMP-3 expression, exert anti-oxidative effects, and promote regenerative effects on ECM.
Article
Multidisciplinary Sciences
Pere Catala, Nathalie Groen, Vanessa L. S. LaPointe, Mor M. Dickman
Summary: The primary culture of corneal endothelial cells (CECs) has limitations in terms of limited expansion and assessing the quality of the culture. Through single-cell RNA sequencing, this study identified the transcriptomic changes and suggested markers to evaluate the quality of primary CEC cultures. This research provides a better understanding of cellular heterogeneity and lays the foundation for improving culture protocols and therapies.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Shao-Wei Chen, Shing-Hsien Chou, Ying-Chang Tung, Fu-Chih Hsiao, Chien-Te Ho, Yi-Hsin Chan, Victor Chien-Chia Wu, An-Hsun Chou, Ming-En Hsu, Pyng-Jing Lin, Winston W. Y. Kao, Pao-Hsien Chu
Summary: The study found altered LUM expression in patients with AD, leading to increased s-LUM levels in blood. Lum(-/-) mice exhibited augmented AD pathogenesis, while no significant pathologic changes in AA were observed.
Article
Environmental Sciences
Paula Ramos-Silva, Mari-Lee Odendaal, Deborah Wall-Palmer, Lisette Mekkes, Katja T. C. A. Peijnenburg
Summary: The study investigated the response of different life stages of atlantid gastropods to ocean acidification. The results showed that juveniles were more sensitive to acidification, experiencing significant changes in shell growth and transcriptomic response. On the other hand, adults had significant changes in gene expression but no significant differences in shell growth.
FRONTIERS IN MARINE SCIENCE
(2022)
Letter
Otorhinolaryngology
Athanasia Printza, Stefanos Triaridis
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Article
Otorhinolaryngology
Konstantinos Valsamidis, Athanasia Printza, Jannis Constantinidis, Areti Okalidou, Stefanos Triaridis
Summary: The study found that septoplasty and inferior turbinate hypertrophy reduction can improve voice nasality and voice-related quality of life. After surgery, there were no significant differences in nasality and voice-related quality of life scores between patients and controls. However, the severity of nasal obstruction symptoms and psychological status significantly affect patients' perceptual assessment of the impact of voice performance on their quality of life.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Letter
Pediatrics
Ioanna Katsagani, Nikolaos Zagkos, Xenophon Sinopidis, Gabriel Dimitriou, Ageliki A. Karatza, Despoina Gkentzi
JOURNAL OF PAEDIATRICS AND CHILD HEALTH
(2022)
Review
Otorhinolaryngology
Chrysoula Vardaxi, Nikolaos Tsetsos, Aikaterini Koliastasi, Alexandros Poutoglidis, Konstantinos Sapalidis, Stefanos Triaridis, Athanasia Printza
Summary: This systematic review investigates the prevalence of dysphagia after thyroidectomy and finds that swallowing impairment significantly increases shortly after surgery but returns to pre-operative levels 2-3 months later. A small proportion of patients still report dysphagia even 1 year after surgery. There is no significant difference between open and endoscopic thyroid surgery at 2-3 months post-surgery.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2022)
Editorial Material
Pediatrics
Dionis Totsila, Athena Kontrafouri, Xenophon Sinopidis
Summary: This study aims to minimize knotting during urethral catheterization in children. To prevent knot formation, the nature of knots, specifically the overhand knot, must be understood. By calculating the maximum length of catheter inserted in the bladder without risk of knotting, the minimum length of catheter needed for an overhand knot was estimated. This theoretical approach provides a rough estimation that may contribute to secure catheterization. Adding the calculated length to the appropriate urethral length for gender and age may reduce the risk of knotting.
JOURNAL OF PEDIATRIC UROLOGY
(2023)
Review
Medicine, General & Internal
Elisavet Papadopoulou, Konstantinos Sapalidis, Stefanos Triaridis, Athanasia Printza
Summary: Recurrent laryngeal nerve (RLN) injury is a common complication of thyroid and parathyroid surgery, affecting the quality of life of patients. Intraoperative repair of the RLN has shown to improve phonatory function and voice quality, making it a viable alternative to traditional techniques with better long-term results. However, it is not widely used in clinical practice and should be considered if possible.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Konstantinos Zachos, Fevronia Kolonitsiou, Antonios Panagidis, Despoina Gkentzi, Sotirios Fouzas, Vasileios Alexopoulos, Eirini Kostopoulou, Stylianos Roupakias, Aggeliki Vervenioti, Theodore Dassios, George Georgiou, Xenophon Sinopidis
Summary: This study analyzed bacterial cultures from the appendix and peritoneal cavity of 72 children who underwent appendectomy, and found that Escherichia coli, Pseudomonas aeruginosa, and Streptococcus species were the most common pathogens. The same microorganisms were often found in both the appendiceal lumen and the peritoneal cavity of patients with complicated appendicitis. Gram-negative bacteria and polymicrobial cultures in the peritoneal fluid and appendiceal lumen were associated with complicated appendicitis. Polymicrobial cultures in the peritoneal cavity presented a four times higher risk of complicated appendicitis.
Review
Health Care Sciences & Services
Aspasia Louta, Aimilia Kanellopoulou, Loukia Alexopoulou Prounia, Mathiou Filippas, Faidra Foteini Tsami, Athanasios Vlachodimitropoulos, Antonios Vezakis, Andreas Polydorou, Ioannis Georgopoulos, Despoina Gkentzi, Ioannis Spyridakis, Ageliki Karatza, Xenophon Sinopidis
Summary: Lithiasis is a known side effect of ceftriaxone administration in children, and various factors such as sex, age, weight, dosage, and duration of intake can contribute to the formation of calcification or stones in the bile and urine excretory systems. This systematic review aims to investigate the effects of ceftriaxone administration in pediatric patients, including the likelihood of gallstones, nephroliths, or precipitations in both biliary and urinary systems, and explore the relationship with maternal history during pregnancy. Results from 33 appropriate articles suggest that more randomized control studies with long-term outcomes are needed to determine the exact association between ceftriaxone and lithiasis in children.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Medicine, General & Internal
Elena Pavlidou, Athanasios Kyrgidis, Konstantinos Vachtsevanos, Jannis Constantinidis, Stefanos Triaridis, Athanasia Printza
Summary: This study aimed to investigate the effectiveness of an eight-week training protocol paired with accuracy tasks and swallowing exercises in improving tongue strength and swallowing in patients after tongue resection. The results showed significant improvements in maximum isometric pressures, endurance, and swallowing pressures, as well as symptom and function assessments, in the treatment group compared to the follow-up control group.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Medicine, General & Internal
Eirini Kostopoulou, Xenophon Sinopidis, Sotirios Fouzas, Despoina Gkentzi, Theodore Dassios, Stylianos Roupakias, Gabriel Dimitriou
Summary: Diabetic ketoacidosis (DKA) is an acute complication of type 1 diabetes mellitus (T1DM) and occasionally type 2 diabetes mellitus (T2DM), characterized by hyperglycemia, ketonemia and/or ketonuria, and acidemia. Clinical symptoms include dehydration, tachypnea, gastrointestinal symptoms, and reduced level of consciousness, often preceded by polyuria, polydipsia, and weight loss. This review aims to summarize potential pitfalls in the diagnosis and management of DKA.
Article
Pediatrics
Xenophon Sinopidis, Panagiotis Kallianezos, Constantinos Petropoulos, Despoina Gkentzi, Eirini Kostopoulou, Sotirios Fouzas, Theodore Dassios, Aggeliki Vervenioti, Ageliki Karatza, Stylianos Roupakias, Antonios Panagidis, Evangelos Blevrakis, Eleni Jelastopulu
Summary: This study aims to evaluate the stress of children with mild head injuries and their parents' relevant perception during the early post-traumatic period. Results showed that 33.7% of children and 19.0% of parents were diagnosed with stress after one week, and 9.9% of children and 3.9% of parents after one month. It indicates that mild head injuries can have an impact on the emotional well-being of children and should not be overlooked.
Review
Pediatrics
Stylianos Roupakias, Eirini Kostopoulou, Despoina Gkentzi, Sotirios Fouzas, Xenophon Sinopidis
Summary: Infantile hemangiomas are common benign vascular tumors in children that often undergo spontaneous regression but can also result in complications. Predicting their evolution is challenging due to their heterogeneity. This review highlights the difficulties in early clinical evaluation, particularly for primary care providers, and emphasizes the importance of practical scoring tools for referral and consultation.
PEDIATRIC INVESTIGATION
(2023)
Article
Health Care Sciences & Services
Eirini Papachristou, Savas Deftereos, Panagoula Oikonomou, Konstantina Bekiaridou, Soultana Foutzitzi, Ioannis Gogoulis, Xenophon Sinopidis, Konstantinos Romanidis, Alexandra Tsaroucha, Katerina Kambouri
Summary: The COVID-19 pandemic and stay-at-home regulations have led to an increase in child injuries at home in Greece. This study examines the types and frequency of these injuries during the COVID-19 lockdown, as well as parents' suggestions for preventing such injuries. The survey was conducted from November to December 2021 and involved parents completing an anonymous questionnaire. The findings reveal that 39.3% of parents reported an increase in accidents at home, with injuries being the most common type. Most accidents occurred indoors and affected children aged 0-4 years. Rural/island areas or suburbs had a higher proportion of child accidents. Accidents were more likely to happen when children were with their grandparents, nanny, or alone, compared to being with their parents. Parents who had difficulty supervising their children experienced more accidents, while those who knew how to provide a safe home did not report an increase in accidents.
