Tuberculosis, Pulmonary Cavitation, and Matrix Metalloproteinases

Regulation of matrix metalloproteinase-1, -3, and -9 in Mycobacterium tuberculosis-dependent respiratory networks by the rapamycin-sensitive PI3K/p70S6K cascade

(2013) Shivani Singh et al.   FASEB JOURNAL

Procollagen III N-terminal Propeptide and Desmosine are Released by Matrix Destruction in Pulmonary Tuberculosis

(2013) Jo Seddon et al.   JOURNAL OF INFECTIOUS DISEASES

Induced Sputum MMP-1, -3 & -8 Concentrations during Treatment of Tuberculosis

(2013) Cesar A. Ugarte-Gil et al.   PLoS One

CD4+ cell-dependent granuloma formation in humanized mice infected with mycobacteria

(2013) F. Heuts et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracellular matrix metalloproteinase-2 (MMP-2) regulates human platelet activation via hydrolysis of talin

(2013) G. Soslau et al.   THROMBOSIS AND HAEMOSTASIS

Ethnic Variation in Inflammatory Profile in Tuberculosis

(2013) Anna K. Coussens et al.   PLoS Pathogens

Doxycycline and HIV Infection Suppress Tuberculosis-induced Matrix Metalloproteinases

(2012) Naomi F. Walker et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Host Genotype-Specific Therapies Can Optimize the Inflammatory Response to Mycobacterial Infections

(2012) David M. Tobin et al.   CELL

Nitric oxide inhibits the accumulation of CD4+CD44hiTbet+CD69loT cells in mycobacterial infection

(2012) John E. Pearl et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Comparison of localized versus systemic levels of Matrix metalloproteinases (MMPs), its tissue inhibitors (TIMPs) and cytokines in tuberculous and non-tuberculous pleuritis patients

(2012) Swetha Sundararajan et al.   HUMAN IMMUNOLOGY

Activation of AMP-activated protein kinase α2 by nicotine instigates formation of abdominal aortic aneurysms in mice in vivo

(2012) Shuangxi Wang et al.   NATURE MEDICINE

Phosphodiesterase-4 Inhibition Combined with Isoniazid Treatment of Rabbits with Pulmonary Tuberculosis Reduces Macrophage Activation and Lung Pathology

(2011) Selvakumar Subbian et al.   AMERICAN JOURNAL OF PATHOLOGY

Effect of doxycycline in patients of moderate to severe chronic obstructive pulmonary disease with stable symptoms

(2011) PrashantS Dalvi et al.   Annals of Thoracic Medicine

Additional Drug Resistance in Mycobacterium tuberculosis Isolates From Resected Cavities Among Patients With Multidrug-Resistant or Extensively Drug-Resistant Pulmonary Tuberculosis

(2011) R. R. Kempker et al.   CLINICAL INFECTIOUS DISEASES

MMP-1 drives immunopathology in human tuberculosis and transgenic mice

(2011) Paul Elkington et al.   JOURNAL OF CLINICAL INVESTIGATION

Mycobacterium tuberculosis-infected human monocytes down-regulate microglial MMP-2 secretion in CNS tuberculosis via TNFα, NFκB, p38 and caspase 8 dependent pathways

(2011) Justin A Green et al.   Journal of Neuroinflammation

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

(2011) Maria M. Mihaylova et al.   NATURE CELL BIOLOGY

Tuberculosis Immunopathology: The Neglected Role of Extracellular Matrix Destruction

(2011) P. T. Elkington et al.   Science Translational Medicine

Pathology of post primary tuberculosis of the lung: An illustrated critical review

(2011) Robert L. Hunter   TUBERCULOSIS

Phosphodiesterase-4 Inhibition Alters Gene Expression and Improves Isoniazid – Mediated Clearance of Mycobacterium tuberculosis in Rabbit Lungs

(2011) Selvakumar Subbian et al.   PLoS Pathogens

The tissue inhibitors of metalloproteinases (TIMPs): An ancient family with structural and functional diversity

(2010) Keith Brew et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Caseation of human tuberculosis granulomas correlates with elevated host lipid metabolism

(2010) Mi-Jeong Kim et al.   EMBO Molecular Medicine

Serine protease activity contributes to control of Mycobacterium tuberculosis in hypoxic lung granulomas in mice

(2010) Stephen T. Reece et al.   JOURNAL OF CLINICAL INVESTIGATION

Strains of Mycobacterium tuberculosis from Western Maharashtra, India, Exhibit a High Degree of Diversity and Strain-Specific Associations with Drug Resistance, Cavitary Disease, and Treatment Failure

(2010) A. Chatterjee et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Mycobacterium tuberculosis Upregulates Microglial Matrix Metalloproteinase-1 and -3 Expression and Secretion via NF- B- and Activator Protein-1-Dependent Monocyte Networks

(2010) J. A. Green et al.   JOURNAL OF IMMUNOLOGY

An interferon-inducible neutrophil-driven blood transcriptional signature in human tuberculosis

(2010) Matthew P. R. Berry et al.   NATURE

Joint Effect of MCP-1 Genotype GG and MMP-1 Genotype 2G/2G Increases the Likelihood of Developing Pulmonary Tuberculosis in BCG-Vaccinated Individuals

(2010) Malathesha Ganachari et al.   PLoS One

Transcriptional Reprogramming in Nonhuman Primate (Rhesus Macaque) Tuberculosis Granulomas

(2010) Smriti Mehra et al.   PLoS One

STAT3, p38 MAPK, and NF-κB Drive Unopposed Monocyte-Dependent Fibroblast MMP-1 Secretion in Tuberculosis

(2009) Cecilia M. O'Kane et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Neutrophils Are the Predominant Infected Phagocytic Cells in the Airways of Patients With Active Pulmonary TB

(2009) Seok-Yong Eum et al.   CHEST

Animal models of tuberculosis

(2009) Douglas Young   EUROPEAN JOURNAL OF IMMUNOLOGY

Systemic MMP inhibition for periodontal wound repair: results of a multi-centre randomized-controlled clinical trial

(2009) Ricardo Gapski et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Matrix Metalloproteinase-1 Is Regulated in Tuberculosis by a p38 MAPK-Dependent, p-Aminosalicylic Acid-Sensitive Signaling Cascade

(2009) L. Rand et al.   JOURNAL OF IMMUNOLOGY

Dexamethasone, Cerebrospinal Fluid Matrix Metalloproteinase Concentrations and Clinical Outcomes in Tuberculous Meningitis

(2009) Justin A. Green et al.   PLoS One

Tuberculous Granuloma Induction via Interaction of a Bacterial Secreted Protein with Host Epithelium

(2009) H. E. Volkman et al.   SCIENCE

Liquefaction and cavity formation in pulmonary TB: A simple method in rabbit skin to test inhibitors

(2009) Arthur M. Dannenberg   TUBERCULOSIS

What Animal Models Teach Humans about Tuberculosis

(2008) Ashwin S. Dharmadhikari et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Therapeutic Use of Infliximab in Tuberculosis to Control Severe Paradoxical Reaction of the Brain and Lymph Nodes

(2008) Timothy K. Blackmore et al.   CLINICAL INFECTIOUS DISEASES

Monocyte-dependent oncostatin M and TNF-α synergize to stimulate unopposed matrix metalloproteinase-1/3 secretion from human lung fibroblasts in tuberculosis

(2008) Cecilia M. O'Kane et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

High MMP-9 activity characterises pleural tuberculosis correlating with granuloma formation

(2008) P. Sheen et al.   EUROPEAN RESPIRATORY JOURNAL

1α,25-dihydroxyvitamin D3inhibits matrix metalloproteinases induced byMycobacterium tuberculosisinfection

(2008) Anna Coussens et al.   IMMUNOLOGY

Detection and Molecular Characterization of 9000-Year-Old Mycobacterium tuberculosis from a Neolithic Settlement in the Eastern Mediterranean

(2008) Israel Hershkovitz et al.   PLoS One

Effect of matrix metalloproteinase-9 −1562C/T gene polymorphism on manifestations of pulmonary tuberculosis

(2008) Seung Heon Lee et al.   TUBERCULOSIS

Matrix metalloproteinase-1 polymorphism in Taiwanese patients with endobronchial tuberculosis

(2007) Han-Pin Kuo et al.   TUBERCULOSIS