Review
Biochemistry & Molecular Biology
Maria-Elpida Christopoulou, Eleni Papakonstantinou, Daiana Stolz
Summary: Matrix metalloproteinases (MMPs) are proteolytic enzymes that regulate airway remodeling and may contribute to the development of emphysema in chronic obstructive pulmonary disease (COPD). This literature review examines the role of different MMPs in COPD, their regulation by tissue inhibitors, and the potential therapeutic targeting of MMPs in COPD. Recent clinical trials supporting this approach are also discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Peng Zhou, Chao Yang, Shan Zhang, Zun-Xiang Ke, Dian-Xi Chen, Yi-Qing Li, Qin Li
Summary: The importance of early diagnosis and treatment of diabetes and its cutaneous complications is increasingly recognized. High glucose affects collagen gene expression in human dermal fibroblasts, leading to an imbalance of matrix metalloproteinases and tissue inhibitors of metalloproteinases. Inhibiting MMP-2 and MMP-9 can alleviate collagen deposition disorder in the skin of diabetic mice.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Hector Vazquez-Lorente, Dusko M. Dundjerovic, Svetislav B. Tatic, Sara Rodriguez-Menendez, Hector Gonzalez-Iglesias, Claudio M. Gomes, Ivan R. Paunovic, Vesna V. Dragutinovic
Summary: The content of trace elements in medullary thyroid carcinoma (MTC) is related to its related biomarkers, especially zinc (Zn), which is correlated with the proportion and intensity of matrix metalloproteinases (MMPs) and tissue inhibitors of matrix metalloproteinases (TIMPs).
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Review
Immunology
Mina Alimohammadi, Ali Rahimi, Fatemeh Faramarzi, Monireh Golpour, Reza Jafari-Shakib, Reza Alizadeh-Navaei, Alireza Rafiei
Summary: CoQ10 supplementation significantly decreased levels of inflammatory biomarkers and MMPs in patients with breast cancer, suggesting a potential benefit in breast cancer treatment. Further controlled trials in other types of cancer are needed to confirm the effects of CoQ10 on tumor therapy.
INFLAMMOPHARMACOLOGY
(2021)
Article
Oncology
Ruth M. Escalona, George Kannourakis, Jock K. Findlay, Nuzhat Ahmed
Summary: This study analyzed the expression of TIMPs and associated MMPs in different stages and grades of serous ovarian tumors, as well as their response to chemotherapy treatment. The results showed that TIMPs and MMPs are differentially expressed in ovarian tumors and are associated with cancer stem cells.
FRONTIERS IN ONCOLOGY
(2022)
Review
Chemistry, Medicinal
Nabangshu Das, Colette Benko, Sean E. Gill, Antoine Dufour
Summary: Researchers are currently focusing on developing more selective MMP inhibitors by targeting other domains of MMPs through specific small molecule inhibitors or monoclonal antibodies. In addition, they are exploring unbiased global approaches, such as proteomics and N-terminomics, to discover new MMP substrates.
Review
Biochemistry & Molecular Biology
Jagoda Kruszewska, Agnieszka Cudnoch-Jedrzejewska, Katarzyna Czarzasta
Summary: Obesity is a growing problem, affecting two-thirds of adults and increasing the risk of cardiovascular diseases. Chronic obesity can also lead to heart failure with preserved ejection fraction. Excessive collagen deposition in the extracellular matrix during obesity can stiffen the myocardium and impair heart function. This review discusses the rationale and potential factors behind this process.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Zahra Pezeshkian, Stefania Nobili, Noshad Peyravian, Bahador Shojaee, Haniye Nazari, Hiva Soleimani, Hamid Asadzadeh-Aghdaei, Maziar Ashrafian Bonab, Ehsan Nazemalhosseini-Mojarad, Enrico Mini
Summary: Colorectal cancer (CRC) is a common global cancer derived from polyps, with Matrix Metalloproteinases (MMPs) playing a critical role in its initiation and progression. The expression of various MMPs in CRC patients is associated with a poor prognosis, and although research has explored MMP inhibition and targeted therapy for CRC, there is still insufficient understanding of the role of MMPs in polyp malignancy.
Article
Immunology
Gokul Raj Kathamuthu, Kadar Moideen, Kannan Thiruvengadam, Rathinam Sridhar, Dhanaraj Baskaran, Subash Babu
Summary: This study investigated the levels of circulating MMPs and TIMPs in TBL individuals with and without helminth coinfection, revealing that MMPs and TIMPs were elevated in TBL-Hel+ coinfected individuals. Regression analysis showed that these changes were independent of age, sex, and culture status. The MMP-2 ratio with all TIMPs was significantly associated with TBL-helminth coinfection, indicating a profound effect of helminth infection on TBL pathogenesis and immunity.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biology
Ritva Nissi, Markku Santala, Anne Talvensaari-Mattila
Summary: This study analyzed the serum levels of MMP-9, TIMP-1, and MMP-2/TIMP-2 during normal pregnancy. It was found that MMP-9 and TIMP-1 levels remained stable throughout pregnancy, while there was a slight increase in MMP-2/TIMP-2 complex after week 15 with no statistical significance.
BMC RESEARCH NOTES
(2021)
Article
Anatomy & Morphology
Hector Vazquez-Lorente, Dusko M. Dunderovic, Svetislav B. Tatic, Sanja Radojevic-Skodric, Claudio M. Gomes, Ivan R. Paunovic, Vesna Dragutinovic
Summary: This study aimed to evaluate the role of MMPs 2 and 9, TIMPs, S100 protein, and amyloid in the diagnosis of MTC. The results showed a direct correlation between MMPs 2 and 9 and traditional biomarkers of MTC. Therefore, combining the analysis of MMPs 2 and 9 with traditional biomarkers could be a useful strategy in the diagnosis of MTC.
APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY
(2023)
Review
Oncology
Amit Khurana, Nilofer Sayed, Prince Allawadhi, Ralf Weiskirchen
Summary: Liver fibrosis is a major complication of chronic liver disorders, driven by chronic inflammation and activation of hepatic stellate cells. The imbalance in ECM proteins plays a crucial role in fibrosis progression, providing novel therapeutic avenues for its treatment.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Obstetrics & Gynecology
Laura Governini, Camilla Marrocco, Bianca Semplici, Valentina Pavone, Giuseppe Belmonte, Stefano Luisi, Felice Petraglia, Alice Luddi, Paola Piomboni
Summary: The study compared the expression profiles of MMPs and TIMPs in the endometrium of women with and without type 3 leiomyomas, finding differential expression and localization of these proteins in leiomyoma patients, along with associations with key molecules involved in the inflammatory pathway.
FERTILITY AND STERILITY
(2021)
Review
Biochemistry & Molecular Biology
Moataz Elgezawi, Rasha Haridy, Khalid Almas, Moamen A. Abdalla, Omar Omar, Hatem Abuohashish, Abeer Elembaby, Uta Christine Woelfle, Yasir Siddiqui, Dalia Kaisarly
Summary: This review article discusses the roles of Matrix metalloproteinases (MMPs) in dental and periodontal tissues, as well as their potential as biomarkers for diagnosis and treatment. The article provides insights into the involvement of MMPs in development, remodeling, degradation, and turnover of dental and periodontal tissues, and their signals in the pathogenesis and wound healing. The review identified 119 published papers, two textbooks, and two doctoral theses as the basis for the discussion. MMPs are seen as significant proteases with potential diagnostic and prognostic value. Understanding their role in dental and periodontal lesions and dentine-pulp wound healing is crucial for future diagnostic and therapeutic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Physiology
Zahra Pairo, Abdolhossein Parnow, Payam Sari Aslani, Payam Mohammadi, Shahla Mirzaeei, Magni Mohr
Summary: This study found that moderate-intensity aerobic training has positive effects on circulatory inflammation factors and health indicators in female migraineurs, suggesting it as a non-pharmacological therapeutic method.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
(2023)
