Article
Biochemistry & Molecular Biology
Alessia Furgiuele, Franca Marino, Emanuela Rasini, Massimiliano Legnaro, Alessandra Luini, Maria Giulia Albizzati, Alessia di Flora, Barbara Pacchetti, Marco Cosentino
Summary: This study investigated the effects of CBD on human peripheral blood mononuclear cells (PBMCs) and CD4+ T cells, and found that CBD can affect cytokine production, cell proliferation, and the functional properties of regulatory T cells. However, the effects of CBD on cell proliferation and protein production were inconsistent, suggesting a complex activity that warrants further investigation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Farshad Babaeijandaghi, Adrianna Paiero, Reece Long, Lin Wei Tung, Shannon Percival Smith, Ryan Cheng, Joshua Smandych, Nasim Kajabadi, Chih-Kai Chang, Amirhossein Ghassemi, William D. M. Kennedy, Hesham Soliman, Peter W. Schutz, Fabio M. Rossi
Summary: In this study, it is found that natural killer (NK) cells are the main source of IFN gamma in regenerating muscle. The production of IFN gamma is also limited to a small population of T cells. However, NK cells do not play a major role in muscle regeneration. The absence of IFN gamma per se has no effect on muscle regeneration, but its role is partially unmasked when TNF alpha is also neutralized.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Chemistry, Medicinal
Se Yun Jeong, Hyung-Seok Yu, Moon-Jin Ra, Sang-Mi Jung, Jeong-Nam Yu, Jin-Chul Kim, Ki Hyun Kim
Summary: This study identified nine secondary metabolites from the ethanolic extract of Equisetum arvense and found that some of these compounds have anti-inflammatory properties, suggesting their potential as prophylactic or therapeutic agents for dermatitis.
Article
Biochemistry & Molecular Biology
Monica M. Van Acker, Rebekah R. Schwartz, Kelly Andrews, Kristina Seiffert-Sinha, Animesh A. Sinha
Summary: This study found that blood relatives of AA patients show similar elevation of Th1 and Th17 pathway cytokines, suggesting a genetic basis for Th1 and Th17 dysregulation in AA. The elevation of Th17-related cytokines in an unrelated control individual may suggest predictive value.
Article
Biochemistry & Molecular Biology
Thuzar Hla Shwe, Peraphan Pothacharoen, Thanyaluck Phitak, Benjawan Wudtiwai, Prachya Kongtawelert
Summary: In this study, the synergistic upregulation of PD-L1 expression in HepG2 cells by a combination of IFNγ and TNFα was observed, with STAT1 activation playing a major role in this synergistic effect. Atorvastatin was found to inhibit the induction of PD-L1 by either IFNγ alone or IFNγ/TNFα combination treatment in HepG2 cells. These findings suggest that atorvastatin may impact tumor immune response through inhibiting PD-L1 induction in cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Respiratory System
Devine Jackson, Joshua Walum, Priyanka Banerjee, Brandon W. Lewis, Y. S. Prakash, Venkatachalem Sathish, Zhaohui Xu, Rodney D. Britt
Summary: In this study, the effects of TNF alpha and IFN gamma on corticosteroid sensitivity in pediatric airway smooth muscle tissue were investigated. The results showed that TNF alpha had a greater impact on gene expression compared to IFN gamma, and the combined effects of TNF alpha and IFN gamma enhanced the expression of pro-inflammatory genes and pathways related to asthma pathogenesis. These findings highlight the importance of Th1-associated cytokines in promoting inflammation and hypercontractility in severe asthma.
RESPIRATORY RESEARCH
(2022)
Article
Oncology
Nishant Chovatiya, Kawaljit Kaur, Sara Huerta-Yepez, Po-Chun Chen, Adam Neal, Gabriella DiBernardo, Serhat Gumrukcu, Sanaz Memarzadeh, Anahid Jewett
Summary: We studied the sensitivity of different ovarian tumor cell lines to NK cell-mediated cytotoxicity and found that the levels of tumor differentiation and aggressiveness were correlated with the sensitivity to NK cell killing. Poorly differentiated ovarian tumors were unable to upregulate MHC-class I under activating conditions, which may be a specific feature of ovarian tumors. NK cells showed targeted killing of these tumors and could be utilized in immunotherapeutic strategies.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Amelia Barilli, Giulia Recchia Luciani, Rossana Visigalli, Roberto Sala, Maurizio Soli, Valeria Dall'Asta, Bianca Maria Rotoli
Summary: This study explores the mechanisms underlying the modulation of iNOS expression in human alveolar cells. The researchers found that cytokines secreted by SARS-CoV-2 spike S1-activated macrophages markedly induce iNOS expression, which can be suppressed by the drug baricitinib. These findings are important for understanding the inflammatory response mechanisms in COVID-19 and identifying potential therapeutic drugs.
Review
Clinical Neurology
Chang-He Liu, Na Hua, Huai-Yu Yang
Summary: The levels of peripheral CRP, IL-6, IL-2, and TNF-alpha were significantly higher in patients with panic disorder compared to healthy controls, while IL-1 beta, IL-10, and IFN-gamma levels did not show significant differences. However, studies involving IL-6, IL-1 beta, IL-10, and IFN-gamma in panic disorder patients exhibited high heterogeneity.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2021)
Article
Biochemistry & Molecular Biology
Chunyan Shao, Chenwen Zhu, Yun Zhu, Jiqing Hao, Yongxiang Li, Huaqing Hu, Li Si, Fei Zhong, Xuefu Wang, Hua Wang
Summary: Our study demonstrates the decreased frequency, altered phenotypes, and partially impaired function of MAIT cells in patients with gastric cancer, indicating a potential MAIT cell-based immunological surveillance of gastric cancer. This highlights the importance of further investigating the role of MAIT cells in malignant diseases to better understand their impact on disease progression and potential therapeutic implications.
CELL AND BIOSCIENCE
(2021)
Article
Immunology
Riti Sharan, Dhiraj Kumar Singh, Jyothi Rengarajan, Deepak Kaushal
Summary: Tuberculosis, caused by Mycobacterium tuberculosis, is a global infectious disease with significant mortality. Effective T cell responses, particularly CD4(+) and CD8(+) T cells, play crucial roles in TB immunity. Studies on early T cell responses in different infection doses reveal the importance of cytokine responses in antimycobacterial immunity.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Tomoko Matsuda, Naotomo Kambe, Riko Takimoto-Ito, Yoko Ueki, Satoshi Nakamizo, Megumu K. Saito, Syuji Takei, Nobuo Kanazawa
Summary: Blau syndrome is an autoinflammatory granulomatous disease caused by mutations in the NOD2 gene. Clinical manifestations appear before the age of four. While there is no specific curative treatment, anti-TNF therapy plays a central role in correcting the abnormalities associated with the disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Sarmini Munisamy, Ammu Kutty Radhakrishnan, Premdass Ramdas, Priscilla Josephine Samuel, Vivek Ajit Singh
Summary: The study found that CD4(+) T-cells and certain cytokines levels were significantly reduced in sarcoma patients compared to healthy controls. Additionally, five genes were found to be dysregulated in sarcoma patients.
Article
Oncology
Paige C. Arneson-Wissink, Jason D. Doles
Summary: Skeletal muscle wasting is a key driver of negative clinical outcomes and is associated with a range of pathologies including cancer. Cancer cachexia is a multi-factorial syndrome that includes skeletal muscle wasting, but remains understudied. Research suggests that amino acid metabolic disruption is linked to myoblast defects induced by cancer cell conditioned media.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Andrew J. Freeman, Stephin J. Vervoort, Jessica Michie, Kelly M. Ramsbottom, John Silke, Conor J. Kearney, Jane Oliaro
Summary: The study found that melanoma cells lacking HOIP are highly susceptible to NK and CD8(+) T cell-mediated killing, and genetic deletion or pharmacological inhibition of HOIP can enhance this sensitivity. The results suggest that HOIP inhibition could be a potential strategy to improve the killing capacity of TNF and IFN-gamma in immunotherapy.
Article
Multidisciplinary Sciences
Berit Carow, Thomas Hauling, Xiaoyan Qian, Igor Kramnik, Mats Nilsson, Martin E. Rottenberg
NATURE COMMUNICATIONS
(2019)
Article
Immunology
Maria Sjoestrand, Berit Carow, William A. Nyberg, Ruxandra Covacu, Martin E. Rottenberg, Alexander Espinosa
Article
Public, Environmental & Occupational Health
Alfred Njamnshi, Paul Etet, Leonard Ngarka, Stephen Perrig, Gabriela Olivera, Leonard Nfor, Wepnyu Njamnshi, Alphonse Acho, Jean-Jacques Muyembe, Marina Bentivoglio, Martin Rottenberg, Peter Kennedy
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2020)
Article
Immunology
Juan I. Basile, Ruining Liu, Wenjun Mou, Yu Gao, Berit Carow, Martin E. Rottenberg
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Immunology
Yu Gao, Ruining Liu, Chenfei He, Juan Basile, Mattias Vesterlund, Marie Wahren-Herlenius, Alexander Espinoza, Cassandra Hokka-Zakrisson, Fahad Zadjali, Akihiko Yoshimura, Mikael Karlsson, Berit Carow, Martin E. Rottenberg
Summary: SOCS3 is a critical regulator of immune responses and inflammation, with its expression in thymic stromal cells being essential for T cell development and maintenance of thymus architecture. The inhibition of SOCS3 led to impaired thymocyte differentiation, proliferation, and increased apoptosis at different cell stages, ultimately affecting the generation of recent thymic emigrants in peripheral organs. The interaction between SOCS3 in thymic epithelial cells and TRIM 21 had significant implications for thymic cellularity and gene expression related to T cell selection and lympho-stromal interactions.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Juan Zhang, Graciela Teran, Mihaela Popa, Harsha Madapura, Marcus James Graeme Watson Ladds, Danai Lianoudaki, Jacob Grunler, Marie Arsenian-Henriksson, Emmet McCormack, Martin Enrique Rottenberg, Sergiu-Bogdan Catrina, Sonia Lain, Suhas Darekar
Summary: Pharmacological inhibition of DHODH reduces mitochondrial respiration, promotes glycolysis, enhances GLUT4 translocation, increases expression of GDF15 through p53 activation, and leads to reduced appetite and prolonged lifespan. DHODH inhibitors also elevate levels of circulating GDF15 and improve metabolic balance in obesity-induced diabetes models.
Article
Immunology
Kiran Iqbal Masood, Muhammad Irfan, Qamar Masood, Maliha Yameen, Bushra Jamil, Nanik Ram, Shoaib Rao, Martin Rottenberg, Zahra Hasan
Summary: The study shows that diabetic patients with LTBi exhibit elevated levels of inflammatory and anti-inflammatory cytokines, along with reduced SOCS3 mRNA expression. Poor glycemic control in diabetes results in further inflammatory dysregulation, impacting the activation of IFN-gamma and IL-6.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Infectious Diseases
Gabriela C. Olivera, Leonie Vetter, Chiara Tesoriero, Federico Del Gallo, Gustav Hedberg, Juan Basile, Martin E. Rottenberg
Summary: In the early stage of T.b.b. infection, the predominant T cells in the brain express an effector-memory phenotype, while tissue resident memory T cells develop in the late stage. Both CD4 and CD8 T cells are independently redundant for the penetration of T.b.b. into the brain parenchyma.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Editorial Material
Immunology
Miriam Postan, Martin E. Rottenberg
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Anastasia Magoulopoulou, Xiaoyan Qian, Todia Pediatama Setiabudiawan, Sergio Marco Salas, Chika Yokota, Martin E. Rottenberg, Mats Nilsson, Berit Carow
Summary: This study investigates the local interactions between Mycobacterium tuberculosis (Mtb) and the immune system in the lungs of TB mice using in situ sequencing (ISS) technique. By developing automated analysis pipelines, the researchers were able to determine the spatial distribution of immune transcripts in relation to bacteria. The analysis revealed different patterns of immune activation and antigen presentation in infected and non-infected cells, providing insights into the immune microenvironments of Mtb in the lungs.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Microbiology
Graciela Teran, Hanxiong Li, Sergiu-Bogdan Catrina, Ruining Liu, Susanna Brighenti, Xiaowei Zheng, Jakob Grunler, Susanne Nylen, Berit Carow, Martin E. Rottenberg
Summary: People with diabetes who are also infected with M. tuberculosis are at a higher risk of developing tuberculosis. The mechanisms behind this increased risk are not well understood. This study shows that the transcription factor HIF-1 plays a crucial role in the outcome of M. tuberculosis infection in macrophages. High glucose and reactive carbonyl compounds inhibit HIF-1 responses, leading to impaired control of intracellular M. tuberculosis. Treatment with a HIF-1 stabilizer restores mycobacterial control in the presence of glucose or carbonyl stress. The findings suggest that targeting HIF-1 may reduce the risk of developing tuberculosis in people with diabetes.
Article
Multidisciplinary Sciences
Ruining Liu, Victoria Muliadi, Wenjun Mou, Hanxiong Li, Juan Yuan, Johan Holmberg, Benedict J. Chambers, Nadeem Ullah, Jakob Wurth, Mohammad Alzrigat, Susanne Schlisio, Berit Carow, Lars Gunnar Larsson, Martin E. Rottenberg
Summary: In this study, the researchers investigated the role of hypoxia-inducible factors (HIFs) in the regulation of T cell responses during Mycobacteria tuberculosis infection. They found that mice lacking von Hippel-Lindau factor (VHL) in T cells were more susceptible to M. tuberculosis infection and exhibited reduced accumulation and impaired function of mycobacteria-specific T cells. Interestingly, deficiency in HIF-1 in T cells did not have an impact on M. tuberculosis control. These findings suggest that VHL plays an important role in T cell responses during M. tuberculosis infection, which is dependent on HIF-1.
NATURE COMMUNICATIONS
(2022)