Article
Respiratory System
Nicolas Casco, Alberto Levi Jorge, Domingo Juan Palmero, Jan-Willem Alffenaar, Justin Denholm, Greg J. Fox, Wafaa Ezz, Jin-Gun Cho, Alena Skrahina, Varvara Solodovnikova, Pierre Bachez, Alberto Piubello, Marcos Abdo Arbex, Tatiana Alves, Marcelo Fouad Rabahi, Giovana Rodrigues Pereira, Roberta Sales, Denise Rossato Silva, Muntasir M. Saffie, Ruth Caamano Miranda, Viviana Cancino, Monica Carbonell, Catalina Cisterna, Clorinda Concha, Arturo Cruz, Nadia Escobar Salinas, Macarena Espinoza Revillot, Joaquin Farias Valdes, Israel Fernandez, Ximena Flores, Patricia Gallegos Tapia, Ana Garavagno, Carolina Guajardo Vera, Martina Hartwig Bahamondes, Luis Moyano Merino, Eduardo Munoz, Camila Munoz, Indira Navarro, Jorge Navarro Subiabre, Carlos Ortega, Sofia Palma, Ana Maria Pradenas, Gloria Pereira, Patricia Perez Castillo, Monica Pinto, Rolando Pizarro, Francisco Rivas Bidegain, Patricia Rodriguez, Cristina Sanchez, Angeles Serrano Salinas, Aline Soto, Carolina Taiba, Margarita Venegas, Maria Soledad Vergara Riquelme, Evelyn Vilca, Claudia Villalon, Edith Yucra, Yang Li, Andres Cruz, Beatriz Guelvez, Regina Victoria Plaza, Kelly Yoana Tello Hoyos, Claire Andrejak, Francois-Xavier Blanc, Samir Dourmane, Antoine Froissart, Armine Izadifar, Frederic Riviere, Frederic Schlemmer, Katerina Manika, Boubacar Djelo Diallo, Souleymane Hassane-Harouna, Norma Artiles, Licenciada Andrea Mejia, Nitesh Gupta, Pranav Ish, Gyanshankar Mishra, Samridhi Sharma, Rupak Singla, Zarir F. Udwadia, Francesca Alladio, Fabio Angeli, Andrea Calcagno, Rosella Centis, Luigi Ruffo Codecasa, Lia D'Ambrosio, Angelo De Lauretis, Susanna Esposito, Beatrice Formenti, Alberto Gaviraghi, Vania Giacomet, Delia Goletti, Gina Gualano, Alberto Matteelli, Giovanni Battista Migliori, Ilaria Motta, Fabrizio Palmieri, Emanuele Pontali, Tullio Prestileo, Niccolo Riccardi, Laura Saderi, Matteo Saporiti, Giovanni Sotgiu, Claudia Stochino, Marina Tadolini, Alessandro Torre, Simone Villa, Dina Visca, Edvardas Danila, Saulius Diktanas, Ruy Lopez Ridaura, Fatima Leticia Luna Lopez, Marcela Munoz Torrico, Adrian Rendon, Onno W. Akkerman, Mahamadou Bassirou Souleymane, Seif Al-Abri, Fatma Alyaquobi, Khalsa Althohli, Edwin Aizpurua, Rolando Gonzales, Julio Jurado, Alejandra Loban, Sarita Aguirre, Rosarito Coronel Teixeira, Viviana De Egea, Sandra Irala, Angelica Medina, Guillermo Sequera, Natalia Sosa, Fatima Vazquez, Felix K. Llanos-Tejada, Selene Manga, Renzo Villanueva-Villegas, David Araujo, Raquel Duarte, Tania Sales Marques, Victor Ionel Grecu, Adriana Socaci, Olga Barkanova, Maria Bogorodskaya, Sergey Borisov, Andrei Mariandyshev, Anna Kaluzhenina, Tatjana Adzic Vukicevic, Maja Stosic, Darius Beh, Deborah Ng, Catherine W. M. Ong, Ivan Solovic, Keertan Dheda, Phindile Gina, Jose A. Caminero, Jose Cardoso-Landivar, Maria Luiza De Souza Galvao, Angel Dominguez-Castellano, Jose-Maria Garcia-Garcia, Israel Molina Pinargote, Sarai Quiros Fernandez, Adrian Sanchez-Montalva, Eva Tabernero Huguet, Miguel Zabaleta Murguiondo, Pierre-Alexandre Bart, Jesica Mazza-Stalder, Freya Bakko, James Barnacle, Annabel Brown, Shruthi Chandran, Kieran Killington, Kathy Man, Padmasayee Papineni, Simon Tiberi, Natasa Utjesanovic, Dominik Zenner, Jasie L. Hearn, Scott Heysell, Laura Young
Summary: This study provides insights into the features of individuals co-infected with tuberculosis (TB) and coronavirus disease 2019 (COVID-19), and the determinants of mortality and other outcomes. The results suggest that co-infection with TB and COVID-19 is associated with higher mortality, with age, male gender, and invasive ventilation being independent contributors to death. The study highlights the importance of prioritizing TB patients for COVID-19 preventative efforts, including vaccination.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Article
Immunology
Xuan Ying Poh, Jia Mei Hong, Chen Bai, Qing Hao Miow, Pei Min Thong, Yu Wang, Ravisankar Rajarethinam, Cristine S. L. Ding, Catherine W. M. Ong
Summary: This study developed a murine CNS-TB model that mimics the neurobehavioral changes and immunopathology of human CNS-TB infection. By injecting Mycobacterium tuberculosis into the third ventricle of mice, the researchers observed pathological changes and clinical symptoms similar to human CNS-TB. This model is important for studying host-pathogen interactions and evaluating therapeutic agents for CNS-TB.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Chemistry, Analytical
Alice H. Iles, Peijun J. W. He, Ioannis N. Katis, Panagiotis P. Galanis, Anto J. U. K. John, Paul Elkington, Robert W. Eason, Collin L. Sones
Summary: Inflammatory markers CRP and PCT are useful in improving triage speed and preventing inappropriate antibiotic use. A novel multiplexed LFD can rapidly and semi-quantitatively detect CRP and PCT, showing potential for rapid treatment of patients with suspected pneumonia.
Review
Respiratory System
Tommaso Morelli, Kohei Fujita, Gil Redelman-Sidi, Paul T. Elkington
Summary: Immune checkpoint inhibitors (ICIs) have greatly impacted cancer treatment, but immune-related adverse events (irAEs) and infections caused by immunosuppression are common issues. However, some infections can be triggered by ICIs without immunosuppressive treatment, characterized by dysregulated immune responses. A new framework is needed to consider such infections in the context of cancer immunotherapy.
Review
Biochemistry & Molecular Biology
Paul Elkington, Marta E. Polak, Michaela T. Reichmann, Alasdair Leslie
Summary: Mycobacterium tuberculosis is the main pathogen causing tuberculosis and poses a serious threat to human health. Understanding its pathogenic mechanisms is crucial for effectively combating this pathogen. Recent studies have found that extracellular matrix (ECM) remodeling plays an important role in the development of the disease.
TRENDS IN MOLECULAR MEDICINE
(2022)
Review
Medicine, General & Internal
Sally E. Hayward, Anna Deal, Kieran Rustage, Laura B. Nellums, Annika C. Sweetland, Delia Boccia, Sally Hargreaves, Jon S. Friedland
Summary: This systematic review examines the association between mental health and TB disease risk and finds that individuals with mental illnesses, including depression and schizophrenia, are at an increased risk of developing tuberculosis. Therefore, there is a need to screen and treat individuals with mental illnesses for tuberculosis.
Article
Oncology
Kohei Fujita, Paul Elkington, Gil Redelman-Sidi, Osamu Kanai, Yuki Yamamoto, Takuma Imakita, Misato Okamura, Koichi Nakatani, Tadashi Mio
Summary: This study evaluated the conversion rate of interferon-gamma release assay (IGRA) and the incidence of active tuberculosis during immunotherapy, finding that some patients developed IGRA conversion and active tuberculosis during ICI therapy.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Infectious Diseases
G. B. Migliori, S. J. Wu, A. Matteelli, D. Zenner, D. Goletti, S. Ahmedov, S. Al-Abri, D. M. Allen, M. E. Balcells, A. L. Garcia-Basteiro, E. Cambau, R. E. Chaisson, C. B. E. Chee, M. P. Dalcolmo, J. T. Denholm, C. Erkens, S. Esposito, P. Farnia, J. S. Friedland, S. Graham, Y. Hamada, A. D. Harries, A. W. Kay, A. Kritski, S. Manga, B. J. Marais, D. Menzies, D. Ng, L. Petrone, A. Rendon, D. R. Silva, H. S. Schaaf, A. Skrahina, G. Sotgiu, G. Thwaites, S. Tiberi, N. Tukvadze, J-P Zellweger, L. D. Ambrosio, R. Centis, C. W. M. Ong
Summary: These clinical standards provide guidance for clinicians, program managers, and public health officers in assessing and managing tuberculosis infection (TBI) and implementing preventive therapy. This consensus-based document defines eight clinical standards that cover testing, counseling, baseline examinations, treatment regimens, and monitoring for individuals at risk of TB.
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
(2022)
Review
Respiratory System
Laura Saderi, Mariangela Puci, Biagio Di Lorenzo, Rosella Centis, Lia D'Ambrosio, Onno W. Akkerman, Jan-Willem C. Alffenaar, Jose A. Caminero, Jeremiah Muhwa Chakaya, Justin T. Denholm, Xhevat Kurhasani, Catherine W. M. Ong, Adrian Rendon, Denise Rossato Silva, Simon Tiberi, Dominik Zenner, Andrea M. Cabibbe, Giovanni Battista Migliori, Giovanni Sotgiu
Summary: This systematic review aimed to investigate the features of Xpert MTB/XDR and other rapid tests for pre-XDR/XDR-TB, and found that both Xpert MTB/XDR and Geno-Type MTBDRsl are two rapid World Health Organization (WHO)-endorsed tests with similar performance, slightly favoring Xpert.
ARCHIVOS DE BRONCONEUMOLOGIA
(2022)
Letter
Respiratory System
Jose-Maria Garcia-Garcia, Francois-Xavier Blanc, Danilo Buonsenso, Rosella Centis, Luigi Ruffo Codecasa, Lia D'Ambrosio, Delia Goletti, Gina Gualano, Heinke Kunst, Emanuele Pontali, Marina Tadolini, Simon Tiberi, Catherine W. M. Ong, Giovanni Sotgiu, Giovanni Battista Migliori
ARCHIVOS DE BRONCONEUMOLOGIA
(2022)
Article
Infectious Diseases
Ximena Gonzalo, Magdalena K. Bielecka, Liku Tezera, Paul Elkington, Francis Drobniewski
Summary: In this study, a novel physiological 3-D bioelectrospray model of tuberculosis granuloma was used to evaluate the activity of different drugs. The results showed that clofazimine was the most effective drug, while carbapenems and nitazoxanide had less activity against Mycobacterium tuberculosis.
Article
Biology
Mohamed Ahmed, Jared Mackenzie, Liku Tezera, Robert Krause, Barry Truebody, Diana Garay-Baquero, Andres Vallejo, Katya Govender, John Adamson, Hayden Fisher, Jonathan W. Essex, Salah Mansour, Paul Elkington, Adrie J. C. Steyn, Alasdair Leslie
Summary: Studies have shown that Interferon-gamma (IFN-gamma) has a direct effect on the oxygen consumption rate and respiration of Mycobacterium tuberculosis (Mtb), different from other cytokines. Mass spectrometry and molecular modeling studies have revealed that IFN-gamma interacts with mycobacterial membrane protein large 10 (MmpL10). Furthermore, IFN-gamma promotes Mtb growth and eliminates drug-resistant strains.
COMMUNICATIONS BIOLOGY
(2022)
Article
Infectious Diseases
O. W. Akkerman, R. Duarte, S. Tiberi, H. S. Schaaf, C. Lange, J. W. C. Alffenaar, J. Denholm, A. C. C. Carvalho, M. S. Bolhuis, S. Borisov, J. Bruchfeld, A. M. Cabibbe, J. A. Caminero, I Carvalho, J. Chakaya, R. Centis, M. P. Dalcomo, L. D. Ambrosio, M. Dedicoat, K. Dheda, K. E. Dooley, J. Furin, J-M Garcia-Garcia, N. A. H. van Hest, B. C. de Jong, X. Kurhasani, A. G. Martson, S. Mpagama, M. Munoz Torrico, E. Nunes, C. W. M. Ong, D. J. Palmero, R. Ruslami, A. M. Saktiawati, C. Semuto, D. R. Silva, R. Singla, I Solovic, S. Srivastava, J. E. M. de Steenwinkel, A. Story, M. G. G. Sturkenboom, M. Tadolini, Z. F. Udwadia, A. R. Verhage, J. P. Zellweger, G. B. Migliori
Summary: This article presents clinical standards for the diagnosis, treatment, and management of drug-susceptible pulmonary TB (PTB). These consensus-based standards provide guidance for clinicians and program managers to improve patient care and focus on future research priorities.
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
(2022)
Article
Infectious Diseases
T. S. Yee, C. Choong, L. E. Wee, K. C. M. Goh, S. J. Wu, K. M. K. Win, C. W. M. Ong, D. H. L. Ng
Summary: The COVID-19 pandemic has had a significant impact on TB diagnosis in Singapore. Early screening for TB, even among patients with COVID-19, could lead to earlier diagnosis and treatment, thereby breaking the chain of transmission.
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
(2022)
Article
Infectious Diseases
J. W. C. Alffenaar, S. L. Stocker, L. Davies Forsman, A. Garcia-Prats, S. K. Heysell, R. E. Aarnoutse, O. W. Akkerman, A. Aleksa, R. van Altena, W. Arrazola de Onata, P. K. Bhavani, N. Van't Boveneind-Vrubleuskaya, A. C. C. Carvalho, R. Centis, J. M. Chakaya, D. M. Cirillo, J. G. Cho, L. D. Ambrosio, M. P. Dalcolmo, P. Denti, K. Dheda, G. J. Fox, A. C. Hesseling, H. Y. Kim, C. U. Koser, B. J. Marais, I Margineanu, A. G. Martson, M. Munoz Torrico, H. M. Nataprawira, C. W. M. Ong, R. Otto-Knapp, C. A. Peloquin, D. R. Silva, R. Ruslami, P. Santoso, R. M. Savic, R. Singla, E. M. Svensson, A. Skrahina, D. van Soolingen, S. Srivastava, M. Tadolini, S. Tiberi, T. A. Thomas, Z. F. Udwadia, D. H. Vu, W. Zhang, S. G. Mpagama, T. Schon, G. B. Migliori
Summary: This article presents clinical standards for dosing and management of TB drugs, aiming to guide clinicians and program managers in planning and implementing locally appropriate measures for optimal treatment and improved patient care.
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
(2022)