Article
Microbiology
C. Kanipe, P. M. Boggiatto, E. J. Putz, M. V. Palmer
Summary: The study found that BCG vaccination can reduce the number and size of tuberculosis lesions, decrease necrosis, and increase fibrosis in low-grade lesions. Vaccination has minimal impact on mineralization and density of multinucleated giant cells.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Dorcas O. Owusu, Ernest Adankwah, Wilfred Aniagyei, Isaac Acheampong, Difery Minadzi, Augustine Yeboah, Joseph F. Arthur, Millicent Lamptey, Monika M. Vivekanandan, Mohammed K. Abass, Francis Kumbel, Francis Osei-Yeboah, Amidu Gawusu, Linda Batsa Debrah, Alexander Debrah, Ertan Mayatepek, Julia Seyfarth, Richard O. Phillips, Marc Jacobsen
Summary: In Nigeria, BCG vaccination leads to immune conversion and changes in the phenotype of tuberculosis-specific T cells. A study comparing BCG-vaccinated and non-vaccinated infants showed that BCG vaccination causes delayed immune conversion and differences in cell phenotype among tuberculosis patients.
Article
Microbiology
Jayne C. Hope, Hamza Khalid, Michelle L. Thom, Chris J. Howard, Darren J. Shaw
Summary: Mycobacterium bovis is a globally prevalent pathogen causing bovine tuberculosis (bTB) with significant impacts on animal welfare, economy, and public health. Vaccination with Bacille Calmette-Guerin (BCG) could play a crucial role in bTB control. In this study, the protective efficacy and immune responses of BCG vaccination at different ages of calves were compared. The results showed significant protection against M. bovis infection in BCG-vaccinated calves. There was no significant difference in the protective effect between calves vaccinated at one day and at three weeks of age. The expression of antigen-specific IFN-γ levels post-BCG vaccination was significantly correlated with protection from M. bovis infection.
Article
Infectious Diseases
Eamonn Gormley, Deirdre Ni Bhuachalla, Tara Fitzsimons, James O'Keeffe, Guy McGrath, Jamie M. Madden, Naomi Fogarty, Kevin Kenny, Locksley L. Mc Messam, Denise Murphy, Leigh A. L. Corner
Summary: Vaccination of badgers with Mycobacterium bovis Bacille Calmette-Guerin (BCG) has been shown to protect badgers against tuberculosis in experimental trials. The study results suggest that BCG vaccination could indirectly protect unvaccinated badgers, leading to a high level of population immunity against tuberculosis. This indicates that BCG vaccination could be an effective method for reducing tuberculosis incidence in badger populations.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Immunology
Natalie E. Nieuwenhuizen, Joanna Zyla, Ulrike Zedler, Silke Bandermann, Ulrike Abu Abed, Volker Brinkmann, Stefan H. E. Kaufmann
Summary: BCG, the only available vaccine against tuberculosis, was found to have varying efficacy against pulmonary TB based on age and sex. This study revealed that female mice had better protection from BCG vaccination against M. tuberculosis H37Rv challenge, showing lower lung bacterial burdens and less weight loss compared to male mice. It suggests the importance of including both male and female mice in preclinical testing of vaccine candidates.
Article
Veterinary Sciences
Kevina McGill, Tara Fitzsimons, Anthony Duignan, Leigh Corner, Sandrine Lesellier, Eamonn Gormley
Summary: This study finds that serological diagnosis of tuberculosis using tests that target MPB83 may be compromised if badgers are repeatedly vaccinated with BCG Sofia.
RESEARCH IN VETERINARY SCIENCE
(2022)
Article
Immunology
Paulo R. Z. Antas, Andreon S. M. da Silva, Lawrence H. P. Albuquerque, Matheus R. Almeida, Evelyn N. G. S. Pereira, Luiz R. R. Castello-Branco, Carlos G. G. de Ponte
Summary: This study investigates the protective role of BCG in inducing surface biomarkers and analyzes the expression levels of TLR4, B7-1, Dectin-1, EP2, and TIM-3 in monocytes. The results uncover the regulatory effect of BCG on these biomarkers and emphasize the importance of understanding human innate immune responses for vaccine development and infectious disease treatment.
Article
Immunology
Xinying Zhou, Linmiao Lie, Yao Liang, Hui Xu, Bo Zhu, Yingqi Huang, Lijie Zhang, Zelin Zhang, Qianna Li, Qi Wang, Zhenyu Han, Yulan Huang, Honglin Liu, Shengfeng Hu, Chaoying Zhou, Qian Wen, Li Ma
Summary: This study reveals the significant role of GSK-3alpha/beta pathway in regulating immune response of macrophages to Mycobacterium tuberculosis infection. It also demonstrates that PKC-delta and mTOR can influence the activation of GSK-3alpha/beta and subsequently regulate the expression of MMP-1/9. These findings provide new insights into the immune escape mechanism of tuberculosis and the crosstalk between critical signaling pathways.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Infectious Diseases
Berecha Bayissa, Asegedech Sirak, Aboma Zewude, Adane Worku, Balako Gumi, Stefan Berg, R. Glyn Hewinson, James L. N. Wood, Gareth J. Jones, H. Martin Vordermeier, Gobena Ameni
Summary: Bovine tuberculosis poses challenges to intensive dairy production in Ethiopia, and vaccination with BCG could be a cost-effective control strategy. A study evaluated a DIVA skin test based on specific M. bovis proteins, showing higher sensitivity than the traditional SICCT test in differentiating infected and vaccinated cattle.
TRANSBOUNDARY AND EMERGING DISEASES
(2022)
Article
Biochemistry & Molecular Biology
Arzu Ay, Nevra Alkanli, Gokhan Cevik
Summary: In this study, MMP-1 and MMP-3 gene variations were identified as potential genetic risk factors for bladder cancer development in the Thrace population. The distribution of genotypes for MMP-1 and MMP-3 gene variations differed significantly between patients and controls, with certain genotypes more common in patients. The most common haplotype detected in the patient group was 1G/2G-5A/6A.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Viridiana Garcia-Ruiz, Patricia Orduna, Antonia Castillo-Rodal, Teresa J. Flores-Rodriguez, Yolanda Lopez-Vidal
Summary: This study aimed to investigate the differences in glycosylation profiles between two recombinant strains of Mycobacterium microti and found distinct proteome and glycoproteome profiles between the strains.
Article
Immunology
Magdalena Druszczynska, Michal Seweryn, Sebastian Wawrocki, Anna Pankowska, Magdalena Godkowicz, Magdalena Kowalewska-Pietrzak
Summary: The study evaluated the utility of tuberculin skin test (TST) and interferon-gamma release assay (IGRA) in identifying latent tuberculosis infection (LTBI) in BCG-vaccinated Polish children and adolescents exposed to contagious TB. The study also investigated if quantitative assessment of IGRA results could predict active TB disease. The results showed that both TST and IGRA can be used as screening tests for BCG-vaccinated children and adolescents exposed to contagious TB.
Article
Immunology
Azra Blazevic, Rachel L. Edwards, Mei Xia, Christopher S. Eickhoff, Fahreta Hamzabegovic, Krystal A. Meza, Huan Ning, Janice Tennant, Karla J. Mosby, James C. Ritchie, Tigisty Girmay, Lilin Lai, Michele Mccullough, Allison Beck, Colleen Kelley, Srilatha Edupuganti, Sarah Kabbani, Wendy Buchanan, Mamodikoe K. Makhene, Delia Voronca, Sami Cherikh, Johannes B. Goll, Nadine G. Rouphael, Mark J. Mulligan, Daniel F. Hoft
Summary: This study demonstrates that the BCG human challenge model is a feasible approach for assessing in vivo tuberculosis immunity and could facilitate the vaccine development process. The results provide valuable insights into potential biomarkers of mycobacterial immunity and transcriptomic analyses that may aid in understanding the immune component underlying the higher rate of TB disease incidence in males.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Anna Szeremeta, Agnieszka Jura-Poltorak, Aleksandra Zon-Giebel, Krystyna Olczyk, Katarzyna Komosinska-Vassev
Summary: This study investigated the effects of anti-TNF-alpha therapy on RA-associated atherosclerosis and found that the treatment reduced levels of HS/H and markers of endothelial dysfunction, providing a potential means for monitoring treatment efficacy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Ming-Hsien Wu, Te-Cheng Yueh, Wen-Shin Chang, Chia-Wen Tsai, Chun-Kai Fu, Mei-Due Yang, Chien-Chih Yu, Da-Tian Bau
Summary: The study found that MMP-1 gene plays an important role in determining susceptibility to CRC risk in Taiwan, with 1G/2G and 1G/1G genotypes associated with lower risk.
CANCER GENOMICS & PROTEOMICS
(2021)
Article
Oncology
Oscar Arrieta, Andres F. Cardona, Claudio Martin, Luis Mas-Lopez, Luis Corrales-Rodriguez, Guillermo Bramuglia, Omar Castillo-Fernandez, Matthew Meyerson, Eduardo Amieva-Rivera, Alma Delia Campos-Parra, Hernn Carranza, Juan Carlos Gomez de la Torre, Yanina Powazniak, Fernando Aldaco-Sarvide, Carlos Vargas, Mariana Trigo, Manuel Magallanes-Maciel, Jorge Otero, Roberto Sanchez-Reyes, Mauricio Cuello
JOURNAL OF THORACIC ONCOLOGY
(2015)
Article
Immunology
Pedro O. Flores-Villanueva, Malathesha Ganachari, Heinner Guio, Jaime A. Mejia, Julio Granados
JOURNAL OF IMMUNOLOGY
(2018)
Article
Multidisciplinary Sciences
Daniel N. Harris, Wei Song, Amol C. Shetty, Kelly S. Levano, Omar Caceres, Carlos Padilla, Victor Borda, David Tarazona, Omar Trujillo, Cesar Sanchez, Michael D. Kessler, Marco Galarza, Silvia Capristano, Harrison Montejo, Pedro O. Flores-Villanueva, Eduardo Tarazona-Santos, Timothy D. O'Connor, Heinner Guio
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Biochemistry & Molecular Biology
Malgorzata Kloc, Neelam Tejpal, Jitinderpal Sidhu, Malathesha Ganachari, Pedro Flores-Villanueva, Nicholas B. Jennings, Anil K. Sood, Jacek Z. Kubiak, Rafik M. Ghobrial
FOLIA HISTOCHEMICA ET CYTOBIOLOGICA
(2012)
Article
Genetics & Heredity
M. Ganachari, H. Guio, N. Zhao, P. O. Flores-Villanueva
GENES AND IMMUNITY
(2012)
Review
Infectious Diseases
W-X. Feng, P. O. Flores-Villanueva, I. Mokrousov, X-R. Wu, J. Xiao, W-W. Jiao, L. Sun, Q. Miao, C. Shen, D. Shen, F. Liu, Z-W. Jia, A. Shen
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
(2012)
Article
Infectious Diseases
Carlos Eduardo Ferreira, Pablo E. Bonvehi, Juan Carlos Gomez de la Torre, Klever Vinicio Saenz-Flor, Antonio Condino-Neto
Summary: This study proposed recommendations for the ideal use of diagnostic tools for COVID-19 in Latin America, focusing on RT-PCR and high-affinity antibodies tests. A panel of five experts developed guidelines and testing algorithms for different scenarios, emphasizing the importance of serological high-affinity antibody tests in diagnosis and public health strategies. These tests should ideally be conducted 21 days after potential infectious contact to account for seroconversion in exposed individuals.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Miguel Hueda-Zavaleta, Juan C. Gomez de la Torre, Jose Alonso Caceres-Del Aguila, Cecilia Muro-Rojo, Nathalia De la Cruz-Escurra, Daniella Arenas Siles, Diana Minchon-Vizconde, Cesar Copaja-Corzo, Fabrizzio Bardales-Silva, Vicente A. Benites-Zapata, Alfonso J. Rodriguez-Morales
Summary: This prospective cohort study investigated the effects of a heterologous booster on humoral immune response in adult patients who were initially vaccinated with the BBIBP-CorV vaccine. The study found that the antibody levels were higher in previously infected individuals after immunization, while in non-infected individuals, the increase in antibody levels was more pronounced after immunization.
Article
Infectious Diseases
Isabella A. Tickler, Juan Carlos Gomez de la Torreb, Luis Alvarado, Anne E. Obradovich, Fred C. Tenover
Summary: This study reveals the linages and mechanisms of resistance of Pseudomonas aeruginosa circulating in Peru. The results show that the high-risk P. aeruginosa clones ST357 carrying the novel blaIMP-93 gene and ST111 carrying blaIMP-18 and blaVIM-2 genes have become endemic in the region.
JOURNAL OF GLOBAL ANTIMICROBIAL RESISTANCE
(2022)
Article
Immunology
Miguel Hueda-Zavaleta, Juan C. Gomez C. de la Torre, Jose Alonso Caceres-DelAguila, Cecilia Muro-Rojo, Nathalia de la Cruz-Escurra, Cesar Copaja-Corzo, Carlos J. J. Aragon-Ayala, Vicente A. A. Benites-Zapata
Summary: We evaluated the levels of neutralizing antibodies (NAbs) as a protective factor against vaccine breakthrough infection (VBI) in healthcare workers (HCWs) during Peru's third COVID-19 wave. This retrospective cohort study used data from a private laboratory in Lima, Peru, and included HCWs who received either two doses of BBIBP-CorV vaccine or a heterologous booster with BNT162b2. We found that HCWs with higher levels of NAbs, measured at various time points after BBIBP-CorV vaccination, had a lower risk of VBI during the third wave of COVID-19.
Article
Immunology
Juan Gomez C. de la Torre, Miguel Hueda-Zavaleta, Jose Alonso Caceres-DelAguila, Cecilia Muro-Rojo, Nathalia De La Cruz-Escurra, Vicente A. Benites-Zapata
Summary: This prospective cohort study examined the humoral response of healthcare workers who received a fourth dose with a heterologous mRNA1273 booster after a primary regimen of two doses of BBIBP-CorV. The results showed that the fourth dose significantly enhanced the immune response, with antibody levels 2.3 and 1.6 times higher at 30 and 120 days post-vaccination, respectively. Furthermore, individuals who received the mRNA1273 booster and those infected after the third dose with BNT162b2 exhibited higher antibody titers.
Article
Microbiology
Diego Cuicapuza, Luis Alvarado, Norah Tocasca, Daniel Aguilar, Juan Carlos Gomez-de-la-Torre, Guillermo Salvatierra, Pablo Tsukayama, Jesus Tamariz
Summary: We identified five carbapenemase-producing Enterobacterales (CPE) isolates from two healthcare institutions in Lima, Peru. All isolates were carriers of the bla(OXA-48)-like gene and had the bla(OXA-181) gene as the only carbapenemase gene. Other resistance genes and the IncX3 plasmid were also found. This study highlights the increasing public health problem of CPE isolates harboring bla(OXA)-like genes and the wide dissemination of bla(OXA-181) in Peru.
MICROBIOLOGY SPECTRUM
(2023)
Article
Infectious Diseases
Juana M. Huamani-Cordova, Miguel Hueda-Zavaleta, Victor Vargas-Bellina, Lourdes Simbron-Ribbeck, Katty del Rosario Chong-Chinchay, Juan Carlos Gomez de la Torre, Vicente A. Benites-Zapata
Summary: A case series of non-HIV patients with cerebral cryptococcosis after SARS-CoV-2 infection is reported. The majority of these patients had severe symptoms or received immunosuppressants. There is a hypothesis that the CD4+ T lymphocytopenia in these patients may increase the risk of cryptococcosis after SARS-CoV-2 infection.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2023)
Article
Infectious Diseases
Juan C. Gomez de la Torre, Jose Alonso Caceres-DelAguila, Cecilia Muro-Rojo, Nathalia De La Cruz-Escurra, Cesar Copaja-Corzo, Miguel Hueda-Zavaleta, Daniella Arenas Siles, Vicente A. Benites-Zapata
Summary: Insufficient data have been reported about the effect of the inactivated SARS-CoV-2 vaccine (BBIBP-CorV) on the humoral response through time in healthcare workers (HCW). This retrospective cohort study compared the antibody-mediated response provoked by BBIBP-CorV between HCW previously infected with SARS-CoV-2 (PI) and not previously infected (NPI). The study found that there was a progressive decrease in antibody levels over time in both groups, with the NPI group showing a higher decrease.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2022)
Meeting Abstract
Oncology
Luis Mas, Christian Piscocha, Jose Landa, Carlos Roe, Eduardo Roe, Claudia Barletta, Raul E. Velarde, Luis Larrabure, Sandra Jauregui, Christina Flores, Juan C. Gomez de la Torre
JOURNAL OF CLINICAL ONCOLOGY
(2017)