LRRK2 G2019S-induced mitochondrial DNA damage is LRRK2 kinase dependent and inhibition restores mtDNA integrity in Parkinson’s disease
出版年份 2017 全文链接
标题
LRRK2 G2019S-induced mitochondrial DNA damage is LRRK2 kinase dependent and inhibition restores mtDNA integrity in Parkinson’s disease
作者
关键词
-
出版物
HUMAN MOLECULAR GENETICS
Volume 26, Issue 22, Pages 4340-4351
出版商
Oxford University Press (OUP)
发表日期
2017-08-12
DOI
10.1093/hmg/ddx320
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Selective neuronal vulnerability in Parkinson disease
- (2017) D. James Surmeier et al. NATURE REVIEWS NEUROSCIENCE
- Genetics in Parkinson disease: Mendelian versus non-Mendelian inheritance
- (2016) Dena G. Hernandez et al. JOURNAL OF NEUROCHEMISTRY
- Ser(P)-1292 LRRK2 in urinary exosomes is elevated in idiopathic Parkinson's disease
- (2016) Kyle B. Fraser et al. MOVEMENT DISORDERS
- A unifying mechanism in neurodegeneration
- (2016) Christopher A. Ross et al. NATURE
- XRCC1 mutation is associated with PARP1 hyperactivation and cerebellar ataxia
- (2016) Nicolas C. Hoch et al. NATURE
- Mitochondrial DNA exhibits resistance to induced point and deletion mutations
- (2016) William J. Valente et al. NUCLEIC ACIDS RESEARCH
- Inhibitor treatment of peripheral mononuclear cells from Parkinson’s disease patients further validates LRRK2 dephosphorylation as a pharmacodynamic biomarker
- (2016) G. Perera et al. Scientific Reports
- Digital PCR methods improve detection sensitivity and measurement precision of low abundance mtDNA deletions
- (2016) Frances R. Belmonte et al. Scientific Reports
- Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases
- (2016) Martin Steger et al. eLife
- Pharmacological LRRK2 kinase inhibition induces LRRK2 protein destabilization and proteasomal degradation
- (2016) E. Lobbestael et al. Scientific Reports
- Inhibitors of Leucine-Rich Repeat Kinase 2 (LRRK2): Progress and Promise for the Treatment of Parkinson’s Disease
- (2015) Paul Gilligan CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Fibroblast Biomarkers of Sporadic Parkinson’s Disease and LRRK2 Kinase Inhibition
- (2015) G. A. Smith et al. MOLECULAR NEUROBIOLOGY
- Effect of selective LRRK2 kinase inhibition on nonhuman primate lung
- (2015) Reina N. Fuji et al. Science Translational Medicine
- VPS35 Deficiency or Mutation Causes Dopaminergic Neuronal Loss by Impairing Mitochondrial Fusion and Function
- (2015) Fu-Lei Tang et al. Cell Reports
- Clinical Correlations With Lewy Body Pathology inLRRK2-Related Parkinson Disease
- (2015) Lorraine V. Kalia et al. JAMA Neurology
- Leucine-rich repeat kinase 2 inhibitors: a review of recent patents (2011 – 2013)
- (2014) Raghava R Kethiri et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- LRRK2 pathobiology in Parkinson's disease
- (2014) Ian Martin et al. JOURNAL OF NEUROCHEMISTRY
- Interferon-γ induces leucine-rich repeat kinase LRRK2 via extracellular signal-regulated kinase ERK5 in macrophages
- (2014) Martin Kuss et al. JOURNAL OF NEUROCHEMISTRY
- Mutant LRRK2 Toxicity in Neurons Depends on LRRK2 Levels and Synuclein But Not Kinase Activity or Inclusion Bodies
- (2014) G. Skibinski et al. JOURNAL OF NEUROSCIENCE
- Ten Years and Counting: Moving Leucine-Rich RepeatKinase 2 Inhibitors to the Clinic
- (2014) Andrew B. West MOVEMENT DISORDERS
- Mitochondrial DNA damage: Molecular marker of vulnerable nigral neurons in Parkinson's disease
- (2014) Laurie H. Sanders et al. NEUROBIOLOGY OF DISEASE
- Mitochondrial DNA Damage as a Peripheral Biomarker for Mitochondrial Toxin Exposure in Rats
- (2014) Laurie H. Sanders et al. TOXICOLOGICAL SCIENCES
- Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7
- (2014) Ruth Chia et al. Nature Communications
- LRRK2 kinase activity and biology are not uniformly predicted by its autophosphorylation and cellular phosphorylation site status
- (2014) April Reynolds et al. Frontiers in Molecular Neuroscience
- The development of CNS-active LRRK2 inhibitors using property-directed optimisation
- (2013) Madeline E. Kavanagh et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Genetic Correction of a LRRK2 Mutation in Human iPSCs Links Parkinsonian Neurodegeneration to ERK-Dependent Changes in Gene Expression
- (2013) Peter Reinhardt et al. Cell Stem Cell
- Oxidative damage to macromolecules in human Parkinson disease and the rotenone model
- (2013) Laurie H. Sanders et al. FREE RADICAL BIOLOGY AND MEDICINE
- Axonal Degeneration of Nigra-striatum Dopaminergic Neurons Induced by 1-Methyl-4-phenyl-1,2,3, 6-tetrahydropyridine in Mice
- (2013) L-H Li et al. JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
- LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: Reversal by gene correction
- (2013) Laurie H. Sanders et al. NEUROBIOLOGY OF DISEASE
- The G2385R variant of leucine-rich repeat kinase 2 associated with Parkinson's disease is a partial loss-of-function mutation
- (2012) Iakov N. Rudenko et al. BIOCHEMICAL JOURNAL
- Leucine-rich repeat kinase 2 inhibitors: a patent review (2006 – 2011)
- (2012) Xianming Deng et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity
- (2012) C. Yao et al. HUMAN MOLECULAR GENETICS
- Automated imaging system for fast quantitation of neurons, cell morphology and neurite morphometry in vivo and in vitro
- (2012) Victor Tapias et al. NEUROBIOLOGY OF DISEASE
- Screening for Novel LRRK2 Inhibitors Using a High-Throughput TR-FRET Cellular Assay for LRRK2 Ser935 Phosphorylation
- (2012) Spencer B. Hermanson et al. PLoS One
- Ser1292 Autophosphorylation Is an Indicator of LRRK2 Kinase Activity and Contributes to the Cellular Effects of PD Mutations
- (2012) Z. Sheng et al. Science Translational Medicine
- Pharmacological Rescue of Mitochondrial Deficits in iPSC-Derived Neural Cells from Patients with Familial Parkinson's Disease
- (2012) O. Cooper et al. Science Translational Medicine
- Brain Penetrant LRRK2 Inhibitor
- (2012) Hwan Geun Choi et al. ACS Medicinal Chemistry Letters
- Discovery of a Highly Selective, Brain-Penetrant Aminopyrazole LRRK2 Inhibitor
- (2012) Bryan K. Chan et al. ACS Medicinal Chemistry Letters
- Single-Cell Redox Imaging Demonstrates a Distinctive Response of Dopaminergic Neurons to Oxidative Insults
- (2011) Maxx P. Horowitz et al. ANTIOXIDANTS & REDOX SIGNALING
- Phosphorylation of LRRK2 serines 955 and 973 is disrupted by Parkinson’s disease mutations and LRRK2 pharmacological inhibition
- (2011) Elizabeth A. Doggett et al. JOURNAL OF NEUROCHEMISTRY
- DJ-1 knock-down impairs astrocyte mitochondrial function
- (2011) N.J. Larsen et al. NEUROSCIENCE
- DNA repair deficiency in neurodegeneration
- (2011) Dennis Kjølhede Jeppesen et al. PROGRESS IN NEUROBIOLOGY
- Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser910/Ser935, disruption of 14-3-3 binding and altered cytoplasmic localization
- (2010) Nicolas Dzamko et al. BIOCHEMICAL JOURNAL
- Bioenergetics of neurons inhibit the translocation response of Parkin following rapid mitochondrial depolarization
- (2010) Victor S. Van Laar et al. HUMAN MOLECULAR GENETICS
- Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease
- (2010) Byoung Dae Lee et al. NATURE MEDICINE
- On Mitochondria, Mutations, and Methodology
- (2009) Marc Vermulst et al. Cell Metabolism
- The role of dopamine oxidation in mitochondrial dysfunction: implications for Parkinson’s disease
- (2009) Teresa G. Hastings JOURNAL OF BIOENERGETICS AND BIOMEMBRANES
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now