Impaired Inflammatory Responses in Murine Lrrk2-Knockdown Brain Microglia

Genetic mouse models for Parkinson's disease display severe pathology in glial cell mitochondria

(2011) S. Schmidt et al.   HUMAN MOLECULAR GENETICS

Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ)

(2011) Adam D Bachstetter et al.   Journal of Neuroinflammation

A Rat Model of Progressive Nigral Neurodegeneration Induced by the Parkinson's Disease-Associated G2019S Mutation in LRRK2

(2011) J. Dusonchet et al.   JOURNAL OF NEUROSCIENCE

Posttranslational modifications of NF-κB: Another layer of regulation for NF-κB signaling pathway

(2010) Bo Huang et al.   CELLULAR SIGNALLING

LRRK2 Is Involved in the IFN-  Response and Host Response to Pathogens

(2010) A. Gardet et al.   JOURNAL OF IMMUNOLOGY

MKK6 binds and regulates expression of Parkinson’s disease-related protein LRRK2

(2010) Cindy H. Hsu et al.   JOURNAL OF NEUROCHEMISTRY

Enhanced Striatal Dopamine Transmission and Motor Performance with LRRK2 Overexpression in Mice Is Eliminated by Familial Parkinson's Disease Mutation G2019S

(2010) X. Li et al.   JOURNAL OF NEUROSCIENCE

Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease

(2010) Taye H Hamza et al.   NATURE GENETICS

Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease

(2010) Byoung Dae Lee et al.   NATURE MEDICINE

Transcriptional profile of Parkinson blood mononuclear cells with LRRK2 mutation

(2010) Eugénie Mutez et al.   NEUROBIOLOGY OF AGING

Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice

(2010) H.L. Melrose et al.   NEUROBIOLOGY OF DISEASE

Parkinson's Disease and Low Frequency Alleles Found Together ThroughoutLRRK2

(2009) Coro Paisán-Ruiz et al.   ANNALS OF HUMAN GENETICS

LRRK2 enhances oxidative stress-induced neurotoxicity via its kinase activity

(2009) Hye Young Heo et al.   EXPERIMENTAL CELL RESEARCH

Regulation of astrocyte inflammatory responses by the Parkinson’s disease-associated gene DJ-1

(2009) Jens Waak et al.   FASEB JOURNAL

Parkin deficiency increases the resistance of midbrain neurons and glia to mild proteasome inhibition: the role of autophagy and glutathione homeostasis

(2009) Maria J. Casarejos et al.   JOURNAL OF NEUROCHEMISTRY

The Parkinson disease-associated protein kinase LRRK2 exhibits MAPKKK activity and phosphorylates MKK3/6 and MKK4/7,in vitro

(2009) Christian Johannes Gloeckner et al.   JOURNAL OF NEUROCHEMISTRY

Mutant LRRK2 R1441G BAC transgenic mice recapitulate cardinal features of Parkinson's disease

(2009) Yanping Li et al.   NATURE NEUROSCIENCE

A novel LRRK2 mutation in a mainland Chinese patient with familial Parkinson's disease

(2009) Lei Wang et al.   NEUROSCIENCE LETTERS

Genomewide Association Study of Leprosy

(2009) Fu-Ren Zhang et al.   NEW ENGLAND JOURNAL OF MEDICINE

R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice

(2009) Y. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Central and systemic IL-1 exacerbates neurodegeneration and motor symptoms in a model of Parkinson's disease

(2008) M. C. Pott Godoy et al.   BRAIN

LRRK2 regulates synaptic vesicle endocytosis

(2008) Narae Shin et al.   EXPERIMENTAL CELL RESEARCH

Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells

(2008) Edward D. Plowey et al.   JOURNAL OF NEUROCHEMISTRY

Glial Dysfunction in Parkin Null Mice: Effects of Aging

(2008) R. M. Solano et al.   JOURNAL OF NEUROSCIENCE

Parkin Deficiency Increases Vulnerability to Inflammation-Related Nigral Degeneration

(2008) T. C. Frank-Cannon et al.   JOURNAL OF NEUROSCIENCE

Clinical and pathological characteristics of patients with Leucine-rich repeat kinase-2 mutations

(2008) Jason P. Covy et al.   MOVEMENT DISORDERS

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

(2008) Jeffrey C Barrett et al.   NATURE GENETICS

Wild-type LRRK2 but not its mutant attenuates stress-induced cell death via ERK pathway

(2008) Anthony K.F. Liou et al.   NEUROBIOLOGY OF DISEASE

Inflammation as a causative factor in the aetiology of Parkinson's disease

(2007) P S Whitton   BRITISH JOURNAL OF PHARMACOLOGY