Asparagine synthetase: regulation by cell stress and involvement in tumor biology

Dynamic changes in genomic histone association and modification during activation of theASNSandATF3genes by amino acid limitation

(2012) Mukundh N. Balasubramanian et al.   BIOCHEMICAL JOURNAL

ATF4-dependent Regulation of the JMJD3 Gene during Amino Acid Deprivation Can Be Rescued in Atf4-deficient Cells by Inhibition of Deacetylation

(2012) Jixiu Shan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Pancreatic Tumor Sensitivity to Plasma L-Asparagine Starvation

(2012) Emmanuelle Dufour et al.   PANCREAS

ATF5 polymorphisms influence ATF function and response to treatment in children with childhood acute lymphoblastic leukemia

(2011) J. Rousseau et al.   BLOOD

Auto-activation of c-JUNGene by Amino Acid Deprivation of Hepatocellular Carcinoma Cells Reveals a Novel c-JUN-mediated Signaling Pathway

(2011) Lingchen Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Circulating tumour cells demonstrate an altered response to hypoxia and an aggressive phenotype

(2010) K Ameri et al.   BRITISH JOURNAL OF CANCER

AP-1 — The Jun proteins: Oncogenes or tumor suppressors in disguise?

(2010) Eitan Shaulian   CELLULAR SIGNALLING

Finding value in the U.S. food and drug administration's fast track program

(2010) J.M. Reichert et al.   DRUG NEWS & PERSPECTIVES

The GCN2-ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation

(2010) Jiangbin Ye et al.   EMBO JOURNAL

The eIF2 Kinase GCN2 Is Essential for the Murine Immune System to Adapt to Amino Acid Deprivation by Asparaginase1–3

(2010) Piyawan Bunpo et al.   JOURNAL OF NUTRITION

Expression profiling after activation of amino acid deprivation response in HepG2 human hepatoma cells

(2010) Jixiu Shan et al.   PHYSIOLOGICAL GENOMICS

Amino Acid Availability Controls TRB3 Transcription in Liver through the GCN2/eIF2α/ATF4 Pathway

(2010) Valérie Carraro et al.   PLoS One

Amino acid transporters:éminences grisesof nutrient signalling mechanisms?: Figure 1

(2009) Peter M. Taylor   BIOCHEMICAL SOCIETY TRANSACTIONS

Protein or amino acid deprivation differentially regulates the hepatic forkhead box protein A (FOXA) genes through an activating transcription factor-4-independent pathway

(2009) Nan Su et al.   HEPATOLOGY

GCN2 Protein Kinase Is Required to Activate Amino Acid Deprivation Responses in Mice Treated with the Anti-cancer Agent l-Asparaginase

(2009) Piyawan Bunpo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of a Novel Amino Acid Response Pathway Triggering ATF2 Phosphorylation in Mammals

(2009) C. Chaveroux et al.   MOLECULAR AND CELLULAR BIOLOGY

eIF2α kinases GCN2 and PERK modulate transcription and translation of distinct sets of mRNAs in mouse liver

(2009) An N. Dang Do et al.   PHYSIOLOGICAL GENOMICS

ATF4-dependent transcription mediates signaling of amino acid limitation

(2009) Michael S. Kilberg et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

MEK Signaling Is Required for Phosphorylation of eIF2α following Amino Acid Limitation of HepG2 Human Hepatoma Cells

(2008) Michelle M. Thiaville et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

C/EBP Homology Protein (CHOP) Interacts with Activating Transcription Factor 4 (ATF4) and Negatively Regulates the Stress-dependent Induction of the Asparagine Synthetase Gene

(2008) Nan Su et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of eIF2 DirectsATF5Translational Control in Response to Diverse Stress Conditions

(2008) Donghui Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Asparagine synthetase is a predictive biomarker of l-asparaginase activity in ovarian cancer cell lines

(2008) Philip L. Lorenzi et al.   MOLECULAR CANCER THERAPEUTICS

Correlation between asparaginase sensitivity and asparagine synthetase protein content, but not mRNA, in acute lymphoblastic leukemia cell lines

(2007) Nan Su et al.   PEDIATRIC BLOOD & CANCER