Cellular metabolism of tumor-associated macrophages - functional impact and consequences

Tumor-associated macrophages: from basic research to clinical application

(2017) Li Yang et al.   Journal of Hematology & Oncology

Class IIa HDAC inhibition reduces breast tumours and metastases through anti-tumour macrophages

(2017) Jennifer L. Guerriero et al.   NATURE

Lipocalin-2 and iron trafficking in the tumor microenvironment

(2017) Michaela Jung et al.   PHARMACOLOGICAL RESEARCH

Ornithine decarboxylase regulates M1 macrophage activation and mucosal inflammation via histone modifications

(2017) Dana M. Hardbower et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Macrophage Metabolism Controls Tumor Blood Vessel Morphogenesis and Metastasis

(2016) Mathias Wenes et al.   Cell Metabolism

Reprogramming mitochondrial metabolism in macrophages as an anti-inflammatory signal

(2016) Evanna L. Mills et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Metabolic Reprogramming Mediated by the mTORC2-IRF4 Signaling Axis Is Essential for Macrophage Alternative Activation

(2016) Stanley Ching-Cheng Huang et al.   IMMUNITY

Expression Profiling of Macrophages Reveals Multiple Populations with Distinct Biological Roles in an Immunocompetent Orthotopic Model of Lung Cancer

(2016) Joanna M. Poczobutt et al.   JOURNAL OF IMMUNOLOGY

Comprehensive Proteomics Analysis Reveals Metabolic Reprogramming of Tumor-Associated Macrophages Stimulated by the Tumor Microenvironment

(2016) Di Liu et al.   JOURNAL OF PROTEOME RESEARCH

New insights into the multidimensional concept of macrophage ontogeny, activation and function

(2016) Florent Ginhoux et al.   NATURE IMMUNOLOGY

Molecular targets of metformin antitumor action

(2016) Stanisław Sośnicki et al.   Pharmacological Reports

Intracellular Iron Chelation Modulates the Macrophage Iron Phenotype with Consequences on Tumor Progression

(2016) Christina Mertens et al.   PLoS One

Integrating immunometabolism and macrophage diversity

(2016) Maxim N. Artyomov et al.   SEMINARS IN IMMUNOLOGY

Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages

(2016) Jan Van den Bossche et al.   Cell Reports

Transcriptional and metabolic reprogramming induce an inflammatory phenotype in non-medullary thyroid carcinoma-induced macrophages

(2016) Rob J. W. Arts et al.   OncoImmunology

Anti-GD2 mAb and Vorinostat synergize in the treatment of neuroblastoma

(2016) Michiel Kroesen et al.   OncoImmunology

Warburg metabolism in tumor-conditioned macrophages promotes metastasis in human pancreatic ductal adenocarcinoma

(2016) Hweixian Leong Penny et al.   OncoImmunology

Microbial stimulation of different Toll-like receptor signalling pathways induces diverse metabolic programmes in human monocytes

(2016) Ekta Lachmandas et al.   Nature Microbiology

Metabolic communication in tumors: a new layer of immunoregulation for immune evasion

(2016) Ping-Chih Ho et al.   Journal for ImmunoTherapy of Cancer

Enhanced fatty acid oxidation in adipocytes and macrophages reduces lipid-induced triglyceride accumulation and inflammation

(2015) Maria Ida Malandrino et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Glioblastoma cells induce differential glutamatergic gene expressions in human tumor-associated microglia/macrophages and monocyte-derived macrophages

(2015) Judy Choi et al.   CANCER BIOLOGY & THERAPY

M-CSF and GM-CSF Receptor Signaling Differentially Regulate Monocyte Maturation and Macrophage Polarization in the Tumor Microenvironment

(2015) E. Van Overmeire et al.   CANCER RESEARCH

Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

(2015) Eva M. Palsson-McDermott et al.   Cell Metabolism

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

(2015) Abhishek K. Jha et al.   IMMUNITY

Macrophage iron homeostasis and polarization in the context of cancer

(2015) Michaela Jung et al.   IMMUNOBIOLOGY

Ovarian cancer stem cells induce the M2 polarization of macrophages through the PPARγ and NF-κB pathways

(2015) XINCHAO DENG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Palmitoleate Reverses High Fat-induced Proinflammatory Macrophage Polarization via AMP-activated Protein Kinase (AMPK)

(2015) Kenny L. Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis

(2015) Jong-Seok Moon et al.   JOURNAL OF CLINICAL INVESTIGATION

Immunometabolism governs dendritic cell and macrophage function

(2015) Luke A.J. O’Neill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CD147 reprograms fatty acid metabolism in hepatocellular carcinoma cells through Akt/mTOR/SREBP1c and P38/PPARα pathways

(2015) Jibin Li et al.   JOURNAL OF HEPATOLOGY

Control of macrophage metabolism and activation by mTOR and Akt signaling

(2015) Anthony J. Covarrubias et al.   SEMINARS IN IMMUNOLOGY

Inhibition of tumor growth by a newly-identified activator for epidermal fatty acid binding protein

(2015) Enyu Rao et al.   Oncotarget

Deregulation of PPARβ/δ target genes in tumor-associated macrophages by fatty acid ligands in the ovarian cancer microenvironment

(2015) Tim Schumann et al.   Oncotarget

Metformin Reduces Desmoplasia in Pancreatic Cancer by Reprogramming Stellate Cells and Tumor-Associated Macrophages

(2015) Joao Incio et al.   PLoS One

Fatty Acid-Binding Protein E-FABP Restricts Tumor Growth by Promoting IFN-  Responses in Tumor-Associated Macrophages

(2014) Y. Zhang et al.   CANCER RESEARCH

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Transcriptome-Based Network Analysis Reveals a Spectrum Model of Human Macrophage Activation

(2014) Jia Xue et al.   IMMUNITY

Molecular Profiling Reveals a Tumor-Promoting Phenotype of Monocytes and Macrophages in Human Cancer Progression

(2014) Manesh Chittezhath et al.   IMMUNITY

Metabolism of stromal and immune cells in health and disease

(2014) Bart Ghesquière et al.   NATURE

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

Cell-intrinsic lysosomal lipolysis is essential for alternative activation of macrophages

(2014) Stanley Ching-Cheng Huang et al.   NATURE IMMUNOLOGY

Increased metabolites of 5-lipoxygenase from hypoxic ovarian cancer cells promote tumor-associated macrophage infiltration

(2014) Z Wen et al.   ONCOGENE

Amino acids – A life between metabolism and signaling

(2014) Rainer E. Häusler et al.   PLANT SCIENCE

The pentose phosphate pathway and cancer

(2014) Krushna C. Patra et al.   TRENDS IN BIOCHEMICAL SCIENCES

Metabolism via Arginase or Nitric Oxide Synthase: Two Competing Arginine Pathways in Macrophages

(2014) Meera Rath et al.   Frontiers in Immunology

Interleukin-4- and Interleukin-13-Mediated Alternatively Activated Macrophages: Roles in Homeostasis and Disease

(2013) Steven J. Van Dyken et al.   Annual Review of Immunology

Hypoxia enhances lipid uptake in macrophages: Role of the scavenger receptors Lox1, SRA, and CD36

(2013) Margot Crucet et al.   ATHEROSCLEROSIS

Impeding Macrophage Entry into Hypoxic Tumor Areas by Sema3A/Nrp1 Signaling Blockade Inhibits Angiogenesis and Restores Antitumor Immunity

(2013) Andrea Casazza et al.   CANCER CELL

Rottlerin induces autophagy and apoptosis in prostate cancer stem cells via PI3K/Akt/mTOR signaling pathway

(2013) Dhruv Kumar et al.   CANCER LETTERS

Tumor Hypoxia Does Not Drive Differentiation of Tumor-Associated Macrophages but Rather Fine-Tunes the M2-like Macrophage Population

(2013) D. Laoui et al.   CANCER RESEARCH

Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development

(2013) F. Baenke et al.   Disease Models & Mechanisms

Metabolism of inflammation limited by AMPK and pseudo-starvation

(2013) Luke A. J. O'Neill et al.   NATURE

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Fatty acid–induced mitochondrial uncoupling elicits inflammasome-independent IL-1α and sterile vascular inflammation in atherosclerosis

(2013) Stefan Freigang et al.   NATURE IMMUNOLOGY

Osteopontin signaling upregulates cyclooxygenase-2 expression in tumor-associated macrophages leading to enhanced angiogenesis and melanoma growth via α9β1 integrin

(2013) S Kale et al.   ONCOGENE

Inhibition of Tumor Growth and Alteration of Associated Macrophage Cell Type by an HO-1 Inhibitor in Breast Carcinoma-Bearing Mice

(2013) Rui Deng et al.   ONCOLOGY RESEARCH

Eicosanoid Profiling in an Orthotopic Model of Lung Cancer Progression by Mass Spectrometry Demonstrates Selective Production of Leukotrienes by Inflammatory Cells of the Microenvironment

(2013) Joanna M. Poczobutt et al.   PLoS One

Emergence of spatial structure in the tumor microenvironment due to the Warburg effect

(2013) C. Carmona-Fontaine et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production

(2013) A. Michelucci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor-associated macrophages: functional diversity, clinical significance, and open questions

(2013) Subhra K. Biswas et al.   Seminars in Immunopathology

The Sedoheptulose Kinase CARKL Directs Macrophage Polarization through Control of Glucose Metabolism

(2012) Arvand Haschemi et al.   Cell Metabolism

Induction of M2-like macrophages in recipient NOD-scid mice by allogeneic donor CD4+CD25+ regulatory T cells

(2012) Xuelian Hu et al.   Cellular & Molecular Immunology

Lipid metabolism in cancer

(2012) Claudio R. Santos et al.   FEBS Journal

Macrophage polarization and plasticity in health and disease

(2012) Subhra K. Biswas et al.   IMMUNOLOGIC RESEARCH

The immunosuppressive tumour network: myeloid-derived suppressor cells, regulatory T cells and natural killer T cells

(2012) Dennis Lindau et al.   IMMUNOLOGY

Clinical Significance of Tumor-Associated Inflammatory Cells in Metastatic Neuroblastoma

(2012) Shahab Asgharzadeh et al.   JOURNAL OF CLINICAL ONCOLOGY

Pivotal Advance: Arginase-1-independent polyamine production stimulates the expression of IL-4-induced alternatively activated macrophage markers while inhibiting LPS-induced expression of inflammatory genes

(2012) Jan Van den Bossche et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Mechanisms of triglyceride accumulation in activated macrophages

(2012) Kenneth R. Feingold et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Omega-3 Polyunsaturated Fatty Acids Antagonize Macrophage Inflammation via Activation of AMPK/SIRT1 Pathway

(2012) Bingzhong Xue et al.   PLoS One

Prognostic Significance of Tumor-Associated Macrophages in Solid Tumor: A Meta-Analysis of the Literature

(2012) Qiong-wen Zhang et al.   PLoS One

Origins of tumor-associated macrophages and neutrophils

(2012) V. Cortez-Retamozo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alternative Macrophage Activation and Metabolism

(2011) Justin I. Odegaard et al.   Annual Review of Pathology-Mechanisms of Disease

The mitochondrial citrate carrier: a new player in inflammation

(2011) Vittoria Infantino et al.   BIOCHEMICAL JOURNAL

Lipid synthesis in macrophages during inflammation in vivo: Effect of agonists of peroxisome proliferator activated receptors α and γ and of retinoid X receptors

(2011) E. N. Posokhova et al.   BIOCHEMISTRY-MOSCOW

Ferroportin1 deficiency in mouse macrophages impairs iron homeostasis and inflammatory responses

(2011) Z. Zhang et al.   BLOOD

Tumor-Associated Macrophages Mediate Immunosuppression in the Renal Cancer Microenvironment by Activating the 15-Lipoxygenase-2 Pathway

(2011) I. Daurkin et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Linking Lipid Metabolism to the Innate Immune Response in Macrophages through Sterol Regulatory Element Binding Protein-1a

(2011) Seung-Soon Im et al.   Cell Metabolism

Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation

(2011) A. R. Grassian et al.   GENES & DEVELOPMENT

Tumor-associated macrophages in breast cancer: distinct subsets, distinct functions

(2011) Damya Laoui et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Activated CD69+ T Cells Foster Immune Privilege by Regulating IDO Expression in Tumor-Associated Macrophages

(2011) Q. Zhao et al.   JOURNAL OF IMMUNOLOGY

Regulation of Macrophage Arginase Expression and Tumor Growth by the Ron Receptor Tyrosine Kinase

(2011) D. R. Sharda et al.   JOURNAL OF IMMUNOLOGY

Obstacles and opportunities for understanding macrophage polarization

(2011) P. J. Murray et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The Lipogenesis Pathway as a Cancer Target

(2011) Hanley N. Abramson   JOURNAL OF MEDICINAL CHEMISTRY

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

(2011) Christian M. Metallo et al.   NATURE

Tumor-Associated Macrophages (TAMs) Form an Interconnected Cellular Supportive Network in Anaplastic Thyroid Carcinoma

(2011) Bernard Caillou et al.   PLoS One

Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of  -ketoglutarate to citrate to support cell growth and viability

(2011) D. R. Wise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Iron trafficking and metabolism in macrophages: contribution to the polarized phenotype

(2011) Gaetano Cairo et al.   TRENDS IN IMMUNOLOGY

Infiltration of tumour-associated macrophages in prostate biopsy specimens is predictive of disease progression after hormonal therapy for prostate cancer

(2010) Norio Nonomura et al.   BJU INTERNATIONAL

Interactions between lymphocytes and myeloid cells regulate pro- versus anti-tumor immunity

(2010) David G. DeNardo et al.   CANCER AND METASTASIS REVIEWS

Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer

(2010) R. A. Igal   CARCINOGENESIS

Macrophage Diversity Enhances Tumor Progression and Metastasis

(2010) Bin-Zhi Qian et al.   CELL

GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects

(2010) Da Young Oh et al.   CELL

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Role of Ferroportin in Macrophage-Mediated Immunity

(2010) E. E. Johnson et al.   INFECTION AND IMMUNITY

Substrate Fate in Activated Macrophages: A Comparison between Innate, Classic, and Alternative Activation

(2010) J.-C. Rodriguez-Prados et al.   JOURNAL OF IMMUNOLOGY

A general introduction to the biochemistry of mitochondrial fatty acid β-oxidation

(2010) Sander Michel Houten et al.   JOURNAL OF INHERITED METABOLIC DISEASE

Induction of fatty acid synthesis is a key requirement for phagocytic differentiation of human monocytes

(2010) Josef Ecker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arginase: an emerging key player in the mammalian immune system

(2009) Markus Munder   BRITISH JOURNAL OF PHARMACOLOGY

Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability

(2009) F. Colotta et al.   CARCINOGENESIS

Fatty acids and postprandial inflammation

(2009) Andrew N Margioris   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Differential regulation of iron homeostasis during human macrophage polarized activation

(2009) Stefania Recalcati et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

PPAR-δ senses and orchestrates clearance of apoptotic cells to promote tolerance

(2009) Lata Mukundan et al.   NATURE MEDICINE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Alternative Activation of Macrophages: An Immunologic Functional Perspective

(2008) Fernando O. Martinez et al.   Annual Review of Immunology

Mammalian Target of Rapamycin and S6 Kinase 1 Positively Regulate 6-thioguanine-Induced Autophagy

(2008) X. Zeng et al.   CANCER RESEARCH

Adipocyte-Derived Th2 Cytokines and Myeloid PPARδ Regulate Macrophage Polarization and Insulin Sensitivity

(2008) Kihwa Kang et al.   Cell Metabolism

Alternative M2 Activation of Kupffer Cells by PPARδ Ameliorates Obesity-Induced Insulin Resistance

(2008) Justin I. Odegaard et al.   Cell Metabolism

Increased density of tumor-associated macrophages is associated with decreased survival in advanced thyroid cancer

(2008) M. Ryder et al.   ENDOCRINE-RELATED CANCER