The ferroportin-ceruloplasmin system and the mammalian iron homeostasis machine: regulatory pathways and the role of lactoferrin

Ferroportin disease: pathogenesis, diagnosis and treatment

(2017) Antonello Pietrangelo   HAEMATOLOGICA

Lactoferrin: A Natural Glycoprotein Involved in Iron and Inflammatory Homeostasis

(2017) Luigi Rosa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Ferroportin disease: pathogenesis, diagnosis and treatment

(2017) Antonello Pietrangelo   HAEMATOLOGICA

Lactoferrin Efficiently Counteracts the Inflammation-Induced Changes of the Iron Homeostasis System in Macrophages

(2017) Antimo Cutone et al.   Frontiers in Immunology

Lactoferrin Decreases Inflammatory Response by Cystic Fibrosis Bronchial Cells Invaded with Burkholderia Cenocepacia Iron-Modulated Biofilm

(2017) P. Valenti et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

M1 and M2 macrophages derived from THP-1 cells differentially modulate the response of cancer cells to etoposide

(2015) Marie Genin et al.   BMC CANCER

A bacterial homologue of the human iron exporter ferroportin

(2015) Maria Carmela Bonaccorsi di Patti et al.   FEBS LETTERS

Thrombin inhibits the anti-myeloperoxidase and ferroxidase functions of ceruloplasmin: relevance in rheumatoid arthritis

(2015) Alexej V. Sokolov et al.   FREE RADICAL BIOLOGY AND MEDICINE

Outward- and inward-facing structures of a putative bacterial transition-metal transporter with homology to ferroportin

(2015) Reiya Taniguchi et al.   Nature Communications

Lactoferrin differently modulates the inflammatory response in epithelial models mimicking human inflammatory and infectious diseases

(2014) Alessandra Frioni et al.   BIOMETALS

Safety and efficacy of lactoferrin versus ferrous sulphate in curing iron deficiency and iron deficiency anaemia in hereditary thrombophilia pregnant women: an interventional study

(2014) Rosalba Paesano et al.   BIOMETALS

Lactoferrin prevents LPS-induced decrease of the iron exporter ferroportin in human monocytes/macrophages

(2014) Antimo Cutone et al.   BIOMETALS

A structural model of human ferroportin and of its iron binding site

(2014) Maria C. Bonaccorsi di Patti et al.   FEBS Journal

Structure-Function Analysis of the Human Ferroportin Iron Exporter (SLC40A1): Effect of Hemochromatosis Type 4 Disease Mutations and Identification of Critical Residues

(2013) Gérald Le Gac et al.   HUMAN MUTATION

Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells

(2013) Pamela Urrutia et al.   JOURNAL OF NEUROCHEMISTRY

Ceruloplasmin: Macromolecular Assemblies with Iron-Containing Acute Phase Proteins

(2013) Valeriya R. Samygina et al.   PLoS One

Iron-Responsive miR-485-3p Regulates Cellular Iron Homeostasis by Targeting Ferroportin

(2013) Carolyn Sangokoya et al.   PLoS Genetics

A structural perspective on lactoferrin function1This article is part of a Special Issue entitled Lactoferrin and has undergone the Journal's usual peer review process.

(2012) Heather M. Baker et al.   Biochemistry and Cell Biology

Human lactoferrin suppresses TNF-α-induced intercellular adhesion molecule-1 expression via competition with NF-κB in endothelial cells

(2012) Chan Woo Kim et al.   FEBS LETTERS

Reactive oxygen species are involved in ferroportin degradation induced by ceruloplasmin mutant Arg701Trp

(2012) Tiziana Persichini et al.   NEUROCHEMISTRY INTERNATIONAL

Body iron delocalization: the serious drawback in iron disorders in both developing and developed countries

(2012) R Paesano et al.   Pathogens and Global Health

Immune cells and hepatocytes express glycosylphosphatidylinositol-anchored ceruloplasmin at their cell surface

(2011) Liliana Marques et al.   BLOOD CELLS MOLECULES AND DISEASES

Minihepcidins are rationally designed small peptides that mimic hepcidin activity in mice and may be useful for the treatment of iron overload

(2011) Gloria C. Preza et al.   JOURNAL OF CLINICAL INVESTIGATION

Bovine Lactoferrin Counteracts Toll-Like Receptor Mediated Activation Signals in Antigen Presenting Cells

(2011) Patrizia Puddu et al.   PLoS One

Identification and properties of complexes formed by myeloperoxidase with lipoproteins and ceruloplasmin

(2010) Alexej V. Sokolov et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Polarization dictates iron handling by inflammatory and alternatively activated macrophages

(2010) G. Corna et al.   HAEMATOLOGICA

Interleukin-1β induces ceruloplasmin and ferroportin-1 gene expression via MAP kinases and C/EBPβ, AP-1, and NF-κB activation

(2010) Tiziana Persichini et al.   NEUROSCIENCE LETTERS

Functional analysis and theoretical modeling of ferroportin reveals clustering of mutations according to phenotype

(2009) Daniel F. Wallace et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Effect of lactoferrin on oxidative features of ceruloplasmin

(2009) Alexej V. Sokolov et al.   BIOMETALS

The molecular basis of hepcidin-resistant hereditary hemochromatosis

(2009) A. Fernandes et al.   BLOOD

Differential regulation of iron homeostasis during human macrophage polarized activation

(2009) Stefania Recalcati et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

HIF-2α, but not HIF-1α, promotes iron absorption in mice

(2009) Maria Mastrogiannaki et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepcidin Decreases Iron Transporter Expression in Vivo in Mouse Duodenum and Spleen and in Vitro in THP-1 Macrophages and Intestinal Caco-2 Cells

(2009) Bomee Chung et al.   JOURNAL OF NUTRITION

Immunomodulatory effects of lactoferrin on antigen presenting cells

(2008) P PUDDU et al.   BIOCHIMIE

The influence of lactoferrin, orally administered, on systemic iron homeostasis in pregnant women suffering of iron deficiency and iron deficiency anaemia

(2008) R PAESANO et al.   BIOCHIMIE

Ceruloplasmin and myeloperoxidase in complex affect the enzymatic properties of each other

(2008) Alexej V. Sokolov et al.   FREE RADICAL RESEARCH

Dominant Mutants of Ceruloplasmin Impair the Copper Loading Machinery in Aceruloplasminemia

(2008) Maria Carmela Bonaccorsi di Patti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins

(2008) Abbhirami Rajagopal et al.   NATURE