Review
Biochemistry & Molecular Biology
Jolanta Artym, Michal Zimecki, Marian L. Kruzel
Summary: Pregnancy requires higher levels of nutrients, including iron, for the growth and maintenance of the fetus. Iron deficiency during pregnancy can lead to serious health issues, making iron supplementation essential for pregnant women. Studies suggest that lactoferrin can be an effective prophylaxis and treatment for iron deficiency anemia during pregnancy, offering various beneficial effects on iron homeostasis and overall health.
Article
Obstetrics & Gynecology
J. C. Hull, E. M. Bloch, C. Ingram, R. Crookes, J. Vaughan, L. Courtney, A. Jauregui, J. F. Hilton, E. L. Murphy
Summary: This study found that among pregnant women with iron-deficiency anaemia in South Africa, HIV-positive patients had slower hemoglobin recovery in response to oral iron therapy compared to HIV-negative patients, but eventually successful recovery. Effective management of iron deficiency could reduce the incidence of peripartum blood transfusion.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Review
Anesthesiology
C. S. Benson, A. Shah, S. J. Stanworth, C. J. Frise, H. Spiby, S. J. Lax, J. Murray, A. A. Klein
Summary: Iron deficiency and anaemia are significant global health issues for women, with current definitions of anaemia being challenged by recent data. Women are at risk of developing iron deficiency due to menstrual loss, abnormal uterine bleeding, and pregnancy, which can lead to adverse outcomes for both mother and child. Further research is needed to improve understanding and treatment strategies for iron deficiency and anaemia in women.
Review
Nutrition & Dietetics
Anna A. Wawer, Nicolette A. Hodyl, Susan Fairweather-Tait, Bernd Froessler
Summary: Low-grade inflammation often present in individuals with obesity can affect iron uptake and metabolism, increasing the risk of iron deficiency and iron-deficiency anemia. Pregnant women are particularly vulnerable to these risks. Therefore, closer monitoring of iron status and weight gain is recommended for pregnant women living with obesity.
Review
Medicine, General & Internal
Abdulrahman Al-Naseem, Abdelrahman Sallam, Shamim Choudhury, Jecko Thachil
Summary: Iron deficiency without anaemia (IDWA) is more common than iron deficiency anaemia (IDA), but often poorly recognized by clinicians. Diagnosis and management of IDWA relies on various tests and treatments to correct the deficiency and prevent associated risks.
Article
Gastroenterology & Hepatology
Heinz Zoller, Myles Wolf, Irina Blumenstein, Christian Primas, Stefan Lindgren, Lars L. Thomsen, Walter Reinisch, Tariq Iqbal
Summary: Despite comparable treatment efficacy for iron deficiency anaemia, FCM was associated with a higher incidence of hypophosphataemia compared to FDI. Further studies are needed to investigate the long-term clinical consequences of hypophosphataemia and the mechanisms underlying the differential effects of FCM and FDI on patient-reported fatigue.
Article
Multidisciplinary Sciences
Marimuthu Sappani, Thenmozhi Mani, Edwin Sam Asirvatham, Melvin Joy, Malavika Babu, Lakshmanan Jeyaseelan
Summary: This study assesses the trends in prevalence and determinants of severe and moderate anaemia among women of reproductive age in India. The results show that the prevalence of severe and moderate anaemia has not significantly declined in non-pregnant women over the past two decades, while it has decreased in pregnant women but still remains high. Women who are economically poor and without formal education are at higher risk for severe and moderate anaemia. It is necessary to implement targeted anaemia control programs for the most vulnerable and high-risk women, such as those in rural areas, poverty, and illiteracy, to reduce the burden of anaemia among them.
Review
Hematology
J. P. Akshay Kirthan, Manjunath S. Somannavar
Summary: Iron deficiency anaemia (IDA) is a common nutritional deficiency worldwide, affecting around 30% of the global population. Insufficient dietary iron intake and reduced iron absorption contribute to the development of IDA. During pregnancy, iron deficiency can lead to adverse outcomes, and iron supplementation is commonly used to restore iron stores. The development of new types of iron complexes has improved the effectiveness and safety of iron therapy.
ANNALS OF HEMATOLOGY
(2023)
Article
Nutrition & Dietetics
Anna Dera-Szymanowska, Dorota Filipowicz, Natalia Misan, Krzysztof Szymanowski, Thilo Samson Chillon, Sabrina Asaad, Qian Sun, Ewelina Szczepanek-Parulska, Lutz Schomburg, Marek Ruchala
Summary: This study aims to compare iron and calcium levels in singleton and twin pregnancies, and found no significant differences between the two. Prenatal iron supplementation was shown to effectively increase iron levels.
Article
Obstetrics & Gynecology
Terence T. Lao, Lulu L. Wong, Shuk Yi Annie Hui, Daljit S. Sahota
Summary: The purpose of this study was to determine the association between iron deficiency anaemia (IDA) and atonic postpartum haemorrhage (PPH). The results showed that despite the low prevalence, IDA was independently associated with atonic PPH, likely due to placental adaptive changes in the presence of IDA. Correcting and preventing IDA could be the most important measure in countering the rising global prevalence of atonic PPH.
REPRODUCTIVE SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Jonathon Snook, Neeraj Bhala, Ian L. P. Beales, David Cannings, Chris Kightley, Robert Ph Logan, D. Mark Pritchard, Reena Sidhu, Sue Surgenor, Wayne Thomas, Ajay M. Verma, Andrew F. Goddard
Summary: Iron deficiency anaemia is a major global cause of disease burden, diagnosed through blood testing and treated with iron replacement therapy. Causes include poor diet and gastrointestinal pathologies, with endoscopy and radiological scanning used for diagnosis and assessment in some cases.
Article
Food Science & Technology
Salvatore Giovanni Vitale, Maria Fiore, Valentina Lucia La Rosa, Agnese Maria Chiara Rapisarda, Gabriele Mazza, Marco Paratore, Elena Commodari, Salvatore Caruso
Summary: The study aimed to determine the effects of liposomal iron pyrophosphate/ascorbic acid on clinical and psychological outcomes in pregnant women with iron deficiency anaemia. Results showed significant improvements in haematological and mental health outcomes, as well as overall quality of life, suggesting that Sideremil(TM) may be an effective treatment for pregnant women with iron deficiency anaemia. Further studies are needed to confirm these results.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
(2022)
Article
Gastroenterology & Hepatology
Jassin Rashidi-Alavijeh, Nargiz Nuruzade, Alexandra Frey, Eva-Maria Huessler, Anne Hoerster, Amos Cornelius Zeller, Andreas Schuette, Hartmut Schmidt, Katharina Willuweit, Christian Markus Lange
Summary: This study aimed to evaluate the role of iron supplementation in improving the prognosis of patients with cirrhosis. The results showed that an increase in hemoglobin levels was associated with improved transplant-free survival in patients with cirrhosis. The combination of iron supplementation and rifaximin had a stronger effect on prognosis.
Article
Obstetrics & Gynecology
Pablo L. de Vena Franks, Andrew Y. Pan, Manpreet K. Gill, Angela M. K. Cross, Katy L. Konrad, Nicholas J. Lightfoot
Summary: This study aimed to measure the incidence of iron deficiency anaemia in patients undergoing elective caesarean section at the local institution and determine any associated predictors and adverse outcomes. Results showed that 16.2% of women undergoing caesarean section had iron deficiency anaemia, with this group more likely to be Maori or Pacific Island ethnicity, have a higher booking body mass index, and have a greater parity. Pre-operative anaemia was associated with a higher likelihood of post-operative blood transfusion. There is potential for optimization of iron deficiency anaemia in the local population undergoing elective caesarean section.
BMC PREGNANCY AND CHILDBIRTH
(2021)
Article
Nutrition & Dietetics
Nicolai Petry, James P. Wirth, Seth Adu-Afarwuah, Rita Wegmuller, Bradley A. Woodruff, Sherry A. Tanumihardjo, Helena Bentil, William E. S. Donkor, Thomas N. Williams, Setareh Shahab-Ferdows, Lilian Selenje, Abraham Mahama, Matilda Steiner-Asiedu, Fabian Rohner
Summary: In Ghana, iron deficiency, malaria parasitaemia, inflammation, vitamin A deficiency, and stunting were significantly associated with anaemia in children; while iron deficiency, vitamin A deficiency, and inflammation were significantly associated with anaemia in women, with overweight and obese women having lower prevalence of anaemia. Anaemia control programmes should focus on preventing iron deficiency, malaria, and inflammation as main predictors of anaemia in Ghanaian children and women, with region-specific strategies.
MATERNAL AND CHILD NUTRITION
(2021)
Article
Physics, Applied
Chiara Gramaccioni, Yang Yang, Alessandra Procopio, Alexandra Pacureanu, Sylvain Bohic, Emil Malucelli, Stefano Iotti, Giovanna Farruggia, Inna Bukreeva, Andrea Notargiacomo, Michela Fratini, Piera Valenti, Luigi Rosa, Francesca Berlutti, Peter Cloetens, Stefano Lagomarsino
APPLIED PHYSICS LETTERS
(2018)
Article
Biochemistry & Molecular Biology
Francesco Calvani, Antimo Cutone, Maria Stefania Lepanto, Luigi Rosa, Valentino Valentini, Piera Valenti
Article
Biochemistry & Molecular Biology
Romina Mancinelli, Francesca Olivero, Guido Carpino, Diletta Overi, Luigi Rosa, Maria Stefania Lepanto, Antimo Cutone, Antonio Franchitto, Gianfranco Alpini, Paolo Onori, Piera Valenti, Eugenio Gaudio
Editorial Material
Biochemistry & Molecular Biology
Hans J. Vogel, Antimo Cutone, Maria S. Lepanto, Luigi Rosa, Piera Valenti
Review
Immunology
Piera Valenti, Luigi Rosa, Daniela Capobianco, Maria Stefania Lepanto, Elisa Schiavi, Antimo Cutone, Rosalba Paesano, Paola Mastromarino
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Immunology
Maria Stefania Lepanto, Luigi Rosa, Antimo Cutone, Maria Pia Conte, Rosalba Paesano, Piera Valenti
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Antimo Cutone, Maria Stefania Lepanto, Luigi Rosa, Mellani Jinnett Scotti, Alice Rossi, Serena Ranucci, Ida De Fino, Alessandra Bragonzi, Piera Valenti, Giovanni Musci, Francesca Berlutti
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Review
Biochemistry & Molecular Biology
Maria Stefania Lepanto, Luigi Rosa, Rosalba Paesano, Piera Valenti, Antimo Cutone
Article
Multidisciplinary Sciences
Luigi Rosa, Maria Stefania Lepanto, Antimo Cutone, Francesca Berlutti, Massimiliano De Angelis, Vincenzo Vullo, Claudio Maria Mastroianni, Piera Valenti, Alessandra Oliva
SCIENTIFIC REPORTS
(2019)
Article
Biochemistry & Molecular Biology
Maria Stefania Lepanto, Luigi Rosa, Antimo Cutone, Mellani Jinnett Scotti, Antonietta Lucia Conte, Massimiliano Marazzato, Carlo Zagaglia, Catia Longhi, Francesca Berlutti, Giovanni Musci, Piera Valenti, Maria Pia Conte
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Cell Biology
Antimo Cutone, Barbara Colella, Andrea Pagliaro, Luigi Rosa, Maria Stefania Lepanto, Maria Carmela Bonaccorsi di Patti, Piera Valenti, Sabrina Di Bartolomeo, Giovanni Musci
CELLULAR SIGNALLING
(2020)
Article
Cell Biology
Romina Mancinelli, Antimo Cutone, Luigi Rosa, Maria Stefania Lepanto, Paolo Onori, Luigi Pannarale, Antonio Franchitto, Eugenio Gaudio, Piera Valenti
EUROPEAN JOURNAL OF HISTOCHEMISTRY
(2020)
Article
Dentistry, Oral Surgery & Medicine
Giuseppe Giannini, Irene Ragusa, Giulia Nerina Nardone, Sara Soldi, Marina Elli, Piera Valenti, Luigi Rosa, Emanuele Marra, Daniela Stoppoloni, Emilio Merlo Pich
Summary: This study presents a mucoadhesive gel containing probiotics capable of slow release of bacteria to prevent and treat periodontitis. The results show significant and stable release of the bacterial mixture in vitro and improved tissue pathology in a mouse model of periodontitis.
INTERNATIONAL JOURNAL OF DENTISTRY
(2022)
Article
Biochemistry & Molecular Biology
Luigi Rosa, Antimo Cutone, Maria Pia Conte, Elena Campione, Luca Bianchi, Piera Valenti
Summary: This article reviews the antiviral activity of lactoferrin (Lf) against various types of viruses, including SARS-CoV-2. The study found that oral administration of Lf can counteract COVID-19 pathogenesis in the early stage of SARS-CoV-2 infection and have effects on various physiological processes such as inflammation, iron ion regulation, and coagulation balance. Furthermore, the article reveals the binding mechanisms of Lf to host cells and viral particle surface components. In summary, these studies support the use of Lf as an oral medication for treating COVID-19 or as an adjuvant for symptomatic treatment.
Review
Medicine, General & Internal
R. Sangermano, S. Pernarelle, M. Straker, M. S. Lepanto, L. Rosa, A. Cutone, P. Valenti, L. Ottolenghi
CLINICA TERAPEUTICA
(2019)