期刊
BIOMETALS
卷 27, 期 5, 页码 807-813出版社
SPRINGER
DOI: 10.1007/s10534-014-9742-7
关键词
Ferroportin; Lactoferrin; Iron; Inflammation; Interleukin-6
资金
- Sapienza University of Rome Funds
Iron balance is tightly linked to inflammation and it has been demonstrated that many proteins involved in cellular iron management are up- or down-regulated by inflammatory stimuli, ultimately leading to iron retention in the reticuloendothelial system. Ferroportin is a key player in maintenance of correct iron homeostasis, because it is the only known mammalian cellular iron exporter. In this work we show that incubation of THP-1 monocytes/macrophages with lactoferrin prevents the LPS-induced decrease of ferroportin by reducing secretion of IL-6.
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