DNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitination

UHRF1 Overexpression Drives DNA Hypomethylation and Hepatocellular Carcinoma

(2014) Raksha Mudbhary et al.   CANCER CELL

Variant PRC1 Complex-Dependent H2A Ubiquitylation Drives PRC2 Recruitment and Polycomb Domain Formation

(2014) Neil P. Blackledge et al.   CELL

Histone H2A monoubiquitination promotes histone H3 methylation in Polycomb repression

(2014) Reinhard Kalb et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Deciphering key features in protein structures with the new ENDscript server

(2014) Xavier Robert et al.   NUCLEIC ACIDS RESEARCH

Targeting Polycomb to Pericentric Heterochromatin in Embryonic Stem Cells Reveals a Role for H2AK119u1 in PRC2 Recruitment

(2014) Sarah Cooper et al.   Cell Reports

Multivalent histone engagement by the linked tandem Tudor and PHD domains of UHRF1 is required for the epigenetic inheritance of DNA methylation

(2013) S. B. Rothbart et al.   GENES & DEVELOPMENT

The UHRF1 Protein Stimulates the Activity and Specificity of the Maintenance DNA Methyltransferase DNMT1 by an Allosteric Mechanism

(2013) Pavel Bashtrykov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The DNA Methyltransferase Dnmt1 Directly Interacts with the SET and RING Finger-associated (SRA) Domain of the Multifunctional Protein Uhrf1 to Facilitate Accession of the Catalytic Center to Hemi-methylated DNA

(2013) Ahmet Can Berkyurek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replication

(2013) Atsuya Nishiyama et al.   NATURE

Dissection of cell cycle–dependent dynamics of Dnmt1 by FRAP and diffusion-coupled modeling

(2013) Katrin Schneider et al.   NUCLEIC ACIDS RESEARCH

UHRF1 targets DNMT1 for DNA methylation through cooperative binding of hemi-methylated DNA and methylated H3K9

(2013) Xiaoli Liu et al.   Nature Communications

Visualization and targeted disruption of protein interactions in living cells

(2013) Henry D. Herce et al.   Nature Communications

Structural Insight into Coordinated Recognition of Trimethylated Histone H3 Lysine 9 (H3K9me3) by the Plant Homeodomain (PHD) and Tandem Tudor Domain (TTD) of UHRF1 (Ubiquitin-like, Containing PHD and RING Finger Domains, 1) Protein

(2012) Jingdong Cheng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation

(2012) Scott B Rothbart et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CENP-C facilitates the recruitment of M18BP1 to centromeric chromatin

(2012) Silvia Dambacher et al.   Nucleus

Structural basis for site-specific reading of unmodified R2 of histone H3 tail by UHRF1 PHD finger

(2011) Chengkun Wang et al.   CELL RESEARCH

Crystal structure of PHD domain of UHRF1 and insights into recognition of unmodified histone H3 arginine residue 2

(2011) Lulu Hu et al.   CELL RESEARCH

S phase-dependent interaction with DNMT1 dictates the role of UHRF1 but not UHRF2 in DNA methylation maintenance

(2011) Jiqin Zhang et al.   CELL RESEARCH

The Replication Focus Targeting Sequence (RFTS) Domain Is a DNA-competitive Inhibitor of Dnmt1

(2011) Farisa Syeda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cooperative DNA and histone binding by Uhrf2 links the two major repressive epigenetic pathways

(2011) Garwin Pichler et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

UHRF1 Double Tudor Domain and the Adjacent PHD Finger Act Together to Recognize K9me3-Containing Histone H3 Tail

(2011) Si Xie et al.   JOURNAL OF MOLECULAR BIOLOGY

PHD Finger Recognition of Unmodified Histone H3R2 Links UHRF1 to Regulation of Euchromatic Gene Expression

(2011) Eerappa Rajakumara et al.   MOLECULAR CELL

The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1

(2011) Max Felle et al.   NUCLEIC ACIDS RESEARCH

Different Binding Properties and Function of CXXC Zinc Finger Domains in Dnmt1 and Tet1

(2011) Carina Frauer et al.   PLoS One

Structural insight into maintenance methylation by mouse DNA methyltransferase 1 (Dnmt1)

(2011) K. Takeshita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Solution structure of UIM and interaction of tandem ubiquitin binding domains in STAM1 with ubiquitin

(2010) Jongsoo Lim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Usp7 and Uhrf1 control ubiquitination and stability of the maintenance DNA methyltransferase Dnmt1

(2010) Weihua Qin et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

TRIM24 links a non-canonical histone signature to breast cancer

(2010) Wen-Wei Tsai et al.   NATURE

Structure of DNMT1-DNA Complex Reveals a Role for Autoinhibition in Maintenance DNA Methylation

(2010) J. Song et al.   SCIENCE

DNMT1 Stability Is Regulated by Proteins Coordinating Deubiquitination and Acetylation-Driven Ubiquitination

(2010) Z. Du et al.   Science Signaling

Np95 interacts with de novo DNA methyltransferases, Dnmt3a and Dnmt3b, and mediates epigenetic silencing of the viral CMV promoter in embryonic stem cells

(2009) Daniela Meilinger et al.   EMBO REPORTS

Dimerization of DNA methyltransferase 1 is mediated by its regulatory domain

(2009) Karin Fellinger et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins

(2009) Camilla Raiborg et al.   NATURE

The multi-domain protein Np95 connects DNA methylation and histone modification

(2009) Andrea Rottach et al.   NUCLEIC ACIDS RESEARCH

A versatile non-radioactive assay for DNA methyltransferase activity and DNA binding

(2009) Carina Frauer et al.   NUCLEIC ACIDS RESEARCH

Generation and Characterization of a Rat Monoclonal Antibody Specific for PCNA

(2008) Andrea Rottach et al.   HYBRIDOMA

Generation and Characterization of a Rat Monoclonal Antibody Specific for Multiple Red Fluorescent Proteins

(2008) Andrea Rottach et al.   HYBRIDOMA

Structure and Hemimethylated CpG Binding of the SRA Domain from Human UHRF1

(2008) Chengmin Qian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Fluorescent Two-hybrid Assay for Direct Visualization of Protein Interactions in Living Cells

(2008) Kourosh Zolghadr et al.   MOLECULAR & CELLULAR PROTEOMICS

The PHD Domain of Np95 (mUHRF1) Is Involved in Large-Scale Reorganization of Pericentromeric Heterochromatin

(2008) Roberto Papait et al.   MOLECULAR BIOLOGY OF THE CELL

Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism

(2008) Kyohei Arita et al.   NATURE

Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1

(2008) George V. Avvakumov et al.   NATURE

Combinatorial patterns of histone acetylations and methylations in the human genome

(2008) Zhibin Wang et al.   NATURE GENETICS