From inflammaging to healthy aging by dietary lifestyle choices: is epigenetics the key to personalized nutrition?

SIRT1-metabolite binding histone macroH2A1.1 protects hepatocytes against lipid accumulation

(2016) Valerio Pazienza et al.   Aging-US

Changes in the leukocyte methylome and its effect on cardiovascular-related genes after exercise

(2015) Joshua Denham et al.   JOURNAL OF APPLIED PHYSIOLOGY

Integrative analysis of 111 reference human epigenomes

(2015) Anshul Kundaje et al.   NATURE

Function and information content of DNA methylation

(2015) Dirk Schübeler   NATURE

RNA-mediated epigenetic regulation of gene expression

(2015) Daniel Holoch et al.   NATURE REVIEWS GENETICS

Chromatin regulation at the frontier of synthetic biology

(2015) Albert J. Keung et al.   NATURE REVIEWS GENETICS

Krebs cycle intermediates regulate DNA and histone methylation: Epigenetic impact on the aging process

(2014) Antero Salminen et al.   AGEING RESEARCH REVIEWS

A histone point mutation that switches on autophagy

(2014) Tobias Eisenberg et al.   Autophagy

The role of mutation of metabolism-related genes in genomic hypermethylation

(2014) Joshua J. Waterfall et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibiting epigenetic enzymes to improve atherogenic macrophage functions

(2014) Jan Van den Bossche et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Relationship between genome and epigenome - challenges and requirements for future research

(2014) Geneviève Almouzni et al.   BMC GENOMICS

Targeting the histone orthography of cancer: drugs for writers, erasers and readers

(2014) Laia Simó-Riudalbas et al.   BRITISH JOURNAL OF PHARMACOLOGY

Therapeutic perspectives of epigenetically active nutrients

(2014) M Remely et al.   BRITISH JOURNAL OF PHARMACOLOGY

Geroncogenesis: Metabolic Changes during Aging as a Driver of Tumorigenesis

(2014) Lindsay E. Wu et al.   CANCER CELL

Individualized Medicine from Prewomb to Tomb

(2014) Eric J. Topol   CELL

Gerometabolites: The pseudohypoxic aging side of cancer oncometabolites

(2014) JAVIERABEL MENENDEZ MENENDEZ et al.   CELL CYCLE

In Utero Undernutrition in Male Mice Programs Liver Lipid Metabolism in the Second-Generation Offspring Involving Altered Lxra DNA Methylation

(2014) Débora Martínez et al.   Cell Metabolism

Multigenerational Effects of Maternal Undernutrition

(2014) Francine H. Einstein   Cell Metabolism

Nucleocytosolic Depletion of the Energy Metabolite Acetyl-Coenzyme A Stimulates Autophagy and Prolongs Lifespan

(2014) Tobias Eisenberg et al.   Cell Metabolism

Krebs cycle dysfunction shapes epigenetic landscape of chromatin: Novel insights into mitochondrial regulation of aging process

(2014) Antero Salminen et al.   CELLULAR SIGNALLING

DNA Methylation Map of Human Atherosclerosis

(2014) S. Zaina et al.   Circulation-Cardiovascular Genetics

Age-Related Increase in Levels of 5-Hydroxymethylcytosine in Mouse Hippocampus is Prevented by Caloric Restriction

(2014) Leonidas Chouliaras et al.   Current Alzheimer Research

Latest Evidence of the Effects of the Mediterranean Diet in Prevention of Cardiovascular Disease

(2014) G. Chiva-Blanch et al.   Current Atherosclerosis Reports

Altered DNA Methylation and Differential Expression of Genes Influencing Metabolism and Inflammation in Adipose Tissue From Subjects With Type 2 Diabetes

(2014) E. Nilsson et al.   DIABETES

Redox and epigenetic regulation of the APE1 gene in the hippocampus of piglets: The effect of early life exposures

(2014) Sabine A.S. Langie et al.   DNA REPAIR

Epigenetic adaptation to regular exercise in humans

(2014) Charlotte Ling et al.   DRUG DISCOVERY TODAY

Natural compounds in epigenetics: A current view

(2014) Marco Miceli et al.   FOOD AND CHEMICAL TOXICOLOGY

The effect of genotype and in utero environment on interindividual variation in neonate DNA methylomes

(2014) A. L. Teh et al.   GENOME RESEARCH

Diet, Metabolites, and “Western-Lifestyle” Inflammatory Diseases

(2014) Alison N. Thorburn et al.   IMMUNITY

Genetic ablation of macrohistone H2A1 leads to increased leanness, glucose tolerance and energy expenditure in mice fed a high-fat diet

(2014) F Sheedfar et al.   INTERNATIONAL JOURNAL OF OBESITY

Diet-induced (epigenetic) changes in bone marrow augment atherosclerosis

(2014) Erik van Kampen et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Human transgenerational responses to early-life experience: potential impact on development, health and biomedical research

(2014) Marcus Pembrey et al.   JOURNAL OF MEDICAL GENETICS

Epigenetics in health and disease: heralding the EWAS era

(2014) Therese M Murphy et al.   LANCET

Prevention and management of type 2 diabetes: dietary components and nutritional strategies

(2014) Sylvia H Ley et al.   LANCET

DNA methylation and body-mass index: a genome-wide analysis

(2014) Katherine J Dick et al.   LANCET

Genomic and epigenomic co-evolution in follicular lymphomas

(2014) M Loeffler et al.   LEUKEMIA

Epigenetic Regulation of Macrophage Polarization by DNA Methyltransferase 3b

(2014) Xiaosong Yang et al.   MOLECULAR ENDOCRINOLOGY

Structural insight into autoinhibition and histone H3-induced activation of DNMT3A

(2014) Xue Guo et al.   NATURE

A strand-specific switch in noncoding transcription switches the function of a Polycomb/Trithorax response element

(2014) Veronika A Herzog et al.   NATURE GENETICS

Stem cell aging: mechanisms, regulators and therapeutic opportunities

(2014) Juhyun Oh et al.   NATURE MEDICINE

Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders

(2014) Katrina J. Falkenberg et al.   NATURE REVIEWS DRUG DISCOVERY

The rise of regulatory RNA

(2014) Kevin V. Morris et al.   NATURE REVIEWS GENETICS

Effects of Sulforaphane and 3,3′-Diindolylmethane on Genome-Wide Promoter Methylation in Normal Prostate Epithelial Cells and Prostate Cancer Cells

(2014) Carmen P. Wong et al.   PLoS One

Dietary Flavanols Modulate the Transcription of Genes Associated with Cardiovascular Pathology without Changes in Their DNA Methylation State

(2014) Dragan Milenkovic et al.   PLoS One

In utero undernourishment perturbs the adult sperm methylome and intergenerational metabolism

(2014) E. J. Radford et al.   SCIENCE

You are what you eat, but what about your DNA?

(2014) M. Susiarjo et al.   SCIENCE

New concepts in DNA methylation

(2014) Albert Jeltsch et al.   TRENDS IN BIOCHEMICAL SCIENCES

Advances in epigenome-wide association studies for common diseases

(2014) Dirk S. Paul et al.   TRENDS IN MOLECULAR MEDICINE

Small molecule SIRT1 activators for the treatment of aging and age-related diseases

(2014) Basil P. Hubbard et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Epigenetic mechanisms of importance for drug treatment

(2014) Maxim Ivanov et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Can we use the epigenetic bioactivity of caloric restriction and phytochemicals to promote healthy ageing?

(2014) Michael. S. Christodoulou et al.   MedChemComm

lncRNAs: Linking RNA to Chromatin

(2014) J. L. Rinn   Cold Spring Harbor Perspectives in Biology

Epigenetic dysregulation of the IGF system in placenta of newborns exposed to maternal impaired glucose tolerance

(2014) Véronique Desgagné et al.   Epigenomics

Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys

(2014) Ricki J. Colman et al.   Nature Communications

Nuclear Receptors and Epigenetic Regulation: Opportunities for Nutritional Targeting and Disease Prevention

(2014) Donato F. Romagnolo et al.   Advances in Nutrition

Regulation of DNA Methylation Patterns by CK2-Mediated Phosphorylation of Dnmt3a

(2014) Rachel Deplus et al.   Cell Reports

Linkage of DNA Methylation Quantitative Trait Loci to Human Cancer Risk

(2014) Holger Heyn et al.   Cell Reports

Epigenetics of discordant monozygotic twins: implications for disease

(2014) Juan E Castillo-Fernandez et al.   Genome Medicine

A symbiotic liaison between the genetic and epigenetic code

(2014) Holger Heyn   Frontiers in Genetics

Epigenetic modulation of the drug resistance genes MGMT, ABCB1 and ABCG2 in glioblastoma multiforme

(2013) Moritz C Oberstadt et al.   BMC CANCER

Post-weaning selenium and folate supplementation affects gene and protein expression and global DNA methylation in mice fed high-fat diets

(2013) Emma N Bermingham et al.   BMC Medical Genomics

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Genome-wide Chromatin State Transitions Associated with Developmental and Environmental Cues

(2013) Jiang Zhu et al.   CELL

Influence of Metabolism on Epigenetics and Disease

(2013) William G. Kaelin et al.   CELL

A Radical Signal Activates the Epigenetic Regulation of Longevity

(2013) Mario G. Mirisola et al.   Cell Metabolism

Ten-Eleven Translocation-2 (TET2) Is a Master Regulator of Smooth Muscle Cell Plasticity

(2013) Renjing Liu et al.   CIRCULATION

Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets

(2013) T. A. Dayeh et al.   DIABETOLOGIA

Blood glutathione redox status and global methylation of peripheral blood mononuclear cell DNA in Bangladeshi adults

(2013) Megan M. Niedzwiecki et al.   Epigenetics

Non-coding RNAs as direct and indirect modulators of epigenetic regulation

(2013) Veronica J Peschansky et al.   Epigenetics

Differential DNA methylation patterns between high and low responders to a weight loss intervention in overweight or obese adolescents: the EVASYON study

(2013) Adriana Moleres et al.   FASEB JOURNAL

Maternal folate depletion and high-fat feeding from weaning affects DNA methylation and DNA repair in brain of adult offspring

(2013) Sabine A. S. Langie et al.   FASEB JOURNAL

Age-associated epigenetic drift: implications, and a case of epigenetic thrift?

(2013) A. E. Teschendorff et al.   HUMAN MOLECULAR GENETICS

Obesogenic phenotype of offspring of dams fed a high multivitamin diet is prevented by a post-weaning high multivitamin or high folate diet

(2013) C E Cho et al.   INTERNATIONAL JOURNAL OF OBESITY

Contribution of Lipids in Honeybee (Apis mellifera) Royal Jelly to Health

(2013) Xing'an Li et al.   JOURNAL OF MEDICINAL FOOD

Ascorbic Acid Enhances Tet-Mediated 5-Methylcytosine Oxidation and Promotes DNA Demethylation in Mammals

(2013) Ruichuan Yin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Heterogeneity in Healthy Aging

(2013) D. J. Lowsky et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Overweight, obesity, and outcomes: fat mass and beyond

(2013) Luc F Van Gaal et al.   LANCET

A parallel randomized trial on the effect of a healthful diet on inflammageing and its consequences in European elderly people: Design of the NU-AGE dietary intervention study

(2013) Agnes Berendsen et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Combating inflammaging through a Mediterranean whole diet approach: The NU-AGE project's conceptual framework and design

(2013) Aurelia Santoro et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Epigenetics of gestational diabetes mellitus and offspring health: the time for action is in early stages of life

(2013) H. Lehnen et al.   MOLECULAR HUMAN REPRODUCTION

Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells

(2013) Kathryn Blaschke et al.   NATURE

Chromatin proteins and modifications as drug targets

(2013) Kristian Helin et al.   NATURE

Epigenome-wide association data implicate DNA methylation as an intermediary of genetic risk in rheumatoid arthritis

(2013) Yun Liu et al.   NATURE BIOTECHNOLOGY

The epigenetics pipeline

(2013) Vivian A. DeWoskin et al.   NATURE REVIEWS DRUG DISCOVERY

From promises to practical strategies in epigenetic epidemiology

(2013) Jonathan Mill et al.   NATURE REVIEWS GENETICS

In-solution hybrid capture of bisulfite-converted DNA for targeted bisulfite sequencing of 174 ADME genes

(2013) Maxim Ivanov et al.   NUCLEIC ACIDS RESEARCH

Overlapping effects of genetic variation and epigenetics on drug response: challenges of pharmacoepigenomics

(2013) Ingolf Cascorbi   PHARMACOGENOMICS

Curcumin Modulates DNA Methylation in Colorectal Cancer Cells

(2013) Alexander Link et al.   PLoS One

Combination of Selenium and Green Tea Improves the Efficacy of Chemoprevention in a Rat Colorectal Cancer Model by Modulating Genetic and Epigenetic Biomarkers

(2013) Ying Hu et al.   PLoS One

Dietary Alleviation of Maternal Obesity and Diabetes: Increased Resistance to Diet-Induced Obesity Transcriptional and Epigenetic Signatures

(2013) Linda Attig et al.   PLoS One

Cytokine Induced Phenotypic and Epigenetic Signatures Are Key to Establishing Specific Macrophage Phenotypes

(2013) Nicolai A. Kittan et al.   PLoS One

Twins for epigenetic studies of human aging and development

(2012) Qihua Tan et al.   AGEING RESEARCH REVIEWS

Targeting Prostate Cancer Stem Cells

(2012) Francesco Crea et al.   Anti-Cancer Agents in Medicinal Chemistry

Molecular insight in the multifunctional activities of Withaferin A

(2012) Wim Vanden Berghe et al.   BIOCHEMICAL PHARMACOLOGY

MAOA promoter methylation and susceptibility to carotid atherosclerosis: role of familial factors in a monozygotic twin sample

(2012) Jinying Zhao et al.   BMC Medical Genetics

Metabolic and genetic factors modulating subject specific LDL-C responses to plant sterol therapy1This article is an invited review for the Journal's Made In Canada section. The authors gratefully acknowledge the training that was acquired at the Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba. We would specifically like to thank Dr. Peter Jones for his mentorship and significant contribution to the research contained within this manuscript.

(2012) Todd C. Rideout et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Cancer Genetics and Epigenetics: Two Sides of the Same Coin?

(2012) Jueng Soo You et al.   CANCER CELL

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

Connecting Threads: Epigenetics and Metabolism

(2012) Sayako Katada et al.   CELL

Metabolic Regulation of Epigenetics

(2012) Chao Lu et al.   Cell Metabolism

Redox Mediating Epigenetic Changes Confer Metabolic Memories

(2012) Assam El-Osta   CIRCULATION RESEARCH

Epigenomics and Interindividual Differences in Drug Response

(2012) M Ivanov et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Inflamm-ageing

(2012) Elisa Cevenini et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Developmental origins of non-communicable disease: Implications for research and public health

(2012) Robert Barouki et al.   Environmental Health

Modifying metabolically sensitive histone marks by inhibiting glutamine metabolism affects gene expression and alters cancer cell phenotype

(2012) Natalie E. Simpson et al.   Epigenetics

Prostaglandin E2 increases fibroblast gene-specific and global DNA methylation via increased DNA methyltransferase expression

(2012) Steven K. Huang et al.   FASEB JOURNAL

Multifunctional targets of dietary polyphenols in disease: A case for the chemokine network and energy metabolism

(2012) J. Joven et al.   FOOD AND CHEMICAL TOXICOLOGY

Redox regulation of the epigenetic landscape in Cancer: A role for metabolic reprogramming in remodeling the epigenome

(2012) Michael J. Hitchler et al.   FREE RADICAL BIOLOGY AND MEDICINE

Dietary factors, epigenetic modifications and obesity outcomes: Progresses and perspectives

(2012) F.I. Milagro et al.   MOLECULAR ASPECTS OF MEDICINE

Clocks, Metabolism, and the Epigenome

(2012) Dan Feng et al.   MOLECULAR CELL

Genome-wide Methylation Profiles Reveal Quantitative Views of Human Aging Rates

(2012) Gregory Hannum et al.   MOLECULAR CELL

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Prostaglandin E2 promotes intestinal tumor growth via DNA methylation

(2012) Dianren Xia et al.   NATURE MEDICINE

Epigenetic protein families: a new frontier for drug discovery

(2012) Cheryl H. Arrowsmith et al.   NATURE REVIEWS DRUG DISCOVERY

Epigenetic Editing: targeted rewriting of epigenetic marks to modulate expression of selected target genes

(2012) M. L. de Groote et al.   NUCLEIC ACIDS RESEARCH

Epigenetic impact of dietary polyphenols in cancer chemoprevention: Lifelong remodeling of our epigenomes

(2012) Wim Vanden Berghe   PHARMACOLOGICAL RESEARCH

Maternal exposure to bisphenol A and genistein has minimal effect on Avy/a offspring coat color but favors birth of agouti over nonagouti mice

(2012) C. S. Rosenfeld et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

DNA methylation dynamics, metabolic fluxes, gene splicing, and alternative phenotypes in honey bees

(2012) S. Foret et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The penetrance of an epigenetic trait in mice is progressively yet reversibly increased by selection and environment

(2012) J. E. Cropley et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The Emerging Role of Epigenetic Modifiers Linking Cellular Metabolism and Gene Activity in Cardiac Progenitor Cells

(2012) Verawan Boonsanay et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Epigenetic flexibility in metabolic regulation: disease cause and prevention?

(2012) Henriette Kirchner et al.   TRENDS IN CELL BIOLOGY

Using epigenome-wide association scans of DNA methylation in age-related complex human traits

(2012) Pei-Chien Tsai et al.   Epigenomics

Can We Modify the Intrauterine Environment to Halt the Intergenerational Cycle of Obesity?

(2012) Kristi B. Adamo et al.   International Journal of Environmental Research and Public Health

Fetal epigenetic programming of adipokines

(2012) Andrée-Anne Houde et al.   Adipocyte

The H3K27 demethylase UTX-1 regulates C. elegans lifespan in a germline-independent, insulin-dependent manner

(2011) Travis J. Maures et al.   AGING CELL

Epigenetics and obesity: the devil is in the details

(2011) Paul W Franks et al.   BMC Medicine

Obesity related methylation changes in DNA of peripheral blood leukocytes

(2011) Xiaoling Wang et al.   BMC Medicine

Epigenetic regulation of caloric restriction in aging

(2011) Yuanyuan Li et al.   BMC Medicine

Long Noncoding RNA HOTAIR Regulates Polycomb-Dependent Chromatin Modification and Is Associated with Poor Prognosis in Colorectal Cancers

(2011) R. Kogo et al.   CANCER RESEARCH

ncRNA- and Pc2 Methylation-Dependent Gene Relocation between Nuclear Structures Mediates Gene Activation Programs

(2011) Liuqing Yang et al.   CELL

Ketones and lactate increase cancer cell “stemness,” driving recurrence, metastasis and poor clinical outcome in breast cancer

(2011) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Histone Demethylase UTX-1 Regulates C. elegans Life Span by Targeting the Insulin/IGF-1 Signaling Pathway

(2011) Chunyu Jin et al.   Cell Metabolism

Cancer Chemoprevention by Targeting the Epigenome

(2011) Joseph Huang et al.   CURRENT DRUG TARGETS

Epigenetics in cardiovascular disease

(2011) Apurva V Shirodkar et al.   CURRENT OPINION IN CARDIOLOGY

The oncometabolite 2-hydroxyglutarate inhibits histone lysine demethylases

(2011) Rasheduzzaman Chowdhury et al.   EMBO REPORTS

The epigenetic basis of the Warburg effect

(2011) Xian Wang et al.   Epigenetics

The influence of aging, environmental exposures and local sequence features on the variation of DNA methylation in blood

(2011) Scott M. Langevin et al.   Epigenetics

Hypothesis: Environmental regulation of 5-hydroxymethylcytosine by oxidative stress

(2011) Nancy Chia et al.   Epigenetics

A dual epigenomic approach for the search of obesity biomarkers: DNA methylation in relation to diet-induced weight loss

(2011) Fermin I. Milagro et al.   FASEB JOURNAL

Genome-wide survey reveals predisposing diabetes type 2-related DNA methylation variations in human peripheral blood

(2011) Gidon Toperoff et al.   HUMAN MOLECULAR GENETICS

DNA methylation in cancer development, diagnosis and therapy--multiple opportunities for genotoxic agents to act as methylome disruptors or remediators

(2011) J. Lewandowska et al.   MUTAGENESIS

Royalactin induces queen differentiation in honeybees

(2011) Masaki Kamakura   NATURE

Mapping and analysis of chromatin state dynamics in nine human cell types

(2011) Jason Ernst et al.   NATURE

Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans

(2011) Eric L. Greer et al.   NATURE

Histone methylation makes its mark on longevity

(2011) Shuo Han et al.   TRENDS IN CELL BIOLOGY

Research Highlights: Nutritional status affects the epigenomic profile of peripheral blood cells

(2011) Juleen R Zierath et al.   Epigenomics

5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming

(2011) Mark Wossidlo et al.   Nature Communications

A Sustained Dietary Change Increases Epigenetic Variation in Isogenic Mice

(2011) Cheryl C. Y. Li et al.   PLoS Genetics

Chromatin remodeling in the aging genome of Drosophila

(2010) Jason G. Wood et al.   AGING CELL

Age-associated increase in heterochromatic marks in murine and primate tissues

(2010) Jill A. Kreiling et al.   AGING CELL

Nutrition, Epigenetics, and Developmental Plasticity: Implications for Understanding Human Disease

(2010) Graham C. Burdge et al.   Annual Review of Nutrition

Nature or nurture: Let food be your epigenetic medicine in chronic inflammatory disorders

(2010) Katarzyna Szarc vel Szic et al.   BIOCHEMICAL PHARMACOLOGY

Cancer chemoprevention by dietary polyphenols: Promising role for epigenetics

(2010) Alexander Link et al.   BIOCHEMICAL PHARMACOLOGY

Mild folate deficiency induces genetic and epigenetic instability and phenotype changes in prostate cancer cells

(2010) Gaia Bistulfi et al.   BMC BIOLOGY

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

(2010) Maria E. Figueroa et al.   CANCER CELL

Ketones and lactate “fuel” tumor growth and metastasis

(2010) Gloria Bonuccelli et al.   CELL CYCLE

Histone Methyl Transferases and Demethylases; Can They Link Metabolism and Transcription?

(2010) Raffaele Teperino et al.   Cell Metabolism

Bioenergetics and the epigenome: Interface between the environment and genes in common diseases

(2010) Douglas C. Wallace   Developmental Disabilities Research Reviews

A review of dietary factors and its influence on DNA methylation in colorectal carcinogenesis

(2010) R.P. Arasaradnam et al.   Epigenetics

Epigenetic integration of environmental and genomic signals in honey bees: the critical interplay of nutritional, brain and reproductive networks

(2010) Ryszard Maleszka   Epigenetics

From monogenic to polygenic obesity: recent advances

(2010) Anke Hinney et al.   EUROPEAN CHILD & ADOLESCENT PSYCHIATRY

Regulation of homocysteine metabolism and methylation in human and mouse tissues

(2010) Natalie C. Chen et al.   FASEB JOURNAL

The curious case of aging plasticity in honey bees

(2010) Daniel Münch et al.   FEBS LETTERS

Chromatin structure as a mediator of aging

(2010) Jason Feser et al.   FEBS LETTERS

The epigenome and the mitochondrion: bioenergetics and the environment

(2010) D. C. Wallace   GENES & DEVELOPMENT

Widespread and tissue specific age-related DNA methylation changes in mice

(2010) S. Maegawa et al.   GENOME RESEARCH

Epigenomic communication systems in humans and honey bees: From molecules to behavior

(2010) George L. Gabor Miklos et al.   HORMONES AND BEHAVIOR

Epigenetics and environment: a complex relationship

(2010) Oscar Aguilera et al.   JOURNAL OF APPLIED PHYSIOLOGY

Mammalian circadian clock and metabolism - the epigenetic link

(2010) M. M. Bellet et al.   JOURNAL OF CELL SCIENCE

Epigenetics in atherosclerosis and inflammation

(2010) Rutger J. Wierda et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Discovery and characterization of chromatin states for systematic annotation of the human genome

(2010) Jason Ernst et al.   NATURE BIOTECHNOLOGY

Epigenetics and cardiovascular disease

(2010) José M. Ordovás et al.   Nature Reviews Cardiology

Personalized medicine in oncology: the future is now

(2010) Richard L. Schilsky   NATURE REVIEWS DRUG DISCOVERY

Establishing, maintaining and modifying DNA methylation patterns in plants and animals

(2010) Julie A. Law et al.   NATURE REVIEWS GENETICS

Fetal programming: link between early nutrition, DNA methylation, and complex diseases

(2010) Agata Chmurzynska   NUTRITION REVIEWS

Regulation of microRNAs by Natural Agents: An Emerging Field in Chemoprevention and Chemotherapy Research

(2010) Yiwei Li et al.   PHARMACEUTICAL RESEARCH

DNA Methylation as a Biomarker for Cardiovascular Disease Risk

(2010) Myungjin Kim et al.   PLoS One

Nicotinamide adenine dinucleotide (NAD)-regulated DNA methylation alters CCCTC-binding factor (CTCF)/cohesin binding and transcription at the BDNF locus

(2010) J. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nutritional developmental epigenomics: immediate and long-lasting effects

(2010) L. Attig et al.   PROCEEDINGS OF THE NUTRITION SOCIETY

Developmental origins of metabolic disease: life course and intergenerational perspectives

(2010) Keith M. Godfrey et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases

(2010) Shin-ichiro Imai et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Differential epigenomic and transcriptomic responses in subcutaneous adipose tissue between low and high responders to caloric restriction

(2009) Luigi Bouchard et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

The liver X-receptor gene promoter is hypermethylated in a mouse model of prenatal protein restriction

(2009) Esther M. E. van Straten et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Epigenetics and atherosclerosis

(2009) Mikko P. Turunen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Shaping adult phenotypes through early life environments

(2009) Ian C.G. Weaver   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Transgenerational effects of prenatal exposure to the Dutch famine

(2009) LH Lumey et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Epigenetic regulation of the honey bee transcriptome: unravelling the nature of methylated genes

(2009) Sylvain Foret et al.   BMC GENOMICS

Chromatin Places Metabolism Center Stage

(2009) Andreas G. Ladurner   CELL

Non-CpG Methylation of the PGC-1α Promoter through DNMT3B Controls Mitochondrial Density

(2009) Romain Barrès et al.   Cell Metabolism

Direct and transgenerational impact on Daphnia magna of chemicals with a known effect on DNA methylation

(2009) Michiel B. Vandegehuchte et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

Ten Putative Contributors to the Obesity Epidemic

(2009) Emily J. McAllister et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Inflammation and oncogenesis: a vicious connection

(2009) Sergei I Grivennikov et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Epigenetics, transgenerational effects and risk factors for atherosclerosis

(2009) Gertrud Lund et al.   CURRENT OPINION IN LIPIDOLOGY

Atherosclerosis risk factors can impose aberrant DNA methylation patterns: a tale of traffic and homocysteine

(2009) Gertrud Lund et al.   CURRENT OPINION IN LIPIDOLOGY

MicroRNAs and cancer epigenetics: a macrorevolution

(2009) Veronica Davalos et al.   CURRENT OPINION IN ONCOLOGY

Inflammation, a silent killer in cancer is not so silent!

(2009) Bharat B Aggarwal   CURRENT OPINION IN PHARMACOLOGY

Inflammation and cancer: how friendly is the relationship for cancer patients?

(2009) Bharat B Aggarwal et al.   CURRENT OPINION IN PHARMACOLOGY

Inhibition of Transcription Factors by Plant-Derived Compounds and their Implications in Inflammation and Cancer

(2009) J. Rios et al.   CURRENT PHARMACEUTICAL DESIGN

An Update of the Oxidation-Inflammation Theory of Aging: The Involvement of the Immune System in Oxi-Inflamm-Aging

(2009) Monica Fuente et al.   CURRENT PHARMACEUTICAL DESIGN

Hyperglycemia Induces a Dynamic Cooperativity of Histone Methylase and Demethylase Enzymes Associated With Gene-Activating Epigenetic Marks That Coexist on the Lysine Tail

(2009) D. Brasacchio et al.   DIABETES

Hypothesis: a Unifying Mechanism for Nutrition and Chemicals as Lifelong Modulators of DNA Hypomethylation

(2009) Duk-Hee Lee et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Epigenetic histone acetylation modifiers in vascular remodelling: new targets for therapy in cardiovascular disease

(2009) D. Pons et al.   EUROPEAN HEART JOURNAL

Metabolic defects provide a spark for the epigenetic switch in cancer

(2009) Michael J. Hitchler et al.   FREE RADICAL BIOLOGY AND MEDICINE

Calorie restriction and the exercise of chromatin

(2009) A. Vaquero et al.   GENES & DEVELOPMENT

Is Epigenetics an Important Link between Early Life Events and Adult Disease?

(2009) Robert A. Waterland   Hormone Research in Paediatrics

Absorption of bioactive compounds from steamed broccoli and their effect on plasma glutathione S-transferase activity

(2009) Patrizia Riso et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Grapes, Wines, Resveratrol, and Heart Health

(2009) Alberto A A Bertelli et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Hypothalamic proopiomelanocortin promoter methylation becomes altered by early overfeeding: an epigenetic model of obesity and the metabolic syndrome

(2009) Andreas Plagemann et al.   JOURNAL OF PHYSIOLOGY-LONDON

Hyperactivated NF- B and AP-1 Transcription Factors Promote Highly Accessible Chromatin and Constitutive Transcription across the Interleukin-6 Gene Promoter in Metastatic Breast Cancer Cells

(2009) M. N. Ndlovu et al.   MOLECULAR AND CELLULAR BIOLOGY

Environmental estrogens and obesity

(2009) Retha R. Newbold et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Finding the missing heritability of complex diseases

(2009) Teri A. Manolio et al.   NATURE

Role of Jhdm2a in regulating metabolic gene expression and obesity resistance

(2009) Keisuke Tateishi et al.   NATURE

DNA methylation profiles in monozygotic and dizygotic twins

(2009) Zachary A Kaminsky et al.   NATURE GENETICS

Rethinking how DNA methylation patterns are maintained

(2009) Peter A. Jones et al.   NATURE REVIEWS GENETICS

Epidermal homeostasis: a balancing act of stem cells in the skin

(2009) Cédric Blanpain et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Warburg effect revisited: an epigenetic link between glycolysis and gastric carcinogenesis

(2009) X Liu et al.   ONCOGENE

A Glucose-to-Gene Link

(2009) J. C. Rathmell et al.   SCIENCE

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

(2009) R. J. Colman et al.   SCIENCE

ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation

(2009) K. E. Wellen et al.   SCIENCE

A conceptual framework for the developmental origins of health and disease

(2009) P. D. Gluckman et al.   Journal of Developmental Origins of Health and Disease

Aging and Environmental Exposures Alter Tissue-Specific DNA Methylation Dependent upon CpG Island Context

(2009) Brock C. Christensen et al.   PLoS Genetics

Heterogeneity of Human Macrophages in Culture and in Atherosclerotic Plaques

(2008) Stephen W. Waldo et al.   AMERICAN JOURNAL OF PATHOLOGY

Environmental Epigenetics and Asthma

(2008) Rachel L. Miller et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Transgenerational Epigenetic Effects

(2008) Neil A. Youngson et al.   Annual Review of Genomics and Human Genetics

Dietary Manipulation of Histone Structure and Function

(2008) Barbara Delage et al.   Annual Review of Nutrition

Transgenerational effects of prenatal exposure to the Dutch famine on neonatal adiposity and health in later life

(2008) RC Painter et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Nutrition in early life, and risk of cancer and metabolic disease: alternative endings in an epigenetic tale?

(2008) Graham C. Burdge et al.   BRITISH JOURNAL OF NUTRITION

Xenohormesis: Sensing the Chemical Cues of Other Species

(2008) Konrad T. Howitz et al.   CELL

Role of the Lysine-Specific Demethylase 1 in the Proinflammatory Phenotype of Vascular Smooth Muscle Cells of Diabetic Mice

(2008) Marpadga A. Reddy et al.   CIRCULATION RESEARCH

We are what we eat. The link between diet, evolution and non-genetic inheritance

(2008) Philip Hunter   EMBO REPORTS

Environmental epigenomics in human health and disease

(2008) Dana C. Dolinoy et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Soy Protein Isolate Reduces Hepatosteatosis in Yellow Avy/a Mice Without Altering Coat Color Phenotype

(2008) T. M. Badger et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Time for Epigenetics

(2008) Lucia Altucci et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

DNA methylomes, histone codes and miRNAs: Tying it all together

(2008) Sònia Guil et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Methyl donor supplementation prevents transgenerational amplification of obesity

(2008) R A Waterland et al.   INTERNATIONAL JOURNAL OF OBESITY

Effects of Insulin and Glucose on Cellular Metabolic Fluxes in Homocysteine Transsulfuration, Remethylation,S-Adenosylmethionine Synthesis, and Global Deoxyribonucleic Acid Methylation

(2008) En-Pei Isabel Chiang et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia

(2008) Assam El-Osta et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Epigenetic Multiple Ligands: Mixed Histone/Protein Methyltransferase, Acetyltransferase, and Class III Deacetylase (Sirtuin) Inhibitors

(2008) Antonello Mai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Effect of folate deficiency on placental DNA methylation in hyperhomocysteinemic rats

(2008) Ji-Myung Kim et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Chemical regulation of epigenetic modifications: Opportunities for new cancer therapy

(2008) Yujun George Zheng et al.   MEDICINAL RESEARCH REVIEWS

Botanicals as epigenetic modulators for mechanisms contributing to development of metabolic syndrome

(2008) Heather Kirk et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Targeting Cancer Stem Cells with Phytochemicals

(2008) B. T. Kawasaki et al.   MOLECULAR INTERVENTIONS

Moving AHEAD with an international human epigenome project

(2008) et al.   NATURE

Personal genomes: The case of the missing heritability

(2008) Brendan Maher   NATURE

Chromatin dynamics during epigenetic reprogramming in the mouse germ line

(2008) Petra Hajkova et al.   NATURE

Epigenetics in Cancer

(2008) Manel Esteller   NEW ENGLAND JOURNAL OF MEDICINE

Effect of In Utero and Early-Life Conditions on Adult Health and Disease

(2008) Peter D. Gluckman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Modeling folate, one-carbon metabolism, and DNA methylation

(2008) Cornelia M Ulrich et al.   NUTRITION REVIEWS

Effects of Neonatal Dexamethasone Treatment on the Cardiovascular Stress Response of Children at School Age

(2008) R. Karemaker et al.   PEDIATRICS

Cancer is a Preventable Disease that Requires Major Lifestyle Changes

(2008) Preetha Anand et al.   PHARMACEUTICAL RESEARCH

Targeting Epigenetic Mechanisms: Potential of Natural Products in Cancer Chemoprevention

(2008) Alexander-Thomas Hauser et al.   PLANTA MEDICA

Nutritional Control of Reproductive Status in Honeybees via DNA Methylation

(2008) R. Kucharski et al.   SCIENCE

DNA Oxidation as Triggered by H3K9me2 Demethylation Drives Estrogen-Induced Gene Expression

(2008) B. Perillo et al.   SCIENCE

The Roles of Dietary PPAR Ligands for Metastasis in Colorectal Cancer

(2008) Hiroki Kuniyasu   PPAR Research