Review
Plant Sciences
Jun-Li Wang, Dong-Wei Di, Pan Luo, Li Zhang, Xiao-Feng Li, Guang-Qin Guo, Lei Wu
Summary: This review focuses on the molecular mechanisms through which epigenetic modifications regulate auxin biosynthesis, demonstrating that complex signaling pathways affect gene expression and subsequently protein production.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Qiong Wu, Anders E. Berglund, Arnold B. Etame
Summary: Glioblastoma is highly resistant to standard therapies and the durability of response to the best chemotherapy agent, Temozolomide, is often short-lived due to tumor resistance. The need for therapies that can provide synergy to chemoradiation is urgent, as adaptive resistance evolution in GBM is facilitated through treatment-induced epigenetic modifications. Understanding and targeting these epigenetic modifications associated with GBM resistance is a top priority.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Francisco Gimeno-Valiente, Gerardo Lopez-Rodas, Josefa Castillo, Luis Franco
Summary: This review focuses on the interconnections between epigenetics and alternative splicing in the development of cancer. It discusses the mechanisms involved in these interconnections and the potential diagnostic and therapeutic tools that can be derived from them. The reversible nature of epigenetic alterations and the possibility of correcting aberrant alternative splicing offer promising therapeutic possibilities for cancer treatment.
Review
Genetics & Heredity
Vincenzo Cavalieri
Summary: The emergence of a nucleosome-based chromatin structure during the evolutionary transition from prokaryotes to eukaryotes plays a crucial role in adaptive responses to environmental influence through epigenetic mechanisms involving histones. The overwhelming number of post-translational modifications at multiple residues of histones and their implications in nucleosome dynamics and chromatin processes are discussed in this review.
Review
Plant Sciences
Qingshuai Chen, Jing Zhang, Gang Li
Summary: This article summarizes recent progress in uncovering the epigenetic mechanisms involved in sugar signal transduction, as well as the interactions between sugar signaling and light, temperature, and phytohormone signaling pathways.
TRENDS IN PLANT SCIENCE
(2022)
Article
Multidisciplinary Sciences
Michael Habig, Cecile Lorrain, Alice Feurtey, Jovan Komluski, Eva H. Stukenbrock
Summary: In this study, the authors demonstrated a causal effect of epigenetic modifications on mutation rates in fungal pathogens, as well as the impact of temperature stress and cytosine methylation on the rate and location of spontaneous mutations in the genome. Additionally, they found that histone modifications and transposable elements can significantly affect mutation rates.
NATURE COMMUNICATIONS
(2021)
Review
Immunology
Yuqin Niu, Jianxiang Chen, Yiting Qiao
Summary: Tumorigenesis often involves chronic inflammation and the tumor microenvironment (TME) consists of various cells and extracellular components. Tumor cells and other cells undergo genetic and epigenetic alterations in the TME, with macrophages being the most plastic immune cell type and playing a crucial role in these alterations.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Margarita E. Neganova, Sergey G. Klochkov, Yulia R. Aleksandrova, Gjumrakch Aliev
Summary: Epigenetic changes associated with histone modifications are important in the emergence and maintenance of various cancer types. Inhibitors of enzymes involved in these modifications are promising for anticancer drug development. This review explores the main features of common histone modifications and their role in malignant neoplasms, discussing strategies for inhibitor development and analyzing the use of multitarget drugs as the most promising strategy.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Plant Sciences
Rocio Nunez-Vazquez, Benedicte Desvoyes, Crisanto Gutierrez
Summary: Plants have developed various mechanisms to adapt to abiotic stresses, which involve transcriptional regulation and chromatin modifications. Understanding and manipulating these regulatory networks are crucial for enhancing crop resilience and performance against stress.
FRONTIERS IN PLANT SCIENCE
(2022)
Review
Plant Sciences
Muthusamy Ramakrishnan, Mingbing Zhou, Stanislaus Antony Ceasar, Doulathunnisa Jaffar Ali, Theivanayagam Maharajan, Kunnummal Kurungara Vinod, Anket Sharma, Zishan Ahmad, Qiang Wei
Summary: Somatic embryogenesis is a complex process regulated by genetic and epigenetic factors, including DNA and histone modifications, as well as miRNA regulation. These regulations influence the transition of somatic cells and the development of embryos, with the potential for somatic cell regeneration.
PLANT CELL REPORTS
(2023)
Review
Cell Biology
Sweta Sikder, Ganesan Arunkumar, Daniel P. Melters, Yamini Dalal
Summary: Aging is a universal event characterized by the progressive loss of cell function. In the process of aging, changes in chromatin structure and function occur, which may contribute to age-related tumor formation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chuizheng Kong, Guangyao Zhao, Lifeng Gao, Xiuying Kong, Daowen Wang, Xu Liu, Jizeng Jia
Summary: In this study, the association between transposons (TEs), chromatin states, and chromatin accessibility in Aegilops tauschii was analyzed. It was found that TEs contributed to the diverse distribution of chromatin states and affected the chromatin state and openness of potential regulatory elements. Some TE superfamilies carried active/open chromatin regions. Furthermore, the accessibility shaped by TEs was associated with the histone mark H3K9ac. These findings highlight the role of TEs in shaping the epigenetic landscape and regulating gene expression in Aegilops tauschii.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Environmental Sciences
Arijit Chakraborty, Soma Ghosh, Bratisha Biswas, Sreemanta Pramanik, Jerome Nriagu, Subhamoy Bhowmick
Summary: Arsenic exposure can cause harmful epigenetic alterations, leading to various health complications. This review summarizes the mechanisms underlying arsenic-induced epigenetic changes and proposes therapeutic strategies to alleviate the global burden of arsenic poisoning.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Cell Biology
Zhihui Liu, Weiguo Wang, Yuhan Xia, Yuan Gao, Zhisong Wang, Mingyang Li, Giorgio Antonio Presicce, Liyou An, Fuliang Du
Summary: This study reveals the changes in the epigenetic modification pattern of H4K20me3 during fertilization and somatic cell nuclear transfer (NT). The results show that there are differences in the H4K20me3 pattern between fertilized embryos, NT embryos, and parthenogenetic activation (PA) embryos. H4K20me3 is only present in the maternal pronuclei of fertilized embryos. The intensity of H4K20me3 is significantly lower in fertilized embryos compared to NT and PA embryos. Knockdown of Suv4-20h2 improves the development and cloning efficiency of NT embryos by upregulating reprogramming factors and ZGA-related factors.
CELL PROLIFERATION
(2023)
Review
Dermatology
Chang Zeng, Lam C. Tsoi, Johann E. Gudjonsson
Summary: The incidence of psoriasis is increasing over time, with recent studies pointing towards the importance of epigenetic modifications in its pathogenesis. Aberrant epigenetic patterns, including changes in DNA methylation, histone modifications and non-coding RNA expression, are observed in psoriatic skin. Reversing these epigenetic mechanisms has shown promise in improving psoriatic phenotypes, making epigenetic therapy a potential avenue for treating psoriasis.
EXPERIMENTAL DERMATOLOGY
(2021)