DNA Damage Regulates UHRF1 Stability via the SCFβ-TrCPE3 Ligase

DNA damage-induced activation of ATM promotes β-TRCP-mediated Mdm2 ubiquitination and destruction

(2015) Zhiwei Wang et al.   Oncotarget

UHRF1 Promotes Cell Growth and Metastasis Through Repression of p16ink4a in Colorectal Cancer

(2012) Feng Wang et al.   ANNALS OF SURGICAL ONCOLOGY

M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability

(2012) H. Ma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

UHRF1 depletion causes a G2/M arrest, activation of DNA damage response and apoptosis

(2011) Amy L. Tien et al.   BIOCHEMICAL JOURNAL

Down-regulation of UHRF1, associated with re-expression of tumor suppressor genes, is a common feature of natural compounds exhibiting anti-cancer properties

(2011) Mahmoud Alhosin et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

UHRF1 is associated with tumor recurrence in non-muscle-invasive bladder cancer

(2011) Guo-Liang Yang et al.   MEDICAL ONCOLOGY

The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1

(2011) Max Felle et al.   NUCLEIC ACIDS RESEARCH

The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling

(2011) P. P. Hsu et al.   SCIENCE

Phosphorylation by Casein Kinase I Promotes the Turnover of the Mdm2 Oncoprotein via the SCFβ-TRCP Ubiquitin Ligase

(2010) Hiroyuki Inuzuka et al.   CANCER CELL

A Tissue-Specific Atlas of Mouse Protein Phosphorylation and Expression

(2010) Edward L. Huttlin et al.   CELL

Usp7 and Uhrf1 control ubiquitination and stability of the maintenance DNA methyltransferase Dnmt1

(2010) Weihua Qin et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

DNMT1 maintains progenitor function in self-renewing somatic tissue

(2010) George L. Sen et al.   NATURE

Adenovirus-mediated expression of UHRF1 reduces the radiosensitivity of cervical cancer HeLa cells to γ-irradiation

(2009) Xin-li Li et al.   ACTA PHARMACOLOGICA SINICA

UHRF1 recruits the histone acetyltransferase Tip60 and controls its expression and activity

(2009) Mayada Achour et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Induction of apoptosis by thymoquinone in lymphoblastic leukemia Jurkat cells is mediated by a p73-dependent pathway which targets the epigenetic integrator UHRF1

(2009) Mahmoud Alhosin et al.   BIOCHEMICAL PHARMACOLOGY

Interplay between Np95 and Eme1 in the DNA damage response

(2008) Helena Mistry et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The PHD Domain of Np95 (mUHRF1) Is Involved in Large-Scale Reorganization of Pericentromeric Heterochromatin

(2008) Roberto Papait et al.   MOLECULAR BIOLOGY OF THE CELL

SCFβ-TRCP controls oncogenic transformation and neural differentiation through REST degradation

(2008) Thomas F. Westbrook et al.   NATURE

Control of chromosome stability by the β-TrCP–REST–Mad2 axis

(2008) Daniele Guardavaccaro et al.   NATURE

The SRA domain of UHRF1 flips 5-methylcytosine out of the DNA helix

(2008) Hideharu Hashimoto et al.   NATURE

Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism

(2008) Kyohei Arita et al.   NATURE

Structural basis for recognition of hemi-methylated DNA by the SRA domain of human UHRF1

(2008) George V. Avvakumov et al.   NATURE

UHRF1 binds G9a and participates in p21 transcriptional regulation in mammalian cells

(2008) Jong Kyong Kim et al.   NUCLEIC ACIDS RESEARCH