标题
Conformational control of the bacterial Clp protease by natural product antibiotics
作者
关键词
-
出版物
NATURAL PRODUCT REPORTS
Volume 34, Issue 7, Pages 815-831
出版商
Royal Society of Chemistry (RSC)
发表日期
2017-04-05
DOI
10.1039/c6np00125d
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- RelA Mutant Enterococcus faecium with Multiantibiotic Tolerance Arising in an Immunocompromised Host
- (2017) Erin S. Honsa et al. mBio
- Characterization of Gain-of-Function Mutant Provides New Insights into ClpP Structure
- (2016) Tengfeng Ni et al. ACS Chemical Biology
- New antibiotics from Nature’s chemical inventory
- (2016) Timothy A. Wencewicz BIOORGANIC & MEDICINAL CHEMISTRY
- Bacterial proteases, untapped antimicrobial drug targets
- (2016) Elizabeth Culp et al. JOURNAL OF ANTIBIOTICS
- Development and Characterization of Potent Cyclic Acyldepsipeptide Analogues with Increased Antimicrobial Activity
- (2016) Jordan D. Goodreid et al. JOURNAL OF MEDICINAL CHEMISTRY
- Sclerotiamide: The First Non-Peptide-Based Natural Product Activator of Bacterial Caseinolytic Protease P
- (2016) Nathan P. Lavey et al. JOURNAL OF NATURAL PRODUCTS
- Acyldepsipeptide antibiotics kill mycobacteria by preventing the physiological functions of the ClpP1P2 protease
- (2016) Kirsten Famulla et al. MOLECULAR MICROBIOLOGY
- Arginine phosphorylation marks proteins for degradation by a Clp protease
- (2016) Débora Broch Trentini et al. NATURE
- A Conformationally Constrained Cyclic Acyldepsipeptide Is Highly Effective in Mice Infected with Methicillin-Susceptible and -Resistant Staphylococcus aureus
- (2016) Marios Arvanitis et al. PLoS One
- Natural products as a source of drug leads to overcome drug resistance
- (2015) Lynn L Silver Future Microbiology
- A rufomycin analogue is an anti-tuberculosis drug lead targeting CLPC1 with no cross resistance to ecumicin
- (2015) M Choules et al. PLANTA MEDICA
- The Mycobacterium tuberculosis ClpP1P2 Protease Interacts Asymmetrically with Its ATPase Partners ClpX and ClpC1
- (2015) Julia Leodolter et al. PLoS One
- AAA+ chaperones and acyldepsipeptides activate the ClpP protease via conformational control
- (2015) Malte Gersch et al. Nature Communications
- The Cyclic Peptide Ecumicin Targeting ClpC1 Is Active against Mycobacterium tuberculosis In Vivo
- (2014) Wei Gao et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- A Simple Fragment of Cyclic Acyldepsipeptides Is Necessary and Sufficient for ClpP Activation and Antibacterial Activity
- (2014) Daniel W. Carney et al. CHEMBIOCHEM
- Lassomycin, a Ribosomally Synthesized Cyclic Peptide, Kills Mycobacterium tuberculosis by Targeting the ATP-Dependent Protease ClpC1P1P2
- (2014) Ekaterina Gavrish et al. CHEMISTRY & BIOLOGY
- A β-Lactone-Based Antivirulence Drug AmelioratesStaphylococcus aureusSkin Infections in Mice
- (2014) Franziska Weinandy et al. ChemMedChem
- Dynamics of the ClpP serine protease: A model for self-compartmentalized proteases
- (2014) Kaiyin Liu et al. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Quorum sensing-mediated regulation of staphylococcal virulence and antibiotic resistance
- (2014) Rachna Singh et al. Future Microbiology
- Restriction of the Conformational Dynamics of the Cyclic Acyldepsipeptide Antibiotics Improves Their Antibacterial Activity
- (2014) Daniel W. Carney et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Substrate delivery by the AAA+ ClpX and ClpC1 unfoldases activates the mycobacterial ClpP1P2 peptidase
- (2014) Karl R. Schmitz et al. MOLECULAR MICROBIOLOGY
- The role of thiol oxidative stress response in heat-induced protein aggregate formation during thermotolerance inBacillus subtilis
- (2014) Stephanie Runde et al. MOLECULAR MICROBIOLOGY
- Discovery and Characterization of the Tuberculosis Drug Lead Ecumicin
- (2014) Wei Gao et al. ORGANIC LETTERS
- Crystal structure of Mycobacterium tuberculosis ClpP1P2 suggests a model for peptidase activation by AAA+ partner binding and substrate delivery
- (2014) K. R. Schmitz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Post-Translational Regulation via Clp Protease Is Critical for Survival of Mycobacterium tuberculosis
- (2014) Ravikiran M. Raju et al. PLoS Pathogens
- The Mechanism of Caseinolytic Protease (ClpP) Inhibition
- (2013) Malte Gersch et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Acyldepsipeptides inhibit the growth of renal cancer cells through G1 phase cell cycle arrest
- (2013) Shan Xu et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Bacterial cell division as a target for new antibiotics
- (2013) Peter Sass et al. CURRENT OPINION IN MICROBIOLOGY
- Proteases in Mycobacterium tuberculosis pathogenesis: potential as drug targets
- (2013) David M Roberts et al. Future Microbiology
- Bacterial caseinolytic proteases as novel targets for antibacterial treatment
- (2013) Heike Brötz-Oesterhelt et al. INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
- Clp chaperones and proteases are central in stress survival, virulence and antibiotic resistance of Staphylococcus aureus
- (2013) Dorte Frees et al. INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
- The ClpP peptidase of Wolbachia endobacteria is a novel target for drug development against filarial infections
- (2013) Andrea Schiefer et al. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
- Structural Basis of Mycobacterial Inhibition by Cyclomarin A
- (2013) Dileep Vasudevan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Helix Unfolding/Refolding Characterizes the Functional Dynamics ofStaphylococcus aureusClp Protease
- (2013) Fei Ye et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Activation of ClpP Protease by ADEP Antibiotics: Insights from Hydrogen Exchange Mass Spectrometry
- (2013) Modupeola A. Sowole et al. JOURNAL OF MOLECULAR BIOLOGY
- Activated ClpP kills persisters and eradicates a chronic biofilm infection
- (2013) B. P. Conlon et al. NATURE
- The active ClpP protease fromM. tuberculosisis a complex composed of a heptameric ClpP1 and a ClpP2 ring
- (2012) Tatos Akopian et al. EMBO JOURNAL
- Insights into Structural Network Responsible for Oligomerization and Activity of Bacterial Virulence Regulator Caseinolytic Protease P (ClpP) Protein
- (2012) Malte Gersch et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Trapping and Proteomic Identification of Cellular Substrates of the ClpP Protease in Staphylococcus aureus
- (2012) Jingyuan Feng et al. JOURNAL OF PROTEOME RESEARCH
- ClpP: A structurally dynamic protease regulated by AAA+ proteins
- (2012) John A. Alexopoulos et al. JOURNAL OF STRUCTURAL BIOLOGY
- New insights on the structure of the anti-TB peptide H14: Crystal structure, 1H NMR full spin analysis, and biosynthetic pathway
- (2012) W Gao et al. PLANTA MEDICA
- Mycobacterium tuberculosis ClpP1 and ClpP2 Function Together in Protein Degradation and Are Required for Viability in vitro and During Infection
- (2012) Ravikiran M. Raju et al. PLoS Pathogens
- A Conformational Switch Underlies ClpP Protease Function
- (2011) Sebastian R. Geiger et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- The Natural Product Cyclomarin Kills Mycobacterium Tuberculosis by Targeting the ClpC1 Subunit of the Caseinolytic Protease
- (2011) Esther K. Schmitt et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- ClpXP, an ATP-powered unfolding and protein-degradation machine
- (2011) Tania A. Baker et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
- Assembly and proteolytic processing of mycobacterial ClpP1 and ClpP2
- (2011) Nadia Benaroudj et al. BMC BIOCHEMISTRY
- Activators of Cylindrical Proteases as Antimicrobials: Identification and Development of Small Molecule Activators of ClpP Protease
- (2011) Elisa Leung et al. CHEMISTRY & BIOLOGY
- Validation of the Essential ClpP Protease in Mycobacterium tuberculosis as a Novel Drug Target
- (2011) J. Ollinger et al. JOURNAL OF BACTERIOLOGY
- Structural Switching ofStaphylococcus aureusClp Protease
- (2011) Jie Zhang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- New Insights into Staphylococcus aureus Stress Tolerance and Virulence Regulation from an Analysis of the Role of the ClpP Protease in the Strains Newman, COL, and SA564
- (2011) Dorte Frees et al. JOURNAL OF PROTEOME RESEARCH
- Structural insights into the conformational diversity of ClpP from Bacillus subtilis
- (2011) Byung-Gil Lee et al. MOLECULES AND CELLS
- Structure and mechanism of the hexameric MecA–ClpC molecular machine
- (2011) Feng Wang et al. NATURE
- Antibiotic acyldepsipeptides activate ClpP peptidase to degrade the cell division protein FtsZ
- (2011) P. Sass et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Staphylococcus aureus RNome and Its Commitment to Virulence
- (2011) Brice Felden et al. PLoS Pathogens
- High-Resolution Phenotypic Profiling Defines Genes Essential for Mycobacterial Growth and Cholesterol Catabolism
- (2011) Jennifer E. Griffin et al. PLoS Pathogens
- Diversity-oriented synthesis of cyclic acyldepsipeptides leads to the discovery of a potent antibacterial agent
- (2010) Aaron M. Socha et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Acyldepsipeptide Antibiotics Induce the Formation of a Structured Axial Channel in ClpP: A Model for the ClpX/ClpA-Bound State of ClpP
- (2010) Dominic Him Shun Li et al. CHEMISTRY & BIOLOGY
- Binding of the ClpA Unfoldase Opens the Axial Gate of ClpP Peptidase
- (2010) Grégory Effantin et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism
- (2010) Byung-Gil Lee et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Structural and Theoretical Studies Indicate that the Cylindrical Protease ClpP Samples Extended and Compact Conformations
- (2010) Matthew S. Kimber et al. STRUCTURE
- Structurally Refined β-Lactones as Potent Inhibitors of Devastating Bacterial Virulence Factors
- (2009) Thomas Böttcher et al. CHEMBIOCHEM
- The antibiotic ADEP reprogrammes ClpP, switching it from a regulated to an uncontrolled protease
- (2009) Janine Kirstein et al. EMBO Molecular Medicine
- RseA, the SigE specific anti-sigma factor ofMycobacterium tuberculosis, is inactivated by phosphorylation-dependent ClpC1P2 proteolysis
- (2009) Subhasis Barik et al. MOLECULAR MICROBIOLOGY
- Adapting the machine: adaptor proteins for Hsp100/Clp and AAA+ proteases
- (2009) Janine Kirstein et al. NATURE REVIEWS MICROBIOLOGY
- Staphylococcus aureus ClpC ATPase is a late growth phase effector of metabolism and persistence
- (2009) Indranil Chatterjee et al. PROTEOMICS
- Optimal Efficiency of ClpAP and ClpXP Chaperone-Proteases Is Achieved by Architectural Symmetry
- (2009) Željka Maglica et al. STRUCTURE
- β-Lactones as Privileged Structures for the Active-Site Labeling of Versatile Bacterial Enzyme Classes
- (2008) Thomas Böttcher et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- The ClpP N-Terminus Coordinates Substrate Access with Protease Active Site Reactivity†
- (2008) Laura D. Jennings et al. BIOCHEMISTRY
- ClpP Hydrolyzes a Protein Substrate Processively in the Absence of the ClpA ATPase: Mechanistic Studies of ATP-Independent Proteolysis†
- (2008) Laura D. Jennings et al. BIOCHEMISTRY
- Protein unfolding by a AAA+ protease is dependent on ATP-hydrolysis rates and substrate energy landscapes
- (2008) Andreas Martin et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
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