Crystal structure of Mycobacterium tuberculosis ClpP1P2 suggests a model for peptidase activation by AAA+ partner binding and substrate delivery

Restriction of the Conformational Dynamics of the Cyclic Acyldepsipeptide Antibiotics Improves Their Antibacterial Activity

(2014) Daniel W. Carney et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Substrate delivery by the AAA+ ClpX and ClpC1 unfoldases activates the mycobacterial ClpP1P2 peptidase

(2014) Karl R. Schmitz et al.   MOLECULAR MICROBIOLOGY

Antibacterial Activity of and Resistance to Small Molecule Inhibitors of the ClpP Peptidase

(2013) Corey L. Compton et al.   ACS Chemical Biology

Loss of mitochondrial peptidase Clpp leads to infertility, hearing loss plus growth retardation via accumulation of CLPX, mtDNA and inflammatory factors

(2013) S. Gispert et al.   HUMAN MOLECULAR GENETICS

A Bacterial Toxin Inhibits DNA Replication Elongation through a Direct Interaction with the β Sliding Clamp

(2013) Christopher D. Aakre et al.   MOLECULAR CELL

Mycobacterium tuberculosis ClpP Proteases Are Co-transcribed but Exhibit Different Substrate Specificities

(2013) Yoann Personne et al.   PLoS One

The active ClpP protease fromM. tuberculosisis a complex composed of a heptameric ClpP1 and a ClpP2 ring

(2012) Tatos Akopian et al.   EMBO JOURNAL

ClpP: A structurally dynamic protease regulated by AAA+ proteins

(2012) John A. Alexopoulos et al.   JOURNAL OF STRUCTURAL BIOLOGY

Mycobacterium tuberculosis ClpP1 and ClpP2 Function Together in Protein Degradation and Are Required for Viability in vitro and During Infection

(2012) Ravikiran M. Raju et al.   PLoS Pathogens

AAA+ Proteases: ATP-Fueled Machines of Protein Destruction

(2011) Robert T. Sauer et al.   Annual Review of Biochemistry

Validation of the Essential ClpP Protease in Mycobacterium tuberculosis as a Novel Drug Target

(2011) J. Ollinger et al.   JOURNAL OF BACTERIOLOGY

Acyl depsipeptide (ADEP) resistance in Streptomyces

(2011) M. Gominet et al.   MICROBIOLOGY-SGM

High-Resolution Phenotypic Profiling Defines Genes Essential for Mycobacterial Growth and Cholesterol Catabolism

(2011) Jennifer E. Griffin et al.   PLoS Pathogens

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The ClpP protease homologue is required for the transmission traits and cell division of the pathogen Legionella pneumophila

(2010) Xiang-hui Li et al.   BMC MICROBIOLOGY

Acyldepsipeptide Antibiotics Induce the Formation of a Structured Axial Channel in ClpP: A Model for the ClpX/ClpA-Bound State of ClpP

(2010) Dominic Him Shun Li et al.   CHEMISTRY & BIOLOGY

Control of Substrate Gating and Translocation into ClpP by Channel Residues and ClpX Binding

(2010) Mary E. Lee et al.   JOURNAL OF MOLECULAR BIOLOGY

ClpXP Protease Regulates the Type III Secretion System ofDickeya dadantii3937 and Is Essential for the Bacterial Virulence

(2010) Yan Li et al.   MOLECULAR PLANT-MICROBE INTERACTIONS

Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism

(2010) Byung-Gil Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Characterization of a Clp Protease Gene Regulator and the Reaeration Response in Mycobacterium tuberculosis

(2010) Ashley M. Sherrid et al.   PLoS One

The antibiotic ADEP reprogrammes ClpP, switching it from a regulated to an uncontrolled protease

(2009) Janine Kirstein et al.   EMBO Molecular Medicine

Helicobacter pylori mutants defective in the clpP ATP-dependant protease and the chaperone clpA display reduced macrophage and murine survival

(2008) Michael F. Loughlin et al.   MICROBIAL PATHOGENESIS