The ClpP peptidase of Wolbachia endobacteria is a novel target for drug development against filarial infections

Immunization with L. sigmodontis Microfilariae Reduces Peripheral Microfilaraemia after Challenge Infection by Inhibition of Filarial Embryogenesis

(2012) Sebastian Ziewer et al.   PLoS Neglected Tropical Diseases

Both asymmetric mitotic segregation and cell-to-cell invasion are required for stable germline transmission of Wolbachia in filarial nematodes

(2012) F. Landmann et al.   Biology Open

Filariasis in Africa—treatment challenges and prospects

(2011) A. Hoerauf et al.   CLINICAL MICROBIOLOGY AND INFECTION

Antibiotic acyldepsipeptides activate ClpP peptidase to degrade the cell division protein FtsZ

(2011) P. Sass et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phenotypic Evidence of Emerging Ivermectin Resistance in Onchocerca volvulus

(2011) Mike Y. Osei-Atweneboana et al.   PLoS Neglected Tropical Diseases

Acyldepsipeptide Antibiotics Induce the Formation of a Structured Axial Channel in ClpP: A Model for the ClpX/ClpA-Bound State of ClpP

(2010) Dominic Him Shun Li et al.   CHEMISTRY & BIOLOGY

Binding of the ClpA Unfoldase Opens the Axial Gate of ClpP Peptidase

(2010) Grégory Effantin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lymphatic filariasis and onchocerciasis

(2010) Mark J Taylor et al.   LANCET

Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism

(2010) Byung-Gil Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The antibiotic ADEP reprogrammes ClpP, switching it from a regulated to an uncontrolled protease

(2009) Janine Kirstein et al.   EMBO Molecular Medicine

Functional conservation of the lipid II biosynthesis pathway in the cell wall-less bacteriaChlamydiaandWolbachia: why is lipid II needed?

(2009) Beate Henrichfreise et al.   MOLECULAR MICROBIOLOGY

Adapting the machine: adaptor proteins for Hsp100/Clp and AAA+ proteases

(2009) Janine Kirstein et al.   NATURE REVIEWS MICROBIOLOGY

Newly acquired Onchocerca volvulus filariae after doxycycline treatment

(2009) Sabine Specht et al.   PARASITOLOGY RESEARCH

Doxycycline Treatment ofBrugia malayi–Infected Persons Reduces Microfilaremia and Adverse Reactions after Diethylcarbamazine and Albendazole Treatment

(2008) Taniawati Supali et al.   CLINICAL INFECTIOUS DISEASES

Filariasis: new drugs and new opportunities for lymphatic filariasis and onchocerciasis

(2008) Achim Hoerauf   CURRENT OPINION IN INFECTIOUS DISEASES