Substrate delivery by the AAA+ ClpX and ClpC1 unfoldases activates the mycobacterial ClpP1P2 peptidase

Antibacterial Activity of and Resistance to Small Molecule Inhibitors of the ClpP Peptidase

(2013) Corey L. Compton et al.   ACS Chemical Biology

The Mechanism of Caseinolytic Protease (ClpP) Inhibition

(2013) Malte Gersch et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Clp chaperones and proteases are central in stress survival, virulence and antibiotic resistance of Staphylococcus aureus

(2013) Dorte Frees et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Disruption of Oligomerization and Dehydroalanine Formation as Mechanisms for ClpP Protease Inhibition

(2013) Malte Gersch et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Antibiotic resistance: global response needed

(2013) Simon J Howard et al.   LANCET INFECTIOUS DISEASES

Mycobacterium tuberculosis ClpP Proteases Are Co-transcribed but Exhibit Different Substrate Specificities

(2013) Yoann Personne et al.   PLoS One

Interaction specificity between the chaperone and proteolytic components of the cyanobacterial Clp protease

(2012) Anders Tryggvesson et al.   BIOCHEMICAL JOURNAL

The active ClpP protease fromM. tuberculosisis a complex composed of a heptameric ClpP1 and a ClpP2 ring

(2012) Tatos Akopian et al.   EMBO JOURNAL

Insights into Structural Network Responsible for Oligomerization and Activity of Bacterial Virulence Regulator Caseinolytic Protease P (ClpP) Protein

(2012) Malte Gersch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of the Cdc48bullet20S Proteasome as an Ancient AAA+ Proteolytic Machine

(2012) D. Barthelme et al.   SCIENCE

Mycobacterium tuberculosis ClpP1 and ClpP2 Function Together in Protein Degradation and Are Required for Viability in vitro and During Infection

(2012) Ravikiran M. Raju et al.   PLoS Pathogens

Vibralactone as a Tool to Study the Activity and Structure of the ClpP1P2 Complex from Listeria monocytogenes

(2011) Evelyn Zeiler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A Conformational Switch Underlies ClpP Protease Function

(2011) Sebastian R. Geiger et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Role of Intracellular Proteases in the Antibiotic Resistance, Motility, and Biofilm Formation of Pseudomonas aeruginosa

(2011) Lucía Fernández et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Assembly and proteolytic processing of mycobacterial ClpP1 and ClpP2

(2011) Nadia Benaroudj et al.   BMC BIOCHEMISTRY

Validation of the Essential ClpP Protease in Mycobacterium tuberculosis as a Novel Drug Target

(2011) J. Ollinger et al.   JOURNAL OF BACTERIOLOGY

Site-Directed Methyl Group Labeling as an NMR Probe of Structure and Dynamics in Supramolecular Protein Systems: Applications to the Proteasome and to the ClpP Protease

(2011) Tomasz L. Religa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fast, scalable generation of high-quality protein multiple sequence alignments using Clustal Omega

(2011) F. Sievers et al.   Molecular Systems Biology

Structural insights into the conformational diversity of ClpP from Bacillus subtilis

(2011) Byung-Gil Lee et al.   MOLECULES AND CELLS

Structure and mechanism of the hexameric MecA–ClpC molecular machine

(2011) Feng Wang et al.   NATURE

High-Resolution Phenotypic Profiling Defines Genes Essential for Mycobacterial Growth and Cholesterol Catabolism

(2011) Jennifer E. Griffin et al.   PLoS Pathogens

Acyldepsipeptide Antibiotics Induce the Formation of a Structured Axial Channel in ClpP: A Model for the ClpX/ClpA-Bound State of ClpP

(2010) Dominic Him Shun Li et al.   CHEMISTRY & BIOLOGY

Control of Substrate Gating and Translocation into ClpP by Channel Residues and ClpX Binding

(2010) Mary E. Lee et al.   JOURNAL OF MOLECULAR BIOLOGY

Multidrug-resistant and extensively drug-resistant tuberculosis: a threat to global control of tuberculosis

(2010) Neel R Gandhi et al.   LANCET

Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism

(2010) Byung-Gil Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A new bioinformatics analysis tools framework at EMBL-EBI

(2010) M. Goujon et al.   NUCLEIC ACIDS RESEARCH

Structural and Theoretical Studies Indicate that the Cylindrical Protease ClpP Samples Extended and Compact Conformations

(2010) Matthew S. Kimber et al.   STRUCTURE

RseA, the SigE specific anti-sigma factor ofMycobacterium tuberculosis, is inactivated by phosphorylation-dependent ClpC1P2 proteolysis

(2009) Subhasis Barik et al.   MOLECULAR MICROBIOLOGY

β-Lactones as Specific Inhibitors of ClpP Attenuate the Production of Extracellular Virulence Factors ofStaphylococcus aureus

(2008) Thomas Böttcher et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Extensively drug-resistant tuberculosis

(2008) Mandeep Jassal et al.   LANCET INFECTIOUS DISEASES

Protein unfolding by a AAA+ protease is dependent on ATP-hydrolysis rates and substrate energy landscapes

(2008) Andreas Martin et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis

(2008) S. P. S. Rao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA