Activated ClpP kills persisters and eradicates a chronic biofilm infection

RETRACTED: (p)ppGpp Controls Bacterial Persistence by Stochastic Induction of Toxin-Antitoxin Activity

(2013) Etienne Maisonneuve et al.   CELL

Molecular Mechanism of Bacterial Persistence by HipA

(2013) Elsa Germain et al.   MOLECULAR CELL

A flexible C-terminal linker is required for proper FtsZ assemblyin vitroand cytokinetic ring formationin vivo

(2013) P. J. Buske et al.   MOLECULAR MICROBIOLOGY

Platforms for antibiotic discovery

(2013) Kim Lewis   NATURE REVIEWS DRUG DISCOVERY

Sticking together: building a biofilm the Bacillus subtilis way

(2013) Hera Vlamakis et al.   NATURE REVIEWS MICROBIOLOGY

Killing by Bactericidal Antibiotics Does Not Depend on Reactive Oxygen Species

(2013) I. Keren et al.   SCIENCE

Bacterial Biofilms: Development, Dispersal, and Therapeutic Strategies in the Dawn of the Postantibiotic Era

(2013) M. Kostakioti et al.   Cold Spring Harbor Perspectives in Medicine

Pharmacodynamics, Population Dynamics, and the Evolution of Persistence in Staphylococcus aureus

(2013) Paul J. T. Johnson et al.   PLoS Genetics

Persister-promoting bacterial toxin TisB produces anion-selective pores in planar lipid bilayers

(2012) Philip A. Gurnev et al.   FEBS LETTERS

Recover the lost art of drug discovery

(2012) Kim Lewis   NATURE

Vancomycin Bactericidal Activity as a Predictor of 30-Day Mortality in Patients with Methicillin-ResistantStaphylococcus aureusBacteremia

(2011) Motoyasu Miyazaki et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Activators of Cylindrical Proteases as Antimicrobials: Identification and Development of Small Molecule Activators of ClpP Protease

(2011) Elisa Leung et al.   CHEMISTRY & BIOLOGY

Antibiotic acyldepsipeptides activate ClpP peptidase to degrade the cell division protein FtsZ

(2011) P. Sass et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bacterial persistence by RNA endonucleases

(2011) Etienne Maisonneuve et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reversed-phase chromatography with multiple fraction concatenation strategy for proteome profiling of human MCF10A cells

(2011) Yuexi Wang et al.   PROTEOMICS

Evolution of Multidrug Resistance during Staphylococcus aureus Infection Involves Mutation of the Essential Two Component Regulator WalKR

(2011) Benjamin P. Howden et al.   PLoS Pathogens

Persister Cells

(2010) Kim Lewis   Annual Review of Microbiology

Acyldepsipeptide Antibiotics Induce the Formation of a Structured Axial Channel in ClpP: A Model for the ClpX/ClpA-Bound State of ClpP

(2010) Dominic Him Shun Li et al.   CHEMISTRY & BIOLOGY

Emergence of Pseudomonas aeruginosa Strains Producing High Levels of Persister Cells in Patients with Cystic Fibrosis

(2010) L. R. Mulcahy et al.   JOURNAL OF BACTERIOLOGY

The Generating Function of CID, ETD, and CID/ETD Pairs of Tandem Mass Spectra: Applications to Database Search

(2010) Sangtae Kim et al.   MOLECULAR & CELLULAR PROTEOMICS

Structures of ClpP in complex with acyldepsipeptide antibiotics reveal its activation mechanism

(2010) Byung-Gil Lee et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ciprofloxacin Causes Persister Formation by Inducing the TisB toxin in Escherichia coli

(2010) Tobias Dörr et al.   PLOS BIOLOGY

Patients with Long-Term Oral Carriage Harbor High-Persister Mutants of Candida albicans

(2009) M. D. LaFleur et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Chromosomal Toxin Gene yafQ Is a Determinant of Multidrug Tolerance for Escherichia coli Growing in a Biofilm

(2009) J. J. Harrison et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The antibiotic ADEP reprogrammes ClpP, switching it from a regulated to an uncontrolled protease

(2009) Janine Kirstein et al.   EMBO Molecular Medicine

Proteolysis during long-term glucose starvation inStaphylococcus aureusCOL

(2009) Stephan Michalik et al.   PROTEOMICS

DeconMSn: a software tool for accurate parent ion monoisotopic mass determination for tandem mass spectra

(2008) A. M. Mayampurath et al.   BIOINFORMATICS

Skin and Soft‐Tissue Infections Caused by Community‐Acquired Methicillin‐ResistantStaphylococcus aureus

(2008) Martin E. Stryjewski et al.   CLINICAL INFECTIOUS DISEASES

MASIC: A software program for fast quantitation and flexible visualization of chromatographic profiles from detected LC–MS(/MS) features

(2008) Matthew E. Monroe et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

A small SOS-induced toxin is targeted against the inner membrane in Escherichia coli

(2008) Cecilia Unoson et al.   MOLECULAR MICROBIOLOGY

Fully Automated Four-Column Capillary LC−MS System for Maximizing Throughput in Proteomic Analyses

(2007) Eric A. Livesay et al.   ANALYTICAL CHEMISTRY