An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ

Mass Spectrometry Based Method to Increase Throughput for Kinome Analyses Using ATP Probes

(2013) F. E. McAllister et al.   ANALYTICAL CHEMISTRY

Increasing the Multiplexing Capacity of TMTs Using Reporter Ion Isotopologues with Isobaric Masses

(2012) Graeme C. McAlister et al.   ANALYTICAL CHEMISTRY

PPARγ agonists Induce a White-to-Brown Fat Conversion through Stabilization of PRDM16 Protein

(2012) Haruya Ohno et al.   Cell Metabolism

Frequency-Modulated Pulses of ERK Activity Transmit Quantitative Proliferation Signals

(2012) John G. Albeck et al.   MOLECULAR CELL

Combined BRAF and MEK Inhibition in Melanoma with BRAF V600 Mutations

(2012) Keith T. Flaherty et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rapid and Reproducible Single-Stage Phosphopeptide Enrichment of Complex Peptide Mixtures: Application to General and Phosphotyrosine-Specific Phosphoproteomics Experiments

(2011) Arminja N. Kettenbach et al.   ANALYTICAL CHEMISTRY

Dissociation of the Glucose and Lipid Regulatory Functions of FoxO1 by Targeted Knockin of Acetylation-Defective Alleles in Mice

(2011) Alexander S. Banks et al.   Cell Metabolism

Transcriptional Control of Adipose Lipid Handling by IRF4

(2011) Jun Eguchi et al.   Cell Metabolism

In Situ Kinase Profiling Reveals Functionally Relevant Properties of Native Kinases

(2011) Matthew P. Patricelli et al.   CHEMISTRY & BIOLOGY

Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation

(2011) Jang Hyun Choi et al.   NATURE

MS3 eliminates ratio distortion in isobaric multiplexed quantitative proteomics

(2011) Lily Ting et al.   NATURE METHODS

PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse

(2011) P. V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

In Vivo Systems Analysis Identifies Spatial and Temporal Aspects of the Modulation of TNF- -Induced Apoptosis and Proliferation by MAPKs

(2011) K. S. Lau et al.   Science Signaling

A Tissue-Specific Atlas of Mouse Protein Phosphorylation and Expression

(2010) Edward L. Huttlin et al.   CELL

Deficiency in the extracellular signal-regulated kinase 1 (ERK1) protects leptin-deficient mice from insulin resistance without affecting obesity

(2010) J. Jager et al.   DIABETOLOGIA

Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARγ by Cdk5

(2010) Jang Hyun Choi et al.   NATURE

Improved insulin sensitivity by calorie restriction is associated with reduction of ERK and p70S6K activities in the liver of obese Zucker rats

(2009) Yanbin Zheng et al.   JOURNAL OF ENDOCRINOLOGY

Regulation of Hippocampal and Behavioral Excitability by Cyclin-Dependent Kinase 5

(2009) Ammar H. Hawasli et al.   PLoS One

The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901

(2008) Stephen D. Barrett et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Deregulated Cdk5 promotes oxidative stress and mitochondrial dysfunction

(2008) Kai-Hui Sun et al.   JOURNAL OF NEUROCHEMISTRY

Dissection of the insulin signaling pathway via quantitative phosphoproteomics

(2008) M. Kruger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA