Rapid, direct activity assays for Smoothened reveal Hedgehog pathway regulation by membrane cholesterol and extracellular sodium
出版年份 2017 全文链接
标题
Rapid, direct activity assays for Smoothened reveal Hedgehog pathway regulation by membrane cholesterol and extracellular sodium
作者
关键词
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出版物
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 114, Issue 52, Pages E11141-E11150
出版商
Proceedings of the National Academy of Sciences
发表日期
2017-12-12
DOI
10.1073/pnas.1717891115
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling
- (2017) Xu Xiao et al. MOLECULAR CELL
- 3.3 Å structure of Niemann–Pick C1 protein reveals insights into the function of the C-terminal luminal domain in cholesterol transport
- (2017) Xiaochun Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Stromal Gli2 activity coordinates a niche signaling program for mammary epithelial stem cells
- (2017) Chen Zhao et al. SCIENCE
- Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling
- (2016) Pengxiang Huang et al. CELL
- Interaction of G protein coupled receptors and cholesterol
- (2016) Gerald Gimpl CHEMISTRY AND PHYSICS OF LIPIDS
- Hedgehog Signal Transduction: Key Players, Oncogenic Drivers, and Cancer Therapy
- (2016) Ekaterina Pak et al. DEVELOPMENTAL CELL
- Structural basis of Smoothened regulation by its extracellular domains
- (2016) Eamon F. X. Byrne et al. NATURE
- Orthogonal lipid sensors identify transbilayer asymmetry of plasma membrane cholesterol
- (2016) Shu-Lin Liu et al. Nature Chemical Biology
- Nanodiscs for structural and functional studies of membrane proteins
- (2016) Ilia G Denisov et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Endogenous B-ring oxysterols inhibit the Hedgehog component Smoothened in a manner distinct from cyclopamine or side-chain oxysterols
- (2016) Navdar Sever et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Control of inflammation by stromal Hedgehog pathway activation restrains colitis
- (2016) John J. Lee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Smoothened Regulation: A Tale of Two Signals
- (2016) Angela M. Arensdorf et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth
- (2016) Marco Gerling et al. Nature Communications
- Nanodiscs for structural and functional studies of membrane proteins
- (2016) Ilia G Denisov et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling
- (2016) Giovanni Luchetti et al. eLife
- Modulation of Ciliary Phosphoinositide Content Regulates Trafficking and Sonic Hedgehog Signaling Output
- (2015) Marcelo Chávez et al. DEVELOPMENTAL CELL
- Phosphoinositides Regulate Ciliary Protein Trafficking to Modulate Hedgehog Signaling
- (2015) Francesc R. Garcia-Gonzalo et al. DEVELOPMENTAL CELL
- Reduced cholesterol levels impair Smoothened activation in Smith–Lemli–Opitz syndrome
- (2015) Robert Blassberg et al. HUMAN MOLECULAR GENETICS
- Regulation of the oncoprotein Smoothened by small molecules
- (2015) Hayley J Sharpe et al. Nature Chemical Biology
- Nascent chain-monitored remodeling of the Sec machinery for salinity adaptation of marine bacteria
- (2015) Eiji Ishii et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The role of ciliary trafficking in Hedgehog receptor signaling
- (2015) Jynho Kim et al. Science Signaling
- The role of ciliary trafficking in Hedgehog receptor signaling
- (2015) Jynho Kim et al. Science Signaling
- Hedgehog Signaling Restrains Bladder Cancer Progression by Eliciting Stromal Production of Urothelial Differentiation Factors
- (2014) Kunyoo Shin et al. CANCER CELL
- Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival
- (2014) Berna C. Özdemir et al. CANCER CELL
- Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma
- (2014) Andrew D. Rhim et al. CANCER CELL
- Identification of recurrent SMO and BRAF mutations in ameloblastomas
- (2014) Robert T Sweeney et al. NATURE GENETICS
- Stromal response to Hedgehog signaling restrains pancreatic cancer progression
- (2014) J. J. Lee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- G-protein-coupled receptors, Hedgehog signaling and primary cilia
- (2014) Saikat Mukhopadhyay et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- Allosteric sodium in class A GPCR signaling
- (2014) Vsevolod Katritch et al. TRENDS IN BIOCHEMICAL SCIENCES
- Targeting of Smoothened for therapeutic gain
- (2014) Martial Ruat et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- Hedgehog Pathway Modulation by Multiple Lipid Binding Sites on the Smoothened Effector of Signal Response
- (2013) Benjamin R. Myers et al. DEVELOPMENTAL CELL
- Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling
- (2013) Daniel Nedelcu et al. Nature Chemical Biology
- The mechanisms of Hedgehog signalling and its roles in development and disease
- (2013) James Briscoe et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Human cytochromes P450 in health and disease
- (2013) D. W. Nebert et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
- TPC Proteins Are Phosphoinositide- Activated Sodium-Selective Ion Channels in Endosomes and Lysosomes
- (2012) Xiang Wang et al. CELL
- Oxysterols are allosteric activators of the oncoprotein Smoothened
- (2012) Sigrid Nachtergaele et al. Nature Chemical Biology
- A Luminescent Biosensor with Increased Dynamic Range for Intracellular cAMP
- (2011) Brock F. Binkowski et al. ACS Chemical Biology
- Structure and function of a membrane component SecDF that enhances protein export
- (2011) Tomoya Tsukazaki et al. NATURE
- Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder
- (2011) Kunyoo Shin et al. NATURE
- The primary cilium: a signalling centre during vertebrate development
- (2010) Sarah C. Goetz et al. NATURE REVIEWS GENETICS
- Evaluating Smoothened as a G-protein-coupled receptor for Hedgehog signalling
- (2010) Katie L. Ayers et al. TRENDS IN CELL BIOLOGY
- Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus
- (2009) J. Kim et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Fifty years of advances in bile acid synthesis and metabolism
- (2008) David W. Russell JOURNAL OF LIPID RESEARCH
- Membrane lipids: where they are and how they behave
- (2008) Gerrit van Meer et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Engineered disulfide bonds support the functional rotation mechanism of multidrug efflux pump AcrB
- (2008) Markus A Seeger et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
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