PI(4)P Promotes Phosphorylation and Conformational Change of Smoothened through Interaction with Its C-terminal Tail

Modulation of Ciliary Phosphoinositide Content Regulates Trafficking and Sonic Hedgehog Signaling Output

(2015) Marcelo Chávez et al.   DEVELOPMENTAL CELL

Phosphoinositides Regulate Ciliary Protein Trafficking to Modulate Hedgehog Signaling

(2015) Francesc R. Garcia-Gonzalo et al.   DEVELOPMENTAL CELL

The role of ciliary trafficking in Hedgehog receptor signaling

(2015) Jynho Kim et al.   Science Signaling

The role of ciliary trafficking in Hedgehog receptor signaling

(2015) Jynho Kim et al.   Science Signaling

Hedgehog-regulated atypical PKC promotes phosphorylation and activation of Smoothened and Cubitus interruptus inDrosophila

(2014) Kai Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hedgehog Pathway Modulation by Multiple Lipid Binding Sites on the Smoothened Effector of Signal Response

(2013) Benjamin R. Myers et al.   DEVELOPMENTAL CELL

Structure of the human smoothened receptor bound to an antitumour agent

(2013) Chong Wang et al.   NATURE

The mechanisms of Hedgehog signalling and its roles in development and disease

(2013) James Briscoe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

CARMIL leading edge localization depends on a non-canonical PH domain and dimerization

(2013) Adam Zwolak et al.   Nature Communications

Structural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signalling

(2013) Rajashree Rana et al.   Nature Communications

Structure and function of the Smoothened extracellular domain in vertebrate Hedgehog signaling

(2013) Sigrid Nachtergaele et al.   eLife

Hh-induced Smoothened conformational switch is mediated by differential phosphorylation at its C-terminal tail in a dose- and position-dependent manner

(2012) Junkai Fan et al.   DEVELOPMENTAL BIOLOGY

USP8 Promotes Smoothened Signaling by Preventing Its Ubiquitination and Changing Its Subcellular Localization

(2012) Ruohan Xia et al.   PLOS BIOLOGY

Hedgehog-Regulated Ubiquitination Controls Smoothened Trafficking and Cell Surface Expression in Drosophila

(2012) Shuang Li et al.   PLOS BIOLOGY

Quantification of PtdInsP3 molecular species in cells and tissues by mass spectrometry

(2011) Jonathan Clark et al.   NATURE METHODS

Mechanisms and functions of Hedgehog signalling across the metazoa

(2011) Philip W. Ingham et al.   NATURE REVIEWS GENETICS

Sonic Hedgehog Dependent Phosphorylation by CK1α and GRK2 Is Required for Ciliary Accumulation and Activation of Smoothened

(2011) Yongbin Chen et al.   PLOS BIOLOGY

Mechanism and evolution of cytosolic Hedgehog signal transduction

(2010) C. W. Wilson et al.   DEVELOPMENT

Role of Lipid Metabolism in Smoothened Derepression in Hedgehog Signaling

(2010) Amir Yavari et al.   DEVELOPMENTAL CELL

Genetic and biochemical definition of the Hedgehog receptor

(2010) X. Zheng et al.   GENES & DEVELOPMENT

G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila

(2010) Y. Chen et al.   GENES & DEVELOPMENT

Casein Kinase 2 Promotes Hedgehog Signaling by Regulating both Smoothened and Cubitus Interruptus

(2010) Hongge Jia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ihog and Boi are essential for Hedgehog signaling in Drosophila

(2010) Darius Camp et al.   Neural Development

Evaluating Smoothened as a G-protein-coupled receptor for Hedgehog signalling

(2010) Katie L. Ayers et al.   TRENDS IN CELL BIOLOGY

Patched regulates Smoothened trafficking using lipoprotein-derived lipids

(2009) H. Khaliullina et al.   DEVELOPMENT

INPP5E mutations cause primary cilium signaling defects, ciliary instability and ciliopathies in human and mouse

(2009) Monique Jacoby et al.   NATURE GENETICS

Selective translocation of intracellular Smoothened to the primary cilium in response to Hedgehog pathway modulation

(2009) Yu Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hedgehog signal transduction by Smoothened: Pharmacologic evidence for a 2-step activation process

(2009) R. Rohatgi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PP4 and PP2A regulate Hedgehog signaling by controlling Smo and Ci phosphorylation

(2008) H. Jia et al.   DEVELOPMENT

Hedgehog Signaling in Development and Cancer

(2008) Jin Jiang et al.   DEVELOPMENTAL CELL

The Skap-hom Dimerization and PH Domains Comprise a 3′-Phosphoinositide-Gated Molecular Switch

(2008) Kenneth D. Swanson et al.   MOLECULAR CELL