Hedgehog induces formation of PKA-Smoothened complexes to promote Smoothened phosphorylation and pathway activation

The Ciliary G-Protein-Coupled Receptor Gpr161 Negatively Regulates the Sonic Hedgehog Pathway via cAMP Signaling

(2013) Saikat Mukhopadhyay et al.   CELL

Decoding the phosphorylation code in Hedgehog signal transduction

(2013) Yongbin Chen et al.   CELL RESEARCH

Smoothened Oligomerization/Higher Order Clustering in Lipid Rafts Is Essential for High Hedgehog Activity Transduction

(2013) Dawei Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of Hedgehog signaling by loss of GNAS causes heterotopic ossification

(2013) Jean B Regard et al.   NATURE MEDICINE

Positive and Negative Regulation of Gli Activity by Kif7 in the Zebrafish Embryo

(2013) Ashish Kumar Maurya et al.   PLoS Genetics

Smoothened transduces Hedgehog signal by forming a complex with Evc/Evc2

(2012) Cuiping Yang et al.   CELL RESEARCH

Hh-induced Smoothened conformational switch is mediated by differential phosphorylation at its C-terminal tail in a dose- and position-dependent manner

(2012) Junkai Fan et al.   DEVELOPMENTAL BIOLOGY

The Hedgehog Signal Transduction Network

(2012) D. J. Robbins et al.   Science Signaling

Hedgehog-Regulated Ubiquitination Controls Smoothened Trafficking and Cell Surface Expression in Drosophila

(2012) Shuang Li et al.   PLOS BIOLOGY

Gli Proteins in Development and Disease

(2011) Chi-chung Hui et al.   Annual Review of Cell and Developmental Biology

Protein kinase A acts at the basal body of the primary cilium to prevent Gli2 activation and ventralization of the mouse neural tube

(2011) M. Tuson et al.   DEVELOPMENT

The Hedgehog-induced Smoothened conformational switch assembles a signaling complex that activates Fused by promoting its dimerization and phosphorylation

(2011) Q. Shi et al.   DEVELOPMENT

Drosophila G-protein-coupled receptor kinase 2 regulates cAMP-dependent Hedgehog signaling

(2011) S. Cheng et al.   DEVELOPMENT

Mechanisms and functions of Hedgehog signalling across the metazoa

(2011) Philip W. Ingham et al.   NATURE REVIEWS GENETICS

Sequential Phosphorylation of Smoothened Transduces Graded Hedgehog Signaling

(2011) Y. Su et al.   Science Signaling

Sonic Hedgehog Dependent Phosphorylation by CK1α and GRK2 Is Required for Ciliary Accumulation and Activation of Smoothened

(2011) Yongbin Chen et al.   PLOS BIOLOGY

Mechanism and evolution of cytosolic Hedgehog signal transduction

(2010) C. W. Wilson et al.   DEVELOPMENT

G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila

(2010) Y. Chen et al.   GENES & DEVELOPMENT

The Mammalian Cos2 Homolog Kif7 Plays an Essential Role in Modulating Hh Signal Transduction during Development

(2009) Setsu Endoh-Yamagami et al.   CURRENT BIOLOGY

Sonic-hedgehog-mediated proliferation requires the localization of PKA to the cilium base

(2009) M. Barzi et al.   JOURNAL OF CELL SCIENCE

Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling

(2009) K. F. Liem et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Kinesin Protein Kif7 Is a Critical Regulator of Gli Transcription Factors in Mammalian Hedgehog Signaling

(2009) H. O.-L. Cheung et al.   Science Signaling

PP4 and PP2A regulate Hedgehog signaling by controlling Smo and Ci phosphorylation

(2008) H. Jia et al.   DEVELOPMENT

Hedgehog Signaling in Development and Cancer

(2008) Jin Jiang et al.   DEVELOPMENTAL CELL

G protein Gαi functions immediately downstream of Smoothened in Hedgehog signalling

(2008) Stacey K. Ogden et al.   NATURE