Hedgehog reciprocally controls trafficking of Smo and Ptc through the Smurf family of E3 ubiquitin ligases

SUMO regulates the activity of Smoothened and Costal-2 in Drosophila Hedgehog signaling

(2017) Jie Zhang et al.   Scientific Reports

Regulation of Smoothened Trafficking and Hedgehog Signaling by the SUMO Pathway

(2016) Guoqiang Ma et al.   DEVELOPMENTAL CELL

Regulation of Smoothened Phosphorylation and High-Level Hedgehog Signaling Activity by a Plasma Membrane Associated Kinase

(2016) Shuangxi Li et al.   PLOS BIOLOGY

Control of the dynamics and homeostasis of theDrosophilaHedgehog receptor Patched by two C2-WW-HECT-E3 Ubiquitin ligases

(2015) Amira Brigui et al.   Open Biology

Hedgehog induces formation of PKA-Smoothened complexes to promote Smoothened phosphorylation and pathway activation

(2014) S. Li et al.   Science Signaling

Switch of PKA substrates from Cubitus interruptus to Smoothened in the Hedgehog signalosome complex

(2014) Nadia Ranieri et al.   Nature Communications

Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception

(2014) Shen Yue et al.   eLife

Decoding the phosphorylation code in Hedgehog signal transduction

(2013) Yongbin Chen et al.   CELL RESEARCH

Drosophila Vps36 regulates Smo trafficking in Hedgehog signaling

(2013) X. Yang et al.   JOURNAL OF CELL SCIENCE

The mechanisms of Hedgehog signalling and its roles in development and disease

(2013) James Briscoe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Activation of Smurf E3 Ligase Promoted by Smoothened Regulates Hedgehog Signaling through Targeting Patched Turnover

(2013) Shoujun Huang et al.   PLOS BIOLOGY

USP8 Promotes Smoothened Signaling by Preventing Its Ubiquitination and Changing Its Subcellular Localization

(2012) Ruohan Xia et al.   PLOS BIOLOGY

Hedgehog-Regulated Ubiquitination Controls Smoothened Trafficking and Cell Surface Expression in Drosophila

(2012) Shuang Li et al.   PLOS BIOLOGY

Gli Proteins in Development and Disease

(2011) Chi-chung Hui et al.   Annual Review of Cell and Developmental Biology

Sonic Hedgehog Dependent Phosphorylation by CK1α and GRK2 Is Required for Ciliary Accumulation and Activation of Smoothened

(2011) Yongbin Chen et al.   PLOS BIOLOGY

Role of the Drosophila Non-Visual ß-Arrestin Kurtz in Hedgehog Signalling

(2011) Cristina Molnar et al.   PLoS Genetics

Mechanism and evolution of cytosolic Hedgehog signal transduction

(2010) C. W. Wilson et al.   DEVELOPMENT

G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila

(2010) Y. Chen et al.   GENES & DEVELOPMENT

Self-Induced Patched Receptor Down-Regulation Modulates Cell Sensitivity to the Hedgehog Morphogen Gradient

(2010) A. Casali   Science Signaling

Intestinal Stem Cells in Mammals and Drosophila

(2009) Andreu Casali et al.   Cell Stem Cell

Regulation of Smoothened by Drosophila G-protein-coupled receptor kinases

(2009) Shuofei Cheng et al.   DEVELOPMENTAL BIOLOGY

Hedgehog Signaling in Development and Cancer

(2008) Jin Jiang et al.   DEVELOPMENTAL CELL

Nedd4 Mediates Agonist-dependent Ubiquitination, Lysosomal Targeting, and Degradation of the β2-Adrenergic Receptor

(2008) Sudha K. Shenoy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY