The role of exosomes in adult neurogenesis: implications for neurodegenerative diseases

Extracellular vesicles, the emerging mirrors of brain physiopathology

(2023) Amanda Cano et al.   International Journal of Biological Sciences

Exosomes derived from bone-marrow mesenchymal stem cells alleviate cognitive decline in AD-like mice by improving BDNF-related neuropathology

(2022) Sen Liu et al.   Journal of Neuroinflammation

Exosome-shuttled miR-672-5p from anti-inflammatory microglia repair traumatic spinal cord injury by inhibiting AIM2/ASC/Caspase-1 signaling pathway mediated neuronal pyroptosis

(2022) Zheng Zhou et al.   JOURNAL OF NEUROTRAUMA

Impact of endolysosomal dysfunction upon exosomes in neurodegenerative diseases

(2022) Maria Izco et al.   NEUROBIOLOGY OF DISEASE

Neuron secrete exosomes containing miR-9-5p to promote polarization of M1 microglia in depression

(2022) Xian Xian et al.   JOURNAL OF NANOBIOTECHNOLOGY

Aβ and Tau Regulate Microglia Metabolism via Exosomes in Alzheimer’s Disease

(2022) Yuanxin Zhao et al.   Biomedicines

Alzheimer PHF-tau aggregates do not spread tau pathology to the brain via the Retino-tectal projection after intraocular injection in male mouse models

(2022) M.-A. de Fisenne et al.   NEUROBIOLOGY OF DISEASE

Mesenchymal stem cell-derived exosomes altered neuron cholesterol metabolism via Wnt5a-LRP1 axis and alleviated cognitive impairment in a progressive Parkinson’s disease model

(2022) Xiaomin Xu et al.   NEUROSCIENCE LETTERS

Potential of extracellular vesicles in the Parkinson's disease – Pathological mediators and biomarkers

(2021) Yuan Zhao et al.   NEUROCHEMISTRY INTERNATIONAL

Adult hippocampal neurogenesis in aging and Alzheimer's disease

(2021) Kelsey R. Babcock et al.   Stem Cell Reports

Microglial Exosomes in Neurodegenerative Disease

(2021) Min Guo et al.   Frontiers in Molecular Neuroscience

Regulation of Adult Mammalian Neural Stem Cells and Neurogenesis by Cell Extrinsic and Intrinsic Factors

(2021) Shuzo Matsubara et al.   Cells

Engineered Exosomes: a Promising Drug Delivery Strategy for Brain Disease

(2021) Yuan Jiang et al.   CURRENT MEDICINAL CHEMISTRY

Proteopathic tau primes and activates interleukin-1β via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway

(2021) Shanya Jiang et al.   Cell Reports

Exosomal microRNAs from mesenchymal stem/stromal cells: Biology and applications in neuroprotection

(2021) Aida Nasirishargh et al.   World Journal of Stem Cells

Brain Exosomes: Friend or Foe in Alzheimer’s Disease?

(2021) Sharanjot Kaur et al.   MOLECULAR NEUROBIOLOGY

Exosomes isolated during dopaminergic neuron differentiation suppressed neuronal inflammation in a rodent model of Parkinson’s disease

(2021) Yongang Li et al.   NEUROSCIENCE LETTERS

Impact of neurodegenerative diseases on human adult hippocampal neurogenesis

(2021) J. Terreros-Roncal et al.   SCIENCE

Emerging concepts in the treatment of optic neuritis: mesenchymal stem cell-derived extracellular vesicles

(2021) Anagha Aneesh et al.   Stem Cell Research & Therapy

Parkinson's disease, aging and adult neurogenesis: Wnt/β‐catenin signalling as the key to unlock the mystery of endogenous brain repair

(2020) Bianca Marchetti et al.   AGING CELL

Proteomic and biological profiling of extracellular vesicles from Alzheimer's disease human brain tissues

(2020) Satoshi Muraoka et al.   Alzheimers & Dementia

Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s disease

(2020) Sahil Khan et al.   Current Neuropharmacology

Synergies in exosomes and autophagy pathways for cellular homeostasis and metastasis of tumor cells

(2020) Leila Salimi et al.   Cell and Bioscience

Aging and sex: Impact on microglia phagocytosis

(2020) Natalia Yanguas‐Casás et al.   AGING CELL

Exosome biogenesis, secretion and function of exosomal miRNAs in skeletal muscle myogenesis

(2020) Binglin Yue et al.   CELL PROLIFERATION

Astrocyte-derived extracellular vesicles: Neuroreparative properties and role in the pathogenesis of neurodegenerative disorders

(2020) Raghavendra Upadhya et al.   JOURNAL OF CONTROLLED RELEASE

Neural Stem Cell Niche and Adult Neurogenesis

(2020) Yue Li et al.   NEUROSCIENTIST

Extracellular Vesicles, Influential Players of Intercellular Communication within Adult Neurogenic Niches

(2020) Morris Losurdo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Genetic and Environmental Factors in P arkinson's Disease Converge on Immune Function and Inflammation

(2020) Elizabeth M. Kline et al.   MOVEMENT DISORDERS

Brain‐derived neurotropic factor mediates neuroprotection of mesenchymal stem cell‐derived extracellular vesicles against severe intraventricular hemorrhage in newborn rats

(2020) So Yoon Ahn et al.   Stem Cells Translational Medicine

CNS-derived extracellular vesicles from superoxide dismutase 1 (SOD1)G93A ALS mice originate from astrocytes and neurons and carry misfolded SOD1

(2019) Judith M. Silverman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increased DJ-1 and α-Synuclein in Plasma Neural-Derived Exosomes as Potential Markers for Parkinson’s Disease

(2019) Zhen-Hua Zhao et al.   Frontiers in Aging Neuroscience

MAP4K4 Activation Mediates Motor Neuron Degeneration in Amyotrophic Lateral Sclerosis

(2019) Chen Wu et al.   Cell Reports

Meso scale discovery-based assays for the detection of aggregated huntingtin

(2019) Wolfgang Reindl et al.   PLoS One

Adult Neurogenesis, Glia, and the Extracellular Matrix

(2019) Elise C. Cope et al.   Cell Stem Cell

Neural stem cell-derived small extracellular vesicles attenuate apoptosis and neuroinflammation after traumatic spinal cord injury by activating autophagy

(2019) Yuluo Rong et al.   Cell Death & Disease

Exosomes

(2019) D. Michiel Pegtel et al.   Annual Review of Biochemistry

Hippocampal stem cells promotes synaptic resistance to the dysfunctional impact of amyloid beta oligomers via secreted exosomes

(2019) Maria-Adelaide Micci et al.   Molecular Neurodegeneration

Exosomes released from neural progenitor cells and induced neural progenitor cells regulate neurogenesis through miR-21a

(2019) Yizhao Ma et al.   Cell Communication and Signaling

Exosome Determinants of Physiological Aging and Age-Related Neurodegenerative Diseases

(2019) Marianna D’Anca et al.   Frontiers in Aging Neuroscience

The Role of Vesicle Trafficking and Release in Oligodendrocyte Biology

(2019) Cory R. Reiter et al.   NEUROCHEMICAL RESEARCH

Exosome reporter mice reveal the involvement of exosomes in mediating neuron to astroglia communication in the CNS

(2019) Yuqin Men et al.   Nature Communications

Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers

(2018) Maitrayee Sardar Sinha et al.   ACTA NEUROPATHOLOGICA

The role of adult hippocampal neurogenesis in brain health and disease

(2018) Tomohisa Toda et al.   MOLECULAR PSYCHIATRY

Applications of stem cell-derived exosomes in tissue engineering and neurological diseases

(2018) Baichuan Sun et al.   REVIEWS IN THE NEUROSCIENCES

Selective vulnerability in neurodegenerative diseases

(2018) Hongjun Fu et al.   NATURE NEUROSCIENCE

Intermittent hypoxia disrupts adult neurogenesis and synaptic plasticity in the dentate gyrus

(2018) Maggie A Khuu et al.   JOURNAL OF NEUROSCIENCE

Neuron-astrocyte signaling is preserved in the aging brain

(2017) Marta Gómez-Gonzalo et al.   GLIA

Mutant Huntingtin Inhibits αB-Crystallin Expression and Impairs Exosome Secretion from Astrocytes

(2017) Yan Hong et al.   JOURNAL OF NEUROSCIENCE

Amyotrophic lateral sclerosis

(2017) Michael A van Es et al.   LANCET

Neurofilament light protein in blood as a potential biomarker of neurodegeneration in Huntington's disease: a retrospective cohort analysis

(2017) Lauren M Byrne et al.   LANCET NEUROLOGY

The release and trans-synaptic transmission of Tau via exosomes

(2017) Yipeng Wang et al.   Molecular Neurodegeneration

Exosomes Secreted from HEK293-APP Swe/Ind Cells Impair the Hippocampal Neurogenesis

(2017) Tingting Zheng et al.   NEUROTOXICITY RESEARCH

MSCs-Derived Exosomes and Neuroinflammation, Neurogenesis and Therapy of Traumatic Brain Injury

(2017) Yongxiang Yang et al.   Frontiers in Cellular Neuroscience

The BAF45D Protein Is Preferentially Expressed in Adult Neurogenic Zones and in Neurons and May Be Required for Retinoid Acid Induced PAX6 Expression

(2017) Chao Liu et al.   Frontiers in Neuroanatomy

Exosomes from NSC-34 Cells Transfected with hSOD1-G93A Are Enriched in miR-124 and Drive Alterations in Microglia Phenotype

(2017) Sara Pinto et al.   Frontiers in Neuroscience

The role of exosomes in the pathogenesis of Alzheimer’ disease

(2017) Tingting Xiao et al.   Translational Neurodegeneration

Human-to-mouse prion-like propagation of mutant huntingtin protein

(2016) Iksoo Jeon et al.   ACTA NEUROPATHOLOGICA

Exosome secretion is a key pathway for clearance of pathological TDP-43

(2016) Yohei Iguchi et al.   BRAIN

Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior

(2016) J. Tiago Gonçalves et al.   CELL

Physiological and pathological impact of exosomes of adipose tissue

(2016) Yan Zhang et al.   CELL PROLIFERATION

Potential Transfer of Polyglutamine and CAG-Repeat RNA in Extracellular Vesicles in Huntington’s Disease: Background and Evaluation in Cell Culture

(2016) Xuan Zhang et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Mature neurons modulate neurogenesis through chemical signals acting on neural stem cells

(2016) Ricardo Pardal et al.   DEVELOPMENT GROWTH & DIFFERENTIATION

Exosomes from adipose-derived stem cells ameliorate phenotype of Huntington's diseasein vitromodel

(2016) Mijung Lee et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Cargo proteins of plasma astrocyte-derived exosomes in Alzheimer’s disease

(2016) Edward J. Goetzl et al.   FASEB JOURNAL

Impaired activation of ALS monocytes by exosomes

(2016) Lisa Zondler et al.   IMMUNOLOGY AND CELL BIOLOGY

Extracellular Vesicles Exploit Viral Entry Routes for Cargo Delivery

(2016) Helena M. van Dongen et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Severely impaired hippocampal neurogenesis associates with an early serotonergic deficit in a BAC α-synuclein transgenic rat model of Parkinson's disease

(2016) Zacharias Kohl et al.   NEUROBIOLOGY OF DISEASE

Dynamic structural flexibility of α-synuclein

(2016) Danielle E. Mor et al.   NEUROBIOLOGY OF DISEASE

Potential Therapies by Stem Cell-Derived Exosomes in CNS Diseases: Focusing on the Neurogenic Niche

(2016) Alejandro Luarte et al.   Stem Cells International

Amyloid β Is Not the Major Factor Accounting for Impaired Adult Hippocampal Neurogenesis in Mice Overexpressing Amyloid Precursor Protein

(2016) Hongyu Pan et al.   Stem Cell Reports

Dopamine Receptor Antagonists Enhance Proliferation and Neurogenesis of Midbrain Lmx1a-expressing Progenitors

(2016) Eva Hedlund et al.   Scientific Reports

Adult Neurogenesis: Beyond Learning and Memory

(2015) Heather A. Cameron et al.   Annual Review of Psychology

Pathologic Potential of Astrocytic Vesicle Traffic: New Targets to Treat Neurologic Diseases?

(2015) Nina Vardjan et al.   CELL TRANSPLANTATION

Exosomes from dental pulp stem cells rescue human dopaminergic neurons from 6-hydroxy-dopamine–induced apoptosis

(2015) Akvilė Jarmalavičiūtė et al.   CYTOTHERAPY

TDP-43 is intercellularly transmitted across axon terminals

(2015) Marisa S. Feiler et al.   JOURNAL OF CELL BIOLOGY

Quantification of mutant huntingtin protein in cerebrospinal fluid from Huntington’s disease patients

(2015) Edward J. Wild et al.   JOURNAL OF CLINICAL INVESTIGATION

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

Molecular mechanisms in the regulation of adult neurogenesis during stress

(2015) Martin Egeland et al.   NATURE REVIEWS NEUROSCIENCE

Deciphering the role of exosomes in tuberculosis

(2015) Nicole A. Kruh-Garcia et al.   TUBERCULOSIS

Exosome Biogenesis, Regulation, and Function in Viral Infection

(2015) Marta Alenquer et al.   Viruses-Basel

Clinically early-stage CSPα mutation carrier exhibits remarkable terminal stage neuronal pathology with minimal evidence of synaptic loss

(2015) Bruno A. Benitez et al.   Acta Neuropathologica Communications

Plasma exosomal α-synuclein is likely CNS-derived and increased in Parkinson’s disease

(2014) Min Shi et al.   ACTA NEUROPATHOLOGICA

Peripheral biomarkers of oxidative stress and their limited potential in evaluation of clinical features of Huntington's patients

(2014) Irene Ciancarelli et al.   BIOMARKERS

Hippocampal Lewy pathology and cholinergic dysfunction are associated with dementia in Parkinson’s disease

(2014) Hélène Hall et al.   BRAIN

Exosomes in diagnostic and therapeutic applications: biomarker, vaccine and RNA interference delivery vehicle

(2014) Cecilia Lässer   EXPERT OPINION ON BIOLOGICAL THERAPY

Specific Disruption of Hippocampal Mossy Fiber Synapses in a Mouse Model of Familial Alzheimer's Disease

(2014) Scott A. Wilke et al.   PLoS One

Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms

(2014) Leslie I. Grad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reconstituting Vascular Microenvironment of Neural Stem Cell Niche in Three-Dimensional Extracellular Matrix

(2014) Yoojin Shin et al.   Advanced Healthcare Materials

Human Adult White Matter Progenitor Cells Are Multipotent Neuroprogenitors Similar to Adult Hippocampal Progenitors

(2014) Xenia Lojewski et al.   Stem Cells Translational Medicine

Mutant Copper-Zinc Superoxide Dismutase (SOD1) Induces Protein Secretion Pathway Alterations and Exosome Release in Astrocytes

(2013) Manuela Basso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Features of wild-type human SOD1 limit interactions with misfolded aggregates of mouse G86R Sod1

(2013) David A Qualls et al.   Molecular Neurodegeneration

State of play in amyotrophic lateral sclerosis genetics

(2013) Alan E Renton et al.   NATURE NEUROSCIENCE

The Impact of Adult Neurogenesis on Olfactory Bulb Circuits and Computations

(2012) Gabriel Lepousez et al.   Annual Review of Physiology

Phosphorylated neurofilament heavy subunit (pNF-H) in peripheral blood and CSF as a potential prognostic biomarker in amyotrophic lateral sclerosis

(2012) K. B. Boylan et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Exosomal cell-to-cell transmission of alpha synuclein oligomers

(2012) Karin M Danzer et al.   Molecular Neurodegeneration

Region-specific changes in the immunoreactivity of SIRT1 expression in the central nervous system of SOD1G93A transgenic mice as an in vivo model of amyotrophic lateral sclerosis

(2011) Jae Chul Lee et al.   BRAIN RESEARCH

In Vivo Clonal Analysis Reveals Self-Renewing and Multipotent Adult Neural Stem Cell Characteristics

(2011) Michael A. Bonaguidi et al.   CELL

Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia

(2011) Han-Xiang Deng et al.   NATURE

Elevated CSF TDP-43 levels in amyotrophic lateral sclerosis: Specificity, sensitivity, and a possible prognostic value

(2010) Yu-Ichi Noto et al.   Amyotrophic Lateral Sclerosis

Direct Transfer of α-Synuclein from Neuron to Astroglia Causes Inflammatory Responses in Synucleinopathies

(2010) He-Jin Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The neuropathology of probable Alzheimer disease and mild cognitive impairment

(2009) Julie A. Schneider et al.   ANNALS OF NEUROLOGY

Cerebrospinal Fluid β-Amyloid 42 and Tau Proteins as Biomarkers of Alzheimer-Type Pathologic Changes in the Brain

(2009) Tero Tapiola et al.   ARCHIVES OF NEUROLOGY

Cytoplasmic penetration and persistent infection of mammalian cells by polyglutamine aggregates

(2009) Pei-Hsien Ren et al.   NATURE CELL BIOLOGY

miR-124 regulates adult neurogenesis in the subventricular zone stem cell niche

(2009) Li-Chun Cheng et al.   NATURE NEUROSCIENCE

Increased TDP-43 protein in cerebrospinal fluid of patients with amyotrophic lateral sclerosis

(2008) Takashi Kasai et al.   ACTA NEUROPATHOLOGICA