Review
Cell & Tissue Engineering
Hadi Yari, Maria Mikhailova, Mahsa Mardasi, Mohsen Jafarzadehgharehziaaddin, Somayeh Shahrokh, Lakshmi Thangavelu, Hosein Ahmadi, Navid Shomali, Yoda Yaghoubi, Majid Zamani, Morteza Akbari, Samira Alesaeidi
Summary: Accumulating evidence suggests that the pleiotropic effects of mesenchymal stromal cells (MSCs) are mainly mediated by the releases of soluble paracrine mediators, rather than their differentiation competencies. MSC-derived exosomes hold great potential for the treatment of neurodegeneration-associated neurological diseases due to their unique immunomodulatory and regenerative attributes. These exosomes can cross the blood-brain barrier (BBB) and efficiently deliver their cargo to damaged brain tissue, influencing various biological processes in neurons, oligodendrocytes, and astrocytes.
STEM CELL RESEARCH & THERAPY
(2022)
Review
Biochemistry & Molecular Biology
Mahdi Ahmadi, Monireh Mahmoodi, Maryam Shoaran, Fereshteh Nazari-Khanamiri, Jafar Rezaie
Summary: New therapeutic approaches are urgently needed for combating metastatic cancers, which cause over 8 million deaths per year worldwide. Mesenchymal stem cells (MSCs) have shown potential as a novel treatment option for cancer, with their exosomes playing a crucial role in regulating tumor progression. However, there is still controversy surrounding the exact association between MSC-derived exosomes and tumors. Nevertheless, the use of MSC-derived exosomes as drug delivery systems and standalone therapeutics is actively being explored, and engineering these exosomes to target tumor cells shows promise in improving the efficacy of antitumor therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Mehrdad Hajinejad, Sajad Sahab-Negah
Summary: Neuroinflammation plays a crucial role in neurological disorders, and mesenchymal stem cells can modulate inflammation and microglia/macrophage polarization through exosome secretion. Studies have shown that miRNAs contained in exosomes have the potential to impact recipient cell behavior, providing a novel therapeutic approach for addressing inflammatory pathways in neurological diseases.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Naina Soni, Suchi Gupta, Surender Rawat, Vishnu Krishnakumar, Sujata Mohanty, Arup Banerjee
Summary: This study investigates the effects of exosomes derived from different sources on immune cells. The expression levels of miRNAs varied within different MSCs and exosomes, and most miRNAs had expression profiles different from their respective sources. Exosomes from different sources had different abilities to induce neurogenesis and angiogenesis, as well as varying effects on PBMC proliferation, neutrophil survival, and NET formation.
Article
Materials Science, Multidisciplinary
Xuewei Zhang, Bixue Wang, Hua Hong, Ying Wang, Jiashang Liu, Changsheng Liu, Xi Chen
Summary: Damaged neurons and harsh microenvironments contribute to the injury cascades following TBI. MSC therapy using dBECM-based hydrogel shows promise in promoting TBI repair by improving neuron compensation, structural regeneration, alleviating neuroinflammation, and promoting microglia polarization. This study highlights the importance of combining dBECM and MSCs as a critical vehicle for neurogenesis and immunoregulation in TBI repair.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2023)
Review
Cell & Tissue Engineering
Lin Zhong, Jingjing Wang, Peng Wang, Xiaoyin Liu, Peng Liu, Xu Cheng, Lujia Cao, Hongwei Wu, Jing Chen, Liangxue Zhou
Summary: Regenerative repair of the brain after traumatic brain injury remains a clinical challenge, and exosome therapy presents a promising strategy for novel regenerative therapies. Prior research has shown that exosomes produced by neural stem cells can participate in the physiological and pathological changes associated with TBI and have potential neuroregulatory and repair functions.
STEM CELL RESEARCH & THERAPY
(2023)
Review
Medicine, Research & Experimental
Soudeh Moghadasi, Marischa Elveny, Heshu Sulaiman Rahman, Wanich Suksatan, Abduladheem Turki Jalil, Walid Kamal Abdelbasset, Alexei Valerievich Yumashev, Siavash Shariatzadeh, Roza Motavalli, Farahnaz Behzad, Faroogh Marofi, Ali Hassanzadeh, Yashwant Pathak, Mostafa Jarahian
Summary: The exosomes derived from MSCs are potential nanocarriers for diagnosis and therapy, transferring functional molecules to target cells to promote tissue repair in various human disorders. Compared to MSCs, MSC-exosomes are more stable and have reduced safety risks, making them a promising cell-free therapeutic strategy in regenerative medicine.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Review
Cell & Tissue Engineering
Ali Hassanzadeh, Heshu Sulaiman Rahman, Alexander Markov, Judi Januadi Endjun, Angelina Olegovna Zekiy, Max Stanley Chartrand, Nasrin Beheshtkhoo, Mohammad Amin Jadidi Kouhbanani, Faroogh Marofi, Marzieh Nikoo, Mostafa Jarahian
Summary: The recent focus on MSCs and their applications in biomedical science has shifted towards developing cell-free therapies, particularly focusing on the potential of MSC-released exosomes. These nano-sized vesicles play a crucial role in tissue recovery by maintaining stem cells, enhancing regeneration, and modulating immune responses. However, their specific role in cancer treatment remains a challenge, calling for further research and development in understanding their mechanisms and optimizing their therapeutic potential.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Oncology
Mir Sadat-Ali, Dakheel Al-Dakheel, Haifa Al-Turki, Sadananda Acharya
Summary: The study demonstrates that autologous bone marrow-derived osteoblasts have a significant impact on reversing osteoporosis in rabbits, with the most improvement seen in the osteoblasts, MSCs, and exosomes group.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Cell Biology
Zhongfei Zhang, Xiaoxiong Zou, Run Zhang, Yu Xie, Zhiming Feng, Feng Li, Jianbang Han, Haitao Sun, Qian Ouyang, Shiting Hua, Bingke Lv, Tian Hua, Zhizheng Liu, Yingqian Cai, Yuxi Zou, Yanping Tang, Xiaodan Jiang
Summary: The study showed that hUMSC-Exos can attenuate microglia-mediated neuroinflammation and improve neural deficits following ischemic stroke. MiR-146a-5p plays a crucial role in this process.
Review
Biochemistry & Molecular Biology
Michal J. Halicki, Karen Hind, Paul L. Chazot
Summary: This article comprehensively reviews the studies on potential blood-based biomarkers of CTE, discussing common themes and limitations, and suggesting future research directions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Anatomy & Morphology
Jiacheng Lv, Shude Yang, Mengzhu Lv, Jiarui Lv, Yanan Sui, Shu Guo
Summary: Skin photoaging is the damage caused by long-term exposure to ultraviolet radiation, and mesenchymal stem cells (MSCs) have shown enormous potential in preventing and treating skin photoaging through various mechanisms, such as antioxidant effects, anti-apoptotic and anti-inflammatory effects, reduction of matrix metalloproteinases, and promotion of dermal fibroblast proliferation.
Review
Medicine, Research & Experimental
Mohammad Hadi Gerami, Roya Khorram, Soheil Rasoolzadegan, Saeid Mardpour, Pooria Nakhaei, Soheyla Hashemi, Bashar Zuhair Talib Al-Naqeeb, Amir Aminian, Sahar Samimi
Summary: Exosomes are small membranous vesicles secreted by various cells, including MSCs, immune cells, and cancer cells. They play an important role in intercellular communication by delivering proteins, lipids, and genetic components to recipient cells. Exosomes therapy has emerged as a promising cell-free approach for treating human diseases, particularly bone- and joint-associated musculoskeletal disorders, due to their stability, biocompatibility, low immunogenicity, and lack of undesirable effects associated with stem/stromal cells. However, challenges such as limited quantity, lack of reliable potency test, and heterogeneity of exosomes hinder their clinical application.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Review
Immunology
Stephane J. C. Mancini, Karl Balabanian, Isabelle Corre, Julie Gavard, Gwendal Lazennec, Marie-Caroline Le Bousse-Kerdiles, Fawzia Louache, Veronique Maguer-Satta, Nathalie M. Mazure, Fatima Mechta-Grigoriou, Jean-Francois Peyron, Valerie Trichet, Olivier Herault
Summary: Recent advances in understanding the hematopoietic niche have been made through in vitro analysis and animal models. Insights from the study of solid tumor niches can provide valuable information for understanding the hematopoietic niche.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Manuela Zavatti, Martina Gatti, Francesca Beretti, Carla Palumbo, Tullia Maraldi
Summary: This study found that exosomes derived from human amniotic fluid stem cells can alleviate inflammatory injury caused by microglia and significantly recover neurotoxicity. This suggests that hAFSC-exo may serve as a potential therapeutic agent for inflammation-related neurological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)