Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers

Exosomes taken up by neurons hijack the endosomal pathway to spread to interconnected neurons

(2018) Juan Carlos Polanco et al.   Acta Neuropathologica Communications

The Murine Version of BAN2401 (mAb158) Selectively Reduces Amyloid-β Protofibrils in Brain and Cerebrospinal Fluid of tg-ArcSwe Mice

(2018) Stina Tucker et al.   JOURNAL OF ALZHEIMERS DISEASE

Pathological Tau Strains from Human Brains Recapitulate the Diversity of Tauopathies in Nontransgenic Mouse Brain

(2017) Sneha Narasimhan et al.   JOURNAL OF NEUROSCIENCE

Defining the human copper proteome and analysis of its expression variation in cancers

(2017) S. Blockhuys et al.   Metallomics

Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathology

(2017) Jennifer Ngolab et al.   Acta Neuropathologica Communications

Insulin-Degrading Enzyme Sorting in Exosomes: A Secretory Pathway for a Key Brain Amyloid-β Degrading Protease

(2017) Ayelén Bulloj et al.   JOURNAL OF ALZHEIMERS DISEASE

An In Vitro Model for Neuroscience: Differentiation of SH-SY5Y Cells into Cells with Morphological and Biochemical Characteristics of Mature Neurons

(2017) Lotta Agholme et al.   JOURNAL OF ALZHEIMERS DISEASE

Impact of lysosome status on extracellular vesicle content and release

(2016) Erez Eitan et al.   AGEING RESEARCH REVIEWS

Focus on Extracellular Vesicles: Exosomes and Their Role in Protein Trafficking and Biomarker Potential in Alzheimer’s and Parkinson’s Disease

(2016) Laura Vella et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

3D Visualization of the Temporal and Spatial Spread of Tau Pathology Reveals Extensive Sites of Tau Accumulation Associated with Neuronal Loss and Recognition Memory Deficit in Aged Tau Transgenic Mice

(2016) Hongjun Fu et al.   PLoS One

Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study

(2015) Massimo S. Fiandaca et al.   Alzheimers & Dementia

ESCRTs regulate amyloid precursor protein sorting in multivesicular bodies and intracellular amyloid-β accumulation

(2015) James R. Edgar et al.   JOURNAL OF CELL SCIENCE

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

Spreading of pathology in neurodegenerative diseases: a focus on human studies

(2015) Johannes Brettschneider et al.   NATURE REVIEWS NEUROSCIENCE

Altered lysosomal proteins in neural-derived plasma exosomes in preclinical Alzheimer disease

(2015) Edward J. Goetzl et al.   NEUROLOGY

Phenothiazine-Derived Antipsychotic Drugs Inhibit Dynamin and Clathrin-Mediated Endocytosis

(2015) James A. Daniel et al.   TRAFFIC

Analysis of exosome purification methods using a model liposome system and tunable-resistive pulse sensing

(2015) Rebecca E. Lane et al.   Scientific Reports

Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases

(2014) Jing L Guo et al.   NATURE MEDICINE

Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease

(2014) Michael B. Dinkins et al.   NEUROBIOLOGY OF AGING

Spreading of amyloid-β peptides via neuritic cell-to-cell transfer is dependent on insufficient cellular clearance

(2014) Jakob Domert et al.   NEUROBIOLOGY OF DISEASE

MicroRNAs transported by exosomes in body fluids as mediators of intercellular communication in cancer

(2014) Mauricio Rodriguez-dorantes et al.   OncoTargets and Therapy

Neuronal Signaling through Endocytosis

(2014) K. E. Cosker et al.   Cold Spring Harbor Perspectives in Biology

Quantification and Size-profiling of Extracellular Vesicles Using Tunable Resistive Pulse Sensing

(2014) Sybren L. N. Maas et al.   Jove-Journal of Visualized Experiments

Microglia convert aggregated amyloid-β into neurotoxic forms through the shedding of microvesicles

(2013) P Joshi et al.   CELL DEATH AND DIFFERENTIATION

Proteasome inhibition induces stress kinase dependent transport deficits — Implications for Alzheimer's disease

(2013) Lotta Agholme et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte–Neuron Communication

(2013) Carsten Frühbeis et al.   PLOS BIOLOGY

Signaling Pathways in Exosomes Biogenesis, Secretion and Fate

(2013) Lorena Urbanelli et al.   Genes

The Exosome Secretory Pathway Transports Amyloid Precursor Protein Carboxyl-terminal Fragments from the Cell into the Brain Extracellular Space

(2012) Rocio Perez-Gonzalez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spreading of Neurodegenerative Pathology via Neuron-to-Neuron Transmission of  -Amyloid

(2012) S. Nath et al.   JOURNAL OF NEUROSCIENCE

Exosomal cell-to-cell transmission of alpha synuclein oligomers

(2012) Karin M Danzer et al.   Molecular Neurodegeneration

A Network Diffusion Model of Disease Progression in Dementia

(2012) Ashish Raj et al.   NEURON

Capture of Neuroepithelial-Like Stem Cells from Pluripotent Stem Cells Provides a Versatile System for In Vitro Production of Human Neurons

(2012) Anna Falk et al.   PLoS One

Synaptic Vesicle Endocytosis

(2012) Y. Saheki et al.   Cold Spring Harbor Perspectives in Biology

Exosomes: Vehicles for the Transfer of Toxic Proteins Associated with Neurodegenerative Diseases?

(2012) Shayne A. Bellingham et al.   Frontiers in Physiology

Exosome-associated Tau Is Secreted in Tauopathy Models and Is Selectively Phosphorylated in Cerebrospinal Fluid in Early Alzheimer Disease

(2011) Sudad Saman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis

(2011) D. Fitzner et al.   JOURNAL OF CELL SCIENCE

The AAA-ATPase VPS4 Regulates Extracellular Secretion and Lysosomal Targeting of α-Synuclein

(2011) Takafumi Hasegawa et al.   PLoS One

Intraneuronal β-amyloid accumulation and synapse pathology in Alzheimer’s disease

(2010) Gunnar K. Gouras et al.   ACTA NEUROPATHOLOGICA

Endocytosis unplugged: multiple ways to enter the cell

(2010) Sudha Kumari et al.   CELL RESEARCH

High Levels of Exosomes Expressing CD63 and Caveolin-1 in Plasma of Melanoma Patients

(2009) Mariantonia Logozzi et al.   PLoS One

Disruption of fast axonal transport is a pathogenic mechanism for intraneuronal amyloid beta

(2009) G. Pigino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Soluble oligomers of the amyloid β-protein impair synaptic plasticity and behavior

(2008) Dennis J. Selkoe   BEHAVIOURAL BRAIN RESEARCH