Potential of extracellular vesicles in the Parkinson's disease – Pathological mediators and biomarkers

A longitudinal study on α‐synuclein in plasma neuronal exosomes as a biomarker for Parkinson’s disease development and progression

(2020) M. Niu et al.   EUROPEAN JOURNAL OF NEUROLOGY

Serum neuronal exosomes predict and differentiate Parkinson’s disease from atypical parkinsonism

(2020) Cheng Jiang et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Plasma exosomal prion protein levels are correlated with cognitive decline in PD patients

(2020) Bing Leng et al.   NEUROSCIENCE LETTERS

Long Noncoding RNA POU3F3 and α-Synuclein in Plasma L1CAM Exosomes Combined with β-Glucocerebrosidase Activity: Potential Predictors of Parkinson’s Disease

(2020) Jing Zou et al.   Neurotherapeutics

Molecular and Cellular Impact of Inflammatory Extracellular Vesicles (EVs) Derived from M1 and M2 Macrophages on Neural Action Potentials

(2020) Sarah Vakili et al.   Brain Sciences

Paper-based ITP technology: An application to specific cancer-derived exosome detection and analysis

(2020) Shuang Guo et al.   BIOSENSORS & BIOELECTRONICS

Extracellular Vesicles Secreted by Astroglial Cells Transport Apolipoprotein D to Neurons and Mediate Neuronal Survival Upon Oxidative Stress

(2019) Raquel Pascua-Maestro et al.   Frontiers in Cellular Neuroscience

Increased DJ-1 and α-Synuclein in Plasma Neural-Derived Exosomes as Potential Markers for Parkinson’s Disease

(2019) Zhen-Hua Zhao et al.   Frontiers in Aging Neuroscience

Microglia as modulators of exosomal alpha-synuclein transmission

(2019) Yun Xia et al.   Cell Death & Disease

New windows into the brain: Central nervous system-derived extracellular vesicles in blood

(2019) Min Shi et al.   PROGRESS IN NEUROBIOLOGY

Exosomes

(2019) D. Michiel Pegtel et al.   Annual Review of Biochemistry

The multiple roles of exosomes in Parkinson's disease: an overview

(2019) Chiara Porro et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Extracellular microvesicles-derived from microglia treated with unaggregated α-synuclein attenuate mitochondrial fission and toxicity-induced by Parkinsonian toxin MPP+

(2019) Na Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Neuronal exosomes in saliva of Parkinson's disease patients: A pilot study

(2019) Komal Rani et al.   PARKINSONISM & RELATED DISORDERS

Assessing Neuronal and Astrocyte Derived Exosomes From Individuals With Mild Traumatic Brain Injury for Markers of Neurodegeneration and Cytotoxic Activity

(2019) Charisse N. Winston et al.   Frontiers in Neuroscience

Gastrodin combined with rhynchophylline inhibits cerebral ischaemia-induced inflammasome activation via upregulating miR-21–5p and miR-331–5p

(2019) Heng-Sheng Zhang et al.   LIFE SCIENCES

Real-time imaging of multivesicular body–plasma membrane fusion to quantify exosome release from single cells

(2019) Maarten P. Bebelman et al.   Nature Protocols

miR-19b-3p inhibits breast cancer cell proliferation and reverses saracatinib-resistance by regulating PI3K/Akt pathway

(2018) Juan Jin et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Inhibition of microRNA-505 suppressed MPP+-induced cytotoxicity of SHSY5Y cells in an in vitro Parkinson's disease model

(2018) Jianzhong Zhu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Plasma α-synuclein and cognitive impairment in the Parkinson's Associated Risk Syndrome: A pilot study

(2018) Hua Wang et al.   NEUROBIOLOGY OF DISEASE

Exosomal secretion of α-synuclein as protective mechanism after upstream blockage of macroautophagy

(2018) Natascha Fussi et al.   Cell Death & Disease

Proteomic Profiling of Exosomal Proteins for Blood-based Biomarkers in Parkinson's Disease

(2018) Yuki Kitamura et al.   NEUROSCIENCE

Secretion and Uptake of α-Synuclein Via Extracellular Vesicles in Cultured Cells

(2018) Gabriel Gustafsson et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Quantification of brain-derived extracellular vesicles in plasma as a biomarker to diagnose Parkinson's and related diseases

(2018) Takuma Ohmichi et al.   PARKINSONISM & RELATED DISORDERS

The Methods of Choice for Extracellular Vesicles (EVs) Characterization

(2017) Rafal Szatanek et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Microglial-derived microparticles mediate neuroinflammation after traumatic brain injury

(2017) Alok Kumar et al.   Journal of Neuroinflammation

Protein Biomarkers and Neuroproteomics Characterization of Microvesicles/Exosomes from Human Cerebrospinal Fluid Following Traumatic Brain Injury

(2017) Rachna Manek et al.   MOLECULAR NEUROBIOLOGY

High-purity capture and release of circulating exosomes using an exosome-specific dual-patterned immunofiltration (ExoDIF) device

(2017) Yoon-Tae Kang et al.   Nanoscale

MicroRNA biomarkers of Parkinson’s disease in serum exosome-like microvesicles

(2017) Xiang-Yang Cao et al.   NEUROSCIENCE LETTERS

Plasma Extracellular Vesicles Enriched for Neuronal Origin: A Potential Window into Brain Pathologic Processes

(2017) Maja Mustapic et al.   Frontiers in Neuroscience

Elevated LRRK2 autophosphorylation in brain-derived and peripheral exosomes in LRRK2 mutation carriers

(2017) Shijie Wang et al.   Acta Neuropathologica Communications

Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathology

(2017) Jennifer Ngolab et al.   Acta Neuropathologica Communications

CNS tau efflux via exosomes is likely increased in Parkinson's disease but not in Alzheimer's disease

(2016) Min Shi et al.   Alzheimers & Dementia

Detection and isolation of circulating exosomes and microvesicles for cancer monitoring and diagnostics using micro-/nano-based devices

(2016) Jina Ko et al.   ANALYST

Schwann Cell Exosomes Mediate Neuron–Glia Communication and Enhance Axonal Regeneration

(2016) Rodrigo Lopez-Leal et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Chromatography and its hyphenation to mass spectrometry for extracellular vesicle analysis

(2016) Gabriella Pocsfalvi et al.   JOURNAL OF CHROMATOGRAPHY A

Parkin Modulates Endosomal Organization and Function of the Endo-Lysosomal Pathway

(2016) Pingping Song et al.   JOURNAL OF NEUROSCIENCE

Ser(P)-1292 LRRK2 in urinary exosomes is elevated in idiopathic Parkinson's disease

(2016) Kyle B. Fraser et al.   MOVEMENT DISORDERS

Urinary LRRK2 phosphorylation predicts parkinsonian phenotypes in G2019SLRRK2carriers

(2016) Kyle B. Fraser et al.   NEUROLOGY

Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes

(2016) Joanna Kowal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Extracellular Vesicles in Physiology, Pathology, and Therapy of the Immune and Central Nervous System, with Focus on Extracellular Vesicles Derived from Mesenchymal Stem Cells as Therapeutic Tools

(2016) Sylwia Koniusz et al.   Frontiers in Cellular Neuroscience

Induction of α-synuclein aggregate formation by CSF exosomes from patients with Parkinson’s disease and dementia with Lewy bodies

(2015) Anne Stuendl et al.   BRAIN

α-Synuclein strains cause distinct synucleinopathies after local and systemic administration

(2015) W. Peelaerts et al.   NATURE

Directional cell movement through tissues is controlled by exosome secretion

(2015) Bong Hwan Sung et al.   Nature Communications

Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease

(2015) YaXing Gui et al.   Oncotarget

Neuronal exosomes facilitate synaptic pruning by up-regulating complement factors in microglia

(2015) Insaf Bahrini et al.   Scientific Reports

Plasma exosomal α-synuclein is likely CNS-derived and increased in Parkinson’s disease

(2014) Min Shi et al.   ACTA NEUROPATHOLOGICA

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment

(2014) Anne-Maria Poehler et al.   Autophagy

Discovery of the migrasome, an organelle mediating release of cytoplasmic contents during cell migration

(2014) Liang Ma et al.   CELL RESEARCH

Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes

(2014) Stephanie M.Y. Kong et al.   HUMAN MOLECULAR GENETICS

LRRK2 delays degradative receptor trafficking by impeding late endosomal budding through decreasing Rab7 activity

(2014) Patricia Gómez-Suaga et al.   HUMAN MOLECULAR GENETICS

ATP13A2/PARK9 Regulates Secretion of Exosomes and  -Synuclein

(2014) T. Tsunemi et al.   JOURNAL OF NEUROSCIENCE

Regulation of Postsynaptic Retrograde Signaling by Presynaptic Exosome Release

(2013) Ceren Korkut et al.   NEURON

Exosomes of BV-2 cells induced by alpha-synuclein: Important mediator of neurodegeneration in PD

(2013) Chongwang Chang et al.   NEUROSCIENCE LETTERS

Comparative proteomics evaluation of plasma exosome isolation techniques and assessment of the stability of exosomes in normal human blood plasma

(2013) Hina Kalra et al.   PROTEOMICS

Structural and functional characterization of two alpha-synuclein strains

(2013) Luc Bousset et al.   Nature Communications

Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte–Neuron Communication

(2013) Carsten Frühbeis et al.   PLOS BIOLOGY

RISC in PD: the impact of microRNAs in Parkinson's disease cellular and molecular pathogenesis

(2013) Sabrina M. Heman-Ackah et al.   Frontiers in Molecular Neuroscience

Characterization of RNA in exosomes secreted by human breast cancer cell lines using next-generation sequencing

(2013) Piroon Jenjaroenpun et al.   PeerJ

Exosomal cell-to-cell transmission of alpha synuclein oligomers

(2012) Karin M Danzer et al.   Molecular Neurodegeneration

An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration

(2012) Sabrina M Lehmann et al.   NATURE NEUROSCIENCE

Activation of the unfolded protein response enhances motor recovery after spinal cord injury

(2012) V Valenzuela et al.   Cell Death & Disease

Microglial microvesicle secretion and intercellular signaling

(2012) Elena Turola   Frontiers in Physiology

Identification of blood microRNAs associated to Parkinsońs disease

(2011) Regina Margis et al.   JOURNAL OF BIOTECHNOLOGY

Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis

(2011) D. Fitzner et al.   JOURNAL OF CELL SCIENCE

α-Synuclein and tau concentrations in cerebrospinal fluid of patients presenting with parkinsonism: a cohort study

(2011) Brit Mollenhauer et al.   LANCET NEUROLOGY

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Mesenchymal stem cell exosome: a novel stem cell-based therapy for cardiovascular disease

(2011) Ruenn Chai Lai et al.   Regenerative Medicine

Clinical progression in Parkinson disease and the neurobiology of axons

(2010) Hsiao-Chun Cheng et al.   ANNALS OF NEUROLOGY

Cell-Produced  -Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival

(2010) E. Emmanouilidou et al.   JOURNAL OF NEUROSCIENCE

Microglia in the aging brain: relevance to neurodegeneration

(2010) Xiao-Guang Luo et al.   Molecular Neurodegeneration

Significance and confounders of peripheral DJ-1 and alpha-synuclein in Parkinson's disease

(2010) Min Shi et al.   NEUROSCIENCE LETTERS

Glial Innate Immunity Generated by Non-Aggregated Alpha-Synuclein in Mouse: Differences between Wild-type and Parkinson's Disease-Linked Mutants

(2010) Cintia Roodveldt et al.   PLoS One

let-7Overexpression Leads to an Increased Fraction of Cells in G2/M, Direct Down-regulation of Cdc34, and Stabilization of Wee1 Kinase in Primary Fibroblasts

(2009) Aster Legesse-Miller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Microfluidic isolation and transcriptome analysis of serum microvesicles

(2009) Chihchen Chen et al.   LAB ON A CHIP

Differential DJ-1 gene expression in Parkinson's disease

(2009) Ravindran Kumaran et al.   NEUROBIOLOGY OF DISEASE

Debris clearance by microglia: an essential link between degeneration and regeneration

(2008) H. Neumann et al.   BRAIN

LRRK2 regulates synaptic vesicle endocytosis

(2008) Narae Shin et al.   EXPERIMENTAL CELL RESEARCH

Wild Type α-Synuclein Is Degraded by Chaperone-mediated Autophagy and Macroautophagy in Neuronal Cells

(2008) Tereza Vogiatzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted Overexpression of Human α-Synuclein Triggers Microglial Activation and an Adaptive Immune Response in a Mouse Model of Parkinson Disease

(2008) Shaji Theodore et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY