Review
Pharmacology & Pharmacy
Jinxin Tang, Jieyu He, Chengyao Feng, Chao Tu
Summary: MiRNAs are non-coding RNA molecules that play important roles in cancer. Recent studies have shown that exosomal miRNAs play crucial roles in tumor initiation and progression, and have potential diagnostic and therapeutic functions.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Nasrin Ahangar Davoodi, Sajad Najafi, Zari Naderi Ghale-Noie, Ashkan Piranviseh, Samaneh Mollazadeh, Sahar Ahmadi Asouri, Zatollah Asemi, Mohammadamin Morshedi, Seyed Saeed Tamehri Zadeh, Michael R. Hamblin, Amirhossein Sheida, Hamed Mirzaei
Summary: Retinoblastoma (RB) is a rare aggressive intraocular malignancy of childhood that can have severe consequences. Non-coding RNAs (ncRNAs) play important roles in the pathogenesis and development of RB, with different ncRNAs acting as either tumor promoters or suppressors. Understanding the regulatory mechanisms of ncRNAs provides new opportunities for RB therapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Oncology
Shenqi Han, Yongqiang Qi, Yiming Luo, Xiaoping Chen, Huifang Liang
Summary: Exosomal lncRNAs, derived from both cancer cells and stromal cells, play a crucial role in promoting cancer progression by regulating gene expression and mediating the formation of pre-metastatic niches. Understanding the functions of exosomal lncRNAs in cancer development will provide valuable insights for cancer treatment strategies.
FRONTIERS IN ONCOLOGY
(2021)
Review
Multidisciplinary Sciences
Zicong Wang, Wei Tan, Bingyan Li, Jingling Zou, Yun Li, Yangyan Xiao, Yan He, Shigeo Yoshida, Yedi Zhou
Summary: Exosomes, as extracellular vesicles produced by cells, play important roles in intercellular communication and various biological activities. Non-coding RNAs (ncRNAs) can regulate gene expression without encoding proteins. In the context of angiogenesis, abnormal expression of ncRNAs in exosomes can contribute to the development of diseases. This review discusses the physiological and pathological functions of exosomal ncRNAs in angiogenesis, their roles in angiogenesis-related diseases, and their potential applications in drug therapy and diagnostics.
Review
Immunology
Ri Zhang, Yujia Wei, Tingmei Wang, Xiaoqi Nie, Zeqi Shi, Yunhua Deng, Dong Li
Summary: Exosomes, small vesicles coated with phospholipids, are released by cells and contain miRNA that plays a significant role in the pathogenesis of autoimmune skin diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, Research & Experimental
Chuanyun Li, Tong Zhou, Jing Chen, Rong Li, Huan Chen, Shumin Luo, Dexi Chen, Cao Cai, Weihua Li
Summary: Exosomal miRNAs play a critical role in regulating genes and their altered expression is associated with almost all human cancers. They modulate processes that interfere with cancer immunity and microenvironment, and significantly impact tumor growth, invasion, metastasis, angiogenesis, and drug resistance. Understanding the detailed mechanisms of miRNAs in cancer development could contribute to both cancer treatment and prevention of malignant diseases. This review highlights recent advances in cancer-derived exosomal miRNAs, including their sorting and delivery mechanisms, as well as their potential as diagnostic and prognostic markers and in detecting cancer resistance to therapeutic agents.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Review
Oncology
Maryam Hashemipour, Homa Boroumand, Samaneh Mollazadeh, Vida Tajiknia, Zahra Nourollahzadeh, Mina Rohani Borj, Hossein Pourghadamyari, Neda Rahimian, Michael R. Hamblin, Hamed Mirzaei
Summary: miRNAs and lncRNAs play essential biological roles through various mechanisms, regulating gene expression and driving pathways in gynecological cancers. Exosomes serve as natural carriers of non-coding RNAs, focusing research on exosomal microRNAs and long non-coding RNAs for potential therapeutic applications.
GYNECOLOGIC ONCOLOGY
(2021)
Review
Neurosciences
Omid Mohamadzadeh, Mahsasadat Hajinouri, Farzaneh Moammer, Seyed Saeed Tamehri Zadeh, Ghoncheh Omid Shafiei, Ameneh Jafari, Amirreza Ostadian, Sayyed Alireza Talaei Zavareh, Michael R. Hamblin, Arezoo Jafarian Yazdi, Amirhossein Sheida, Hamed Mirzaei
Summary: Nowadays, traumatic brain injury (TBI) is a global concern due to its significant morbidity and long-term consequences that are not fully understood. Cellular pathways such as free radical production, excitotoxicity, apoptosis, and neuroinflammatory responses have been identified in TBI. Non-coding RNAs (ncRNAs) have been found to play a crucial role in post-transcriptional regulation in the brain, and altered levels of ncRNA expression have been observed in both traumatic and non-traumatic brain injuries. This review provides an overview of the primary molecular mechanisms involved in TBI and discusses the latest findings on changes and the role of ncRNAs in TBI from both clinical and experimental research.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jingru Li, Haocheng Ma, Xinyu Wu, Guihu Sun, Ping Yang, Yunzhu Peng, Qixian Wang, Luqiao Wang
Summary: This analytical review provides an overview of the role of non-exosomal non-coding RNAs (non-exo-ncRNAs) and exosomal ncRNAs (exo-ncRNAs) in the pathological development of myocardial infarction (MI). The study comprehensively describes the expression profile, ceRNA network, and biomarkers of non-exo/exo-ncRNAs for MI, and reveals their novel biological correlations through bioinformatics analysis. The findings propose an updated and comprehensive view on the mechanisms, pathophysiology, and biomarker roles of non-exo/exo-ncRNAs in MI, providing a theoretical basis for the clinical management of MI.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2023)
Review
Pathology
Marzie Tabatabaie Nezhad Nezhad, Mohammadreza Rajabi, Pegah Nekooeizadeh, Siavash Sanjari, Bita Pourvirdi, Mohammad Mehdi Heidari, Pegah Veradi Esfahani, Amirhossein Abdoli, Sahar Bagheri, Mohammad Tobeiha
Summary: Systemic lupus erythematosus (SLE), an immunological illness, affects young females and is influenced by individual differences in non-coding RNA expression. Dysregulation of several non-coding RNAs is observed in SLE patients, making them valuable biomarkers for treatment response, diagnosis, and disease activity. Non-coding RNAs also impact immune cell activity and apoptosis, highlighting the need for further investigation. This review summarizes the role of various non-coding RNAs and exosomal non-coding RNAs in SLE.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Review
Biochemistry & Molecular Biology
Shahzad Nawaz Syed, Bernhard Bruene
Summary: This review discusses the potential of MicroRNAs as tools for cancer diagnosis, prognosis, and therapy. The release of miRs into the tumor microenvironment can have both pro- and anti-tumor effects, depending on their source and target cells. The understanding of exosomal and non-exosomal miRs in cancer has provided new insights for potential therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Ya-Ting Chuang, Jen-Yang Tang, Jun-Ping Shiau, Ching-Yu Yen, Fang-Rong Chang, Kun-Han Yang, Ming-Feng Hou, Ammad Ahmad Farooqi, Hsueh-Wei Chang
Summary: Cancer cells produce exosomes to regulate cell functions for tumor progression, and the modulation of exosome processing by natural products is not well understood. This review focuses on the organization of cancer-derived exosomal miRNAs and their processing and cell functions modulation by natural products. It provides a comprehensive understanding of the potential mechanisms and targets for exosome processing and cancer cell functions by natural products.
Review
Cell Biology
Jia Feng, Yifan Zhang, Zhihan Zhu, Chenyang Gu, Ahmed Waqas, Lukui Chen
Summary: Exosomes, as intracellular mediators, have been implicated in the pathophysiological processes of various diseases, including spinal cord injury. They are considered to potentially play a significant role in the treatment of SCI.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biology
Patricia Petrouskova, Nikola Hudakova, Marcela Maloveska, Filip Humenik, Dasa Cizkova
Summary: This review summarizes the research progress on miRNAs as biomarkers of canine mammary cancer, including miRNAs from non-exosomal sources and from exosomes. Some of the miRNAs may be considered potential disease-specific biomarkers in both CMC and HBC.
Review
Biochemistry & Molecular Biology
Meng-Shin Shiao, Jia-Ming Chang, Arb-Aroon Lertkhachonsuk, Naparat Rermluk, Natini Jinawath
Summary: Early detection of EOC is crucial for improving survival rates. Exosomal miRNAs show promise as non-invasive biomarkers for early cancer detection, but stability, sensitivity, and selection of endogenous reference miRNAs are important considerations. Current clinical trials using miRNAs for EOC detection suggest their potential utility in the future.
Article
Medicine, Research & Experimental
Binglin Yue, Jian Wang, Wenxiu Ru, Jiyao Wu, Xiukai Cao, Haiyan Yang, Yongzheng Huang, Xianyong Lan, Chuzhao Lei, Bizhi Huang, Hong Chen
MOLECULAR THERAPY-NUCLEIC ACIDS
(2020)
Article
Biochemistry & Molecular Biology
Hui-Zeng Sun, Zhi Zhu, Mi Zhou, Jian Wang, Michael E. R. Dugan, Le Luo Guan
Summary: This study utilized a large dataset to analyze alternative splicing (AS) events in four tissues, explored AS events related to healthy/unhealthy FA ratio, DE genes, co-expressed genes, and their functions in these tissues. Eight key genes were identified through integrated analysis of DE, co-expressed, and AS genes between animals with high and low healthy/unhealthy FA ratios.
Review
Biochemistry & Molecular Biology
Wenxiu Ru, Xiaoyan Zhang, Binglin Yue, Ao Qi, Xuemei Shen, Yongzhen Huang, Xianyong Lan, Chuzhao Lei, Hong Chen
Article
Biochemistry & Molecular Biology
Binglin Yue, Haiyan Yang, Jiyao Wu, Jian Wang, Wenxiu Ru, Jie Cheng, Yongzheng Huang, Chuzhao Lei, Xianyong Lan, Hong Chen
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biology
Binglin Yue, Haiyan Yang, Jiyao Wu, Jian Wang, Wenxiu Ru, Jie Cheng, Yongzheng Huang, Xianyong Lan, Chuzhao Lei, Hong Chen
Summary: Circular RNA circSVIL promotes bovine myoblast proliferation and inhibits apoptosis, by interacting with STAT1 to inhibit its phosphorylation and affect downstream signaling cascade.
SCIENCE CHINA-LIFE SCIENCES
(2022)
Article
Agriculture, Dairy & Animal Science
Wenxiu Ru, Ao Qi, Xuemei Shen, Binglin Yue, Xiaoyan Zhang, Jian Wang, Hui Cao, Hong Chen
Summary: The study identified circCPE as a regulator in promoting bovine myoblast proliferation and inhibiting apoptosis and differentiation, potentially through a miR138-mediated mechanism. Overexpression of circCPE was shown to attenuate skeletal muscle regeneration in vivo, shedding light on its role in myogenesis.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jian Wang, Bing-Lin Yue, Yong-Zhen Huang, Xian-Yong Lan, Wu-Jun Liu, Hong Chen
Summary: Exosomes, as a type of cell-to-cell communication tool, carry specific RNAs that can be used as diagnostic markers for diseases. The stability and detectability of exosomal RNAs in various biofluids make them ideal biomarkers. However, the knowledge of exosomal biomarkers is still limited.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Binglin Yue, Hui Wang, Xin Cai, Jiabo Wang, Zhixin Chai, Wei Peng, Shi Shu, Changqi Fu, Jincheng Zhong
Summary: Adipose tissue-secreted exosomes play a significant role in the intercellular communication between organs, especially with skeletal muscle. These exosomes transfer various molecules that can affect the physiological and pathological processes in recipient cells. Therefore, studying the regulatory mechanisms of adipose-secreted exosomes and their cellular crosstalk with skeletal muscle is of great importance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Cuicui Cai, Yuan Yue, Binglin Yue
Summary: Skeletal muscle, derived from paraxial mesodermal somites, is the most extensive tissue in mammals and undergoes hyperplasia and hypertrophy to form functional muscle fibers. Characterizing the cellular heterogeneity and transcriptional signatures of skeletal muscle is crucial for understanding its development. Single-cell sequencing technology has enabled the exploration of skeletal muscle cell types and molecular events, providing insights into skeletal muscle pathophysiology.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Xin-Xin Li, Lu-Xuan Yang, Chuang Wang, Hui Li, De-Shun Shi, Jian Wang
Summary: Exosomal proteins, as one of the major components of extracellular vesicles, have been found to have various roles in the development of diseases including carcinoma, sarcoma, melanoma, neurological disorders, immune responses, cardiovascular diseases, and infection. Understanding the functions and mechanisms of exosomal proteins could potentially aid in clinical diagnosis and targeted therapy. However, current knowledge in this field is still limited.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Youzhualamu Yang, Wei Peng, Xiaolong Su, Binglin Yue, Shi Shu, Jikun Wang, Changqi Fu, Jincheng Zhong, Hui Wang
Summary: SIRT1 overexpression inhibits lipid deposition and promotes differentiation in yak intramuscular preadipocytes (YIMAs). Through mRNA-seq and ChIP-seq assays, SIRT1 targets and the epigenetic role of SIRT1 in YIMA adipogenesis were revealed. The study provides insights into the molecular mechanism of intramuscular fat content deposition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
