Discovery of High-Affinity Amyloid Ligands Using a Ligand-Based Virtual Screening Pipeline

Near-infrared fluorescence lifetime imaging of amyloid-β aggregates and tau fibrils through the intact skull of mice

(2023) Steven S. Hou et al.   Nature Biomedical Engineering

A rational design to improve selective imaging of tau aggregates by constructing side substitution on N,N-dimethylaniline/quinoxaline D-π-A fluorescent probe

(2023) Ying Tu et al.   SENSORS AND ACTUATORS B-CHEMICAL

Rational Design of Quinoxalinone-Based Red-Emitting Probes for High-Affinity and Long-Term Visualizing Amyloid-β In Vivo

(2022) Xin-Yao Liu et al.   ANALYTICAL CHEMISTRY

Design and Development of Benzothiazole-Based Fluorescent Probes for Selective Detection of Aβ Aggregates in Alzheimer’s Disease

(2022) Rathnam Mallesh et al.   ACS Chemical Neuroscience

D-π-A-Based Trisubstituted Alkenes as Environmentally Sensitive Fluorescent Probes to Detect Lewy Pathologies

(2022) Qi Zeng et al.   ANALYTICAL CHEMISTRY

Structure–Activity Relationships of Styrylquinoline and Styrylquinoxaline Derivatives as α-Synuclein Imaging Probes

(2022) Kohei Nakagawa et al.   ACS Medicinal Chemistry Letters

Rational design of molecular rotor-based fluorescent probes with bi-aromatic rings for efficient in vivo detection of amyloid-β plaques in Alzheimer's disease

(2022) Nan Yue et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Application of a novel coumarin-derivative near-infrared fluorescence probe to amyloid-β imaging and inhibition in Alzheimer's disease

(2022) Xian Chen et al.   JOURNAL OF LUMINESCENCE

The Cryo-EM Effect: Structural Biology of Neurodegenerative Disease Aggregates

(2021) Benjamin C Creekmore et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Cryptic Sites in Tau Fibrils Explain the Preferential Binding of the AV-1451 PET Tracer toward Alzheimer’s Tauopathy

(2021) N. Arul Murugan et al.   ACS Chemical Neuroscience

Clinical diagnosis of Alzheimer's disease: recommendations of the International Working Group

(2021) Bruno Dubois et al.   LANCET NEUROLOGY

Evaluation of N, O-Benzamide difluoroboron derivatives as near-infrared fluorescent probes to detect β-amyloid and tau tangles

(2021) Yimin Chen et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Picomolar-sensitive β-amyloid fibril fluorophores by tailoring the hydrophobicity of biannulated π-elongated dioxaborine-dyes

(2021) Jusung An et al.   Bioactive Materials

Next generation 3D pharmacophore modeling

(2020) David Schaller et al.   Wiley Interdisciplinary Reviews-Computational Molecular Science

PyrPeg, a Blood-Brain Barrier-Penetrating Two-Photon Imaging Probe, Selectively Detects Neuritic Plaques, not Tau Aggregates

(2020) Ji-Woo Choi et al.   ACS Chemical Neuroscience

[11C]MODAG-001—towards a PET tracer targeting α-synuclein aggregates

(2020) Laura Kuebler et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Causes and Patterns of Dementia: An Update in the Era of Redefining Alzheimer's Disease

(2019) Bryan D. James et al.   Annual Review of Public Health

Rational Design of Near-Infrared AIE-Active Probes: In Situ Mapping of Amyloid-β Plaques with Ultra-Sensitivity and High-Fidelity

(2019) Wei Fu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

What is the Physiological Function of Amyloid-Beta Protein?

(2019) John E. Morley et al.   Journal of Nutrition Health & Aging

Phenolic Bis-styrylbenzo[c]-1,2,5-thiadiazoles as Probes for Fluorescence Microscopy Mapping of Aβ Plaque Heterogeneity

(2019) Jun Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Light and Dark Sides of Virtual Screening: What Is There to Know?

(2019) Aleix Gimeno et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Propagation of Protein Aggregation in Neurodegenerative Diseases

(2019) Jaime Vaquer-Alicea et al.   Annual Review of Biochemistry

Concepts of Artificial Intelligence for Computer-Assisted Drug Discovery

(2019) Xin Yang et al.   CHEMICAL REVIEWS

The neuropathological diagnosis of Alzheimer’s disease

(2019) Michael A. DeTure et al.   Molecular Neurodegeneration

Advances in the development of imaging probes and aggregation inhibitors for alpha-synuclein

(2019) Ming-ming Xu et al.   ACTA PHARMACOLOGICA SINICA

Interrogating Amyloid Aggregates using Fluorescent Probes

(2019) Amir Aliyan et al.   CHEMICAL REVIEWS

Diagnosis and Management of Dementia: Review

(2019) Zoe Arvanitakis et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Alpha Synuclein Fibrils Contain Multiple Binding Sites for Small Molecules

(2018) Chia-Ju Hsieh et al.   ACS Chemical Neuroscience

Different Positron Emission Tomography Tau Tracers Bind to Multiple Binding Sites on the Tau Fibril: Insight from Computational Modeling

(2018) N. Arul Murugan et al.   ACS Chemical Neuroscience

Structure–Property Relationships of Polyethylene Glycol Modified Fluorophore as Near-Infrared Aβ Imaging Probes

(2018) Kaixiang Zhou et al.   ANALYTICAL CHEMISTRY

Conversion of iodine to fluorine-18 based on iodinated chalcone and evaluation for β-amyloid PET imaging

(2018) Sho Kaide et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Detection and Imaging of Aβ1-42 and Tau Fibrils by Redesigned Fluorescent X-34 Analogues

(2018) Jun Zhang et al.   CHEMISTRY-A EUROPEAN JOURNAL

A Systematic Review and Meta-Analysis of the Effectiveness of Acetylcholinesterase Inhibitors and Memantine in Treating the Cognitive Symptoms of Dementia

(2018) Ruth Knight et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

In silico, in vitro and in vivo evaluation of new candidates for alpha-synuclein PET imaging

(2018) Mathieu Verdurand et al.   MOLECULAR PHARMACEUTICS

Fluorescent Imaging of β-Amyloid Using BODIPY Based Near-Infrared Off–On Fluorescent Probe

(2018) Wenming Ren et al.   BIOCONJUGATE CHEMISTRY

Synthesis and evaluation of 1,2,3,4-tetrahydro-1-acridone analogues as potential dual inhibitors for amyloid-beta and tau aggregation

(2018) Peng Lv et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Intramolecular proton and charge transfer of pyrene-based trans-stilbene salicylic acids applied to detection of aggregated proteins

(2018) Jun Zhang et al.   CHEMPHYSCHEM

Amyloid-β Positron Emission Tomography Imaging Probes: A Critical Review

(2018) Vladimir Kepe et al.   JOURNAL OF ALZHEIMERS DISEASE

A new era for understanding amyloid structures and disease

(2018) Matthew G. Iadanza et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Advances in the Development of Shape Similarity Methods and Their Application in Drug Discovery

(2018) Ashutosh Kumar et al.   Frontiers in Chemistry

Molecular Imaging of β-Amyloid Plaques with Near-Infrared Boron Dipyrromethane (BODIPY)-Based Fluorescent Probes

(2018) Hiroyuki Watanabe et al.   Molecular Imaging

The Binding of BF-227-Like Benzoxazoles to Human α-Synuclein and Amyloid β Peptide Fibrils

(2018) Lee Josephson et al.   Molecular Imaging

Machine Learning-based Virtual Screening and Its Applications to Alzheimer’s Drug Discovery: A Review

(2018) Kristy A. Carpenter et al.   CURRENT PHARMACEUTICAL DESIGN

ChEMBL: towards direct deposition of bioassay data

(2018) David Mendez et al.   NUCLEIC ACIDS RESEARCH

Protein misfolding in neurodegenerative diseases: implications and strategies

(2017) Patrick Sweeney et al.   Translational Neurodegeneration

Selective Interaction of Lansoprazole and Astemizole with Tau Polymers: Potential New Clinical Use in Diagnosis of Alzheimer's Disease

(2017) Leonel E. Rojo et al.   JOURNAL OF ALZHEIMERS DISEASE

Candidate PET Radioligand Development for Neurofibrillary Tangles: Two Distinct Radioligand Binding Sites Identified in Postmortem Alzheimer’s Disease Brain

(2016) Lisheng Cai et al.   ACS Chemical Neuroscience

A Smart Near-Infrared Fluorescence Probe for Selective Detection of Tau Fibrils in Alzheimer’s Disease

(2016) Yujin Seo et al.   ACS Chemical Neuroscience

Optically Pure Diphenoxy Derivatives as More Flexible Probes for β-Amyloid Plaques

(2016) Jianhua Jia et al.   ACS Chemical Neuroscience

Advances in development of fluorescent probes for detecting amyloid-β aggregates

(2016) Ming-ming Xu et al.   ACTA PHARMACOLOGICA SINICA

Amyloid-β Deposits Target Efficient Near-Infrared Fluorescent Probes: Synthesis, in Vitro Evaluation, and in Vivo Imaging

(2016) Hualong Fu et al.   ANALYTICAL CHEMISTRY

A theranostic agent for in vivo near-infrared imaging of β-amyloid species and inhibition of β-amyloid aggregation

(2016) Yinhui Li et al.   BIOMATERIALS

18F-Labeled Benzyldiamine Derivatives as Novel Flexible Probes for Positron Emission Tomography of Cerebral β-Amyloid Plaques

(2016) Zijing Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

What amyloid ligands can tell us about molecular polymorphism and disease

(2016) Harry LeVine et al.   NEUROBIOLOGY OF AGING

Structure–activity relationships of radioiodinated diphenyl derivatives with different conjugated double bonds as ligands for α-synuclein aggregates

(2016) Masahiro Ono et al.   RSC Advances

A High Affinity Red Fluorescence and Colorimetric Probe for Amyloid β Aggregates

(2016) K. Rajasekhar et al.   Scientific Reports

In Vivo Detection of Cerebral Amyloid Fibrils with Smart Dicynomethylene-4H-Pyran-Based Fluorescence Probe

(2015) Yan Cheng et al.   ANALYTICAL CHEMISTRY

Development of alkoxy styrylchromone derivatives for imaging of cerebral amyloid-β plaques with SPECT

(2015) Takeshi Fuchigami et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A pyrane based fluorescence probe for noninvasive prediction of cerebral β-amyloid fibrils

(2015) Yan Cheng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

In vivo fluorescence imaging of β-amyloid plaques with push–pull dimethylaminothiophene derivatives

(2015) Hiroyuki Watanabe et al.   CHEMICAL COMMUNICATIONS

Diarylethene based fluorescent switchable probes for the detection of amyloid-β pathology in Alzheimer's disease

(2015) Guanglei Lv et al.   CHEMICAL COMMUNICATIONS

The synthesis and evaluation of near-infrared probes with barbituric acid acceptors for in vivo detection of amyloid plaques

(2015) Kaixiang Zhou et al.   CHEMICAL COMMUNICATIONS

Preliminary evaluation of fluoro-pegylated benzyloxybenzenes for quantification of β-amyloid plaques by positron emission tomography

(2015) Yanping Yang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

ZINC 15 – Ligand Discovery for Everyone

(2015) Teague Sterling et al.   Journal of Chemical Information and Modeling

Design, Synthesis, and Characterization of 3-(Benzylidene)indolin-2-one Derivatives as Ligands for α-Synuclein Fibrils

(2015) Wenhua Chu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Highly Sensitive Near-Infrared Fluorophores for in Vivo Detection of Amyloid-β Plaques in Alzheimer’s Disease

(2015) Hualong Fu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Two-Photon Absorbing Dyes with Minimal Autofluorescence in Tissue Imaging: Application to in Vivo Imaging of Amyloid-β Plaques with a Negligible Background Signal

(2015) Dokyoung Kim et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis and biological evaluation of 123I-labeled pyridyl benzoxazole derivatives: novel β-amyloid imaging probes for single-photon emission computed tomography

(2015) Hiroyuki Watanabe et al.   RSC Advances

Preliminary Characterization and In Vivo Studies of Structurally Identical 18F- and 125I-Labeled Benzyloxybenzenes for PET/SPECT Imaging of β-Amyloid Plaques

(2015) Yanping Yang et al.   Scientific Reports

Phase 3 Trial of Flutemetamol Labeled With Radioactive Fluorine 18 Imaging and Neuritic Plaque Density

(2015) Craig Curtis et al.   JAMA Neurology

High Affinity Radiopharmaceuticals Based Upon Lansoprazole for PET Imaging of Aggregated Tau in Alzheimer’s Disease and Progressive Supranuclear Palsy: Synthesis, Preclinical Evaluation, and Lead Selection

(2014) Maria V. Fawaz et al.   ACS Chemical Neuroscience

Evaluation of molecules based on the electron donor–acceptor architecture as near-infrared β-amyloidal-targeting probes

(2014) Hualong Fu et al.   CHEMICAL COMMUNICATIONS

Novel 18F-labeled dibenzylideneacetone derivatives as potential positron emission tomography probes for in vivo imaging of β-amyloid plaques

(2014) Zijing Li et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Radioiodinated Benzyloxybenzene Derivatives: A Class of Flexible Ligands Target to β-Amyloid Plaques in Alzheimer’s Brains

(2014) Yanping Yang et al.   JOURNAL OF MEDICINAL CHEMISTRY

In Vivo SPECT Imaging of Amyloid-  Deposition with Radioiodinated Imidazo[1,2-a]Pyridine Derivative DRM106 in a Mouse Model of Alzheimer's Disease

(2014) C.-J. Chen et al.   JOURNAL OF NUCLEAR MEDICINE

Smart Near-Infrared Fluorescence Probes with Donor–Acceptor Structure for in Vivo Detection of β-Amyloid Deposits

(2014) Mengchao Cui et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Designing BODIPY-based probes for fluorescence imaging of β-amyloid plaques

(2014) Fazli Sozmen et al.   RSC Advances

Synthesis and biological evaluation of novel styryl benzimidazole derivatives as probes for imaging of neurofibrillary tangles in Alzheimer’s disease

(2013) Kenji Matsumura et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and biological evaluation of 18F-labled 2-phenylindole derivatives as PET imaging probes for β-amyloid plaques

(2013) Hualong Fu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Hit Identification and Optimization in Virtual Screening: Practical Recommendations Based on a Critical Literature Analysis

(2013) Tian Zhu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel 18F-Labeled Arylquinoline Derivatives for Noninvasive Imaging of Tau Pathology in Alzheimer Disease

(2013) N. Okamura et al.   JOURNAL OF NUCLEAR MEDICINE

Use of a Benzimidazole Derivative BF-188 in Fluorescence Multispectral Imaging for Selective Visualization of Tau Protein Fibrils in the Alzheimer’s Disease Brain

(2013) Ryuichi Harada et al.   MOLECULAR IMAGING AND BIOLOGY

Binding of the Radioligand SIL23 to α-Synuclein Fibrils in Parkinson Disease Brain Tissue Establishes Feasibility and Screening Approaches for Developing a Parkinson Disease Imaging Agent

(2013) Devika P. Bagchi et al.   PLoS One

Development of Novel 123I-Labeled Pyridyl Benzofuran Derivatives for SPECT Imaging of β-Amyloid Plaques in Alzheimer’s Disease

(2013) Masahiro Ono et al.   PLoS One

Proliferation of amyloid- 42 aggregates occurs through a secondary nucleation mechanism

(2013) S. I. A. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Novel radioiodinated 1,3,4-oxadiazole derivatives with improved in vivo properties for SPECT imaging of β-amyloid plaques

(2013) Hiroyuki Watanabe et al.   MedChemComm

Structure–Activity Relationships and in Vivo Evaluation of Quinoxaline Derivatives for PET Imaging of β-Amyloid Plaques

(2013) Masashi Yoshimura et al.   ACS Medicinal Chemistry Letters

BODIPY-Based Molecular Probe for Imaging of Cerebral β-Amyloid Plaques

(2012) Masahiro Ono et al.   ACS Chemical Neuroscience

Synthesis and biological evaluation of novel oxindole derivatives for imaging neurofibrillary tangles in Alzheimer’s disease

(2012) Hiroyuki Watanabe et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

18F-Labeled 2-phenylquinoxaline derivatives as potential positron emission tomography probes for in vivo imaging of β-amyloid plaques

(2012) Pingrong Yu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and biological evaluation of radioiodinated quinacrine-based derivatives for SPECT imaging of Aβ plaques

(2012) Takeshi Fuchigami et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Aβ Imaging: feasible, pertinent, and vital to progress in Alzheimer’s disease

(2012) Victor L. Villemagne et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Comparison of the binding characteristics of [18F]THK-523 and other amyloid imaging tracers to Alzheimer’s disease pathology

(2012) Ryuichi Harada et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Novel 18F-Labeled Benzoxazole Derivatives as Potential Positron Emission Tomography Probes for Imaging of Cerebral β-Amyloid Plaques in Alzheimer’s Disease

(2012) Mengchao Cui et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Evaluation of Novel 18F Labeled 2-Pyridinylbenzoxazole and 2-Pyridinylbenzothiazole Derivatives as Ligands for Positron Emission Tomography (PET) Imaging of β-Amyloid Plaques

(2012) Mengchao Cui et al.   JOURNAL OF MEDICINAL CHEMISTRY

In vitro characterization of [18F]-florbetaben, an Aβ imaging radiotracer

(2012) Michelle T. Fodero-Tavoletti et al.   NUCLEAR MEDICINE AND BIOLOGY

Development of Positron Emission Tomography β-Amyloid Plaque Imaging Agents

(2012) Chester A. Mathis et al.   SEMINARS IN NUCLEAR MEDICINE

ANCA: A Family of Fluorescent Probes that Bind and Stain Amyloid Plaques in Human Tissue

(2011) Willy M. Chang et al.   ACS Chemical Neuroscience

Rhodanine and Thiohydantoin Derivatives for Detecting Tau Pathology in Alzheimer’s Brains

(2011) Masahiro Ono et al.   ACS Chemical Neuroscience

Bivalent Ligand Containing Curcumin and Cholesterol as a Fluorescence Probe for Aβ Plaques in Alzheimer’s Disease

(2011) Kai Liu et al.   ACS Chemical Neuroscience

Amyloid Precursor Protein Processing and Alzheimer's Disease

(2011) Richard J. O'Brien et al.   Annual Review of Neuroscience

Synthesis and evaluation of benzofuran-2-yl(phenyl)methanone derivatives as ligands for β-amyloid plaques

(2011) Mengchao Cui et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Aromatic radiofluorination and biological evaluation of 2-aryl-6-[18F]fluorobenzothiazoles as a potential positron emission tomography imaging probe for β-amyloid plaques

(2011) Byung Chul Lee et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and in vitro evaluation of fluorinated styryl benzazoles as amyloid-probes

(2011) Goreti Ribeiro Morais et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel quinoxaline derivatives for in vivo imaging of β-amyloid plaques in the brain

(2011) Mengchao Cui et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and evaluation of 1-(4-[18F]fluoroethyl)-7-(4′-methyl)curcumin with improved brain permeability for β-amyloid plaque imaging

(2011) Iljung Lee et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A dual fluorinated and iodinated radiotracer for PET and SPECT imaging of β-amyloid plaques in the brain

(2011) Hiroyuki Watanabe et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease

(2011) M. T. Fodero-Tavoletti et al.   BRAIN

State-of-the-art in ligand-based virtual screening

(2011) Peter Ripphausen et al.   DRUG DISCOVERY TODAY

Amyloid imaging

(2011) Victor L. Villemagne et al.   INTERNATIONAL PSYCHOGERIATRICS

Use of Florbetapir-PET for Imaging β-Amyloid Pathology

(2011) Christopher M. Clark   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Novel18F-Labeled Benzofuran Derivatives with Improved Properties for Positron Emission Tomography (PET) Imaging of β-Amyloid Plaques in Alzheimer’s Brains

(2011) Masahiro Ono et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Structure−Affinity Relationships of Novel Dibenzylideneacetone Derivatives as Probes for β-Amyloid Plaques

(2011) Mengchao Cui et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Evaluation of11C-Labeled Imidazo[2,1-b]benzothiazoles (IBTs) as PET Tracers for Imaging β-Amyloid Plaques in Alzheimer’s Disease

(2011) Behrooz H. Yousefi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Phenyldiazenyl benzothiazole derivatives as probes for in vivo imaging of neurofibrillary tangles in Alzheimer's disease brains

(2011) Kenji Matsumura et al.   MedChemComm

18F-Labeled Phenyldiazenyl Benzothiazole for in Vivo Imaging of Neurofibrillary Tangles in Alzheimer's Disease Brains

(2011) Kenji Matsumura et al.   ACS Medicinal Chemistry Letters

Synthesis and characterization of novel phenylindoles as potential probes for imaging of β-amyloid plaques in the brain

(2010) Hiroyuki Watanabe et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and evaluation of novel benzothiazole derivatives based on the bithiophene structure as potential radiotracers for β-amyloid plaques in Alzheimer’s disease

(2010) Meng-Chao Cui et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A novel 18F-labeled pyridyl benzofuran derivative for imaging of β-amyloid plaques in Alzheimer’s brains

(2010) Yan Cheng et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Development of dual functional SPECT/fluorescent probes for imaging cerebral β-amyloid plaques

(2010) Masahiro Ono et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis and biological evaluation of indole-chalcone derivatives as β-amyloid imaging probe

(2010) Mengchao Cui et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of Functionalized Benzoxazoles and Their Binding Affinities to A β42 Fibrils

(2010)   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Binding research on flavones as ligands of β-amyloid aggregates by fluorescence and their 3D-QSAR, docking studies

(2010) Yang Yang et al.   JOURNAL OF MOLECULAR GRAPHICS & MODELLING

Radioiodinated benzimidazole derivatives as single photon emission computed tomography probes for imaging of β-amyloid plaques in Alzheimer's disease

(2010) Mengchao Cui et al.   NUCLEAR MEDICINE AND BIOLOGY

Fluorinated Benzofuran Derivatives for PET Imaging of β-Amyloid Plaques in Alzheimer's Disease Brains

(2010) Yan Cheng et al.   ACS Medicinal Chemistry Letters

Novel Radioiodinated Aurones as Probes for SPECT Imaging of β-Amyloid Plaques in the Brain

(2009) Yoshifumi Maya et al.   BIOCONJUGATE CHEMISTRY

18F-labeled flavones for in vivo imaging of β-amyloid plaques in Alzheimer’s brains

(2009) Masahiro Ono et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and biological evaluation of radioiodinated 2,5-diphenyl-1,3,4-oxadiazoles for detecting β-amyloid plaques in the brain

(2009) Hiroyuki Watanabe et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Push–pull benzothiazole derivatives as probes for detecting β-amyloid plaques in Alzheimer’s brains

(2009) Masahiro Ono et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Rational Design of Amyloid Binding Agents Based on the Molecular Rotor Motif

(2009) Jeyanthy Sutharsan et al.   ChemMedChem

In vitro characterisation of BF227 binding to α-synuclein/Lewy bodies

(2009) Michelle T. Fodero-Tavoletti et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Fluoro-pegylated Chalcones as Positron Emission Tomography Probes for in Vivo Imaging of β-Amyloid Plaques in Alzheimer’s Disease

(2009) Masahiro Ono et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of novel β-amyloid probes based on 3,5-diphenyl-1,2,4-oxadiazole

(2008) Masahiro Ono et al.   BIOORGANIC & MEDICINAL CHEMISTRY

[18F]-labeled isoindol-1-one and isoindol-1,3-dione derivatives as potential PET imaging agents for detection of β-amyloid fibrils

(2008) Ji Hoon Lee et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Curcumin-Derived Pyrazoles and Isoxazoles: Swiss Army Knives or Blunt Tools for Alzheimer's Disease?

(2007) Rajeshwar Narlawar et al.   ChemMedChem