Rational Design of Quinoxalinone-Based Red-Emitting Probes for High-Affinity and Long-Term Visualizing Amyloid-β In Vivo

In Vivo Brain Imaging of Amyloid-β Aggregates in Alzheimer’s Disease with a Near-Infrared Fluorescent Probe

(2021) Jian Wu et al.   ACS Sensors

Donanemab in Early Alzheimer’s Disease

(2021) Mark A. Mintun et al.   NEW ENGLAND JOURNAL OF MEDICINE

Non-invasive recording from the human olfactory bulb

(2020) Behzad Iravani et al.   Nature Communications

Rational Design of a High-Performance Quinoxalinone-Based AIE Photosensitizer for Image-Guided Photodynamic Therapy

(2020) Peng Zhang et al.   ACS Applied Materials & Interfaces

Fluorescent Diagnostic Probes in Neurodegenerative Diseases

(2020) Jin Zhou et al.   ADVANCED MATERIALS

Current strategies for the development of fluorescence-based molecular probes for visualizing the enzymes and proteins associated with Alzheimer’s disease

(2020) Siyue Ma et al.   COORDINATION CHEMISTRY REVIEWS

Rational Design of Near-Infrared AIE-Active Probes: In Situ Mapping of Amyloid-β Plaques with Ultra-Sensitivity and High-Fidelity

(2019) Wei Fu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Harnessing Intramolecular Rotation to Enhance Two-photon Imaging of Aβ Plaques Through Minimizing Background Fluorescence

(2019) Jinwoo Shin et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Environment-Sensitive Near-Infrared Probe for Fluorescent Discrimination of Aβ and Tau Fibrils in AD Brain

(2019) Kaixiang Zhou et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dual-functional red-emitting fluorescent probes for imaging beta-amyloid plaques and viscosity

(2019) Huiya Tan et al.   SENSORS AND ACTUATORS B-CHEMICAL

Cryo-EM structure and polymorphism of Aβ amyloid fibrils purified from Alzheimer’s brain tissue

(2019) Marius Kollmer et al.   Nature Communications

Novel D–A–D based near-infrared probes for the detection of β-amyloid and Tau fibrils in Alzheimer's disease

(2018) Yuying Li et al.   CHEMICAL COMMUNICATIONS

Endoplasmic Reticulum-Targeted Fluorescent Nanodot with Large Stokes Shift for Vesicular Transport Monitoring and Long-Term Bioimaging

(2018) Leilei Shi et al.   Small

Molecular Imaging of β-Amyloid Plaques with Near-Infrared Boron Dipyrromethane (BODIPY)-Based Fluorescent Probes

(2018) Hiroyuki Watanabe et al.   Molecular Imaging

Fibril structure of amyloid-β(1–42) by cryo–electron microscopy

(2017) Lothar Gremer et al.   SCIENCE

Fluoro-substituted cyanine for reliable in vivo labelling of amyloid-β oligomers and neuroprotection against amyloid-β induced toxicity

(2017) Yinhui Li et al.   Chemical Science

Advances in development of fluorescent probes for detecting amyloid-β aggregates

(2016) Ming-ming Xu et al.   ACTA PHARMACOLOGICA SINICA

Imaging of β-amyloid plaques by near infrared fluorescent tracers: a new frontier for chemical neuroscience

(2015) Matteo Staderini et al.   CHEMICAL SOCIETY REVIEWS

Highly Sensitive Near-Infrared Fluorophores for in Vivo Detection of Amyloid-β Plaques in Alzheimer’s Disease

(2015) Hualong Fu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Near-infrared fluorescence molecular imaging of amyloid beta species and monitoring therapy in animal models of Alzheimer’s disease

(2015) Xueli Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peptide dimer structure in an Aβ(1–42) fibril visualized with cryo-EM

(2015) Matthias Schmidt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evaluation of molecules based on the electron donor–acceptor architecture as near-infrared β-amyloidal-targeting probes

(2014) Hualong Fu et al.   CHEMICAL COMMUNICATIONS

PET/SPECT imaging agents for neurodegenerative diseases

(2014) Lin Zhu et al.   CHEMICAL SOCIETY REVIEWS

Smart Near-Infrared Fluorescence Probes with Donor–Acceptor Structure for in Vivo Detection of β-Amyloid Deposits

(2014) Mengchao Cui et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy

(2013) Patrick L. McGeer et al.   ACTA NEUROPATHOLOGICA

BODIPY-Based Molecular Probe for Imaging of Cerebral β-Amyloid Plaques

(2012) Masahiro Ono et al.   ACS Chemical Neuroscience

Dicyanovinylnaphthalenes for neuroimaging of amyloids and relationships of electronic structures and geometries to binding affinities

(2012) A. Petric et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A thienoquinoxaline and a styryl-quinoxaline as new fluorescent probes for amyloid-β fibrils

(2011) Hanane Benzeid et al.   COMPTES RENDUS CHIMIE

Molecular mechanism of Thioflavin-T binding to amyloid fibrils

(2010) Matthew Biancalana et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Synthesis and evaluation of novel benzothiazole derivatives based on the bithiophene structure as potential radiotracers for β-amyloid plaques in Alzheimer’s disease

(2010) Meng-Chao Cui et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel matrix metalloproteinase inhibitors derived from quinoxalinone scaffold (Part I)

(2010) Yonggang Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY

PET imaging of brain amyloid in dementia: a review

(2010) Harriet Quigley et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

The amyloid hypothesis for Alzheimer’s disease: a critical reappraisal

(2009) John Hardy   JOURNAL OF NEUROCHEMISTRY

Design, Synthesis, and Testing of Difluoroboron-Derivatized Curcumins as Near-Infrared Probes for in Vivo Detection of Amyloid-β Deposits

(2009) Chongzhao Ran et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Alzheimer's disease

(2009) Lennart Mucke   NATURE

Smart optical probes for near-infrared fluorescence imaging of Alzheimer’s disease pathology

(2008) Scott B. Raymond et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Synthesis, Photophysical Behavior, and Electronic Structure of Push−Pull Purines

(2008) Roslyn S. Butler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY