Article
Clinical Neurology
Sarah K. Royse, Davneet S. Minhas, Brian J. Lopresti, Alice Murphy, Tyler Ward, Robert A. Koeppe, Santiago Bullich, Susan DeSanti, William J. Jagust, Susan M. Landau
Summary: This study addressed challenges in multisite studies using multiple beta-amyloid radiotracers by deriving standardized Centiloid transformations and internally consistent positivity thresholds for [F-18]florbetaben (FBB) and [F-18]florbetapir (FBP) PET data. The findings demonstrate the feasibility of harmonized PET acquisition and analysis and the internal consistency of positivity thresholds in standardized units, contributing to improved replicability in research and clinical trials.
ALZHEIMERS RESEARCH & THERAPY
(2021)
Article
Neurosciences
Wojciech K. Panek, David M. Murdoch, Margaret E. Gruen, Freya M. Mowat, Robert D. Marek, Natasha J. Olby
Summary: Similar neurological disorders associated with aging, such as Alzheimer's disease and canine cognitive dysfunction syndrome, have been observed in both humans and dogs. The concentrations of A beta 42 and A beta 40 in plasma increase with age in both species, but decrease in individuals with the diseases.
MOLECULAR NEUROBIOLOGY
(2021)
Editorial Material
Neurosciences
Poul F. Hoilund-Carlsen, Mona-Elisabeth Revheim, Abass Alavi, Nagichettiar Satyamurthy, Jorge R. Barrio
Summary: Using amyloid PET imaging as the primary efficacy measure in Alzheimer's disease immunotherapy trials is unjustified due to lack of specificity and questionable quantification models. The FDA should require rigorous evidence and documentation before granting approval to other immunotherapy candidates.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Medicine, General & Internal
Poul F. Hoilund-Carlsen, Mona-Elisabeth Revheim, Tommaso Costa, Kasper P. Kepp, Rudolph J. Castellani, George Perry, Abass Alavi, Jorge R. Barrio
Summary: In June 2021, the FDA accelerated approved aducanumab and in January 2023 also lecanemab, based on perceived drug-induced removal of cerebral amyloid-beta as assessed by amyloid-PET and, in the case of lecanemab, limited clinical efficacy assumption. Approval for donanemab is pending further data. However, published trial data indicate minimal and uncertain clinical benefits, similar to conventional medication. Additionally, amyloid-PET signal decrease may reflect increased cell damage instead of amyloid removal, as supported by increased amyloid-related imaging abnormalities and brain volume loss in treated patients compared to placebo. We also question the current AD diagnostic criteria based on amyloid-PET imaging biomarkers and recommend future anti-AD therapy trials to incorporate (1) diagnosis based on cognitive decline and decreased cerebral metabolism assessed by FDA-approved FDG-PET, (2) therapy efficacy determined by cognitive ability, cerebral metabolism by FDG-PET, and brain volumes by MRI, and (3) neuropathologic examination of all deaths occurring in these trials.
Article
Clinical Neurology
Patrick Oeckl, Marina Bluma, Marco Bucci, Steffen Halbgebauer, Konstantinos Chiotis, Anna Sandebring-Matton, Nicholas J. Ashton, Guglielmo Di Molfetta, Lana Grotschel, Miia Kivipelto, Kaj Blennow, Henrik Zetterberg, Irina Savitcheva, Agneta Nordberg, Markus Otto
Summary: Plasma beta-synuclein levels were found to be higher in individuals with Alzheimer's disease and mild cognitive impairment with amyloid-beta positivity. It demonstrated good discrimination and prediction of amyloid-beta status. The correlation between plasma beta-synuclein and amyloid-beta PET was observed in multiple cortical regions. These findings suggest that beta-synuclein is not a direct marker of amyloid-beta pathology and highlight the different longitudinal dynamics of synaptic degeneration and amyloid deposition in Alzheimer's disease.
ALZHEIMERS & DEMENTIA
(2023)
Article
Medicine, General & Internal
Sung-Eun Chung, Hyung-Ji Kim, Sungyang Jo, Sunju Lee, Yoojin Lee, Jee Hoon Roh, Jae-Hong Lee
Summary: Accumulation of aggregated amyloid-beta (A beta) in the brain is considered the first pathological event within the pathogenesis of Alzheimer's disease (AD). This study found that the posterior cingulate/precuneus and the lateral temporal and parietal cortices may be the earliest areas to be affected by A beta accumulation.
Article
Clinical Neurology
Clifford R. Jack Jr, Heather J. Wiste, Alicia Algeciras-Schimnich, Dan J. Figdore, Christopher G. Schwarz, Val J. Lowe, Vijay K. Ramanan, Prashanthi Vemuri, Michelle M. Mielke, David S. Knopman, Jonathan Graff-Radford, Bradley F. Boeve, Kejal Kantarci, Petrice M. Cogswell, Matthew L. Senjem, Jeffrey L. Gunter, Terry M. Therneau, Ronald C. Petersen
Summary: Staging the severity of Alzheimer's disease pathology is important for therapeutic trials and clinical prognosis. Biomarkers such as amyloid and tau PET can be used for disease staging, but plasma biomarkers would be more practical.
Article
Clinical Neurology
Jay Shah, Fei Gao, Baoxin Li, Valentina Ghisays, Ji Luo, Yinghua Chen, Wendy Lee, Yuxiang Zhou, Tammie L. S. Benzinger, Eric M. Reiman, Kewei Chen, Yi Su, Teresa Wu
Summary: A Residual Inception Encoder-Decoder Neural Network model was developed and validated to harmonize amyloid PET imaging data from different tracers, resulting in significantly stronger correlations between global amyloid burden indices and voxel-wise measurements in both training and testing cohorts. Further investigation is ongoing to improve the model and apply it to additional tracers.
ALZHEIMERS & DEMENTIA
(2022)
Article
Medicine, General & Internal
Shizuo Hatashita, Daichi Wakebe
Summary: This study found that some initially amyloid-negative non-demented subjects converted to globally amyloid-positive during a long-term follow-up, with some association with the APOE epsilon 4 allele. Early regional increases in PIB DVR were most frequently observed in the right lateral temporal cortex.
Article
Clinical Neurology
Qihui Zhang, Xiaobin Zhao, Peng Lei, Hank F. Kung, Zhi Yang, Lin Zhu, Shujing Wang, Hua Zhu, Xiangxi Meng, Yunyun Duan, Li Sun, Jianwei Pan, Ruixue Ma, Haiyan Hong, Xingquan Zhao, Andrew Demchuk, Eric E. Smith, Yongjun Wang
Summary: This study investigated the distribution of the novel PET ligand [68Ga] Ga-p14-032 in patients diagnosed clinically with probable CAA and found that it exhibited stronger cortical retention in CAA patients compared to AD and NC patients. The results suggest that [68Ga] Ga-p14-032 may be a useful tracer for diagnosing CAA by preferentially binding to vascular amyloid.
FRONTIERS IN NEUROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Anne-Cathrine S. Vogt, Gary T. Jennings, Mona O. Mohsen, Monique Vogel, Martin F. Bachmann
Summary: Alzheimer's disease is the most common form of dementia and is responsible for 60-70% of cases. The number of people with dementia is expected to triple by 2050 due to an aging population. Currently, there are only symptomatic treatments available, making it crucial to develop novel therapeutic strategies to prevent or delay the onset of Alzheimer's disease. This mini-review focuses on the understanding of Alzheimer's disease pathobiology and discusses current immunomodulating therapies targeting amyloid-beta protein.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Chemistry, Medicinal
Weimin Qiu, Hui Liu, Yijun Liu, Xin Lu, Lei Wang, Yanyu Hu, Feng Feng, Qi Li, Haopeng Sun
Summary: Alzheimer's disease (AD) is a difficult to treat progressive neurodegenerative disease characterized by the accumulation of amyloid beta (A beta) plaques in the brain. A beta interacts with various receptors on the plasma membrane and mediates signaling pathways that contribute to the development of AD. Despite ongoing research, there are currently no effective medications for AD. This review discusses the importance of A beta in the pathogenesis of AD, recent progress in targeting A beta-related receptors and compounds, and the challenges and opportunities in developing effective therapies for AD.
MEDICINAL RESEARCH REVIEWS
(2023)
Article
Endocrinology & Metabolism
Esen Saka, Lutfiye Ozlem Atay, Umit Ozgur Akdemir, Ezgi Yetim, Erdem Balci, Ethem Murat Arsava, Mehmet Akif Topcuoglu
Summary: This study investigates the relationship between amyloid load and vasomotor reactivity in Alzheimer's disease. The results show a significant negative association between amyloid load and vasomotor reactivity. Additionally, vasomotor reactivity is positively correlated with metabolic activity and cerebral blood flow, and negatively correlated with age and white matter lesion volume.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Review
Clinical Neurology
Lizhen Cheng, Wei Li, Yixin Chen, Yijia Lin, Beiyun Wang, Qihao Guo, Ya Miao
Summary: Plasma A beta 42 values and plasma A beta 42/A beta 40 ratio could serve as independent biomarkers for predicting A beta-PET status, while plasma A beta 40 values may not distinguish between PET (+) and PET (-) individuals.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Neurosciences
Lauren Edwards, Kelsey R. Thomas, Alexandra J. Weigand, Emily C. Edmonds, Alexandra L. Clark, Kayla S. Walker, Einat K. Brenner, Daniel A. Nation, Pauline Maillard, Mark W. Bondi, Katherine J. Bangen
Summary: This study found that white matter hyperintensity (WMH) volume can moderate the association between AD biomarkers and cognition, with a quadratic effect between WMH and A beta on memory; however, there was no interaction between linear or quadratic effects of WMH and A beta on executive function; additionally, there was no interaction between WMH volume and tau-PET on cognitive measures.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Peripheral Vascular Disease
Joong Hyun Kim, Young-Hwa Kim, Young Joo Kim, Bo Yeun Yang, Jae Min Jeong, Hyewon Youn, Dong Soo Lee, Jae Sung Lee
Article
Radiology, Nuclear Medicine & Medical Imaging
Jin Chul Paeng, Yun-Sang Lee, Jae Sung Lee, Jae Min Jeong, Ki-Bong Kim, June-Key Chung, Dong Soo Lee
ANNALS OF NUCLEAR MEDICINE
(2013)
Article
Oncology
Yujin Oh, Yun-Sang Lee, Yu Hua Quan, Yeonho Choi, Jae Min Jeong, Beop-Min Kim, Hyun Koo Kim
ANNALS OF SURGICAL ONCOLOGY
(2014)
Article
Chemistry, Medicinal
Ji Who Kim, Jae Sung Lee, Su Jin Kim, Lathika Hoigebazar, Kwang-Hee Shin, Kyung-Sang Yu, Wonsik Ahn, Jae Min Jeong, Dong Soo Lee
ARCHIVES OF PHARMACAL RESEARCH
(2012)
Article
Biochemistry & Molecular Biology
Dinesh Shetty, Jae Min Jeong, Young Ju Kim, Ji Youn Lee, Lathika Hoigebazar, Yun-Sang Lee, Dong Soo Lee, June-Key Chung
BIOORGANIC & MEDICINAL CHEMISTRY
(2012)
Article
Cardiac & Cardiovascular Systems
Jae Seon Eo, Jin Chul Paeng, Song Lee, Yun-Sang Lee, Jae Min Jeong, Keon Wook Kang, June-Key Chung, Dong Soo Lee
CORONARY ARTERY DISEASE
(2013)
Article
Endocrinology & Metabolism
Euitae Kim, Oliver D. Howes, Bo-Hyung Kim, Jae Min Jeong, Jae Sung Lee, In-Jin Jang, Sang-Goo Shin, Federico E. Turkheimer, Shitij Kapur, Jun Soo Kwon
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2012)
Article
Chemistry, Medicinal
Lathika Hoigebazar, Jae Min Jeong, Ji-Youn Lee, Dinesh Shetty, Bo Yeun Yang, Yun-Sang Lee, Dong Soo Lee, June-Key Chung, Myung Chul Lee
JOURNAL OF MEDICINAL CHEMISTRY
(2012)
Article
Radiology, Nuclear Medicine & Medical Imaging
Young Kyoung Lee, Jae Min Jeong, Lathika Hoigebazar, Bo Yeun Yang, Yun-Sang Lee, Byung Chul Lee, Hyewon Youn, Dong Soo Lee, June-Key Chung, Myung Chul Lee
JOURNAL OF NUCLEAR MEDICINE
(2012)
Article
Biotechnology & Applied Microbiology
Jun Sung Kim, Young-Hwa Kim, Jin Hyun Kim, Keon Wook Kang, Eunju Lee Tae, Hyewon Youn, Daehong Kim, Seok-Ki Kim, Jung-Taek Kwon, Myung-Haing Cho, Yun-Sang Lee, Jae Min Jeong, June-Key Chung, Dong Soo Lee
Article
Radiology, Nuclear Medicine & Medical Imaging
Jong Jin Lee, Dinesh Shetty, Yun-Sang Lee, Sang Eun Kim, Young Joo Kim, Mi Kyung Hong, Ji Yeon Son, Jae Min Jeong
NUCLEAR MEDICINE AND BIOLOGY
(2012)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ji Youn Lee, Jae Min Jeong, Young Ju Kim, Hyuk-Jin Jeong, Yun-Sang Lee, Dong Soo Lee, June-Key Chung
NUCLEAR MEDICINE AND BIOLOGY
(2014)
Article
Multidisciplinary Sciences
Hongyoon Choi, Yu Kyeong Kim, So Won Oh, Hyung-Jun Im, Do Won Hwang, Hyejin Kang, Boeun Lee, Yun-Sang Lee, Jae Min Jeong, E. Edmund Kim, June-Key Chung, Dong Soo Lee
Article
Neurosciences
Euitae Kim, Oliver D. Howes, Federico E. Turkheimer, Bo-Hyung Kim, Jae Min Jeong, Ji Who Kim, Jae Sung Lee, In-Jin Jang, Sang-Goo Shin, Shitij Kapur, Jun Soo Kwon
PSYCHOPHARMACOLOGY
(2013)
Article
Biochemical Research Methods
Hongyoon Choi, Ji Hoon Phi, Jin Chul Paeng, Seung-Ki Kim, Yun-Sang Lee, Jae Min Jeong, June-Key Chung, Dong Soo Lee, Kyu-Chang Wang