Article
Chemistry, Multidisciplinary
Keliang Li, Shanchao Wu, Gaopan Dong, Yu Li, Wei Wang, Guoqiang Dong, Zhanying Hong, Minyong Li, Chunquan Sheng
Summary: Kirsten rat sarcoma viral oncogene homolog (KRAS)-phosphodiesterase-delta (PDEd) is a promising target for antitumor drug discovery. Highly efficient and environmentally sensitive fluorescent probes of PDEd (DS-Probes) were designed and showed higher binding affinity and selectivity. These probes can conveniently and efficiently label PDEd in live cells and tumor tissues, facilitating PDEd-based mechanism elucidation, drug discovery, and pathologic diagnosis.
CHINESE CHEMICAL LETTERS
(2023)
Article
Engineering, Chemical
Fabio de Moliner, Ina Biazruchka, Karolina Konsewicz, Sam Benson, Suraj Singh, Jun-Seok Lee, Marc Vendrell
Summary: This research optimized a general synthetic approach to prepare a small library of near-infrared-emitting C-bridged nitrobenzodiazoles and identified compound 3i as a potential chemosensor to discriminate between Fe2+ and Fe3+ ions in aqueous media.
FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING
(2022)
Article
Medicine, Research & Experimental
Sam Benson, Alex Kiang, Charles Lochenie, Navita Lal, Syam Mohan P. C. Mohanan, Gareth O. S. Williams, Kevin Dhaliwal, Bethany Mills, Marc Vendrell
Summary: Bacterial infections pose significant challenges to human health, leading to high antibiotic usage, morbidity, hospitalizations, and approximately 8 million deaths worldwide annually. The overuse of antibiotics and lack of antimicrobial innovations have resulted in antimicrobial resistant pathogens that may reverse the progress of modern medicine. Photodynamic therapeutics have the potential to kill bacteria, but there are limited agents that can target pathogens effectively with minimal off-target effects.
Article
Chemistry, Multidisciplinary
Rong Miao, Jing Li, Chao Wang, Xuefeng Jiang, Ying Gao, Xiaoling Liu, Dan Wang, Xin Li, Xiaogang Liu, Yu Fang
Summary: By replacing dialkylated amino donors with an N-methylpyrrole group to enhance twisted intramolecular charge transfer (TICT), a simple and general method to engineer highly environmentally sensitive fluorescent probes is reported. These probes demonstrate outstanding sensitivity to polarity and viscosity, as well as distinct aggregation-induced emission (AIE) characteristics. The molecular design strategy is expected to inspire the creation of many environmentally sensitive probes.
Article
Chemistry, Analytical
Leina Dou, Qing Li, Yuchen Bai, Jiaqian Kou, Xiaonan Wang, Qian Zhao, Xuezhi Yu, Kai Wen, Zhanhui Wang, Jianzhong Shen, Wenbo Yu
Summary: Aggregation-induced emission luminogens (AIE-gens) have great potential for bacterial imaging and detection without complicated labeling or washing steps. In this study, we investigated the mechanism of their bacterial Light-Up behavior using large-scale molecular dynamics simulations. We proposed that the triphenylamine motif of TBP-1 plays a crucial role in the fluorescence turn-on and bacterial Light-Up. Based on this, we developed a heterogeneous lateral flow immunoassay (LFIA) for foodborne pathogen detection with improved sensitivity and specificity.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Analytical
Rubing Han, Jin Yu, Yunpeng Wang, Yuru Chen, Xiaoli Zhang, Rubo Zhang, Jing Jing, Xiaoling Zhang
Summary: Parkinson's disease is a common neurodegenerative disease that is difficult to diagnose early. Nitroxyl has been found to play a role in the formation of Parkinson's disease. However, there is little research on the content of nitroxyl during Parkinson's disease. In this study, a probe called HX-HNO was synthesized to detect the content of nitroxyl in a Parkinson's disease model, showing excellent selectivity and sensitivity.
SENSORS AND ACTUATORS B-CHEMICAL
(2024)
Article
Chemistry, Applied
Qing Kong, Jing Wang, Yahui Chen, Shiyue Zheng, Xiaoqiang Chen, Yihuan Wang, Fang Wang
Summary: This study designed and synthesized three fluorescent probes capable of efficiently detecting esterase, exhibiting high sensitivity and specificity in living cells. Test strip experiments also demonstrated their ability to recognize esterase with remarkable color changes.
Review
Chemistry, Inorganic & Nuclear
Ya-Lin Qi, Hai-Rong Wang, Li-Li Chen, Long Guo, Yu-Yao Cao, Yu-Shun Yang, Yong-Tao Duan, Hai-Liang Zhu
Summary: Imaging biomarkers related to CNS is crucial for studying mental illnesses, with fluorescence imaging being considered as an effective and non-invasive tracking tool. In recent years, an increasing number of fluorescent probes have been proposed for tracking molecules in CNS, providing new possibilities for future medical research.
COORDINATION CHEMISTRY REVIEWS
(2021)
Article
Chemistry, Analytical
Dmytro Dziuba
Summary: Fluorescent nucleoside analogues (FNAs) are important tools in studying the interactions of nucleic acids with nucleic acid-binding proteins. They enable real-time monitoring of binding interactions in solutions, with high sensitivity. FNAs are also used to study the conformational dynamics of biomolecular complexes. Therefore, FNAs have potential applications in fundamental biological research and molecular diagnostics drug discovery.
METHODS AND APPLICATIONS IN FLUORESCENCE
(2022)
Review
Biotechnology & Applied Microbiology
Yue Sun, Manlin Fu, Mianli Bian, Qing Zhu
Summary: Temperature is an important biophysical parameter that is closely related to cellular metabolic activity. Fluorescence probes are ideal for detecting temperature changes in cells due to their sensitivity, selectivity, and noninvasive nature. This paper provides a summary of the recent progress in organic small molecule temperature-sensitive fluorescence probes, including their common response modes, practical applications in living cells and animal models, and the potential for clinical use.
BIOTECHNOLOGY AND BIOENGINEERING
(2023)
Article
Chemistry, Multidisciplinary
Yujie Sun, Zhenzhong Lu, Wenlin Ma, Rui Wang, Chengwu Zhang, Jinhua Liu
Summary: A simple and efficient fluorescent biosensing platform based on porous organic polymer (POP) nanospheres was developed for simultaneous detection of multiplexed DNA. This platform utilizes electrostatic attraction and pi-pi stacking interactions to efficiently quench the fluorescence emission of dye-labeled single-stranded DNA (ssDNA), allowing for quick and sensitive detection of target DNA. The biosensor can sensitively and specifically identify three target DNAs with detection limits as low as 50 pM, and is successfully applied in detecting DNA in human serum for potential early clinical diagnosis.
Article
Engineering, Biomedical
Siddhi Gupta, Deepak Kumar Mishra, Mehak Zahoor Khan, Varsha Saini, Devashish Mehta, Sandeep Kumar, Aditya Yadav, Madhurima Mitra, Parul Rani, Mukesh Singh, Chayan Kanti Nandi, Prasenjit Das, Vineet Ahuja, Vinay Kumar Nandicoori, Avinash Bajaj
Summary: This study presents a fluorescent probe, P4, that can specifically detect mycobacterium species with high sensitivity and specificity. Unlike other enzyme-dependent probes, P4 probe can detect mycobacteria even in fixed mouse and human tissue. Therefore, P4 probe has potential applications in the diagnosis and prognosis of tuberculosis.
ADVANCED HEALTHCARE MATERIALS
(2022)
Article
Chemistry, Organic
Michael Noden, Scott D. Taylor
Summary: The research reported the enantioselective synthesis of two small and environmentally sensitive fluorescent amino acids through alkylation, which exhibit a significant increase in fluorescence as environmental polarity decreases. One of these amino acids was successfully incorporated into a highly active analog of the cyclic lipopeptide antibiotic for probing its interaction with model liposomes, lipopolysaccharides, and live bacteria.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Materials Science, Multidisciplinary
Huadong Liu, Hewei Li, Kezhen Du, Haoxuan Xu
Summary: In this paper, yellow fluorescent carbon dots (Y-CDs) were successfully synthesized and used as sensing probes for the detection of Hg2+ ions. The Y-CDs exhibited excellent performance with high selectivity and low detection limit. Additionally, a portable fluorescence test paper was prepared based on Y-CDs, and the mechanism of fluorescence quenching was investigated by synthesizing Y-CDs@ZIF-8 composites.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Chemistry, Analytical
Wei Feng, Hao Li, Min-Jie Xue, Qiao-Li Zhang, Shi-Lei Liu, Qin-Hua Song
Summary: In this study, four quinoline-2-thiones were developed as fluorescent probes for the rapid and sensitive detection of sulfur mustard gas and its analogues. The probes exhibited high sensitivity and selectivity, showing potential application in the field detection of mustard gas.
ANALYTICA CHIMICA ACTA
(2021)
Article
Biochemistry & Molecular Biology
Yuying Li, Kaixiang Zhou, Wentao Guo, Mengchao Cui
Summary: This study focused on designing 2-phenylbenzoheterocycles with chiral dihydroxyl side chains as beta-amyloid imaging probes, which exhibited good binding affinities and improved brain kinetics compared to existing derivatives. The (S, R)-[F-18]14 probe showed high affinity and specificity to A beta plaques, making it a promising potential PET imaging probe for early diagnosis of Alzheimer's disease.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Physical
Longfei Zhang, Xin Gong, Chuan Tian, Hualong Fu, Hongwei Tan, Jiapei Dai, Mengchao Cui
Summary: This study designed a new series of near-infrared probes with different numbers of conjugated triple bonds for efficient detection of A beta plaques.
JOURNAL OF PHYSICAL CHEMISTRY B
(2021)
Article
Medicine, Research & Experimental
Kaixiang Zhou, Fan Yang, Yuying Li, Yimin Chen, Xiaojun Zhang, Jinming Zhang, Junfeng Wang, Jiapei Dai, Lisheng Cai, Mengchao Cui
Summary: This study evaluated three pairs of optically pure F-18-labeled 2-phenylquinoxaline derivatives as potential Tau imaging agents for AD diagnosis, showing high selectivity and affinity for Tau tangles over A beta. The PET probes (R)-[F-18]5 and (S)-[F-18]16 demonstrated promising brain penetration, kinetics, and stability, making them suitable candidates for Tau tangle imaging.
MOLECULAR PHARMACEUTICS
(2021)
Article
Chemistry, Medicinal
Xiaojun Zhang, Yitian Wu, Qi Zeng, Tianxin Xie, Shulin Yao, Jinming Zhang, Mengchao Cui
Summary: The study designed, synthesized, and evaluated three more lipophilic F-18-labeled PSMA tracers, investigating the effect of lipophilicity on their distribution and excretion in different species. Higher lipophilicity led to increased radioactivity accumulation in the liver of primates and humans, as well as reduced excretion to the bladder through urine. The screened tracer [F-18]8c showed low bladder retention and good imaging properties in patients with prostate cancer.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Longfei Zhang, Xiaojing Shi, Yuying Li, Xiaojiang Duan, Zeyu Zhang, Hualong Fu, Xing Yang, Jie Tian, Zhenhua Hu, Mengchao Cui
Summary: A novel probe PSMA-1092 with high affinity for PSMA was developed for precise tumor resection in radical prostatectomy, showing excellent performance in delineating tumor margin and detecting residual tumors in real-time NIR-II imaging, offering promising potential for clinical practice.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Ying Zhang, Tao Wang, Xiaojun Zhang, Winnie Deuther-Conrad, Hualong Fu, Mengchao Cui, Jinming Zhang, Peter Brust, Yiyun Huang, Hongmei Jia
Summary: In this study, a series of indole-based derivatives were synthesized as novel sigma-2 receptor ligands, and two ligands with high affinity and selectivity were radiolabeled with F-18. Biodistribution studies in rodents showed that the radioligand [F-18]9 displayed high brain uptake and brain-to-blood ratio. Pre-treatment experiments and ex vivo autoradiography confirmed the specific binding of [F-18]9 to sigma-2 receptors in the brain. Dynamic positron emission tomography imaging further confirmed the regional distribution and specific binding of [F-18]9 in the rat brain.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Biotechnology & Applied Microbiology
Jiaying Zhang, Zefang Lin, Xiaojun Zhang, Rong Lin, Mengchao Cui, Weibing Miao, Shaobo Yao
Summary: The injection of Ga-68-DOTA-DiPSMA is safe and associated with low absorbed and effective doses. Ga-68-DOTA-DiPSMA demonstrates favorable kinetics and imaging characteristics, showing potential as an alternative for gallium-68-labeled PSMA clinical PET.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Ying Wang, Li Cai, Kaixiang Zhou, Mengchao Cui, Shaobo Yao
Summary: This study reported a fully automated radiosynthetic procedure of a novel tau tracer [F-18]-S16 and evaluated its safety, biodistribution, and dosimetry in healthy volunteers as well as its potential utility in Alzheimer's disease (AD). The results showed that [F-18]-S16 could be synthesized automatically with favorable biodistribution and safety in humans. [F-18]-S16 PET demonstrated high image quality for imaging tau deposition in AD and distinguishing AD from healthy controls.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Geriatrics & Gerontology
Wei Dong, Meng-Chao Cui, Wen-Zheng Hu, Qi Zeng, Yi-Long Wang, Wei Zhang, Yue Huang
Summary: SQSTM1/p62 plays an important role in the progression of Alzheimer's disease (AD) through its associations with A beta(42) levels in cerebrospinal fluid (CSF) and A beta deposition in the brain of AD patients, as revealed by genetic associations and immunoreactivity analysis.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Review
Chemistry, Multidisciplinary
Yuying Li, Tianqing Liu, Mengchao Cui
Summary: This review summarizes the latest development of Tau tracers and analyzes their chemical structures and biological properties. The limitations of current tracers and considerations for the development of new tracers are also discussed.
CHINESE CHEMICAL LETTERS
(2022)
Article
Geriatrics & Gerontology
Liping Fu, Jinming Zhang, Kaixiang Zhou, Xiaojun Zhang, Hengge Xie, Mingwei Zhu, Mengchao Cui, Ruimin Wang
Summary: This study evaluates the effectiveness of a new tracer, [F-18]-S16, in distinguishing patients with AD from HCs. The results show that [F-18]-S16 exhibits increased cortical uptake in AD patients, suggesting its potential for in vivo detection of tau protein.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Chemistry, Medicinal
Tianxin Xie, Yuying Li, Chuan Tian, Chang Yuan, Bin Dai, Shubo Wang, Kaixiang Zhou, Jiaqi Liu, Hongwei Tan, Yi Liang, Jiapei Dai, Baian Chen, Mengchao Cui
Summary: This study developed a novel probe TNIR7-1A that can selectively detect NFTs and clearly distinguish tauopathy from the control group in vivo.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Yuying Li, Kaixiang Zhou, Xiaojun Zhang, Hailong Zhao, Xiaoming Wang, Ruilin Dong, Yan Wang, Baian Chen, Xiao-xin Yan, Jiapei Dai, Yanying Sui, Jinming Zhang, Mengchao Cui
Summary: We have discovered and developed a class of diaryl-azine derivatives for detecting Afi plaques in the AD brain using PET imaging. After comprehensive assessments, we identified a promising Afi-PET tracer, [18F]92, with high binding affinity to Afi aggregates, significant binding ability with AD brain sections, and optimal brain pharmacokinetic properties. The first in-human PET study showed that [18F]92 displayed low white matter uptake and could bind to Afi pathology for distinguishing AD from healthy controls, making it a promising PET tracer for visualizing Afi pathology in AD patients.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Xu Zhou, Lin-Lin Dong, Yuying Li, Meng-Chao Cui, Lang-Tao Shen
Summary: Prostate-specific membrane antigen (PSMA) is a significant target for prostate cancer diagnosis and therapy. The combination of DUPA with a multidentate bifunctional chelator successfully targets PSMA and forms a new precursor for gallium-68 radiopharmaceutical, DUPA beta-Ala-KC18. This novel compound displays binding affinity to PSMA.
RESULTS IN CHEMISTRY
(2021)